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| Number | Title | Issue Date |
| 6921757 | Organic compounds Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals ... | 07/26/2005 |
| 6054446 | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecul... | 04/25/2000 |
| 5986115 | 7-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ... | 11/16/1999 |
| 5981517 | Androstene derivatives The invention provides new androstene derivatives having anti-inflammatory activity, pharmaceutical compositions containing them, and methods of administering them to warm-blooded animals in the treatment of inflammation. The active compounds are alkyl ... | 11/09/1999 |
| 5866560 | 7-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ... | 02/02/1999 |
| 5262090 | 16-benzalandrosta-1,4-diene-3,17-dione compounds and non-linear optical material Non-linear optical materials using a 16-benzalandrosta-1,4-diene-3,17-dione compound represented by the formula [I] ##STR1## wherein R is hydrogen, alkyl or other specified substituents, have a high non-linear optical constant, and can provide a non-... | 11/16/1993 |
| 5252564 | Method to decrease cortisol secretion by feeding melengesterol acetate A method for decreasing the adrenal secretion of glucocorticoids, especially cortisol, in male livestock without substantially suppressing the animal's immune system by oral or other administration of effective doses of melengesterol acetate (MGA) or deri... | 10/12/1993 |
| 5204337 | Estrogen nucleus derivatives for use in inhibition of sex steroid activity Novel compounds for the inhibition of sex steroid activity for the treatment of both androgen-related and estrogen-related diseases include for example 15- and 16-halo substituted compounds such as: ##STR1## The compounds are characterized by an estr... | 04/20/1993 |
| 5194602 | 9-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids New 9-hydroxy-17-methylene steroids are prepared by the introduction of a substituted 17-methylene group in 9-hydroxyandrost-4-ene-3, 17-dione. The resulting compounds are useful starting compounds in the synthesis of corticosteroids.... | 03/16/1993 |
| 5001119 | 16-substituted androstanes and 16-substituted androstenes Compounds of the formula: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.... | 03/19/1991 |
| 4804656 | Novel androstane-17ଲ-carboxylic acid esters The invention refers to compounds having anti-inflammatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula X1 represents a hydrogen, chlorine, bromine or fluorine atom; X2 r... | 02/14/1989 |
| 4710495 | Soft steroids having anti-inflammatory activity Novel soft steroid anti-inflammatory agents, said agents being esters or thioesters of 17-alkoxy-11ଲ-hydroxyandrost-4-en-3-one-17ଲ-carboxylic acids, pharmaceutical compositions containing said agents, novel chemical intermediates u... | 12/01/1987 |
| 4650610 | Androstane carbothioic acids Androstane carbothioic acids of the formula: ##STR1## wherein R1 represents a hydrogen atom, a hydroxy group in the -configuration, a methyl group which may be in either the - or ଲ-configuration, or a methylene group; R... | 03/17/1987 |
| 4614621 | Ethynylation of 16-methylene-17-keto steroids The process of the present invention transforms 16-methylene-17-keto steroids (I) to the corresponding 17-ethynyl-17ଲ-hydroxy-16-methylene steroids (II).... | 09/30/1986 |
| 4609651 | 11ଲ-arylestradienes, their production, and pharmaceutical preparations containing same 11ଲ-Arylestradienes of general Formula I are disclosed ##STR1## wherein R2 is a hydrogen atom, a methyl group, or an ethyl group, R3 is a hydrogen atom or an acyl group, R1 and A-B have various meanings, which possess ant... | 09/02/1986 |
| 4602008 | Alkylated etiocholanolones and use as an anti-diabetic, anti-obesity and erythropoietic agent 16-Alkylated and 16-alkylated-7-hydroxy 5ଲ-androstan-3-ol-17-one, and the esters and ethers thereof, are used as an anti-diabetic, anti-obesity and erythropoietic agent in mammals.... | 07/22/1986 |
| 4588529 | Mercury removal process Oxymercuration reaction products (I) and/or mercury contaminated steroids (I) are purified by dissolving the compound in a suitable solvent and contacting with a metal dust selected from zinc, copper or iron and a suitable acid.... | 05/13/1986 |
| 4578221 | Androstane carbothioic acids Androstane carbothioic acids of the formula: ##STR1## wherein R1 represents a hydrogen atom, a hydroxy group in the -configuration, a methyl group which may be in either the - or ଲ-configuration, or a methylene group; R... | 03/25/1986 |
| 4567001 | 16-Methylene-17-hydroxy-progesterones 16-Methylene-17-keto steroids (III) are transformed to the corresponding 16-methylene-17-hydroxyprogesterones (VII) which are intermediates useful in the production of betamethasone, diflorasone diacetate and melengesterol acetate.... | 01/28/1986 |
| 4567002 | Process for the preparation of 17-haloethynyl steroids, and novel 17-haloethynyl steroids 17-haloethynyl steroids of the partial formula ##STR1## wherein R1 is hydrogen or methyl, R2 is alkyl of 1-4 carbon atoms, acyl of 1-7 carbon atoms, trimethylsilyl, 2-tetrahydropyranyl, or nitrate, X is bromine or iodine, and V is me... | 01/28/1986 |
| 4529548 | 17ଲ-(substituted thio)androstenes Antiinflammatory activity is exhibited by steroids having the formula ##STR1## or the 1,2-dehydro derivative thereof, wherein R1 is alkyl, alkanoyloxyalkyl, arylcarbonyloxyalkyl, alkenyl, alkynyl, cycloalkyl, aryl or arylalkyl; R2 | 07/16/1985 |
| 4526720 | Process to prepare stabilized monolithium acetylide The process of the present invention uses an amine to prepare monolithium acetylide which is sufficiently stable at up to 0° and yet is sufficiently reactive to react with 16-substituted-17-keto steroids producing the useful 17-ethynyl-17ଲ-h... | 07/02/1985 |
| 4447363 | Androstene-17-dithioketals Antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, 6,7-dehydro and 15,16-dehydro derivatives thereof, wherein one of R1 and R2 is alkyl, cycloalkyl, aryl, arylalkyl, or --CH2... | 05/08/1984 |
| 4443377 | Isomerization-acylation process 17-Hydroxy-6,16-dimethylenepregn-4-ene-3,20-dione simultaneously isomerized and acylated to 17-hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione 17-acetate.... | 04/17/1984 |
| 4427592 | Androstene-17-dithioketals Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, and 6,7-dehydro derivatives thereof, wherein one of R1 and R2 is alkyl, aryl, arylalkyl, or cycloalkyl, and the oth... | 01/24/1984 |
| 4416821 | Process for preparing 16-methylene steroids A process is disclosed for the production of 17-keto-16-methylene steroids (III) from the corresponding readily available 17-keto steroid (I) via a novel intermediate (II).... | 11/22/1983 |
| 4346037 | Base catalyzed acylation with enol esters This invention relates to processes for base catalyzed acylations using enol esters, for example, isopropenyl acetate. Particularly, the processes are useful for acylating acid sensitive alcohols including hydroxy steroids.... | 08/24/1982 |
| 4335121 | Androstane carbothioates Compounds of the formula ##STR1## wherein R1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R2 represents a group COR6 where R6 is a C1-3 alkyl group or OR2 | 06/15/1982 |
| 4333928 | 16 -Alkyl steroids, their preparation, and pharmaceutical preparations thereof 16 -Alkyl steroids of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is hydrogen, alkyl, acyl, or glycosyl R3 is hydrogen or a substituted or unsubstituted, saturated or unsaturated lower hydrocarbon resi... | 06/08/1982 |
| 4311646 | Process for the preparation of 4,6-dien-3-one steroids A 4,6-dien-3-one steroid is produced by brominating an enolic ether of a 4-en-3-one steroid in a water-containing organic solvent which is substantially free from acetic acid and sodium acetate to give a 6-bromosteroid and then dehydrobrominating the 6-br... | 01/19/1982 |
| 4298538 | 16-Dimethylaminomethylene-3-methoxy-1,3,5-(10)-estratrien-17-one, a process for the preparation thereof and its use as a preparative intermediate 16-dimethylaminomethylene-3-methoxy-1,3,5(10)-estratrien-17-one is a valuable new preparative intermediate which may be used, e.g., to prepare 17ଲ-hydroxy-16ଲ-ethyl-4-estren-3-one or 16ଲ-ethylestradiol.... | 11/03/1981 |
| 4285937 | Novel androstadiene-17-carboxylic acid esters The invention provides novel esters of androstadiene 17-carboxyclic acids of the formula ##STR1## wherein R' represents a hydroxyl group which is esterified with a carboxyclic acid having not more than 7 carbon atoms, R" represents a methyl grou... | 08/25/1981 |
| 4252729 | Steroids and process for their manufacture The present disclosure is concerned with 9-chloro-17-(m-iodobenzyloxy) steroids and a process for their manufacture. The subject compounds are useful as intermediates in the synthesis of pharmacologically-active substances and have themselves been ... | 02/24/1981 |
| 4119625 | Process for the manufacture of steroid carboxylic acids and the esters thereof The present invention provides a novel process for the manufacture of 17- and 17a-carboxylic acids of the androstane and D-homo-androstane series respectively, of the following partial formula of the ring D ##STR1## wherein R represents a hydrogen at... | 10/10/1978 |
| 4092310 | Difluorosteroids and processes for their manufacture A novel group of 18,18-difluorosteroids of the general formula ##STR1## wherein St, R1 and R2 have the meanings given hereinafter is produced by a chemically novel process characterized in that a corresponding 18-oxo compound is... | 05/30/1978 |
| 3980681 | Process for the preparation of 11-ଲ-nitro-oxysteroids Process for preparing 9 -hydroxy-11 ଲ-nitro-oxysteroids having a aromatic ring A wherein an aromatic A-ring-containing 9, 11-unsubstituted steroid or corresponding 9,11-dehydrosteroid is oxidized with ceric ions in the presence of nitrate ion... | 09/14/1976 |
