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| Number | Title | Issue Date |
| 8436194 | Process for the preparation of prostaglandin analogues and intermediates thereof The present application provides intermediates for preparing prostaglandin analogues and processes for preparing prostaglandin analogues and intermediates thereof. The intermediates include: A compound of formula (6): R | 05/07/2013 |
| 8242293 | Method for the synthesis of organic acid esters of 5-hydroxymethylfurfural and their use Method for the manufacture of organic acid esters of 5-hydroxymethylfurfural by reacting a fructose or glucose-containing starting material with an organic acid or its anhydride in the presence of a catalytic or sub-stoechiometric amount of solid acid catalyst. The ... | 08/14/2012 |
| 7897795 | Process for the preparation of prostaglandin analogues and intermediates thereof The present application provides intermediates for preparing prostaglandin analogues and processes for preparing prostaglandin analogues and intermediates thereof. The intermediates include: A compound of formula (6): R | 03/01/2011 |
| 7361679 | 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same The present invention relates to a 2-phenyl-3-heteroarylpropionic acid derivative or a salt thereof, and also relates to a pharmaceutical agent and a VLA-4 and/or LPAM-1 antagonist each of which contains the same as an active ingredient. ... | 04/22/2008 |
| 7196089 | EPreceptor antagonists Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O... | 03/27/2007 |
| 7148363 | Process for preparing acrylate compound An acrylate compound of formula (4): is produced by allowing an acrylic acid compound of formula (1): to react with an unsaturated compound of formula (2) or... | 12/12/2006 |
| 7129268 | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives Novel compounds of the general formula (I), wherein Ar, R1, R2, X1, X2, Y1, Y, and Z are as defined in the specification, the use of these compounds as pharm... | 10/31/2006 |
| 6833462 | Process for preparing acrylate compound An acrylate compound of formula (4): is produced by allowing an acrylic acid compound of formula (1): to react with an unsaturated compound of formula (2) or (3): | 12/21/2004 |
| 6797723 | Heterocycle substituted diphenyl leukotriene antagonists The invention relates to novel heterocycle substituted diphenyl leukotriene B4 (LTB4) antagonists, to compositions containing such compounds, and to methods of using such compounds for treatment of inflammatory diseases. ... | 09/28/2004 |
| 6602900 | Cyclopentane heptan(ENE)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate either t... | 08/05/2003 |
| 6573390 | Cyclopentane heptan (ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents The present invention provides cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups, e.g. 1-OH cyclopentane heptanoic acid, 2 heteroarylalkenyl de... | 06/03/2003 |
| 6555577 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 04/29/2003 |
| 6420392 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammato... | 07/16/2002 |
| 6225288 | Gamma-ketoacid dipeptides as inhibitors of caspase-3 Compounds represented by formula I: ##STR1## as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, whic... | 05/01/2001 |
| 6159988 | Arylcycloalkyl derivatives, their production and their use Compounds of formula I, ##STR1## and the physiologically tolerable salts thereof, wherein the substituents R1 -R4 have the meanings given in the specifications and show an activity against inflammatory conditions.... | 12/12/2000 |
| 6143787 | Pharmaceutical composition containing 4-oxo-butynic acids The present invention relates to a pharmaceutical composition comprising, as active principle, a compound of formula: ##STR1## in which the groups A and B are chosen, independently of each other, from: a mono-, bi- or tricyclic aryl group having from... | 11/07/2000 |
| 6096902 | Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents The present invention provides cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups, e.g. 1-OH cyclopentane heptanoic acid, 2 heteroarylalkenyl de... | 08/01/2000 |
| 6030993 | 2-hydroxypropionic acid derivative and its manufacturing method This invention relates to a novel 2-hydroxypropionic acid derivative and its manufacturing method. Based on its mechanism to inhibit the CPT I, 2-hydroxypropionic acid derivative of this invention has blood glucose lowering effects so that the derivative ... | 02/29/2000 |
| 5985919 | (Het)aryloxy-, -thio- , aminocrotonates, methods of preparing them and their use as insecticides and fungicides (Het)aryloxy-, -thio- and -aminocrotonates of the formula I ##STR1## where the substituents have the following meanings: U is oxygen, sulfur or amino; V is oxygen, sulfur, amino or alkylamino; X, Y and Z independently of one another are .dbd.N-- or .dbd.C... | 11/16/1999 |
| 5968942 | - and ଲ-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors - and ଲ-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 10/19/1999 |
| 5856323 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira... | 01/05/1999 |
| 5808101 | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, are capable of lowering intraocular pressure in the eye of a mammal.... | 09/15/1998 |
| 5629340 | Angiogenesis inhibitor and novel compound An angiogenesis inhibitor comprising, as an active agent, Compound (I) represented by the formula below: ##STR1## where R1 is a lower alkyl group, an alkoxycarbonyl group or a carboxyl group; and R2, R3 and R4 | 05/13/1997 |
| 5602104 | Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same A polycyclic aromatic compound having the formula ##STR1## and its salts have useful therapeutic and cosmetic action particularly in psoriasis. In the formula, X represents --CH.dbd.CH--, O or S, R1 represents hydrogen, branched alkyl having 3-... | 02/11/1997 |
| 5602196 | Bisphenol ester derivatives Stabilisers of formula I ##STR1## wherein R1 and R2 may be C1 -C5 alkyl, the substituents R3 to R8 may be hydrogen, the variable n may be 1 or 2, and, when n is 1, A may be an alkoxy r... | 02/11/1997 |
| 5527827 | Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis Compounds having the Formula I: R1 R2 C(OR3)--Ar1 --X--Ar2 --C(Ar3).dbd.CHCO2 H I are inhibitors of leukotriene biosynthesis. These compounds are useful as ... | 06/18/1996 |
| 5514679 | Therapeutic phenoxyalklpyridazines and intermediates therefor Compounds of the formula ##STR1## wherein: R1 and R2 are independently hydrogen, halo, alkyl, alkenyl, alkoxy, hydroxy, hydroxyalkyl, hydroxyhaloalkyl, alkoxyalkyl, alkylthioalkynyl, hydroxyalkoxy, alkylthioalkyl, alkylsulfinyla... | 05/07/1996 |
| 5514694 | Peptidyl ketoamides A novel class of peptide -ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula Y--CO... | 05/07/1996 |
| 5463083 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammato... | 10/31/1995 |
| 5455265 | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist... | 10/03/1995 |
| 5434151 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira... | 07/18/1995 |
| 5434267 | Process for the preparation of substituted 3-alkoxyacrylates Process for the preparation of compounds of the formula (I) ##STR1## in which R1, R2, R3, X and n have the meaning given in the description, by reacting acetates with carbon monoxide in the presence of a basic auxilia... | 07/18/1995 |
| 5366984 | Methyl -arylacrylates substituted by a heterocyclic radical and their use Methyl -arylacrylates substituted by a heterocyclic radical and having the general formula ##STR1## where R is alkyl, alkenyl, haloalkyl, cycloalkyl, alkoxy, alkylcarbonyl, alkoxycarbonyl, halogen or aryl, the aromatic ring being unsubstituted... | 11/22/1994 |
| 5358938 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl terahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiphenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respirato... | 10/25/1994 |
| 5338844 | 2-substituted-2-cyclopentenone compound and anticancer agent and bone formation accelerator comprising same as active ingredient A 2-substituted-2-cyclopentenone compound represented by the following formula (I) and an anticancer agent and a bone formation accelerator comprising the same as an effective active ingredient: ##STR1##... | 08/16/1994 |
| 5300676 | Herbicidal fluorine-substituted alpha-(5-aryloxynaphthalen-1-yl-oxy)-propionic acid derivatives Fluorine-substituted -(5-aryloxy-naphthalen-1-yl-oxy)-propionic derivatives of the formula ##STR1## wherein R1, R2, R3, R4 and R5, as defined herein, are useful as herbicides. Processes an... | 04/05/1994 |
| 5292839 | Allyl peroxyketal chain transfer agents Novel unsaturated peroxyketals useful as molecular weight regulators in polymerization reactions are disclosed. Also disclosed are a polymerization process employing these novel unsaturated peroxyketals as molecular weight regulators, polymers and oligome... | 03/08/1994 |
| 5258521 | Process of producing optically active propionic acid ester derivatives Processes for producing optically active ester derivatives are disclosed. According to the present invention an optically active aryloxyphenoxy propionate derivative is produced by reacting a chlorinated heterocyclic aromatic compound with (2R)-2-(4-hydro... | 11/02/1993 |
| 5258477 | Monomers and polymers containing acetal and aldehyde groups Various novel acetal- and aldehyde-containing monomers are prepared. They can be polymerized and copolymerized by conventional polymerization techniques. The polymers contain repeating units derived from one or more ethylenically or allylically unsaturate... | 11/02/1993 |
| 5238957 | Esters of 2,2-dimethyl-cyclopropane-carboxylic acid New esters of 2,2-dimethyl-cyclopropane-carboxylic acid, which are endowed ith insecticidal and acaricidal activity, have the general formula: ##STR1## wherein: represents ##STR2## or a R1 --Y--CF2 --C.tbd.C-- group; Y rep... | 08/24/1993 |
