Class 549/61 - Cyano bonded directly to the hetero ring

Subclass of Class 549 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the -CN group is bonded directly to ring
No. of patents: 143
Last issue date: 02/21/2012

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Number	Title	Issue Date
8119821	Sweetener compositions and methods of making them The present invention provides compositions comprising sucralose and 4-amino-5,6-dimethylthieno [2,3-d]pyrimidine-2(1H)-one or salts, solvates, and/or esters thereof and methods of making the compositions by spray drying. The present invention also provides ingestib...	02/21/2012
7642361	Thiophene and furan compounds The present invention relates to thiophene and furan compounds and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's...	01/05/2010
7459568	Alpha crystalline form of strontium ranelate Alpha crystalline form of strontium ranelate of formula (I): characterized by its powder X-ray diffraction diagram and by a water content of from 22 to 24%. Medicinal products containing the same which are useful in...	12/02/2008
7423170	Anticancer agents based on regulation of protein prenylation Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g....	09/09/2008
7214805	Process for the industrial synthesis of strontium ranelate and its hydrates The process for the industrial The synthesis of strontium ranelate of formula (I): and its hydrates. ...	05/08/2007
7138529	Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the...	11/21/2006
7138530	Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I...	11/21/2006
7105683	Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates The process for the industrial the synthesis of the compound of formula (I): Application to the the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates. ...	09/12/2006
7091364	Process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates The process for the industrial synthesis of compounds of formula (I): wherein R and R′, which are the same or different, each represent linear or branched (C1–C6)alkyl. Applicati...	08/15/2006
7084170	Thiophene-amd thiazolesulfonamides as antineoplastic agents The present invention provides antineoplastic compounds of the formula: and antineoplastic methods. ...	08/01/2006
7019024	Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ...	03/28/2006
7015337	Process for preparing 5-aminomethyl-2-thiophenecarbonitrile HCl by one-pot reaction The present invention provides a novel process for preparing a compound represented by the above formula 7, which is an important intermediate for an oral thrombin inhibitor, by one-pot reaction. In accordance with the present invention, the above intermediate for t...	03/21/2006
7014796	Nonlinear optical compounds and methods for their preparation Nonlinear optically active compounds, methods for making nonlinear optically active compounds, compounds useful for making nonlinear optically active compounds, methods for making compounds useful for making nonlinear optically active compounds, macrostructures that...	03/21/2006
6992047	Method of microencapsulating an agricultural active having a high melting point and uses for such materials A method of producing a controlled release form of an agricultural active material includes the provision of an organic liquid composition in which the active is present, but where the liquid composition is free from aromatic solvents and is maintained below the nor...	01/31/2006
6864375	Highly stable and efficient nonlinear optical chromophores for electro-optic polymers In various embodiments, chromophores are described that include novel electron acceptors, novel electron donors, and/or novel conjugated bridges that are useful in nonlinear optical applications. In some embodiments, the present invention provides chromophore archit...	03/08/2005
6840965	P-aminophenols and colorants containing said compounds The object of the invention are p-aminophenol derivatives of general formula (I) or physiologically tolerated, water-soluble salts thereof and oxidative coloring preparations based on a developer-coupler combination co...	01/11/2005
6835745	Phenyl substituted thiophenes as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, X, and Y are as defined in the specificat...	12/28/2004
6695978	Mono-, oligo- and polymers of benzo[b]thiophene and 2,2'-bisbenzo[b]thiophene and their use as charge transport materials Conjugated mono-, oligo- and polymers of benzo[b]thiophene and bisbenzo[b]thiophene are useful as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors, electroluminescent, photovo...	02/24/2004
6686478	Thienylsulphonylamino(thio)carbonyl compounds The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), ##STR1## in which Q represents oxygen or sulphur, R1 represents cyano, halogen or in each case optionally cyano-, halogen- or C1 -C...	02/03/2004
6680337	Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The present invention provides cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups, e.g. 1-OH cyclopentane heptanoic acid, 2 heteroarylalkenyl de...	01/20/2004
6660868	Photo-induced phase transition organic material A photo-induced phase transition organic material is composed of a diheteroarylethene-based compound within which the photo-chromic reaction occurs in the crystalline state. The diheteroarylethene-based compound of the present invention reversibly changes...	12/09/2003
6566536	Thienylsulphonylamino(thio)carbonyl compounds The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), ##STR1## in which Q represents oxygen or sulphur, R1 represents cyano, halogen or in each case optionally cyano-, halogen- or C1 -C...	05/20/2003
6566375	Elevation of HDL cholesterol by 4-[(aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula ##STR1## wherein: R	05/20/2003
6541632	Process for producing heterocyclic nitriles A carbocyclic or heterocyclic compound, ammonia and an oxygen-containing gas are subjected to fluid catalytic reaction in vapor phase in the presence of a catalyst containing alkali metal to produce an aromatic or heterocyclic nitrile. The use of the cata...	04/01/2003
6485886	Oxime derivatives and the use thereof as latent acids New oxime derivatives of formula (I) or. (II), wherein m is 0 or 1; R1 inter alia is phenyl, naphthyl, anthracyl, phenanthryl or a heteroaryl radical; R'1 is for example C2 -C12 alkylene, phenylene, naphthylene;...	11/26/2002
6392048	Process for preparing carbocyclic or heterocyclic nitriles by vapor phase ammoxidation The present invention provides a process for preparing carbocyclic or heterocyclic nitrites by the vapor phase contact ammoxidation of carbocyclic compounds or heterocyclic compounds, in which the reaction is carried out effectively without the increase o...	05/21/2002
6339161	Group 8, 9 or 10 transition metal catalyst for olefin polymerization Olefin co- or homopolymers having a good molecular weight and short chain branching may be prepared in the presence of a tridentate complex of a Group 8, 9 or 10 metal....	01/15/2002
6268504	Aryloxy-alkyl-dialkylamines The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: ##STR1## wherein: R1 and R2 are, independently, selected from H;...	07/31/2001
6248773	Cyclopentane heptan(ene)oic acid, 2-heteroarylalk(en)yl derivatives as therapeutic agents The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-heteroarylalk(en)yl derivatives as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: ##STR1## wherein the hatch...	06/19/2001
6166074	Pharmaceutical compositions Pharmaceutical compositions which are useful for the treatment of cancer or illnesses which arise due to an abnormally elevated cell proliferation comprise acyl derivatives of aromatic aldehydes, especially arylidene diesters and ଱-alkoxyarylidene e...	12/26/2000
6160129	Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate either th...	12/12/2000
6153759	Heterocyclic benzoyl intermediates for herbicidal compounds Heterocyclic substituted benzoyl derivatives of the formula ##STR1## where Z is a 5-membered or 6-membered heterocyclic, saturated or unsaturated radical containing one to three hetero atoms selected from the group consisting of oxygen, sulfur and ni...	11/28/2000
6150397	5-aroylnaphthalene derivatives as anti-inflammatory agents The present invention relates to certain 5-aroylnaphthalene derivatives of formula (I): ##STR1## that are inhibitors of prostaglandin G/H synthase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the...	11/21/2000
6121202	Thienyloxypyridines and-pyrimidines useful as herbicidal agents The present invention provides a herbicidal compound of formula I, methods for the preparation thereof and intermediates useful therefor. ##STR1## wherein X and Y are each independently O or S; Z is N or CR4....	09/19/2000
6084108	Synthesis of 3-carbomethoxy-4,5-dimethylthiophene Fungicides having thiophene rings may be made from the intermediate compound 3-carbomethoxy-4,5-dimethylthiophene. That compound, and related compounds, may be produced by reacting an alpha mercaptoketone, e.g., 3-mercapto-2-butanone, with an acrylate, e....	07/04/2000
6063928	5-lipoxygenase inhibitors Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyr...	05/16/2000
6057342	Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a...	05/02/2000
6046229	Polyaryl antitumor agents A compound of the formula: Ar1 --B--Ar2 wherein Ar1 is unsubstituted or substituted phenyl, thienyl, furanyl, or pyrrolyl, in which each substituent of the substituted phenyl, substituted thienyl, substituted furanyl, and subst...	04/04/2000
6005113	Long wavelength dyes for infrared tracing The invention relates to fluorescent dyes that are substituted or unsubstituted derivatives of 1-(isoindolyl)methylene-isoindole that are bound through both isoindole nitrogens to a boron difluoride moiety, forming a fluorescent dibenzopyrrometheneboron d...	12/21/1999
5994563	Arylmethylphosphonic acid derivatives useful in treating bone wasting diseases Benzyl-phosphonate compounds represented by the formula I: ##STR1## are disclosed as useful in treating bone wasting diseases and as an immunosuppresant....	11/30/1999

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Class 549/61 - Cyano bonded directly to the hetero ring