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| Number | Title | Issue Date |
| 7259166 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of... | 08/21/2007 |
| 7166622 | Substituted phenylsulfonamide inhibitors of beta amyloid production Compounds of Formula I, wherein R1–R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs ther... | 01/23/2007 |
| 7098201 | Heteroaromatic derivatives having an inhibitory activity against HIV integrase A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORA wherein RA is hydrogen or ester residue, —CONRBRC wher... | 08/29/2006 |
| 6855835 | Allomorph of isomer Z hydrochloride of alkylaminofurane derivative Allomorph of Z isomer of N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine hydrochloride, with two carbon atoms linked by a rigid ethylenic bond, marked by an asterisk (*), characterized by the following structural fo... | 02/15/2005 |
| 6747146 | Method of producing nitroguanidine- and nitroenamine derivatives Method of producing compounds of formula wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cyc... | 06/08/2004 |
| 6703425 | Sulfonamide derivatives The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders ##STR1##... | 03/09/2004 |
| 6677341 | (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and m... | 01/13/2004 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6552086 | Sulfonamide derivatives The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.... | 04/22/2003 |
| 6528651 | Method for production of 1,3-disubtituted 2-nitroguanidines The present invention relates to a process for the preparation of compounds of the formula (I) ##STR1## by reacting compounds of the formula (II) ##STR2## in which Het, R1, R2 and R4 are as defined in the description, with... | 03/04/2003 |
| 6451792 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): ##STR1## wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.... | 09/17/2002 |
| 6444840 | C11 oxymyl and hydroxylamino prostaglandins useful as FP agonists The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R1, R2, R3, R4, R5, R6, W, ... | 09/03/2002 |
| 6410780 | C11 oxymyl and hydroxylamino prostaglandins useful as medicaments The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R1, R2, R3, R4, R5, R6, W, ... | 06/25/2002 |
| 6380429 | Preparation of sulfonyl imine compounds Disclosed is a process for the oxidation of sulfonamides to sulfonyl imines using chromium (IV) dioxide as the oxidant.... | 04/30/2002 |
| 6359156 | Oxime amides and hydrazone amides having fungicidal activity The invention relates to compounds having usefulness in the control of Take-All disease in plants, particularly cereals, a method for the control of Take-All disease, and fungicidal compositions for carrying out the method. Compounds of the invention are ... | 03/19/2002 |
| 6358981 | Sulphonamide derivatives The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing th... | 03/19/2002 |
| 6342633 | O-benzyl oxime ether derivatives and their use as pesticides Compounds of the formula I ##STR1## in which Y is hydrogen, C1 -C4 alkyl, C1 -C4 alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, Z is a group a) ##STR2## R1 ... | 01/29/2002 |
| 6255340 | Pesticidal composition A pesticidal composition comprising prallethrin and a neonicotinoid compound given in the following formula (1), (2) or (3), as an active ingredient ##STR1## wherein, A represents a 6-chloro-3-pyridyl, 2-chloro-5-thiazolyl, tetrahydrofuran-2-yl, tetr... | 07/03/2001 |
| 6211240 | O-benzyl oxime ether derivatives and their use as pesticides Compounds of the formula I ##STR1## in which Y is hydrogen, C1 -C4 alkyl, C1 -C4 alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, Z is a group a) ##STR2## R1 ... | 04/03/2001 |
| 6200353 | Coupler for use in oxidative hair dyeing Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula at least one coupler comprising a compound of the formula: ##STR1## wherein R is selected from the group consisting of C1 to C2 alkyl ... | 03/13/2001 |
| 6187944 | Acrylonitrile compounds, process for their production and pesticides containing them Acrylonitrile compounds having pesticidal activity of formula (I) and salts thereof. ##STR1## wherein Q is ##STR2## Y is .dbd.C(R4)-- or .dbd.N--, R1 is alkyl, haloalkyl, etc., each of R2 and R3 is halogen,... | 02/13/2001 |
| 6166003 | Heterocyclic compounds for cancer chemoprevention A compound comprising a heterocyclic moiety, such as a thiophene, covalently attached to an alkylene isothiocyanate moiety. The compound is effective to prevent the occurrence or progression of cancer or a precancerous condition, and can be used for thera... | 12/26/2000 |
| 6143790 | L-N6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors There is disclosed a novel amino glycol derivatives of L-N6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.... | 11/07/2000 |
| 6124466 | Nitroisourea derivative A novel nitroisourea derivative and a process for producing the same, which is an important intermediate for the production of a nitroguanidine derivative having an insecticidal activity, and a process for producing a nitroguanidine derivative having an i... | 09/26/2000 |
| 6124356 | Fungicides A fungicidal compound of formula (I): or a stereoisomer thereof, wherein A is CH or N, B is OCH3 or NHCH3, E is --NR1 --C(CH3).dbd.N-- or --N.dbd.C(CH3)--NR1 --, R1 is H, C1... | 09/26/2000 |
| 6100253 | Tricycle substituted with azaheterocyclic carboxylic acids The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to me... | 08/08/2000 |
| 6008247 | 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii agents Compounds according to the formula: ##STR1## wherein: R1 and R2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R | 12/28/1999 |
| 5856323 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira... | 01/05/1999 |
| 5750714 | Process for the manufacture of related intermediates including cistofur A process of manufacture of: R--CH2 --S--CH2 --CH2 --NH2 2HC1 wherein R is selected from the group consisting of ##STR1## is provided, the said process comprising reacting R--CH2 OH.HCL with HSCH... | 05/12/1998 |
| 5696275 | Process for the manufacture of pharmaceutical grade ranitidine base A process for the manufacture of pharmaceutical grade ranitidine base(N-2-5-(Dimethylamino)methyl!-2-furanyl!methyl!thio!ethyl-N'-methy l-2-nitro-1, 1-ethenediamine), is described. In-vitro and in-vivo pharmacological studies and acute toxicity stu... | 12/09/1997 |
| 5686588 | Amine acid salt compounds and process for the production thereof A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and having crystalline structure of uniform size and shape.... | 11/11/1997 |
| 5672724 | Processes for preparing ranitidine The present invention relates to a novel method for preparing ranitidine and pharmaceutically acceptable salts thereof.... | 09/30/1997 |
| 5670671 | Process for the production of an improved form of form 1 ranitidine Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics, said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent havin... | 09/23/1997 |
| 5604229 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 02/18/1997 |
| 5580893 | Nitroxyalkylamide derivatives Nitroxyalkylamide compounds having the formula: R1 --(A)n --CONH--B'--ONO2 wherein R1 is an optionally substituted furyl, furyloxy, thienyl, thienyloxy, isoxazolyl, phenoxy, phenylthio or 1,4-dibenzodioxanyl, A ... | 12/03/1996 |
| 5574054 | Quaternary ammonium salts and use thereof as medicine Novel quaternary ammonium salts having utility in the medical field for treating gastrointestinal disorders.... | 11/12/1996 |
| 5543425 | Method of inhibiting platelet aggregation using phenyl amidine thio derivatives This invention relates to a method of inhibiting platelet aggregation comprising administering compounds having the following formula ##STR1##... | 08/06/1996 |
| 5532267 | Amidinonaphthyl furancarboxylate derivatives and acid addition salts therof Amidinonaphthyl furancarboxylate derivatives of the formula I ##STR1## wherein A is a single bond or A denotes (a) a phenyl group, cyclopentyl group, or cyclohexyl group, (b) an alkenylphenyl group, alkylphenyl group, phenylalkenyl group, or phenylal... | 07/02/1996 |
| 5523423 | Form of form 1 Ranitidine Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics, said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent havin... | 06/04/1996 |
| 5455265 | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist... | 10/03/1995 |
