Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 7312181 | Acylated thiosemicarbazides as herbicides The present invention provides compounds of Formula I: wherein Ar1 is aryl or heteroaryl, Ar2 is aryl or heteroaryl, and R is a suitable organic group. Herbicidal composition comprising such... | 12/25/2007 |
| 7202247 | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the ... | 04/10/2007 |
| 7196089 | EPreceptor antagonists Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O... | 03/27/2007 |
| 7135574 | Process for the preparation of cyclic diketones The present invention relates to a process for the preparation of compounds of formula I wherein the substituents are as defined in claim 1, by conversion of a compound of formula II | 11/14/2006 |
| 6762198 | Dihetero-substituted metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): | 07/13/2004 |
| 6753391 | Ring-opened azlactone chain transfer agents for radical polymerization Chain transfer agents for controlled radical polymerizations (RAFT) are described. The chain transfer agents have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers. ... | 06/22/2004 |
| 6747104 | Azlactone photoiniferters for radical polymerization Photoiniferters for controlled radical polymerizations are described. The photoiniferters have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers. ... | 06/08/2004 |
| 6720425 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity. ... | 04/13/2004 |
| 6620841 | Aromatic heterocycle compounds having HIV integrase inhibiting activities A compound of the formula (I): ##STR1## wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is --COORA wherein RA is hydrogen or ester residue, --CONRB RC wherein RB and RC... | 09/16/2003 |
| 6566381 | Hetero-substituted metalloprotease inhibitors Heterocyclic substituted compounds having the general structure: ##STR1## which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes.... | 05/20/2003 |
| 6559100 | 2-benzoyl-cyclohexane-1,3-diones Substituted 2-benzoylcyclohexane-1,3-diones of the formula I ##STR1## where: R1 and R2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, C1 -C6 -alkyl, C1 -C6 -haloalkyl, C1 | 05/06/2003 |
| 6555690 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 04/29/2003 |
| 6515137 | Catalytic processes employing chiral imidazolidinone-based catalyst composition Acid addition salts of imidazolidinones are provided as catalysts for transforming a functional group within a first reactant by reaction with a second reactant. Exemplary first reactants are ,ଲ-unsaturated carbonyl compounds such as ,... | 02/04/2003 |
| 6420392 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammato... | 07/16/2002 |
| 6376429 | Benzoylcyclohexanediones, process for their preparation and their use as herbicides and plant growth regulators Benzoylcyclohexanediones of the formula (I), process for their preparation and their use as herbicides and plant growth regulators are described. ##STR1## In this formula (I), R11, R2, R3, R4, R5 | 04/23/2002 |
| 6316630 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are int... | 11/13/2001 |
| 6277833 | Substituted triols Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.... | 08/21/2001 |
| 6258822 | Urokinase inhibitors Compounds having the formula ##STR1## are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.... | 07/10/2001 |
| 6228848 | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities Aryl-substituted and aryl and (3-oxo-1-propenly)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invented RAR antagonists... | 05/08/2001 |
| 6204388 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are int... | 03/20/2001 |
| 6201013 | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group Compounds of the formula: ##STR1## are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simples viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses -6 and -7, and Kaposi h... | 03/13/2001 |
| 6191292 | Precursors of the A-ring of vitamin D and method and intermediates for the preparation thereof The invention relates to precursors of the A-ring of vitamin D, of the formula (I): ##STR1## in which A, R, R1 and R2 are as defined in the specification. The invention also relates to a method of preparing compounds (I) comprising t... | 02/20/2001 |
| 6160129 | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate either th... | 12/12/2000 |
| 6153770 | Furfurylthioalkanes, a process for their preparation and their use The invention relates to new furfurylthioalkanes of the formula ##STR1## wherein n can be zero or 1 R represents the methyl or ethyl radical if n is 0, and represents hydrogen or the methyl radical if n is 1, and R' represents methyl or ethyl, a process f... | 11/28/2000 |
| 6153759 | Heterocyclic benzoyl intermediates for herbicidal compounds Heterocyclic substituted benzoyl derivatives of the formula ##STR1## where Z is a 5-membered or 6-membered heterocyclic, saturated or unsaturated radical containing one to three hetero atoms selected from the group consisting of oxygen, sulfur and ni... | 11/28/2000 |
| 6057342 | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a... | 05/02/2000 |
| 6040274 | 2-Aroylcyclohexanediones, their preparation and their use as herbicides or plant growth-regulating agents 2- Aroylcyclohexanediones I ##STR1## where X, Y=O or S; Ar=phenyl or heteroaryl in each case having 1-4 substituents: halogen, cyano, nitro, --N.dbd.N--Ph, C1 -C4 -alkoxycarbonyl, --N(R9)--COR10, --N(R... | 03/21/2000 |
| 6004903 | 2-Anylocyclohexanediones having improved herbicidal properties Benzoyl derivatives of the formula I ##STR1## where Z is a 5-membered or 6-membered heterocyclic, saturated or unsaturated radical containing one to three hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen, Q is a cyclohex... | 12/21/1999 |
| 5952316 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 09/14/1999 |
| 5939268 | Combinatorial libraries of molecules and methods for producing same This invention features methods of synthesizing combinatorial libraries of chemical compounds, and combinatorial libraries of chemical compounds formed by the methods of this invention. Specifically, Diels-Alder chemistry is utilized to generate libraries... | 08/17/1999 |
| 5912388 | Preparation of aldehydes or ketones from alcohols A process for preparing an aldehyde or ketone comprising reacting a primary or secondary alcohol with oxygen in the presence of a base, a catalytic amount of a copper salt and a suitable lignad under anhydrous conditions.... | 06/15/1999 |
| 5856323 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira... | 01/05/1999 |
| 5780629 | Polymerizable, chiral compounds and their use The invention relates to chiral compounds containing at least one divalent or polyvalent chiral group, at least one polymerizable group, at least one spacer and at least one mesogenic group, and to their use as polymerizable, chiral dopes for the preparat... | 07/14/1998 |
| 5767141 | Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Propane derivatives of the formula I ##STR1## in which the radicals have the meanings stated in the description, a process for the pre... | 06/16/1998 |
| 5723681 | 3,3-(disubstituted)cyclohexan-1-01 dimers and related compounds The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-ol dimers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production ... | 03/03/1998 |
| 5703017 | 3-(Het) arylcarboxylic acid derivatives, their preparation and intermediates for their preparation 3-(Het)arylcarboxylic acid derivatives of the formula I ##STR1## where R is formyl, CO2 H or a radical hydrolyzable to COOH and the other substituents have the following meanings: R2 and R3 are each halogen, alkyl, haloalk... | 12/30/1997 |
| 5684206 | ଲ-aminovinyl ketones, a preparation process and their use in the preparation of ଲ-diketones Novel ଲ-aminovinyl ketones of the general formula ##STR1## wherein R1 is, in particular, an alkenyl, alkynyl, cycloalkyl or cycloalkenyl group; R2 is, in particular, an electron-attracting substituent such as nitro, acyl, ... | 11/04/1997 |
| 5681848 | Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents The invention relates to 7-5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxycyclopentyl(enyl)!heptanoic or heptenoic acids and derivatives of said adds, wherein one or more of said hydroxy groups are replaced ... | 10/28/1997 |
| 5663367 | 2,4-pentadienoic acid derivatives having retinoid-like biological activity Compounds of Formula 1 ##STR1## wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, ##STR2## Y is cycloalkyl or cycloalkenyl of 3 to 8 carbons optionally substituted with one or two R4 | 09/02/1997 |
| 5618943 | Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity Compounds of the formula ##STR1## the symbols have the meaning described in the specification have retinoid-like biological activity.... | 04/08/1997 |
