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| Number | Title | Issue Date |
| 8183402 | Industrial method for the synthesis of 17-acetoxy-11β[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process The present invention relates to a process for the synthesis of the 17-acetoxy-11β-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I): from 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(11)-d... | 05/22/2012 |
| 8044223 | Crystalline 19-norsteroids The present invention are two crystalline salts, 17α-acetoxy-21-methoxy-11β-(4-,N,N-dimethylaminophenyl)-19 norpregna-4,9-diene-3,20-dione hydrochloride and 17α-acetoxy-21-methoxy-11β-(4-,N,N-dimethylaminophenyl)-19 norpregna-4,9-diene-3,20-dione hydrobromide, o... | 10/25/2011 |
| 7235655 | Processes to prepare eplerenone The present invention involves intermediates, including a 7α-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent. ... | 06/26/2007 |
| 7087591 | 21-substituted progesterone derivatives as new antiprogestational agents A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —C... | 08/08/2006 |
| 6900193 | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents The present invention relates, inter alia, to compounds having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)... | 05/31/2005 |
| 6861415 | 21-substituted progesterone derivatives as new antiprogestational agents A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, â€... | 03/01/2005 |
| 6768014 | PROCESS FOR PREPARING 17α-ACETOXY-11β-[4-N,N(DIMETHYLAMINO)PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIENE-3,20-DIONE, INTERMEDIATES USEFUL IN THE PROCESS , AND PROCESSES FOR PREPARING SUCH INTERMEDIATES A compound having general formula (I) in which R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH3 and —CHOHCH3; R | 07/27/2004 |
| 6365582 | S-substitute 11ଲ-benzaldoxime-estra-4, 9-diene-carbonic acid thiolesters, method for the production thereof and pharmaceutical preparations containing these compounds Thiol esters of S-substituted 11ଲ-benzaldoxime-estra-4,9-dien-carboxylic acids of the formula I ##STR1## their pharmaceutically acceptable salts, a method for their synthesis and pharmaceutical preparations containing these compounds are described. ... | 04/02/2002 |
| 6037339 | C-11 substituted steroids for treating menopausal complaints A C-11 substituted steroid and a method of use of a C-11 substituted steroid to treat osteoporosis.... | 03/14/2000 |
| 5723638 | Process for 20-oxo-17,21-diol steroids The invention is drawn to a process for the preparation of a steroid of the formula ##STR1## wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and theo A, B, C, and D ring system has at ... | 03/03/1998 |
| 5710144 | C-11 substituted steroids for treating menopausal complaints A C-11 substituted steroid and a method of use of a C-11 substituted steroid to treat osteoporosis.... | 01/20/1998 |
| 5710293 | Method of preparation of ester derivatives of steroids The present invention relates to a method of using a perchloric acid catalyzed reaction to make acyl derivatives of norprogesterone compounds and, in particular, 16-methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione.... | 01/20/1998 |
| 5616742 | Process for preparing ÆŠ9,11 and 21-chloro corticosteroids Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2 Cl2 and imidazole, or PPh3 and CCl4. The disclosed process ... | 04/01/1997 |
| 5608093 | Corticosteroid 17-alkyl carbonate 21-[0]-carboxylic and carbonic esters, and pharmaceuticals containing these compounds Corticoid 17-alkyl carbonate 21-carboxylic and carbonic esters of the formula I ##STR1## are described in which A is CHOH and CHCl, CH2, C.dbd.O or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH3 ; R(1) is aryl or heta... | 03/04/1997 |
| 5502222 | Process for preparing delta 9,11 and 21-chloro corticosteroids Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO.sub. Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selecti... | 03/26/1996 |
| 5446036 | 13-alkyl-11beta-phenylgonanes There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R2 is alpha- or beta-position methyl or ethyl; R1 is selected from heteroaryl radicals, cycloalkyl radicals, cycloalkenyl r... | 08/29/1995 |
| 5412091 | 16-methyl-ÆŠ1,4-pregnadiene-3,20-dione A compound of the formula ##STR1## in which ##STR2## is either a 3-keto-ÆŠ4-system or a 3-keto -ÆŠ1,4-system or a 3-OR4 - ÆŠ5-system in which R4 is hydrogen or a protector group of hydroxy, R is methyl --CH2... | 05/02/1995 |
| 5352808 | Process for steroid preparation A process for the preparation of a compound of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl a... | 10/04/1994 |
| 5273971 | 13-alkyl-11ଲ-phenylgonanes There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R2 is alpha- or beta-position methyl or ethyl; R1 is selected from heteroaryl radicals, cycloalkyl radicals, cycloalkenyl r... | 12/28/1993 |
| 4956482 | Process for the preparation of pregnane derivatives Known pregnane derivatives are prepared by esterification of know androstane derivatives to give new esters of Formula III ##STR1## wherein in each case symbolizes a single bond or a double bond, n is 1 or 2, R1 is hydrogen or methyl, R2... | 09/11/1990 |
| 4948533 | 11a-hydroxy steroid diester The present invention relates to 21-(3-carboxy-1-oxopropoxy) -17-hydroxy-11-(3,3-dimethyl-1-oxobutoxy)pregna-1,4-diene-3, 20 dione and pharmaceutically acceptable salts thereof which are useful steroid prodrugs.... | 08/14/1990 |
| 4933332 | 11-desoxy-17--hydroxycorticosterone derivatives 11-Desoxy-17-hydroxycorticosterone derivatives of the general formula: ##STR1## wherein R is --OC(CH2)n C6 H4 N(CH2 CH2 Cl)2, n=1,3.... | 06/12/1990 |
| 4929395 | 16-methylation process C16 -unsaturated corticoids are readily transformed to the corresponding 16-methyl-17-hydroxy corticoids by use of a ÆŠ17 (20)-20-silyl ether.... | 05/29/1990 |
| 4921638 | 17ଲ-cyano-9,17-dihydroxyandrost-4-en-3-one The invention is the compound 17ଲ-cyano-9, 17-dihydroxyandrost-4-en-3-one (I) which is particularly useful as an intermediate in the production of the 17-halo silyl ethers (II).... | 05/01/1990 |
| 4920216 | Selective chlorination of steroids and other substrates directed by covalently linked pyridine derivatives acting as templates This invention concerns a method of substituting a chlorine atom for a predetermined hydrogen atom located within an organic compound which comprises contacting the organic compound containing the predetermined hydrogen atom with an esterifying agent comp... | 04/24/1990 |
| 4913852 | Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with pregnane derivatives Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of ÆŠ-4-pregnene-3,20-dione or with derivatives of ÆŠ-1,4-pregnadiene-3,20-dione of the general formulas (I), (II) and (III), having glucoco... | 04/03/1990 |
| 4870069 | 11ଲ-alkynyl-estrenes and -estradienes, their production and pharmaceutical preparations containing them 11ଲ-substituted steroids of the formula ##STR1## wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pentagonal ... | 09/26/1989 |
| 4831131 | 11ଲ,17-Dihydroxy-17ଲ-cyano-androstanes Using cyanohydrin intermediates, 17-keto steroids are transformed to corticoids and 17-acyl progesterones.... | 05/16/1989 |
| 4810701 | 11-desoxy-17-hydroxycorticosterone derivatives 11-Desoxy-17-hydroxycorticosterone derivatives of the general formula: ##STR1## wherein R is --OC(CH2)n C6 H4 N(CH2 CH2 Cl)2, n=1,3.... | 03/07/1989 |
| 4708823 | 17 -chloroethynyl pregnane derivatives Known pregnane derivatives are prepared by esterificiation of known androstane derivatives to give new ester of Formula III ##STR1## wherein in each case symbolizes a single bond or a double bond, n is 1 or 2, R1 is hydrogen or methyl, R | 11/24/1987 |
| 4704455 | 16-methylatedÆŠ17(20)-corticoids C16 -unsaturated corticoids are readily transformed to the corresponding 16-methyl-17-hydroxy corticoids by use of a ÆŠ17 (20)-20-silyl ether.... | 11/03/1987 |
| 4655971 | Novel process for the preparation of steroidal esters A process for the preparation of corticosteriod esters of the formula ##STR1## in which ---- signifies that a double bond can be present; X is hydrogen, chlorine or fluorine; R1 is hydrogen, fluorine, chlorine or methyl, which may be either &#x... | 04/07/1987 |
| 4634695 | Steroid derivatives Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the... | 01/06/1987 |
| 4613463 | Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid This invention discloses an improved process for the production of corticoids from 17-hydroxy steroids utilizing peroxymonosulfate.... | 09/23/1986 |
| 4600538 | Corticosteroids from 17-keto steroids via 20-cyano-ÆŠ17 (20)-pregnanes The process of the present invention transforms 17-keto steroids (I) to the corresponding corticoids (IV) in three steps.... | 07/15/1986 |
| 4588718 | Carboxy containing ester prodrugs of corticosteroids A compound of the formula ##STR1## wherein St represents a corticosteroid moiety bonded to the carbonyl via the 21-hydroxy group of said corticosteroid; wherein Z is a bond or --O--; wherein n is an integer from 4 to 9; wherein Q is (1) Y--CH2 ... | 05/13/1986 |
| 4588530 | Anti-inflammatory prednisolone steroids Derivatives of prednisolone of the formula ##STR1## wherein CR1 is C.dbd.O, -HCOH, ଲ-HCOH, or a mixture of -HCOH and ଲ-HCOH CR2 is HC(OH) OR6 or HCO when CR1 is C.dbd.O; CR2 | 05/13/1986 |
| 4585591 | 17ଲ-ethynylsteroids and process for preparing same This is disclosed novel intermediates, i.e. 17ଲ-ethynylsteroids, which are useful for the preparation of corticoids such as hydrocortisone and prednisolone, and a process for preparing the same.... | 04/29/1986 |
| 4568492 | ÆŠ16-20-Keto steroid conversion to 17-hydroxy-20-keto steroids ÆŠ16-20-keto steroids (I) are converted to 17-hydroxy-20-keto steroids (III) in 2 steps, hydrosilylation followed by peracid oxidation.... | 02/04/1986 |
| 4567002 | Process for the preparation of 17-haloethynyl steroids, and novel 17-haloethynyl steroids 17-haloethynyl steroids of the partial formula ##STR1## wherein R1 is hydrogen or methyl, R2 is alkyl of 1-4 carbon atoms, acyl of 1-7 carbon atoms, trimethylsilyl, 2-tetrahydropyranyl, or nitrate, X is bromine or iodine, and V is me... | 01/28/1986 |
