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| Number | Title | Issue Date |
| 7326799 | Epoxycarboxamide compound, azide compound, and amino alcohol compound, and process for preparing alpha-keto amide compound using them The present invention is to provide manufacturing intermediates which can be led to useful α-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide epoxycarboxamide compounds, azide compounds and amino a... | 02/05/2008 |
| 6841536 | Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof Disclosed is a prodrug of the formula: where A is a sulfur or a selenium, and R is derived from a mono- di- or oligo- saccharide. Also disclosed is a prodrug of the formula: | 01/11/2005 |
| 6812229 | Carbamate derivative and agricultural/horticultural fungicide It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate derivative represented by the general formula [I] | 11/02/2004 |
| 6743929 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 06/01/2004 |
| 6437134 | Process for a phenylthiobutyl-isoquinoline and intermediates therefor A method for making phenylthiobutyl-isoquinoline compounds of formula ##STR1## and novel intermediates therefor.... | 08/20/2002 |
| 6376468 | Protein:prenyl transferase inhibitors The invention pertains to novel peptide analogs suitable for inhibiting protein:prenyl transferases. As such they are therapeutically useful in e.g. inhibiting oncogenesis and other unwanted cell proliferation, and in supressing aberrant high signal trans... | 04/23/2002 |
| 6369188 | Polyfunctional urethane- or urea-containing oligomers and polymers prepared therefrom Polyfunctional polymerizable urethane- or urea-containing oligomers allow the design, adjustment, and regulation of chemical and physical properties of the described oligomers. The invention discloses the formulas and compositions of these oligomers, meth... | 04/09/2002 |
| 6278002 | Process for the preparation of (2r,3s)-3-amino-1,2-oxirane A process for producing (2R,3S)-3-amino-4-phenylbutane-1,2-epoxide compounds which comprises treating a (2S,3S)-3-amino-1-halo-2-hydroxy-4-phenylbutane compound or a (2S,3S)-3-amino-4-phenylbutane-1,2-epoxide with a carboxylic acid quaternary ammoniu... | 08/21/2001 |
| 6268533 | Formoterol process A method is disclosed for the preparation of optically pure isomers of formoterol by the reaction of an optically pure 4-benzyloxy-3-formamidostyrene oxide with an optically pure 4-methoxy--methyl-N-(phenylmethyl)benzeneethanamine followed by ... | 07/31/2001 |
| 6239296 | Process for a phenylthiobutyl-isoquinoline and intermediates therefor Intermediate compounds useful for making phenylthiobutyl-isoquinoline compounds of formula ##STR1##... | 05/29/2001 |
| 6225478 | Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient Novel iridoid derivatives represented by general formula (I): ##STR1## and a vascularization inhibitor having for its active ingredient said derivative are disclosed. This vascularization inhibitor has remarkable vascularization inhibitory effects unaccom... | 05/01/2001 |
| 6207704 | Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluatin... | 03/27/2001 |
| 6147224 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1 R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent ar... | 11/14/2000 |
| 6133457 | Process for preparing pharmaceutical compounds A compound of formula IV ##STR1## wherein G is C1 -C12 alkyl, C2 -C12 alkenyl, C2 -C12 alkynyl or Ar; Ar is an aromatic or heteroaromatic group or a substituted aromatic or heteroaroma... | 10/17/2000 |
| 6127556 | Epoxide formation by continuous in-situ synthesis process In a method of preparing an aminoepoxide wherein a protected aminoaldehyde is reacted with a halomethyl organometallic reagent in an appropriate solvent at a temperature above -80° C., wherein said halomethyl organometallic reagent is formed by reaction ... | 10/03/2000 |
| 6013836 | Insecticidal N'-substituted-N,N'-disubstitutedhydrazines This invention relates to N'-substituted-N,N'-disubstitutedhydrazines of formula I ##STR1## wherein X and X' are independently O, S, or NR; A' and B' are independently substituted or unsubstituted aryl or aromatic heterocycle; wherein F is alkyl... | 01/11/2000 |
| 5994539 | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases Compounds of formula ##STR1## wherein R, R1, R2, R3, R4, m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active i... | 11/30/1999 |
| 5977387 | Process for preparing pharmaceutical compounds This invention provides processes for preparing cryptophycin compounds and novel intermediates which are useful in such processes.... | 11/02/1999 |
| 5977388 | Compounds useful for preparing an ,'-diaminoalcohol A process for the manufacture of the ,'-diaminoalcohol of formula ##STR1## is via N-protected L-phenylalanine lower alkyl esters, corresponding N-protected -amino-'-haloketones, and -amino-'-haloalcohols... | 11/02/1999 |
| 5965609 | Borneol esters, process for their production, and their pharmaceutical use The invention concernes borneol esters of general formula (I), in which R1 means T--C(O)--CH(OR6)--(NR7a R7b)--R8, C(O)--CH(OR6a)--CH[NR7 (C(O)--CH(OR6b)--CH (NR7a | 10/12/1999 |
| 5883264 | Process for preparing optically active trans-3-phenylglycidamide compounds Process for preparing optically active trans-3-phenylglycidamide compound, which comprises subjecting racemic trans-3-phenylglycidamide compound of the formula (I) ##STR1## wherein Ring A is substituted or unsubstituted benzene, and R1 is ... | 03/16/1999 |
| 5883121 | Epoxysuccinamide derivative or salt thereof, and medicine comprising the same The invention relates an epoxysuccinamide derivative represented by the general formula (1) ##STR1## wherein R1 and R2 are the same or different from each other and independently represent H or an aromatic hydrocarbon group or a... | 03/16/1999 |
| 5792792 | Borenol derivatives, process for their production and their pharmaceutical use The invention relates to borneol derivatives of general formula I ##STR1## in which R1 means C(O)--CH(OR6)--CH(NHR7)--R8, R2 means hydrogen, --OH, C1 -C10 alkyl, C1 -C... | 08/11/1998 |
| 5744621 | Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof Cis-epoxide compounds of formula (I-1) and pharmaceutically acceptable salts, hydrates and solvates thereof: ##STR1## wherein: R1 is a cycloalkyl, or aryl-substituted lower alkyl group; A is a functionalized acyl group of the formula ##STR... | 04/28/1998 |
| 5736620 | Glycidyl ether compounds containing mesogenic moieties Epoxy resins containing rodlike mesogenic moieties are prepared from phenolic hydroxyl containing compounds which contain such moieties.... | 04/07/1998 |
| 5693859 | Process of producing intermediates for use in production of alkoxyiminoacetamides and intermediates to be used therein There is disclosed a process of producing an -ketamide as an intermediate for use in the production of various alkoxyiminoacetamide compounds which are useful as fungicides. Also disclosed is an intermediate to be used in this process.... | 12/02/1997 |
| 5670675 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula A-X-B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl, (... | 09/23/1997 |
| 5578608 | Symmetrical diaryl and diheteroanyl cis epoxy alkanes antiviral compounds An HIV protease inhibiting compound of formula I ##STR1## wherein: R is C1 -C6 alkyl, cycloalkyl, heterocycle, unsaturated heterocycle, aryl, cycloalkyl (C1 -C4)alkyl, heterocycle(C1 -C4 | 11/26/1996 |
| 5563168 | O-Benzyloxime ethers and crop protection agents containing these compounds O-Benzyloxime ethers of the formula I ##STR1## where 5 X is substituted or unsubstituted CH2, NOalkyl Y is O, S, NR5 R1, R2, R5 are H, alkyl Z1, Z2 are H, halogen, methyl, methoxy, cy... | 10/08/1996 |
| 5502252 | Process of producing intermediates for use in production of alkoxyiminoacetamides and intermediates to be used therein There is disclosed a process of producing an -ketamide as an intermediate for use in the production of various alkoxyiminoacetamide compounds which are useful as fungicides. Also disclosed is an intermediate to be used in this process.... | 03/26/1996 |
| 5495029 | (Meth)acrylates containing urethane groups Novel (meth)acrylates containing urethane groups Novel (meth)acrylates which also contain urethane groups and other polymerizable groups in one and the same molecule and can be polymerized either by means of free radicals and/or cationically are used for ... | 02/27/1996 |
| 5481012 | Process for selective epoxidation of unsaturated (meth)acrylic compounds and new bifunctional (meth)acrylates obtained Process for the epoxidation of an unsaturated (meth)acrylic compound of formula: ##STR1## in which R1 is chosen from H and C1 -C5 -alkyl; R2 is chosen from H, alkyl and aryl; R3 is a straight-cha... | 01/02/1996 |
| 5391735 | Process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane in the form of single diastereoisomers, to certain of these diastereoisomers, and to compounds which are intermediates in the new ... | 02/21/1995 |
| 5387657 | Epoxy resins containing thiadiazole and/or oxadiazole moieties Epoxy resins containing more than one vicinal epoxide group per molecule and at least one thiadiazole, oxadiazole or both thiadiazole and oxadiazole moiety per molecule are disclosed, as well as curable and cured compositions thereof. Certain of these epo... | 02/07/1995 |
| 5318989 | Cytotoxic bicyclo [7.3.1.]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof The present invention relates to a novel and efficient process for the preparation of 8-hydroxybicyclo[7.3.1]tridec-4-ene-2,6-diyne ring system which is part of the aglycone of esperemicin and to novel cytotoxic antitumor agents having said bicyclic ring ... | 06/07/1994 |
| 5290887 | Epoxy resins containing thiadiazole and/or oxadiazole moieties Epoxy resins containing more than one vicinal epoxide group per molecule and at least one thiadiazole, oxadiazole or both thiadiazole and oxadiazole moiety per molecule are disclosed, as well as curable and cured compositions thereof. Certain of these epo... | 03/01/1994 |
| 5266612 | Imide epoxy resin composition for sealing semiconductor elements An epoxy resin composition for sealing semiconductor elements comprising o-cresol-novolak type epoxy resins, curing agents, curing accelerators, inorganic fillers, plasticizers and imide-epoxy resins having the formula (I) is disclosed. Use of the imide-e... | 11/30/1993 |
| 5218075 | Amide and hydroxymethyl functionalized polyethers as thermoplastic barrier resins Polyethers having improved barrier to oxygen are normally solid, thermoplastic polyethers having aromatic ether repeating units in their backbones and pendent hydroxyl moieties and pendent amido, N-substituted amido and/or hydroxyalkyl moieties. Such poly... | 06/08/1993 |
| 5204370 | Bis-(hydroxyalkylamino)-anthraquinone inhibitors of protein kinase C The present invention provides novel substituted anthraquinones having the formula ##STR1## wherein R1 and R2 are independently H, C1 -C10 alkyl, aryl, arylalkyl, alkylaryl; n and m are independently 1, 2, ... | 04/20/1993 |
| 5189082 | Imide epoxy resins for sealing semiconductor elements The present invention relates to novel epoxy resin compositions for sealing semiconductor elements, which comprise 0.1 to 20.0% by weight of imide-epoxy resins represented by the general formula (I) together with epoxy resins, curing agents, curing promot... | 02/23/1993 |
