Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7820839 | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof The invention relates to a second-generation-fatty acid conjugate and pharmaceutical compositions thereof. The second-generation-fatty acid conjugate are useful in the treatment of cancer in a human in need thereof. ... | 10/26/2010 |
| 7615653 | Anti-tuberculosis taxane compounds The present invention relates to compounds having the formula (I): ... | 11/10/2009 |
| 7414073 | Cytotoxic agents containing novel potent taxanes and their therapeutic use Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selec... | 08/19/2008 |
| 7393569 | Polymerizable liquid crystal composition and polymer thereof A polymerizable liquid crystal composition containing compounds represented by the formula (1-1) and the formula (1-2), compounds represented by the formula (2-1) and the formula (2-2), and a compound represented by the formula (3-1): | 07/01/2008 |
| 7390898 | Cytotoxic agents containing novel potent taxanes and their therapeutic use Included within the scope of the present invention are potent taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell pop... | 06/24/2008 |
| 7368473 | Paclitaxel enhancer compounds One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with b... | 05/06/2008 |
| 7354985 | Fluorinated thermoset polyurethane elastomers prepared from polyether prepolymers formed from mono-substituted fluorinated oxetane monomers This application is directed to novel fluorinated polymers and prepolymers derived from mono-substituted oxetane monomers having fluorinated alkoxymethylene side-chains and the method of making these compositions. The mono-substituted fluorinated oxetane monomers ha... | 04/08/2008 |
| 7332554 | Polymers with new sequence distributions The invention relates to new polymerization processes including diluents including hydrofluorocarbons and their use to produce novel polymers with new sequence distributions. In particular, the invention relates to copolymers of an isoolefin, preferably isobutylene,... | 02/19/2008 |
| 7332555 | Polymers with new sequence distributions The invention relates to new polymerization processes including diluents including hydrofluorocarbons and their use to produce novel polymers with new sequence distributions. In particular, the invention relates to copolymers of an isoolefin, preferably isobutylene,... | 02/19/2008 |
| 7326796 | Fluorinated monomers, fluorinated polymers having polycyclic groups with fused 4-membered heterocyclic rings, useful as photoresists, and processes for microlithography The present invention provides novel fluorine-containing copolymers which comprise at least one fluorinated olefin, at least one polycyclic ethylenically unsaturated monomer with a fused 4-membered heterocyclic ring and, optionally, other components. The copolymers ... | 02/05/2008 |
| 7317113 | Process for the preparation of the 14β-hydroxy-baccatin III-1,14-carbonate A process for the preparation of 14β-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity. ... | 01/08/2008 |
| 7309755 | Method of producing polycarbonate articles by rotation molding and rotation molded articles made by the method A method for making a polycarbonate article is described wherein the article is made by rotation molding a melt polycarbonate having a weight average molecular weight from 25,000 to about 36,000. The melt polycarbonate is produced by transesterifying a diaryl carbon... | 12/18/2007 |
| 7307176 | Inclusion complex of taxol with 2-hydroxypropyl-beta-cyclodextrin The present invention relates to a method for producing a 2-hydroxypropyl-beta-cyclodextrin inclusion complex of taxol, said 2-hydroxypropyl-beta-cyclodextrin having a degree of substitution of 0.4 to about 0.9, wherein the method comprises admixing the 2-hydroxypro... | 12/11/2007 |
| 7288665 | Process for selective derivatization of taxanes Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(... | 10/30/2007 |
| 7276499 | Cytotoxic agents comprising taxanes and their therapeutic use A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking gro... | 10/02/2007 |
| 7276228 | Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase Methods are provided for treating hematological disorders by inhibition of DNA hypomethylation and histone deacetylase. Such disorders include, for example, acute promyelocytic leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, myelodysplastic syn... | 10/02/2007 |
| 7264951 | Enhanced production of taxol and taxanes by cell cultures of species This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, med... | 09/04/2007 |
| 7259268 | Method for purification of paclitaxel from paclitaxel-containing materials This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extr... | 08/21/2007 |
| 7247738 | Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids This invention relates to a process for preparation of taxanes comprising subjecting 7,10-diprotected intermediates 7-O-(2-haloacyl)baccatin III 6c or 7,10-O-di-(2-haloacyl)-10-deacetylbaccatin III 6b to a step of coupling with (4S,5R)-3-[(2-alkyl/aryl-... | 07/24/2007 |
| RE39723 | Semi-synthetic taxanes with antitumor and antiangiogenetic activities Seco-baccatin III derivatives of formula: wherein R, R1-R4, R1 R′, R11 R″, and R111 R′″ are disclosed herein; pharmaceutical compositions comprising seco-baccatin ... | 07/10/2007 |
| 7235583 | Fatty acid-anticancer conjugates and uses thereof The invention provides conjugates of fatty acids and anticancer agents useful in treating cancer, and compositions and formulations thereof. Methods for using the conjugates also are provided. ... | 06/26/2007 |
| 7232872 | Polymerization processes The invention provides for a process to produce polymers utilizing a hydrofluorocarbon diluent. ... | 06/19/2007 |
| 7232917 | Cyclic fluorine compounds, polymerizable fluoromonomers, fluoropolymers, and resist materials containing the fluoropolymers and method for pattern formation The present invention provides a fluorine-containing cyclic compound represented by general formula (1): wherein R1 represents a halogen atom, and R2 and R3 each represents hydrog... | 06/19/2007 |
| 7230013 | C10 carbamoyloxy substituted taxane compositions Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents. ... | 06/12/2007 |
| 7226944 | Taxanes having a C7 carbonate substituent Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents. ... | 06/05/2007 |
| 7220872 | Conversion of taxane molecules The invention provides methods and compositions for reductively deoxygenating an amide group at a C-3′ position of a taxane molecule followed by subsequent intra-molecular acyl migration of an acyl group to the C-3′ position. ... | 05/22/2007 |
| 7217819 | Cytotoxic agents comprising taxanes and their therapeutic use A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking gro... | 05/15/2007 |
| 7214750 | Polymerization processes The invention relates to new processes to produce polymers utilizing bayonette cooled slurry reactor systems and diluents including hydrofluorocarbons. ... | 05/08/2007 |
| 7202370 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and th... | 04/10/2007 |
| 7186849 | C7 ester substituted taxanes Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents. ... | 03/06/2007 |
| 7176325 | Selective acylation of secondary hydroxyl groups The invention provides methods and compositions for selectively acylating a specific hydroxyl group in a molecule of interest containing at least two unprotected secondary hydroxyl groups. Although the methods and compositions of the invention have general applicabi... | 02/13/2007 |
| 7176326 | β-Lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes Novel β-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling β-lactams to form such sidechain-bearing taxanes, and to novel sid... | 02/13/2007 |
| 7169307 | Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from This invention teaches a purification technology to extract an organic solution of paclitaxel by using a “Load and Lock Axial Compression Column” for industrial scale preparative high performance liquid chromatography. The “Load and Lock Axial Compression Colu... | 01/30/2007 |
| 7169446 | Oxetane compound, actinic ray curable composition, ink composition for ink jet recording, and image formation method Disclosed is an oxetane compound represented by the following formula (I), (II), (III), (IV) or (V): ... | 01/30/2007 |
| 7161098 | Method and system for sticky key prevention for keyboard or keypad devices A method and system of minimizing sticky keys in an electronic device having a body, circuitry, and a plurality of keypads is disclosed. The method and system comprise providing a protectant coating; and applying the protectant coating on surfaces of both the keypad... | 01/09/2007 |
| 7112687 | Methods for obtaining paclitaxel from taxus plants Methods for obtaining paclitaxel from plants containing paclitaxel are disclosed. Plant material is first obtained from plants containing paclitaxel. Paclitaxel is then extracted from the plant material. Subsequently, paclitaxel is separated from the paclitaxel extr... | 09/26/2006 |
| 7100380 | Organic rankine cycle fluid A method of operating an organic rankine cycle system wherein a liquid refrigerant is circulated to an evaporator where heat is introduced to the refrigerant to convert it to vapor. The vapor is then passed through a turbine, with the resulting cooled vapor then pas... | 09/05/2006 |
| 7087710 | Polymeric surfactants derived from cyclic monomers having pendant fluorinated carbon groups A fluorine containing polymer which acts as a wetting, flow or leveling agent, and has at least one polar group. The polymer has at least one pendant or ether side chain containing from about 1 to about 20 carbon atoms with at least 25% of the hydrogen atoms being r... | 08/08/2006 |
| 7078538 | Baccatin III derivatives A process for the preparation of 14 beta-hydroxy-1,4-carbonate-deacetylbaccatin III and intermediates useful for the preparation of novel taxan derivatives with antitumor activity are disclosed. ... | 07/18/2006 |
| 7078432 | Process for the preparation of the 14β-hydroxy-baccatin III-1,14-carbonate A process for the preparation of 14β-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity. ... | 07/18/2006 |
