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| Number | Title | Issue Date |
| 7368072 | Photochromic contact lenses and methods of manufacturing Described are contact lenses having photochromic materials within the central or pupillary area of the lens and methods for manufacturing such lenses. In one method, a photochromic amount of at least one photochromic material is added to the pupillary region of a ca... | 05/06/2008 |
| 7320826 | Photochromic articles with reduced temperature dependency and methods for preparation Described are photochromic articles that include a substrate, a temperature dependent reducing amount of at least one organic photochromic material (b) that changes from more absorbing to less absorbing of radiation in its activating spectral absorbance as the tempe... | 01/22/2008 |
| 7261843 | Photochromic optical article Describes a photochromic article, e.g., an ophthalmic photochromic plastic article, such as a lens, in which the article includes (1) a rigid substrate, e.g., a transparent substrate such as a glass or organic polymeric substrate, as for example, a thermoset or ther... | 08/28/2007 |
| 7262295 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles Described are photochromic materials of indeno [2′,3′:3,4]naphtho[1,2-b]pyran structure, characterized in that they have a nitrogen or sulfur containing substituent at the 11-position ring atom, are substantially free of spiro-substituents at the 13-position and... | 08/28/2007 |
| 7244829 | Compositions and processes for preparing 13-deoxy-anthracyclines 13-benzenesulfonylhydrazone anthracyclines useful in producing improved yields in the synthesis 13-deoxyanthrcyclines, and an improved method of reducing 13-benzene-sulfonylhydrazone anthracyclines to 13-deoxyanthrcyclines wherein the reduction reaction is maintaine... | 07/17/2007 |
| 7166357 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation Described are photochromic articles that include a substrate and a photochromic amount of at least one organic photochromic material (b) represented by graphic formula XIII adapted to change from an unactivated state to an activated state by exposure to radiation su... | 01/23/2007 |
| 7147889 | Organic photochromic compositions of improved kinetic performance Described are imbibition compositions that incorporate kinetic enhancing additive(s) into photochromic polymeric host material. Kinetic enhancing additives include organic polyol(s), epoxy-containing compound(s) or a mixture thereof that improves the performance of ... | 12/12/2006 |
| 7094368 | Pyrano-quinolines, pyrano-quinolinones, combinations thereof, photochromic compositions and articles Described are compositions of at least one material represented by a pyrano[3,2-c]quinoline structure, a pyrano[3,2-c]quinolinone structure or mixtures thereof. The pyrano[3,2-c]quinoline structure is characterized by having a nitrogen atom at the 6-position ring at... | 08/22/2006 |
| 7067505 | Di-steroidal prodrugs of estradiol The present invention is a di-steroidal prodrug of estradiol having the following formula: ... | 06/27/2006 |
| 7067504 | Di-steroidal prodrugs of ethinyl estradiol The present invention is a di-steroidal prodrug of ethinyl estradiol according to formula I: ... | 06/27/2006 |
| 6342480 | Tumor-activated prodrug compounds and treatment The compound (W-Z-M) according to the invention comprises a component (M) chosen from the group consisting of markers and therapeutic agents possessing an intracellular active site (A.S.), linked to a ligand (W-Z) comprising an arm (Z) linked to a termina... | 01/29/2002 |
| 6159931 | Lipid-modified insulin incorporated liposomes for selectively delivering cytotoxic agents to hepatoma cells The present invention provides a lipid-modified insulin comprising an insulin molecule linked to an alkyl group by an amine linkage. Preferably, the alkyl group is a straight chain carbon comprising from about 14 to 20 carbon atoms. Preferably, the alkyl ... | 12/12/2000 |
| 6028207 | Bone resorption inhibition/osteogenesis promotion compound A compound represented by the following formula (I): X--Y--Z (I) where Y is represented by the following formulae: ##STR1## X is a monovalent group of a tetracycline type compounds and Z is a monoent gro... | 02/22/2000 |
| 5998615 | Anthracyclinone derivatives The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and p... | 12/07/1999 |
| 5945518 | Process for the preparation of anthracycline antibiotics A process for the preparation of antibiotics of the anthracycline class of formula (A), wherein R1 is hydrogen, OH, or OCOR2, wherein R2 is a C1 -C4 -alkyl group; which comprises the epimerization of ... | 08/31/1999 |
| 5877158 | Pro-prodrugs, their production and use Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.... | 03/02/1999 |
| 5874412 | Bis-anthracyclines with high activity against doxorubicin resistant tumors The present invention discloses new and novel bisanthracyclines linked through the saccharide portions. These compounds show high activity against two clinically relevant mechanisms of resistance. A novel approach of the invention produces compounds that ... | 02/23/1999 |
| 5814608 | S-fluoro-anthracyclines, processes for their preparation and pharmaceutical compositions containing them 8-fluoro-anthracyclines of formula (I) have anti-tumor activity. ##STR1## wherein: R is chosen in the group consisting of H, OH, OR4 wherein R4 is chosen in the group consisting of CHO, COCH3, acyl derivative of a car... | 09/29/1998 |
| 5731313 | Use of anthracyclinone derivatives in amyloidosis The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and p... | 03/24/1998 |
| 5719130 | Anthracycline derivative having a trifluoromethylated sugar Novel anthracycline derivatives have now been produced, which exhibit higher antitumor activities and lower toxicities than those of daunomycin, adriamycin etc. that have been clinically used as anticancer agents. That is, a daunomycinone or adriamycinone... | 02/17/1998 |
| 5646177 | Glutathione derivatives of anthracyclines Disclosed herein are new anthracyclines which are derived from conjugation with glutathione, for example from conjugation of adriamycin, daunomycin and menogaril with glutathione: compounds 7 I, 7 II, 8 I, 8 II, 9 I and 9II, are obtained by reduction of t... | 07/08/1997 |
| 5606037 | Processes antineoplastic heteronaphthoquinones This invention relates to a naphthoquinone derivatives, to processes and to intermediates for preparing these derivatives, to pharmaceutical composition and to the use of these derivatives as antitumor agents in mammals.... | 02/25/1997 |
| 5594158 | Processes for producing doxorubicin, daunomycinone, and derivatives of doxorubicin Daunomycinone is a known precursor of the well known antibiotic and antineoplastic, doxorubicin. Daunomycinone may be synthesized by preparing mono ketal of a 1,4-naphthoquinone as the precursor of the CD rings of daunomycinone followed by preparing a pre... | 01/14/1997 |
| 5510501 | Saintopin derivatives The present invention relates to Saintopin derivatives represented by the following formula (I): ##STR1## wherein R1 is hydrogen and R2 is SO2 OH (UCE 1022), or R1 is acetyl and R2 is H (Saintopi... | 04/23/1996 |
| 5488119 | Polymerisable photochromic naphthacenediones, polymers of these monomers, process for their preparation and the use thereof Compounds of formulae I and II ##STR1## wherein D is H or --OR wherein R is phenyl and R1 to R4 are H or a substituent such as phenylthio, and one of the substituents R1, R2, R3 and R4... | 01/30/1996 |
| 5407885 | Photochromic naphthacenequinones, process for their preparation and the use thereof Compounds of formula I or V or mixtures thereof ##STR1## wherein R is unsubstituted C6 -C14 aryl or C6 -C14 aryl which is substituted by C1 -C12 alkyl, C1 -C12 al... | 04/18/1995 |
| 5391749 | Substituted naphthacene-5,12-diones and their use Substituted naphthacenediones of the formula I ##STR1## in which R1 to R8 are H and at least one of R1 to R8, for example R2 and R3 or R2 and R6, are, for example, ... | 02/21/1995 |
| 5366966 | Compound UCE6 A compound represented by formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is provided, which has an excellent antitumor activity.... | 11/22/1994 |
| 5294701 | Anthracycline compounds and intermediates This invention provides novel anti-tumour compounds of the formula ##STR1## wherein R1 and R2 are hydrogen or together form an alkyl-, alkoxy- or OH-substituted aromatic group, which optionally contains an N atom as a hetero-ato... | 03/15/1994 |
| 5218130 | 4-substituted anthracyclinones and their preparation 4-substituted anthracyclinones of formula (I) ##STR1## wherein R represents a hydrogen atom or a straight or branched alkyl, alkenyl or alkynyl group having from 1 to 10 carbon atoms, are intermediates in the preparation of antitumor anthracycline gl... | 06/08/1993 |
| 5208354 | Photochromic naphthacenequinones, process for their preparation and the use thereof Compounds of formula I or V or mixtures thereof ##STR1## wherein R is unsubstituted C6 -C14 aryl or C6 -C14 aryl which is substituted by C1 -C12 alkyl, C1 -C12 alkoxy,... | 05/04/1993 |
| 5206395 | Photochromic naphthacenequinones, process for their preparation and the use thereof Compounds of the formula I or V, or mixtures thereof, ##STR1## wherein R is unsubstituted C6 -C14 aryl or C6 -C14 aryl which is substituted by C1 -C12 alkyl, C1 -C12 ... | 04/27/1993 |
| 5206390 | Substituted bisacyloxynaphthacenes Compounds of the formula I ##STR1## in which R1 to R8 independently of one another are H and at least one of R1 to R8 is a substituent belonging to the group --F, --Si(C1 -C4 alkyl) | 04/27/1993 |
| 5200513 | Processes for producing doxorubicin, daunomycinone, and derivatives of doxorubicin To produce doxorubicin and its analogues methyl 3alpha, 5alpha-dihydroxy-5beta-(trimethylsilylethynyl)-2alpha-nitromethylcyclohexa ne-1beta-carboxylate acetonide is condensed with 1,4-dihydro-4,4,5-trimethoxy-1-oxonaphthalene in the presence of 1,8-di... | 04/06/1993 |
| 5180758 | Process for preparing anthracyclinones 4-substituted anthracyclinones of general formula (I): ##STR1## wherein R represents a hydrogen atom or a COOR1 group in which R1 may be a hydrogen atom or an optionally substituted C1 -C10 alkyl group, whi... | 01/19/1993 |
| 5177227 | Photochromic naphthacenequinones, process for their preparation and the use thereof Compounds of formula I or V, or mixtures thereof, ##STR1## wherein R is unsubstituted C6 -C14 aryl or C6 -C14 aryl which is substituted by C1 -C12 alkyl, C1 -C12 ... | 01/05/1993 |
| 5112977 | Substituted naphthacene-5,12-diones Substituted naphthacenediones of the formula I ##STR1## in which R1 to R8 are H and at least one of R1 to R8, for example R2 and R3 or R2 and R6, are, for example, ... | 05/12/1992 |
| 5110960 | Antifungal antibiotics Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.... | 05/05/1992 |
| 5103029 | Process for preparing 4-demethoxydaunomycinone 4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyldaunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound, in an appropriate red... | 04/07/1992 |
| 5091418 | Novel alpha-glucosidase inhibitor, pradimicin Q The present invention relates to a novel -glucosidase inhibitor, pradimicin Q, having the following formula ##STR1## and its pharmaceutically acceptable base salts.... | 02/25/1992 |
