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| Number | Title | Issue Date |
| 7935837 | Process for synthesis of androstane 17-β carbothioic acid and relative compounds thereof A process for synthesis of androstane 17-β carbothioic acid is provided. The process includes mixing an androstane 17-β carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-β carbothioic acid, wherein the androstane 17-... | 05/03/2011 |
| 7893284 | Oestrogen derivatives as inhibitors of steroid sulphatase The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the... | 02/22/2011 |
| 7427610 | 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action Disclosed are compounds of formula I and use thereof in a method of treating a tumor disease that can be influenced positively by the inhibition of tubulin polymerization. ... | 09/23/2008 |
| 7371741 | Estradiol derivatives and pharmaceutical compositions using same Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification. ... | 05/13/2008 |
| 7291609 | Specific glucocorticosteroid compound having anti-inflammatory activity A compound of formula (I): or a physiologically acceptable solvate thereof. ... | 11/06/2007 |
| 7291608 | Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α There are provided compounds of formula (I) wherein the variables are as defined by the present specification; and solvates thereof, processes for preparing them and their use in therapy. ... | 11/06/2007 |
| 7288536 | Specific glucocorticosteroid compound having anti-inflammatory activity A compound of formula (I): wherein X represents O or S; R1 represents C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkylmethyl or C3-8 cy... | 10/30/2007 |
| 7235655 | Processes to prepare eplerenone The present invention involves intermediates, including a 7α-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent. ... | 06/26/2007 |
| 7208613 | Synthesis of s-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate The present invention provides a convenient process for the preparation of S-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate, a compound of formula 1, comprising (a... | 04/24/2007 |
| 7098328 | Method for the preparation of 6α-fluoro corticosteroids A method for producing a 6α-fluorinated corticosteroid or derivative thereof by reacting a 17-hydroxy-21-ester epoxide of Formula II with a stereoselective fluorinating agent to stereoselectively form a 21-ester... | 08/29/2006 |
| 7009063 | Process for the production of oxandrolone The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one; (b) hydroxylating the 17β-hydroxy-17α-methyl-5α-an... | 03/07/2006 |
| 6921757 | Organic compounds Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals ... | 07/26/2005 |
| 6787659 | Process for the production of oxandrolone The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one; (b) hydroxylating the 17β-hydroxy-17α-methyl-5α-an... | 09/07/2004 |
| 6706701 | 6, 7-oxygenated steroids and uses related thereto Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 an... | 03/16/2004 |
| 6689768 | Pharmaceutical preparations for treating side effects during and/or after GnRHa therapy The pharmaceutical preparations for treating side effects, such as hot flashes, prostate enlargement and gynecomastia, during and/or after treatment with analogs or antagonists of gonadotropin-releasing hormone (GnRHa therapy) contain an effective amount ... | 02/10/2004 |
| 6610866 | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces ... | 08/26/2003 |
| 6610675 | Inactive metabolite approach to soft drug design The invention provides novel soft steroidal anti-inflammatory agents, pharmaceutical compositions containing said agents, and methods of administering same to mammals in the treatment of inflammation. Preferred compounds of the invention include haloalkyl... | 08/26/2003 |
| 6596885 | 19-Nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, their use as medicaments and compositions Novel compounds having a formula selected from the group consisting of ##STR1## wherein the substituents are defined as in the specification which are intermediates for the production of vinyl compounds having a remarkable anti-estrogenic and anti-prolife... | 07/22/2003 |
| 6534490 | Unsaturated 14, 15-cyclopropanoandrostanes, method for the production thereof and pharmaceutical preparations containing said compounds Described are new, unsaturated 14,15-cyclopropano-androstanes of general formula (I) and their pharmaceutically acceptable salts, a process for their production and pharmaceutical preparations that contain these compounds. The compounds are characterized ... | 03/18/2003 |
| 6492536 | Steroids, their use as medicaments, their preparation process, the intermediates of this process and the compositions containing them The subject of the invention is the products of formula (I): ##STR1## in which either R1 represents halogen, hydroxyl, (C1 -C8) alkyloxy or (C1 -C12) acyloxy, and R2 represents halogen or h... | 12/10/2002 |
| 6468981 | Compositions and methods for targeting pharmaceutically active materials to cells containing androgen receptors A water soluble delivery system for nucleic acids to cells having androgen receptors, preferably prostate cells, is provided comprising a steroid moiety capable of binding to said receptors, said steroid moiety being covalently linked to a polycationic ma... | 10/22/2002 |
| 6436917 | Non-estrogenic estradiol derivative compounds with anti-oxidative activity New non-estrogenic derivative compounds of estradiol, which have no estrogenic activity and comparatively high anti-oxidative activity, are disclosed. These new non-estrogenic derivative compounds are potentially useful as non-estrogenic antioxidants, esp... | 08/20/2002 |
| 6388109 | 14,15-cyclopropano steroids of the 19-norandrostane series, method for the production thereof and pharmaceutical preparations containing said compounds Described are new 14,15-cyclopropano steroids of the 19-norandrostane series of general formula (I) and their pharmaceutically acceptable salts, a process for their production and pharmaceutical preparations that contain these compounds. The compounds are... | 05/14/2002 |
| 6365582 | S-substitute 11ଲ-benzaldoxime-estra-4, 9-diene-carbonic acid thiolesters, method for the production thereof and pharmaceutical preparations containing these compounds Thiol esters of S-substituted 11ଲ-benzaldoxime-estra-4,9-dien-carboxylic acids of the formula I ##STR1## their pharmaceutically acceptable salts, a method for their synthesis and pharmaceutical preparations containing these compounds are described. ... | 04/02/2002 |
| 6080735 | Estra-1,3,5(10)-trien derivatives, processes for their preparation and pharmaceutical compositions containing these compounds This invention is relating to new estra-1,3,5(10)-trien-sulfamates carrying at the 3-position an R--SO2 --O--group, with R being an R1 R2 N--group in which R1 and R2, independently of each other, repr... | 06/27/2000 |
| 5977096 | Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment of diseases due to radical-mediated cell damage. The novel... | 11/02/1999 |
| 5972922 | Steroids which inhibit angiogenesis Novel angiostatic Ɗ4,9(11) -steroids (I), ##STR1## C21 -oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a need for the same. These steroids ... | 10/26/1999 |
| 5914325 | Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances Disclosed are estrane derivatives having a radical-attracting aromatic substituent of the general formula --(CH2)n X attached to the 17-position of the steroid nucleus, wherein X and n are as defined by the specification. The compoun... | 06/22/1999 |
| 5866560 | 7-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ... | 02/02/1999 |
| 5859266 | "N-T-butyl-androst-3-5-diene-17 ଲ-carboxamide-3-carboxylic" acid polymorph A Polymorph "A" a novel polymorphic form of N-t-butyl-androst-3,5-diene-17ଲ-carboxamide-3-carboxylic acid. Novel processes for preparing polymorph "A" are also disclosed.... | 01/12/1999 |
| 5760025 | Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses Compounds of formula (I): ##STR1## wherein: R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R2 is: aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R... | 06/02/1998 |
| 5723455 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 03/03/1998 |
| 5717088 | Method of making steroid derivatives for the treatment of prostatic hypertrophy Compounds of formula (I): ##STR1## wherein: R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R2 is: aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R... | 02/10/1998 |
| 5698720 | Steroid derivatives The invented compound ##STR1## is useful for the production of steroidal-17-amides that have 5-reductase inhibitory activity.... | 12/16/1997 |
| 5693629 | Progesterone compound and use thereof A progesterone compound represented by the following formula (1): ##STR1## wherein R1 represents a C1-C23 hydrocarbon group!, and a neovascularization inhibitor containing the same as the active ingredient. The compound (1) has a potent neova... | 12/02/1997 |
| 5683995 | 17 substituted acyl-3-carboxy 3,5-diene steroidals as -reductase inhibitors Invented are 17 and 17ଲ-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5--reductase. Als... | 11/04/1997 |
| 5641765 | 17-댚nd 17-ଲsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5--reductase Invented are 17 and 17ଲ-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5--reductase. Als... | 06/24/1997 |
| 5641877 | 17- and 17-ଲ substituted acyl-3-carboxy-3, 5-dienes and use in inhibiting 5--reductase Invented are 17 and 17ଲ-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5--reductase. Als... | 06/24/1997 |
| 5633392 | Estrenes for inducing hypothalamic effects The invention relates to estrene steroids, which bind to neuroepithelial receptors. The steroid is preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.... | 05/27/1997 |
| 5618806 | 17 and 17ଲ-substituted estra-1,3,5(10)-triene-3-carbboxlic acid Invented are 17 and 17ଲ-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds. Representative of such compounds include the following ##STR1## wherein Z is or ଲ ##STR2## in which A ... | 04/08/1997 |
