Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7659409 | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with hig... | 02/09/2010 |
| 7645890 | Process for preparing duloxetine and intermediates for use therein A process for preparing (+)duloxetine, or an acid addition salt thereof, which process comprises resolving racemic(±)duloxetine with a chiral acid so as to obtain a salt of the chiral acid and (+)duloxetine, substantially free of (−)duloxetine; and (ii) if desire... | 01/12/2010 |
| 7435563 | Method for the production of (s)-3-methylamino-1-(thien-2-yl)propan-1-ol The present invention relates to a process for the preparation of enantiomerically pure (S)-3-methyl-amino-1-(thien-2-yl)propan-1-ol of the formula II-S by obtainment of (S)-3-hydroxy-3-thien-2-ylpropionitrile from its enan... | 10/14/2008 |
| 7399871 | Crystal forms of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate and the preparation thereof DNT-Oxal crystalline forms and processes for making DNT-Oxal crystalline forms are provided. ... | 07/15/2008 |
| 7381842 | Oxime ester photoinitiators Compounds of the formulae I, II, III, IV and V wherein R1 i.a. is C4-C9cycloalkanoyl, C1-C12alkanoyl, C4-C6alke... | 06/03/2008 |
| 7361769 | Heterocyclyls as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders The present invention discloses compounds of formula I wherein m, n, p, R1, R2 and X, are herein defined, the compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as metho... | 04/22/2008 |
| 7317034 | Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds, processes for their preparation, medicaments and pharmaceutical compositions containing them, and their use in treatment methods and in the preparation of analgesics, in the preparation ... | 01/08/2008 |
| 7314929 | Organoselenium compounds for cancer chemoprevention A compound containing an alkylene selenocyanate or an alkylene isoselenocyanate moiety effective to prevent the occurrence or progression of cancer or a precancerous condition. The compound can be provided and administered in the form of a pharmaceutical composition... | 01/01/2008 |
| 7301031 | Methods for producing hydroxy amino acids, esters, and derivatives thereof A method for producing a hydroxy-amino ester, or derivative thereof, is provided. A substituted β-ketodiester having a ketone group and two ester functional groups is contacted with a ketoreductase under conditions permitting the reduction of the ketone group to an... | 11/27/2007 |
| 7241776 | Cyanoamidine P2Xantagonists for the treatment of pain Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compo... | 07/10/2007 |
| 7208506 | Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and... | 04/24/2007 |
| RE39575 | Substituted thioacetamides The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases. ... | 04/17/2007 |
| 7205331 | Fungicidal carboxamides Compounds of Formula I are disclosed which are useful as fungicides wherein X is —O—, —CH(R11)—or ═C(R11 | 04/17/2007 |
| 7202404 | Fungicidal amides Compounds of Formula I are disclosed which are useful as fungicides wherein R1 is hydrogen; halogen; C1–C2 alkoxy; C1–C2 | 04/10/2007 |
| 7173052 | Resorcinol derivatives The present invention relates to certain resorcinol derivatives and their use as skin lightening agents. ... | 02/06/2007 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7119211 | Process for preparing optically active 3-(methylamino)-1-(2-thienyl) propan-1-ol and intermediates for preparation Disclosed is a process for commercial preparation of 3-(methylamino)-1-(2-thienyl)propan-1-ol (hereinafter abbreviated as “MMAA”) of the formula below: The process is carried out by the diastereomeric salt fo... | 10/10/2006 |
| 7115652 | Aspartyl protease inhibitors The present invention provides compounds having the formula: wherein R1, R′, R2, R3, R3′, R4, X1, X2 and X3 are as defin... | 10/03/2006 |
| 7109356 | Process for racemization The invention relates to the racemization process of the optically active [2-(2-thienyl)ethylamino](2-halogenophenyl)acetamides of general formula (VII) by using basic compounds. The resulting racemic compounds of general formula (VII) can thus be recycled in... | 09/19/2006 |
| 7081535 | Hydroxy-amino acids Hydroxy-amino acids are provided and are prepared by contacting a substituted β-ketodiester having a ketone group and two ester functional groups with a ketoreductase under conditions permitting the reduction of the keytone group to an alcohol. Only one of the este... | 07/25/2006 |
| 7057038 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/06/2006 |
| 7030239 | Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases. ... | 04/18/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6949678 | Oxime ester photoinitiators Compounds of the formulae I, II, III, IV and V wherein R1 i.a. is C4-C9cycloalkanoyl, C1-C12alkanoyl, C4-C6alkenoyl, or benzoyl; R2 | 09/27/2005 |
| 6939967 | Non-proteinogenic L-amino acids Process for production of non-proteinogenic L-amino acids by direct fermentation of a microorganism strain known per se having a deregulated cysteine metabolism in a manner known per se, which comprises adding, during the fermentation, a nucleophilic compound to the... | 09/06/2005 |
| 6936719 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents. ... | 08/30/2005 |
| 6916837 | Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them Amidino derivatives represented by the following general formula (I): {where X is a group represented by R1SO2NR2— (wherein R1 represents optionally substituted C6-14 ... | 07/12/2005 |
| 6846843 | β-thioamino acids Thio-alpha-amino acids of general formula (I), wherein R1, R2 and R3 have the meanings given in the description, methods for producing them, and medicaments containing these compounds. The invention also provides methods for treating... | 01/25/2005 |
| 6841569 | Carbamates of 2-heterocyclic-1,2-ethanediols Carbamate compounds of 2-heteroaryl-1,2-ethanediol are described. The compounds are effective in the treatment of disorders of the central nervous system, especially as anti-convulsive or anti-epileptic agents. ... | 01/11/2005 |
| 6833385 | 3-heteroarylalkyl substituted GABA analogs The invention is a novel series of compounds which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IB... | 12/21/2004 |
| 6809207 | Amino acid derivatives The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydroth... | 10/26/2004 |
| 6797712 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain Compounds of formula I, or a pharmaceutically acceptable salt thereof, The compounds of the present invention are suitable for the treatment of pain and migraine. Also disclosed are method for preparing the compounds, an... | 09/28/2004 |
| 6730784 | Urea derivatives useful as synthetic intermediates Objects of the present invention are to create compounds having urea structure as basic structure and having a sulfur atom and an amide bond in side chains and to find pharmacological effects thereof, particularly TNF-α production inhibitory effects. The pre... | 05/04/2004 |
| 6670486 | Process for racemization The invention relates to the racemisation process of the optically active [2-(2-thienyl)ethylamino](2-halogenophenyl)acetamides of general formula (VII) by using basic compounds. The resulting racemic compounds of general formula (VII) can thus be recycle... | 12/30/2003 |
| 6660728 | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists ##STR1## The present invention relates to thienyl substituted acylguanidine derivatives, such as compounds of formula (I) in which R1, R2, R4, R6, A, B and D have the meanings indicated in the claims, their phys... | 12/09/2003 |
| 6624179 | Geometrical isomers of acrylonitrile compounds, mixture thereof, and process for producing these A geometrical isomer of an acrylonitrile compound represented by the formula (I) or of its salt, or a mixture thereof: ##STR1## [wherein T is phenyl or pyridyl, which is substituted by R2, Q is phenyl, thienyl, pyridyl or benzyl, which may be s... | 09/23/2003 |
| 6613782 | Certain thiol inhibitors of endothelin-converting enzyme Disclosed as endothelin converting enzyme inhibitors are the compounds of the formula ##STR1## wherein the variables have the meanings as defined hereinbefore.... | 09/02/2003 |
| 6605608 | Amino acid derivatives and drugs containing the same as the active ingredient The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). ##STR1## The compounds of the formula (I) possess inhibitory activity of N-type calcium cha... | 08/12/2003 |
| 6593352 | Substituted anthranilic acids, their use as a medicament or diagnostic, and medicament comprising them, and a pharmaceutical combination preparation containing a sodium/hydrogen exchange (NHE) blocker Substituted anthranilic acids of the formula I ##STR1## their use as a medicament or diagnostic, and medicament comprising them, and a pharmaceutical combination preparation containing a sodium/hydrogen exchange (NHE) blocker.... | 07/15/2003 |
| 6566366 | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists Compounds of the formula ##STR1## and salts thereof wherein the substituents are defined as in accordance with the specification useful for the treatment of tumor growth, osteoporosis, inflammation and cardiovascular disorders.... | 05/20/2003 |
