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| Number | Title | Issue Date |
| 7973182 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols A process for the preparation of enantiomerically pure 1-substituted-3-amino-alcohols, particularly of (S)-(−)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of the formula: | 07/05/2011 |
| 7655807 | Low molecular weight conjugated nitrogen compounds and devices fabricated using the same Low molecular weight conjugated nitrogen compounds having linear conjugated chains, and devices fabricated using the conjugated nitrogen compounds as organic semiconductor materials, hole conducting materials, or light-emitting materials. The conjugated nitrogen com... | 02/02/2010 |
| 7560573 | Process for the preparation of (S)-(-)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropananine, a duloxetine intermediate A chiral resolution process for the preparation of (S)-AT-OL, and a process for the racemization of AT-OL are provided. ... | 07/14/2009 |
| 7446213 | Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives Novel methods allowing for the simple optical detection and electrochemical detection of doubled-straded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the... | 11/04/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7358375 | Low molecular weight conjugated nitrogen compounds and devices fabricated using the same Low molecular weight conjugated nitrogen compounds having linear conjugated chains, and devices fabricated using the conjugated nitrogen compounds as organic semiconductor materials, hole conducting materials, or light-emitting materials. The conjugated nitrogen com... | 04/15/2008 |
| 7351825 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/01/2008 |
| 7300951 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof Compounds of Formula (I), are provided where T is CHO, CON, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substit... | 11/27/2007 |
| RE39530 | 3-amino-3-arylpropan-1-ol-compounds, their preparation and use 3-amino-3-arylpropan-1-ol compounds corresponding to the formula I in which R1 to R5, A and X have the meanings according to claim 1, and their preparation and use as medicaments. ... | 03/27/2007 |
| 7161006 | Sulphones for inhibition of gamma secretase The invention provides compounds of formula I: which are inhibitors of γ-secretase and hence useful in the treatment or prevention of Alzheimer's disease. ... | 01/09/2007 |
| 7138530 | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I... | 11/21/2006 |
| 7105545 | N-p-propargyloxyphenethyl-thioacetic acid amides The invention relates to N-propargyloxy-phenethyl thioacetic acid amide derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R | 09/12/2006 |
| 7094911 | Biphenyl and biphenyl-analogous compounds as integrin antagonists The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of can... | 08/22/2006 |
| 7091219 | Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: | 08/15/2006 |
| 7083928 | Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the analytes ... | 08/01/2006 |
| 7084170 | Thiophene-amd thiazolesulfonamides as antineoplastic agents The present invention provides antineoplastic compounds of the formula: and antineoplastic methods. ... | 08/01/2006 |
| 7071358 | Arylsulfonamidobenzylic compounds Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases. ... | 07/04/2006 |
| 7026339 | Inhibitors of HCV NS5B polymerase The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions contai... | 04/11/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 7014796 | Nonlinear optical compounds and methods for their preparation Nonlinear optically active compounds, methods for making nonlinear optically active compounds, compounds useful for making nonlinear optically active compounds, methods for making compounds useful for making nonlinear optically active compounds, macrostructures that... | 03/21/2006 |
| 6960688 | Use of compounds for the elevation of pyruvate dehydrogenase activity The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon ... | 11/01/2005 |
| 6955921 | Trypsin substrate and diagnostic device, and method of using same A compound of the formula (I) wherein R1 is a protecting group for Nα, R2 is a protecting group for NG, and R3 is aryl, and wherein the compound of formula (I) is a trypsin ... | 10/18/2005 |
| 6949563 | (2-carboxamido)(3-amino)thiophene compounds Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is R2 is and R3... | 09/27/2005 |
| 6949536 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated ... | 09/27/2005 |
| 6927224 | Selective estrogen receptor modulators The present invention provides, inter alia, triphenylethylene derivatives, such as, 3-{4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5-yl]-phenyl}-acrylic acid, as selective estrogen receptor modulators. Also provided are methods for the treatment and/or p... | 08/09/2005 |
| 6919369 | Serine protease inhibitors Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders. | 07/19/2005 |
| 6916837 | Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them Amidino derivatives represented by the following general formula (I): {where X is a group represented by R1SO2NR2— (wherein R1 represents optionally substituted C6-14 ... | 07/12/2005 |
| 6903216 | Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, | 06/07/2005 |
| 6890942 | Acyl sulfonamides as inhibitors of HIV integrase The present invention relates a series of compounds of Formula I wherein R1, R2, R3, and B are as defined in the specification. The compounds are useful for the inhibition of HIV integr... | 05/10/2005 |
| 6878742 | Heterocyclic sulfonamide inhibitors of beta amyloid production Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable... | 04/12/2005 |
| 6878723 | LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ... | 04/12/2005 |
| 6849635 | Sulfonamides The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II. ... | 02/01/2005 |
| 6849660 | Antimicrobial biaryl compounds Provided are antibacterial compounds having Formula I: In such compositions, X is O or S; Y is CH2; n is 0 or 1. One of R1 and R1′ is —C(O)NR5R5′ | 02/01/2005 |
| 6800764 | Process for the synthesis of chirally pure beta-amino-alcohols A process is provided for preparing chirally pure S-enantiomers of α-amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the formula (R)2CH(CH2)nCH2X; b) adding the organome... | 10/05/2004 |
| 6768024 | Triamine derivative melanocortin receptor ligands and methods of using same The invention provides triamine derivative melanocortin receptor ligands of the formula: wherein R1 to R8 and n have the meanings provided herein. The invention further provides methods of using the... | 07/27/2004 |
| 6743929 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 06/01/2004 |
| 6734207 | Cytotoxic compounds Compounds are described that bind to tubulin causing tubulin depolymerization and inhibiting tubulin polymerization. The compounds of the invention are therapeutically effective to inhibit cellular proliferation, for example, as effective anti-cancer agents. The com... | 05/11/2004 |
| 6727238 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi... | 04/27/2004 |
| 6716995 | Design and synthesis of advanced NLO materials for electro-optic applications In various embodiments, chromophores are described that include novel electron acceptors, novel electron donors, and/or novel conjugated bridges that are useful in nonlinear optical applications. In some embodiments, the present invention provides chromophore archit... | 04/06/2004 |
| 6706755 | Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 03/16/2004 |
