Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8115020 | Processes for the preparation and purification of hydroxymethylfuraldehyde and derivatives A method for utilizing an industrially convenient fructose source for a dehydration reaction converting a carbohydrate to a furan derivative is provided. Recovery methods also are provided. Embodiments of the methods improve upon the known methods of producing furan... | 02/14/2012 |
| 7432382 | Conversion of 2,5-(hydroxymethyl)furaldehyde to industrial derivatives, purification of the derivatives, and industrial uses therefor A method of preparing 2,5-bis(hydroxymethyl)tetrahydrofuran comprises heating a reaction mixture comprising 2,5-(hydroxymethyl)furaldehyde, an organic solvent, and a catalyst system comprising nickel and zirconium at a temperature, for a time, and at a pressure suff... | 10/07/2008 |
| 7307100 | 2-Benzoylchromone derivatives Novel compounds of the formula I in which R, X, n and m are as defined herein are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection of the st... | 12/11/2007 |
| 7268160 | Remedies The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor producti... | 09/11/2007 |
| 7145015 | Benzocycloheptenes, process for their production, pharmaceutical preparations that contain that latter as well as their use for the production of pharmaceutical agents Benzocycloheptenes of formula (I), in which R1, R2 and Y have the meanings that indicated herein, exhibit selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therap... | 12/05/2006 |
| 7049449 | Method for the preparation of lariciresinol cyclolariciresinol and secoisolariciresinol A method for the preparation of lariciresinol, cyclolariciresinol or secoisolariciresinol, which method includes the steps of a) reducing hydroxymatairesinol to give 7-hydroxy-secoisolariciresinol, and b) subjecting the 7-hydroxy-secoisolariciresinol obtained in ste... | 05/23/2006 |
| 7012094 | Substituted furans and furanones for the treatment of inflammation A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defin... | 03/14/2006 |
| 6909014 | Intermediates for the synthesis of ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 06/21/2005 |
| 6840965 | P-aminophenols and colorants containing said compounds The object of the invention are p-aminophenol derivatives of general formula (I) or physiologically tolerated, water-soluble salts thereof and oxidative coloring preparations based on a developer-coupler combination co... | 01/11/2005 |
| 6831106 | Vitamin D analogues The present invention relates to novel triaromatic compounds having the general formula (I): as well as to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veteri... | 12/14/2004 |
| 6750247 | Sponge-derived terpenoids and methods of use Compounds that are effective lipoxygenase inhibitors, and methods and pharmaceutical compositions for inhibiting lipoxygenases and for treatment of lipoxygenase-mediated conditions in humans and other subjects. The compounds, methods and pharmaceutical compositions ... | 06/15/2004 |
| 6713507 | Ether compounds and compositions for cholesterol management and related uses The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 03/30/2004 |
| 6624316 | Method for obtaining 2-bromo-5-(2-bromo-2-nitrovinyl)-furan The present invention refers to a new procedure for obtaining and purifying 2-bromo-5-(2-bromo-2-nitrovinyl)-furan in one reaction step starting with 2-nitrovinylfuran, and maintains high indexes of purity and an appropriate yield. The process involves th... | 09/23/2003 |
| 6420392 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammato... | 07/16/2002 |
| 6372922 | Process for the production of (-) 3,4-divanillyl tetrahydrofuran The present invention relates to a process for the production of (-)3,4-divanillyl tetrahydrofiran of formula (2) which comprises (a) isolating) (-) secoisolariciresinol of formula (1) from the heartwood and roots of Taxus wallichiana by an improved proce... | 04/16/2002 |
| 6369102 | Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 04/09/2002 |
| 6339163 | Tetrahydrofuran derivatives that can be used as detergent compositions for gasoline-type fuels Compositions that comprise at least one compound that corresponds to general formula (I): ##STR1## in which n is a number from 0 to 20; R1, R2, R3 and R4 each represent a hydrogen atom or a hydrocarbon radical, for example alkyl, with 1 to 30 carbon ... | 01/15/2002 |
| 6277833 | Substituted triols Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.... | 08/21/2001 |
| 6258841 | Tubulin binding compounds (COBRA) Novel tubulin binding compounds having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds a... | 07/10/2001 |
| 6248773 | Cyclopentane heptan(ene)oic acid, 2-heteroarylalk(en)yl derivatives as therapeutic agents The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-heteroarylalk(en)yl derivatives as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: ##STR1## wherein the hatch... | 06/19/2001 |
| 6235956 | Acetals, their preparation and their use An acetal, wherein the acetal is 2,2-di(tetrahydrofurfuryloxy)propane as well as processed for producing the acetal and methods of using the acetal.... | 05/22/2001 |
| 6191292 | Precursors of the A-ring of vitamin D and method and intermediates for the preparation thereof The invention relates to precursors of the A-ring of vitamin D, of the formula (I): ##STR1## in which A, R, R1 and R2 are as defined in the specification. The invention also relates to a method of preparing compounds (I) comprising t... | 02/20/2001 |
| 6160129 | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate either th... | 12/12/2000 |
| 6150540 | Versatile intermediate for annonaceous acetogenins A tetrahydrofuran (THF) epoxide and method of its preparation according to a novel stereoselective synthetic method. The compounds of the invention are used to prepare therapeutically active mono-THF and bis-THF containing Annonaceous Acetogenins.... | 11/21/2000 |
| 6124344 | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate either th... | 09/26/2000 |
| 6057342 | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a... | 05/02/2000 |
| 6051725 | Epoxidation of ricinic compounds using a phase-transfer catalyst Unsaturated or polyunsaturated, conjugated or nonconjugated hydrocarbons are reacted with an oxidizing agent including hydroperoxides and monopersulfate compounds in the presence of phase-transfer catalysts. Suitable hydrocarbons include ricinic compounds... | 04/18/2000 |
| 6020339 | Aryl furan derivatives as PDE IV inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## ... | 02/01/2000 |
| 5972991 | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate eit... | 10/26/1999 |
| 5945549 | Production of aqueous solutions of mixtures of formyltertrahydrofuran and hydrates thereof Disclosed is a process for the recovery of formyltetrahydrofurans (FTHF's) produced by the rhodium-catalyzed hydroformylation of 2,5-dihydrofuran (2,5-DHF) wherein the FTHF's are recovered as an equilibrium mixture of 2- & 3-FTHF and their hydrates, 2- an... | 08/31/1999 |
| 5919965 | Non-nucleotide phosphorus ester oligomers A phosphorus ester oligomer having the structure: ##STR1## wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, alkyl- or aryl-substituted amino and... | 07/06/1999 |
| 5914410 | Intermediates for annonaceous acetogenins Novel tetrahydrofuran-epoxide compounds are described as intermediates for the preparation of non-adjacent bis-THF-acetogenins of pharmaceutical interest. Also described is a novel stereocontrolled synthesis for preparing such intermediates starting with ... | 06/22/1999 |
| 5874460 | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Compounds of the formula ##STR1## where W is (CH2)n where n is 1 or 2, or n is 0 and W represents lower alkyl groups attached to each oxygen; m is an integer between 1 and 8; R1 is COOH or a pharmaceutically acceptable sal... | 02/23/1999 |
| 5856323 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira... | 01/05/1999 |
| 5849858 | Resinous binder compositions Furfuryl alcohol/formaldehyde resins exhibiting high water compatibility and low amounts of volatile organic compounds such as furfuryl alcohol.... | 12/15/1998 |
| 5780629 | Polymerizable, chiral compounds and their use The invention relates to chiral compounds containing at least one divalent or polyvalent chiral group, at least one polymerizable group, at least one spacer and at least one mesogenic group, and to their use as polymerizable, chiral dopes for the preparat... | 07/14/1998 |
| 5741914 | Resinous binder compositons Furfuryl alcohol/formaldehyde resins exhibiting high water compatibility and low amounts of volatile organic compounds such as furfuryl alcohol.... | 04/21/1998 |
| 5731345 | Seco-D steroids active on the cardiovascular system and pharmaceutical compositions containing same Seco-D steroid derivatives having the formula ##STR1## wherein R, R1, R2 and R3 have the meanings specified in the specification, useful as cardiovascular agents and pharmaceutical compositions containing same, are di... | 03/24/1998 |
| 5629340 | Angiogenesis inhibitor and novel compound An angiogenesis inhibitor comprising, as an active agent, Compound (I) represented by the formula below: ##STR1## where R1 is a lower alkyl group, an alkoxycarbonyl group or a carboxyl group; and R2, R3 and R4 | 05/13/1997 |
| 5618932 | Photoactive compounds and compositions A new photoactive compound for use in the formulation of a photoresist comprises a bisphenol compound having an alkyl linkage substituted with a heterocyclic group. The new photoactive compound may be admixed with an alkali soluble resin to formulate a ph... | 04/08/1997 |
