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| Number | Title | Issue Date |
| 8076496 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 12/13/2011 |
| 7319164 | 5-azido-laevulinic acid, method for the production thereof and its use The present invention relates to 5-azido levulinic acid, a process for its preparation, its use. Using 5-azido levulinic acid as starting material for the synthesis of 5-amino levulinic acid hydrochloride it is possible to obtain the latter in good yield an in pharm... | 01/15/2008 |
| 7109359 | Polyazido compounds The invention relates to a novel polyazido compound: 2,2-dinitro-1,3-diazidopropane. ... | 09/19/2006 |
| 7070941 | Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and a... | 07/04/2006 |
| 7026296 | Methods of treating dry eye disorders Inhibitors of cytokine synthesis in nonimmune, resident ocular surface cells are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. ... | 04/11/2006 |
| RE38947 | Method of enantioselectively catalyzing a reaction A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented radially to the axis of the nucleus. Each of these ligands includes a... | 01/24/2006 |
| 6846946 | Process for making organic products and improving the quality of non-product streams using phase transfer catalysis A method for preparing organic products from aqueous solutions, such as waste or byproduct liquid streams and waste or byproduct gas or vapor streams, uses phase transfer catalysis to transfer a chemical species in low concentration from the aqueous solution to the ... | 01/25/2005 |
| 6841690 | Polyazido compounds This invention relates to a series of novel compounds having the general structures A and B: including 2-azido-2-azidomethyl-1,3-diazidopropane (1), 2-azidomethyl-2-hydroxy-1,3-diazidopropane (2), 2-azidomethyl-2-nitra... | 01/11/2005 |
| 6806365 | N-alkanoylphenylalamine derivatives Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related t... | 10/19/2004 |
| 6593314 | Neuraminidase inhibitors The present invention provides compounds of formula Ia and Ib ##STR1## or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminid... | 07/15/2003 |
| 6441205 | Synthetic precursors to 4-(P-methoxyphenyl)-2-amino-butane The invention provides a novel compound 4-(p-methoxy-phenyl)-2-aminobutane exhibiting growth inhibition and antifeedant activity and represented by the structural formula. ##STR1## C11 H17 ON=4-(p-methoxy phenyl)-2-amino butane and a... | 08/27/2002 |
| 6423865 | Compounds and their application as well as a method of producing liquid crystalline polymers therefrom The invention relates to compounds with the general formula Y1 --A1 --M1 --A2 --Y2 wherein Y1 and Y2 are different from each other and Y1 is an acrylate or methacrylate res... | 07/23/2002 |
| 6392067 | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive int... | 05/21/2002 |
| 6320062 | 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders 15-HETE derivatives with enhanced metabolic stability and methods of their use for treating dry eye are disclosed.... | 11/20/2001 |
| 6313326 | Compounds and their application as well as a method of producing liquid crystalline polymers therefrom The invention relates to compounds with the general formula Y1 --A1 --M1 --A2 --Y2 wherein Y1 and Y2 are different from each other and Y1 is an acrylate or methacrylate res... | 11/06/2001 |
| 6232451 | Process for the preparation of organic azides A process for the addition of an azide function to an organic compound in which process a mixture is prepared by adding an epoxide-derivative of the organic compound and an alkali metal azide salt to a solvent is described. The mixture is heated to a reac... | 05/15/2001 |
| 6201153 | Synthesis of midodrine HCI from a novel intermediate 1-(2',5'-dimethoxyphenyl)-2-azidoethanone Midodrine hydrochloride, &#b1;1-(2',5'-dimethoxyphenyl)-2-glycineamido-ethanol-(1)-HCl, is prepared from a novel intermediate, 1-(2',5'-dimethoxyphenyl)-2-azidoethanone.... | 03/13/2001 |
| 6140529 | Synthesis of optically active cyclohexylphenylglycolate esters A process for the preparation of optically active cyclohexylphenylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl... | 10/31/2000 |
| 6084107 | Intermediates for making HIV-protease inhibitors HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive int... | 07/04/2000 |
| 6027849 | Ablative imageable element This invention provides an imageable element comprising a substrate having on at least one major surface thereof a layer of energy-sensitive material that is capable of being developed to form a relief image upon exposure to electromagnetic radiation havi... | 02/22/2000 |
| 6013814 | Vitamin D analogues The present invention relates to novel 1-hydroxy vitamin D derivatives in which the 17-position side chain carries an azide or optionally substituted 1,2,3-triazole group, including compounds of general formula (I) where R1 represents a ... | 01/11/2000 |
| 5986088 | Process for the preparation of azide derivatives A process for the preparation of azide derivatives useful as drugs, perfumes or intermediates of dyes by reacting an alcohol derivative with di-p-nitrophenyl phosphorazidate in the presence of 1,8-diazabicyclo[5.4.0]-7-undecene.... | 11/16/1999 |
| 5977366 | 1-substituted, 2-substituted 1H-imidazo[4,5-c] quinolin-4-amines 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermedi... | 11/02/1999 |
| 5892067 | Synthesis of energetic vinyl-terminated polymers Synthesis of a vinyl terminated polymer by reacting a cationically polymeable monomer in the form of a cyclic ether with an acid chloride in a suitable solvent and in the presence of a Lewis acid. The vinyl-terminated polymers can be polymerized with oth... | 04/06/1999 |
| 5814612 | Retinol derivatives and uses thereof The present invention provides a purified retinoid compound characterized by a molecular mass of about 320 daltons and an atomic composition of C20 H32 O3. The present invention also provides a purified retinoid compound h... | 09/29/1998 |
| 5741909 | 1-substituted, 2-substituted 1H-imidazo4,5-C!quinolin-4-amines 1-substituted, 2-substituted 1H-imidazo4,5-c!-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermed... | 04/21/1998 |
| 5675029 | Cyclic process for activation, use and recovery of phase-transfer catalysts A process of making certain compounds using a phase transfer catalyst that permits the recovery and recycle of the phase transfer catalyst.... | 10/07/1997 |
| 5608090 | GABA and L-glutamic acid analogs for antiseizure treatment A compound of the formula ##STR1## wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen,... | 03/04/1997 |
| 5605899 | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermedi... | 02/25/1997 |
| 5583208 | Ganglioside GM3 derivatives containing fluorine in ceramide portion A ganglioside GM3 derivative containing fluorine atoms in a ceramide portion thereof, represented by the formula: ##STR1## in which m is an integer of at least 2, n is an integer of 0 to 7 provided that m is larger than n, and R represents an alkyl g... | 12/10/1996 |
| 5580999 | Alcohols Novel alcohols of the formula ##STR1## wherein Ra is azido or phthalimido, R4 is alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, R7 and R8 together are a trimethylene or tetramethylene group which is o... | 12/03/1996 |
| 5565585 | Azido diacetal propane derivatives A new and practical method for synthesizing heterocyclic polyhydroxylated alkaloids using enzymatic aldol condensation and catalytic intramolecular reductive amination is disclosed.... | 10/15/1996 |
| 5532390 | Energetic azide plasticizer Novel multi-azido formals, acetals and ketals are disclosed, having the following generic formula ##STR1## in which R1, R2, R3, R4, R5, R6, R7 and R8 are independ... | 07/02/1996 |
| 5516776 | Enantioselective synthesis of antifolates A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.... | 05/14/1996 |
| 5488167 | Synthesis of sphingosines Provided by the present invention is a process for the biocatalytic synthesis of optically pure sphingosines from achiral starting material. The stereoisomers of sphingosine are prepared from chiral arene diols using stereospecific reaction techniques to ... | 01/30/1996 |
| 5488166 | Synthesis of sphingosines Provided by the present invention is a process for the biocatalytic synthesis of optically pure sphingosines from achiral starting material. The stereoisomers of sphingosine are prepared from chiral arene diols using stereospecific reaction techniques to ... | 01/30/1996 |
| 5483007 | Cyclic process for activation, use and recovery of phase-transfer catalysts A process of making poly(glycidyl azide) and 3,6 -dioxadecyl thiocyanate using a phase transfer catalyst that permits the recovery and recycle of the phase transfer catalyst.... | 01/09/1996 |
| 5468841 | Polymerization of energetic, cyclic ether monomers using boron trifluoride tetrahydrofuranate The present invention provides an improved method of carrying out cationic polymerization of cyclic ether monomers substituted with high-energy, electron-withdrawing pendant groups (e.g., BAMO and NMMO). Such cyclic ether monomers are polymerized with an ... | 11/21/1995 |
| 5459134 | (Fused) benz (thio) amides A novel (fused) benz(thio)amide of the general formula: ##STR1## or a non-toxic salt thereof, wherein R4 represents: (i) when B represents a closed ring, a group of the general formula: ##STR2## wherein U represents an oxygen atom or a sul... | 10/17/1995 |
| 5457108 | 5-oxo-dibenzo[a,d]cyclohepta-1,4-dienes The invention relates to substituted 5-oxo-di-benzo[a,d]cyclohepta-1,4-dienes of the formula (I) ##STR1## processes for their preparation and their use as retroviral agents.... | 10/10/1995 |
