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| Number | Title | Issue Date |
| 7868194 | Process for the preparation of 21-hydroxy steroids with control of the epimeric distribution at the C-21 position A process is described for preparing, exclusively by chemical way, 21-hydroxy steroids having progestinic activity, said process having a high stereochemical control at C-21 position. ... | 01/11/2011 |
| 7064116 | GABAmodulating neurosteroids The present invention relates to novel steroid derivatives that ace on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex as well as methods for making the same and their applications to induce anesthesia, in the treatment of stress, anxiety, PMS, ... | 06/20/2006 |
| 6967195 | 2-substituted pregna-1-3,5(10) triene and chola-1,3,5(10) triene derivatives and their biological activity Compounds of formula (I) in which: R1 represents a hydrogen atom or an O-protecting group; R2 represents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; R3 represe... | 11/22/2005 |
| 6953785 | Estra-1,3,5(10)-triene derivatives Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I): {wherein R1 and R2 are the same or differen... | 10/11/2005 |
| 6790970 | (Meth) acrylic acid ester compound The present invention provides a novel (meth)acrylic acid ester compound useful as a resin material for photosensitive compositions, which enables control of the molecular weight of a resin to be prepared. The novel (meth)acrylic acid ester compound is one represent... | 09/14/2004 |
| 6653491 | Method for producing 4,4-dimethyl-3ଲ-hydroxypregna-8, 14-diene-21-carboxylic acid esters and intermediate products obtained by said method The invention relates to a method for representing compounds of the general formula (1). The invention further relates to the hitherto unknown compounds of general formulas (5, 6 and 7) in the form of intermediate products and to the use of 4,4-dimethyl-3... | 11/25/2003 |
| 6635774 | Preparation of sterol and stanol-esters The present invention provides a method for the direct esterification of stanols and sterols with fatty acids to form stanol/sterol-esters. The method provides a synthetic route that is amenable to large scale production of the esters in high yields. A pr... | 10/21/2003 |
| 6608220 | Conversion of bisnoralcohol to bisnoraldehyde The present invention is a process for the conversion of bisnoralcohol to bisnoraldehyde (II), which is a known intermediate in the synthesis of progesterone. ##STR1##... | 08/19/2003 |
| 6552011 | (Androst-5-en-17beta -yl)alkyl sulfoxides and sulfones and their use for control of fertility ##STR1## The invention relates to (androst-5-en-17beta-yl)alkylsulfoxides and sulfones having general formula (I), wherein R1, R2, R3, X and Y are defined in the specification. The compounds of the invention have meiosis inhibiting activity and can be use... | 04/22/2003 |
| 6497987 | Photosensitive lithocholate derivative and chemically amplified photoresist composition containing the same A photosensitive compound, and a chemically amplified photoresist composition containing the photosensitive compound, maintain transparency even when exposed to a short-wavelength light source of 193 nm or below, and exhibit improved adhesion to an underl... | 12/24/2002 |
| 6437156 | 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that the ... | 08/20/2002 |
| 6432938 | 19-nor-cholane steroids as neurochemical initators of change in human hypothalamic function The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that the ... | 08/13/2002 |
| 6313327 | Carboxylic acid derivatives and their synthesis method This invention relates to novel carboxylic acid derivatives represented by the following formula I and their synthesis: ##STR1## wherein, R1 is an hydrogen atom, an alkyl group or an alkoxy group of 1 to 20 carbon atoms in a linear, branched or... | 11/06/2001 |
| 6262282 | 17ଲ-allyloxy(thio)alkyl-androstane derivatives for the modulation of meiosis The invention relates to 17ଲ-allyloxy(thio)alkyl-androstane derivatives having general formula (I) wherein R1 is (H, OR), (H, OSO3 H) or NOR; with R being H, (C1-6)alkyl or (C1-6)acyl; each of R2 | 07/17/2001 |
| 6177420 | 20-aralkyl-5-pregnane derivatives The invention relates to 20-aralkyl-5-pregnane derivative having general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is (H,OR), (H,OSO3 H) or NOR; R is H, (C1-6)alkyl or (C1-6)a... | 01/23/2001 |
| 6080735 | Estra-1,3,5(10)-trien derivatives, processes for their preparation and pharmaceutical compositions containing these compounds This invention is relating to new estra-1,3,5(10)-trien-sulfamates carrying at the 3-position an R--SO2 --O--group, with R being an R1 R2 N--group in which R1 and R2, independently of each other, repr... | 06/27/2000 |
| 6046186 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) wherein r1 is an optional double bond, R1 and R2 are selected from the group consisting of hydrogen and lower alky,... | 04/04/2000 |
| 5994333 | Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that... | 11/30/1999 |
| 5847173 | 21-nor-vitamin D compounds 21-norvitamin D3 analogs in which the methyl group normally attached to the side chain at carbon 20 has been replaced by a hydrogen atom. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lo... | 12/08/1998 |
| 5792759 | 17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl cyclopentaneperhydrophenanthrene derivatives active on the cardiovascular system, a process for their preparation and pharmaceutical compositions containing the same Novel 17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl steroids of the general formula (I) ##STR1## where A, R1 and R2 are defined in the specification are disclosed. The compounds have cardiovascular activity. Pharmaceutic... | 08/11/1998 |
| 5723455 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 03/03/1998 |
| 5541348 | Bile acids for biological and chemical applications and processes for the production thereof Novel bile acids according to the general formula ##STR1## wherein R1 represents a hydroxyl group, R2 and R3 both represent a hydrogen or a hydroxyl group, or R2 represents a hydroxyl group or a ଲ hyd... | 07/30/1996 |
| 5523428 | Process for the production of 1-methyl-3-keto-Ɗ1,4 steroids A process for the production of 1-methyl-3-keto-Ɗ1,4 steroids of general formula I ##STR1## in which St symbolizes the radical of asteroid molecule, where a 3-keto-Ɗ1,4 steroid of general formula II ##STR2## in which... | 06/04/1996 |
| 5508453 | Intermediate for use in the preparation of taurocholanic acids The present invention relates to intermediates for use in the preparation of taurocholanic acids. The intermediates have the following formula (IV): ##STR1## in which A completes the 5ଲ-cyclopentaneperhydrophenanthrene structure of a cholanic a... | 04/16/1996 |
| 5496813 | Spontaneously dispersible concentrates and aqueous microemulsions with steryl retinates having anti-tumor activity There are described spontaneously dispersible agents containing sterolester and/or sterolphosphor compounds having a pronounced antitumour activity. Novel sterolesters and sterolphosphor compounds, their use for treating tumors, and processes for their pr... | 03/05/1996 |
| 5273971 | 13-alkyl-11ଲ-phenylgonanes There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R2 is alpha- or beta-position methyl or ethyl; R1 is selected from heteroaryl radicals, cycloalkyl radicals, cycloalkenyl r... | 12/28/1993 |
| 5272140 | 11-aryl steroid derivatives The invention relates to 11-aryl steroid derivatives, having the structure ##STR1## wherein: R1, R2, R3, and R4 are as described in the specification and to processes for their preparation and to pharmaceutical... | 12/21/1993 |
| 5140106 | Process for the production of 3-deoxy-4-ene steroids A process for the production of 3-deoxy-4-ene steroids of the general formula I ##STR1## is described, in which R1, R2 and R3 mean a hydrogen atom or a methyl group, R4 represents a lower alkyl group, a phe... | 08/18/1992 |
| 5120724 | Aldosterone biosynthesis inhibitor Aldosterone biosynthesis inhibitors having substantially no intrinsic antiandrogenic activity are disclosed as well as pharmaceutical compositions containing such compounds and methods of treatment utilizing these compositions.... | 06/09/1992 |
| 5086047 | Novel steroids A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl, alkylthio and haloalkyl of 1 to 6 carbon atoms, alkenyl and alkynyl of 2 to 6 carbon atoms, option... | 02/04/1992 |
| 5064822 | Novel 3-keto-19-nor-Ɗ4,9 -steroids Novel 3-keto-19-nor-Ɗ4,9 -steroids of the formula ##STR1## wherein R1 is selected from the group consisting of naphthyl, phenylphenyl, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms optionally containing additiona... | 11/12/1991 |
| 5041433 | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5--reductase Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase.... | 08/20/1991 |
| 4940700 | Seco-sterol compounds effective in inducing cell differentiation The invention provides new seco-sterol compounds which are effective in inducing the differentiation of malignant cells and are therefore useful for the treatment of malignancies such as leukemia.... | 07/10/1990 |
| 4927815 | Compounds effective in inducing cell differentiation and process for preparing same This invention provides novel side chain homologs of 1,25-dihydroxyvitamin D3 which exhibit enhanced and highly selective activity in inducing differentiation of malignant cells. It also provides a general method of synthesis applicable ... | 05/22/1990 |
| 4879069 | Fluorescent conjugated polyene sterol derivatives as cell membrane probes The present invention relates to the synthesis of conjugated polyene sterol derivatives, the compounds obtained and to their use as fluorescent probes for cellular membranes. The fluorescent probes of the present invention resemble cholesterol both struct... | 11/07/1989 |
| 4857518 | Hydroxylated 24-homo-vitamin D derivatives and methods for preparing same This invention is directed to new 24-homo-vitamin D compounds, to methods for preparing the same and novel intermediate compounds. The compounds are characterized by vitamin D-like activity of the order of 1,25-dihydroxyvitamin D3, the recogn... | 08/15/1989 |
| 4847012 | Vitamin D related compounds and processes for their preparation The invention relates to a method for preparing vitamin D-related compounds and to certain intermediate compounds in such process. The intermediate compounds are characterized by an aldehyde or ester in the C-22 position in the side chain. The presence of... | 07/11/1989 |
| 4717721 | Sidechain homo-vitamin D compounds with preferential anti-cancer activity This invention relates to a method for enhancing cell differentiation in malignant cells by exposing the cells to a 1-hydroxylated vitamin D derivative characterized by a 17-side chain greater in length than the cholesterol or ergosterol side chain... | 01/05/1988 |
| 4588528 | 1,24-dihydroxy-Ɗ22 -vitamin D3 and process for preparing same The invention provides new derivatives of vitamin D3 and specifically (22E,24R)-1,24-dihydroxy-Ɗ22 -vitamin D3 and (22E,24S)-1,24-dihdroxy-Ɗ22 -vitamin D3. The compounds exhibit vitamin D-like activity i... | 05/13/1986 |
| 4568491 | Process for the preparation of cholesterol derivatives and novel intermediates therefor The invention is concerned with a process for the preparation of 1 hydrogen or hydroxy cholesterol derivatives and intermediates therefor. The compounds of the present invention are useful as intermediates in the preparation of 24,25-dihydroxy and 1³... | 02/04/1986 |
