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| Number | Title | Issue Date |
| 7220730 | Cancer specific radiolabeled conjugates regulated by the cell cycle for the treatment and diagnosis of cancer Radiolabeled conjugates are disclosed which have a component that is effective to target tumor cells, which cells selectively take up and degrade the conjugate, thereby delivering to the tumor cell nucleus a radioisotope capable of being incorporated into the nuclea... | 05/22/2007 |
| 7196074 | Methods of making, using and pharmaceutical formulations comprising 7α, 11β-dimethyl-17β-hydroxyestra-4, 14-dien-3-one and 17 esters thereof Methods of using 7α,11β-dimethyl-17β-hydroxyestra-4,14-dien-3-one (III) and 17 esters thereof for various hormonal therapies, oral and parenteral dosage forms comprising these actives, and processes for their ... | 03/27/2007 |
| 7018994 | 17α-ALKYL-17β-OXY-ESTRATRIENES AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, USE OF THE 17α-ALKYL-17β-OXY-ESTRATRIENES FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS AS WELL AS PHARMACEUTICAL PREPARATIONS The invention relates to 17α-alkyl-17β-oxy-estra-1,3,5(10)-trienes that have an antiestrogenic action with general formula I. In addition, the invention also relates to 17-oxo-estra-1,3,5(10)-trienes as well as 17β-hydroxy-estra-1,3,5(10)-trienes as intermediate ... | 03/28/2006 |
| 6780854 | Orally active androgens Novel, orally active androgens are 7α-substituted Δ14-nandrolone derivatives. The compounds satisfy the general formula: wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1... | 08/24/2004 |
| 6756366 | Orally active androgens Orally Active androgens are derivative of 7α-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6)alkyl, or (C1-6)acyl; R2 is selected from the gro... | 06/29/2004 |
| 6541465 | Orally active androgens Novel, orally active androgens are 7-substituted Ɗ14 -nandrolone derivatives. The compounds satisfy the general formula: ##STR1## wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C... | 04/01/2003 |
| 6080735 | Estra-1,3,5(10)-trien derivatives, processes for their preparation and pharmaceutical compositions containing these compounds This invention is relating to new estra-1,3,5(10)-trien-sulfamates carrying at the 3-position an R--SO2 --O--group, with R being an R1 R2 N--group in which R1 and R2, independently of each other, repr... | 06/27/2000 |
| 5955622 | Method for the preparation of steroid derivative ketal The invention relates to a method for the preparation of a compound of formula II: ##STR1## wherein a compound of formula V: ##STR2## is condensed with a compound of the formula CH3 -C(OR4 O)-(CH2)3 | 09/21/1999 |
| 5952319 | Androgenic steroid compounds and a method of making and using the same An androgenic steroid compound of the formula: ##STR1## wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.... | 09/14/1999 |
| 5866560 | 7-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ... | 02/02/1999 |
| 5795884 | 3-keto-nor-pregnenes substituted in the 6-position and treatment of menopause A 3-keto-19-nor-pregnene of the formula ##STR1## wherein R is selected from the group consisting of hydroxy, acyloxy of an organic carboxylic acid, lower alkoxy, halogen and lower alkyl, R' is selected from the group consisting of hydrogen and haloge... | 08/18/1998 |
| 5319115 | Method for making 3-hydroxy, 3ଲ-substituted-pregnanes This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3-hydroxy,3ଲ-substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereoselectively into... | 06/07/1994 |
| 5096694 | Compounds which are useful, in particular, for radiotherapy or imaging of cancer Compound useful particularly for the treatment by targetted radiotherapy or imaging of cancer, characterized in that the compound is comprised of a molecule susceptible of fixing itself or passing close to the DNA of the target cells, said molecule being ... | 03/17/1992 |
| 5034548 | Steroid derivatives useful as hypocholesterolemics Lanosterols substituted in the 14 and/or 15 position(s) which are active in inhibiting lanosta-8,24-dien-3ଲ-ol 14-methyl-demethylase activity, suppressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity, decreasing cholesterol... | 07/23/1991 |
| 5002753 | Specific ligands for estrogen and progestagen steroid hormone receptors, application and intermediate synthesis products The present invention relates to specific ligands for estrogen or progestagen steroid hormone receptors which have the formula ##STR1## in which X denotes a vinyl group substituted by a radioactive or nonradioactive halogen on the double bond accordi... | 03/26/1991 |
| 5001119 | 16-substituted androstanes and 16-substituted androstenes Compounds of the formula: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.... | 03/19/1991 |
| 4970205 | Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5--reductase Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to redu... | 11/13/1990 |
| 4954446 | Aromatic steroid 5--reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5--reductase including using these compounds to reduce prosta... | 09/04/1990 |
| 4946834 | Phosphonic acid substituted steroids as steroid 5-reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-reductase. Also invented are intermediates used in prepari... | 08/07/1990 |
| 4920114 | 19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors 19-Fluoro- and cyano- substituted 21-hydroxyprogesterone derivatives and related compounds which are active as 19-hydroxylase inhibitors and useful as antihypertensive agents are described herein. The compounds are prepared using appropriate synthetic pat... | 04/24/1990 |
| 4557867 | 11ଲ-Difluoromethyl and (E)- and (Z)-11-fluoromethylene steriods Known reactions are arranged in a novel manner to produce 11ଲ-difluoromethyl and (E)- and (Z)-11-fluoromethylene 19-norandrostenediones and 19-nor-13ଲ-ethylandrostenediones which are useful as contraceptive agents.... | 12/10/1985 |
| 4416822 | 17ଲ-Difluoromethyl steroids 17ଲ-Difluoromethyl steroids are disclosed which have progestational, antiprogestational activity and which are useful as and male and female contraceptive agents.... | 11/22/1983 |
| 4312864 | Branched chain and cycloaliphatic esters of the androstane and destrane series and pharmaceutical compositions containing same There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: ##STR1## or the 5H analog thereof. The steroid esters have androgenic, anabolic, oestrogenic or anti-oestrogenic properties depending upon the ri... | 01/26/1982 |
| 4307087 | Branched chain and cycloaliphatic esters of the androstane and oestrane series and pharmaceutical compositions containing same There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: ##STR1## where R is H or CH3 ; R1 is H or CH3 ; R2 is H or CH3 ; R3 is H, OH, CH3 or ... | 12/22/1981 |
| 4307086 | Branched chain and cycloaliphatic esters of the androstane and destrane series and pharmaceutical compositions containing same There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: ##STR1## where R is H or CH3 ; R1 is H or CH3 ; R2 is H or CH3 ; R3 is H, OH, CH3 or ... | 12/22/1981 |
| 4248790 | Gona-4,9(10)-dienes and process of producing the same New gona-4,9(10)-dienes of formula I ##STR1## where R is alkyl of 1 to 3 carbon atoms and X is Cl, Br, F, N3, SCN, CN, OH, OR'(R'-alkyl), NH2, a substituted amino group or a heterocyclic compound including nitrogen in the ring. ... | 02/03/1981 |
| 4242334 | Corticoid 17-(alkyl carbonates) and processes for their preparation What is disclosed is corticoid 17-(alkyl carbonates) of the formula ##STR1## as defined in the specification, which compounds can be used in veterinary therapy and human therapy, in the form of suspensions, ointments, creams, sprays and the like, for... | 12/30/1980 |
| 4212864 | Branched chain and cycloaliphatic esters of the androstane and oestrane series and pharmaceutical compositions containing same There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: ##STR1## or the 5H analog thereof, where R is H or CH3 ; R1 is H or CH3 ; R2 is H or CH3 ; R3 | 07/15/1980 |
| 4185101 | 1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor 1,3,5(10),6,8-19-Nor-pregnapentaene-20-ones exhibit anti-mitotic activity with minimal or no hormonal activity. They are particularly useful in the treatment and control of psoriasis when applied topically, preferred anti-psoriatic compounds being 1,... | 01/22/1980 |
| 4172132 | 1,3,5(10),6,8,14-19-Nor-pregnahexaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor 1,3,5(10),6,8,14-19 Nor-pregnahexaene-20-ones exhibit anti-mitotic activity with minimal or no hormonal activity. They are particularly useful in the treatment and control of psoriasis when applied topically, a preferred anti-psoriatic compound being ... | 10/23/1979 |
| 4167517 | Gona-4,9(10)-dienes and process of producing the same New gona-4,9(10)-dienes of formula I ##STR1## where R is alkyl of 1 to 3 carbon atoms and X is Cl, Br, F, N3, SCN, CN, OH, OR'(R'=alkyl), NH2, a substituted amino group or a heterocyclic compound including nitrogen in the ring. ... | 09/11/1979 |
| 4092310 | Difluorosteroids and processes for their manufacture A novel group of 18,18-difluorosteroids of the general formula ##STR1## wherein St, R1 and R2 have the meanings given hereinafter is produced by a chemically novel process characterized in that a corresponding 18-oxo compound is... | 05/30/1978 |
| 4083947 | Organ visualization Novel selenium derivatives of steroids have the formula I, ##STR1## where X is hydrogen or acyl, Y is hydrocarbon and n is 0 or 1, preferably 0. Such compounds, labelled with selenium-75 are of use for investigating body function, particularly for im... | 04/11/1978 |
| 4075334 | 6ଲ-Iodomethyl-19-norcholest-5(10)-en-3ଲ-ol and compositions containing same Iodinated compounds useful for photoscanning the adrenal glands.... | 02/21/1978 |
| 4073900 | 11ଲ-FLUOROPREGNENES 11ଲ-Fluoropregnenes of the formula ##STR1## wherein 6 7 IS A SINGLE OR DOUBLE BOND, R1 and R2 each are H or collectively CH2 or a single bond; R3 is H or, when 6 7 is a double bond, H, F or Cl, X or O or HOR... | 02/14/1978 |
| 4031075 | Alkylated pregnanes and process for obtaining same The invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## WHEREIN X = H or halogen; Y = h2, h(oh), h(oacyl), O or H(halogen); R1 = an alkyl group having 1-4 C-atoms; R2 = r | 06/21/1977 |
| 4001220 | 6-(Aminated methyl)-3ଲ-oxy-5-(cholestane-stigmastane)-5,6-diols, salts thereof, and intermediates thereto Preparation and the analgesic, antiulcerogenic, hypolipemic, and antimicrobial activity of 6-(aminated methyl)-3ଲ-oxy-5-(cholestane/stigmastane)-5,6-diols, salts thereof, and intermediates thereto are disclosed.... | 01/04/1977 |
| 3998813 | Process for the preparation of 11ଲ-hydroxy-18-alkyl-estrane compounds The present invention relates to a novel process for the preparation of 11ଲ-hydroxy-18-alkyl-estrane compounds by reacting an 11ଲ-hydroxy-13-methyl-gonane compound with an acylhypoiodite to give an 11ଲ-hydroxy-13-iodomethyl-gonane compou... | 12/21/1976 |
| 3998701 | Process for the preparation of 17-acyl esters of 17, 21-dihydroxysteroids of the pregnane series and novel products A process is disclosed for making 17-monoesters of 17 , 21-dihydroxy steroids by acylating a 17 , 21-dihydroxy steroid phosphate and then subjecting the intermediate 17-acyloxy-21-phosphate to dephosphorylation using an acid phosphatase to a... | 12/21/1976 |
| 3984544 | Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor Novel retinoic acid esters of anti-inflammatory steroids of the pregnane series are described and their use in the treatment and control of acne vulgaris via the topical or intralesional route. A preferred mode of the invention comprises treating acne by ... | 10/05/1976 |
