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| Number | Title | Issue Date |
| 7115653 | Small organic molecule regulators of cell proliferation The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodim... | 10/03/2006 |
| 7056378 | Method for producing vattable organic pigments The invention relates to a method for producing vattable organic pigments. The invention is characterized in that an agueous or an aqueous-organic suspension of a coarse crystalline raw mineral is vatted and re-oxidised, and the pigment suspension is ground to a dia... | 06/06/2006 |
| 6399788 | Process for producing benzothiophenecarboxylic acid amide derivatives A process for preparing a compound having PGD2 antagonism represented by the formula (I), or a pharmaceutically acceptable salt or hydrate thereof, which process comprises reacting an amino alcohol of the formula (II) or its salt with a compoun... | 06/04/2002 |
| 6316487 | Compounds for treatment of cardiac arrhythmia synthesis, and methods of use The subject invention pertains to novel compounds, and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns a method of making the novel compounds. The novel compounds are rapidly metaboli... | 11/13/2001 |
| 6130240 | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use Described is a novel compound and method, useful for treatment of cardiac arrhythmias, especially useful in patients with congestive heart failure (CHF). A process for synthesizing the novel compound is also described.... | 10/10/2000 |
| 6063936 | Aromatic carboxylic acid bicyclic sulfur compounds An aromatic carboxylic acid bicyclic sulfur compound of the following formula: ##STR1## wherein X1 is selected from the group consisting of C1 to C4 alkyl, halogen, C1 to C4 haloalkyl, C2 | 05/16/2000 |
| 5989451 | Compounds and methods for doping liquid crystal hosts This invention provides chiral thioindigo compounds for doping smectic liquid crystal hosts, wherein the compounds modulate a chiral bulk property of an induced chiral smectic liquid crystal phase upon irradiation at a wavelength in the visible range. Mod... | 11/23/1999 |
| 5986109 | Benzothiophene compounds, intermediates, compositions, and methods A compound of fomula XIV: ##STR1## wherein: R1a is --H or --OR7a in which R7a is a hydoxy protecting group; R2a is --H, halo, or OR8a in which R8a is a hydroxy protecting group; and R | 11/16/1999 |
| 5981766 | Process for the preparation of 4,4'-dimethyl-6,6'-dichlorothioindigo 4,4'-Dimethyl-6,6'-dichlorothioindigo is obtained in the stable crystal modification I, distinguished by the fraction angles (2 theta): lines of high intensity: 25.99; 27.26 lines of moderate intensity: 10.27; 12.48; 22.39; 23.91; 24.82; 28.87, by oxidizing 3-hydro... | 11/09/1999 |
| 5981755 | Tachykinin antagonists The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases ... | 11/09/1999 |
| 5977098 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical formulations containing a compound of formula I, and methods of using a compound of formula I for the inhibition of bone... | 11/02/1999 |
| 5952513 | Benzob! thiophene compounds The instant invention provides novel benzob!thiophene compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.... | 09/14/1999 |
| 5863936 | Telomerase inhibitors Methods and compositions for treating cancer and other diseases in which inhibition of telomerase activity can ameliorate disease symptoms or prevent or treat the disease relate to compounds characterized by the following structure: ##STR1## and... | 01/26/1999 |
| 5843965 | Benzo B! thiophene compounds, intermediates, processes, compositions, and methods The instant invention provides novel benzob!thiophene compounds, intermediates, compositions, pharmaceutical formulations, and methods of use for the inhibition of bone loss or bone resorption and for treatment of cardiovascular-related pathological con... | 12/01/1998 |
| 5663375 | Pharmaceutical compounds Pharmaceutical compounds of the formula ##STR1## in which n is 0, 1 or 2 and R1 is attached at any of the positions 7, 8, 9 or 10, and each R1 is halo, carboxy, trifluoromethyl, hydroxy, C1-4 alkyl, C1-4 al... | 09/02/1997 |
| 5635527 | Carboxylic acid compound having condensed ring, salt thereof and pharmaceutical use thereof A novel carboxylic acid compound having a condensed ring, which is represented by the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof ... | 06/03/1997 |
| 5569772 | Process for the synthesis of benzo[b]thiophenes The present invention is directed to a new process for the synthesis of 2-aryl benzo[b]thiophenes, and to novel intermediates therefor.... | 10/29/1996 |
| 5567827 | 4-Hydroxyphenylthio derivatives, their preparation and their use for the preparation of aminoalkoxyphenylsulphonyl derivatives The subject of the invention is 4-hydroxyphenylthio derivatives of general formula: ##STR1## in which: R1 and R2, which are identical or different, each represent hydrogen, a methyl or ethyl radical or a halogen atom, R represen... | 10/22/1996 |
| 5508431 | 4-hydroxyphenylthio derivatives, their preparation and their use for the preparation of aminoalkoxyphenylsulphonyl derivatives The subject of the invention is 4-hydroxyphenylthio derivatives of general formula: ##STR1## in which: R1 and R2, which are identical or different, each represent hydrogen, a methyl or ethyl radical or a halogen atom, R represen... | 04/16/1996 |
| 5426191 | Process for the synthesis of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides An improved process for the preparation of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides is described where a cinnamic acid is converted in the presence of thionyl chloride and a 4-N,N'-disubstituted aminopyridine in one step to the desired product.... | 06/20/1995 |
| 5378699 | Methods of using dihydropyrans Methods of treating an immune disease, cell proliferation, restenosis and vascular smooth muscle cells using the pharmaceutical compounds of the formula ##STR1## in which R2 is phenyl, naphthyl or heteroaryl selected from thienyl, pyr... | 01/03/1995 |
| 5328927 | Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them Compounds of formula (I), and salts and prodrugs thereof ##STR1## wherein Q1 is halo substituted phenyl; naphthyl; indolyl; benzthiophenyl; benzofuranyl; benzyl; or fluorenyl; . . is an optional covalent bond; one of X and Y is H and the othe... | 07/12/1994 |
| 5252749 | Ethers of thienocyclopentanone oximes, their preparation and pharmaceutical compositions containing them The compounds of the invention having the formula: ##STR1## in which: A, which is a ring condensed with cyclopentane, represents a substituted or unsubstituted thiophene ring, Q represents an alkylene chain, R1 and R2 each repre... | 10/12/1993 |
| 5208253 | 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo(b) thiophene-2-carboxamides as inhibitors of cell adhesion 3-Alkyloxy-, aryloxy-, or arylalkyloxy-benzo[b]thiophene-2-carboxamides are described as agents which block leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these com... | 05/04/1993 |
| 5180735 | Cyclohexanol derivatives, production and use thereof The present invention relates to a compound of the formula: ##STR1## wherein A is halogen, N(O)mR1 R2, N.sym. R1 R2 R3 .multidot.X.crclbar., S(O)nR1 or S.sym. | 01/19/1993 |
| 5147889 | 2-hydroxy-3-(aryl-alkanoyl)-benzo[B]thiophenes and compositions thereof Benzo[b]thiophene derivatives of formula ##STR1## their tautomers and salts, in which the index n is 0, 1 or 2, alk is lower alkylene, Ar is phenyl, naphthyl or a monocyclic, five- or six-membered heteroaryl radical, wherein the aromatic radical is u... | 09/15/1992 |
| 5125954 | Herbicidal oxabicycloalkane ethers The present invention relates to novel bicyclo ether derivatives, to compositions containing them, and to their method of use especially to control the growth of undesired vegetation in rice.... | 06/30/1992 |
| 5112852 | Allenyl amines The present invention relates to allenyl amines, more specifically, ଲ-ethenylidene(substituted) ethanamines, possessing antihypertensive activity, and having the general formula ##STR1## wherein n is the integer 0, 1 or 2; each X independently ... | 05/12/1992 |
| 5112851 | Amine derivatives, processes for their production and their use Compounds of formula I ##STR1## wherein R1 represents a group of formula ##STR2## and R2 represents hydrogen or lower alkyl, or R1 and R2 together with the carbon atom to which they are attached repres... | 05/12/1992 |
| 5110829 | 2,2'-thienylbenzothiophenes, their preparation and their use for controlling pests 2,2'-Thienylbenzothiophenes of the general formula I ##STR1## where R1 and R3 independently of one another are each halogen, alkyl, haloalkyl, alkoxy or haloalkoxy, R2 is hydrogen, halogen, alkyl, haloalkyl, alkoxy or... | 05/05/1992 |
| 4853149 | Heterocyclic liquid crystal compounds Heterocyclic liquid crystal compounds containing the structural element ##STR1## wherein M is H, CN,, NCS, halogen or an alkyl group with 1-5 C atoms, X is CR4 or N, Y is CHR4, O, S or NR5, R4 is H, alkyl with 1-15 C... | 08/01/1989 |
| 4791123 | Insecticidal triffluormethyl alkane derivatives There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R1, R2, R3, R4 and A have the meanings given in the description, processes for their preparation and ins... | 12/13/1988 |
| 4742077 | Bicyclic allylether derivatives, processes for their production and their use Compounds of formula I ##STR1## wherein R1 represents a group of formula ##STR2## whereby R4 and R5 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl and X ... | 05/03/1988 |
| 4689087 | Process for the preparation of an organic pigment on the basis of 4,4',7,7'-tetrachloro-thio-indigo A process for the preparation of 4,4',7,7'-tetrachloro-thioindigo pigment which comprises treating a finely divided crude 4,4',7,7'-tetrachloro-thioindigo pigment in anhydrous form at temperatures of from 50° to 180° C. with a nitroaromatic substance wh... | 08/25/1987 |
| 4664693 | 5-[Substituted bicyclic aryl or heteroaryl]cyclohexane-1,3-dione herbicides The invention concerns novel compounds of the formula I ##STR1## wherein: A is selected from CH and N; B is selected from oxygen, sulfur, CH2 and the group N-Z wherein Z is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl... | 05/12/1987 |
| 4663344 | Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor 3-Hydroxybenzo[b]thiophene derivatives, such as 2-aralkyl, 2-alkyl and 2-alkenyl-3-hydroxybenzo[b]-thiophenes, were prepared by, among other methods, ring closure of 2-(2-carboxy-phenylthio)--substituted acetic acids. These compounds are found to b... | 05/05/1987 |
| 4652660 | Process for preparing a thioindigo derivatives comprising cyclizing in a liquid mixture of an aluminium halide an alkali metal halide, and a carboxamide or sulfonamide Process for preparing thioindigo compounds of the formula ##STR1## in which A and B denote identical or different, optionally substituted benzene rings or benzene rings to which may be joined further carbocyclic and heterocyclic rings, characterized ... | 03/24/1987 |
| 4617403 | Process for preparing a pigment based on 4,4',7,7'-tetrachlorothioindigo Process for preparing a strong, non-flocking and rheologically excellent 4,4',7,7'-tetrachlorothioindigo pigment in high yields and high purity, which comprises (a) reacting 2,5 -dichlorophenylthioglycoloyl chloride with Friedel-Crafts catalysts in inorga... | 10/14/1986 |
| 4456762 | Process for the preparation of 4,7-dichloro-3-hydroxy-thionaphthene The invention provides a process for the preparation of 4,7-dichloro-3-hydroxy-thionaphthene by reaction of 2,5-dichlorophenyl-thioglycolic acid chloride in dichloromethane in the presence of Friedel-Crafts catalysts.... | 06/26/1984 |
| 4431824 | Preparation of 4,4',7,7'-tetrachlorothioindigo pigments of high color strength 4,4',7,7'-Tetrachlorothioindigo pigments of high color strength are prepared by oxidizing 3-hydroxy-4,7-dichlorothionaphthene or a mixture of tetrachlorothioindigo and hydroxydichlorothionaphthene in aqueous alkaline suspension with a salt of a nitro-arom... | 02/14/1984 |
