Class 549/491 - Nitrogen attached indirectly to the hetero ring by nonionic bonding

Subclass of Class 549 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein nitrogen is attached indirectly to the
No. of patents: 332
Last issue date: 10/25/2011

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Number	Title	Issue Date
8044222	Aromatic amine derivatives and organic electroluminescent device using same The present invention provides a novel aromatic amine derivative having a specific structure and an organic electroluminescence device in which an organic thin film layer comprising a single layer or plural layers including at least a light emitting layer is interpo...	10/25/2011
7977496	Process for producing nitroguanidine derivatives Disclosed is an improved process for producing nitroguanidine derivatives represented by the formula (3), which has an insecticidal activity, or a salt thereof, wherein the substituents are defined herein, in which nitroiso...	07/12/2011
7432289	5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ...	10/07/2008
7420070	Process for preparing optically active 2,3-dihydrobenzofuran compounds A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: ...	09/02/2008
7414073	Cytotoxic agents containing novel potent taxanes and their therapeutic use Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selec...	08/19/2008
7410999	Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application....	08/12/2008
7405311	Antagonist of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m...	07/29/2008
7371747	Cyanoalkylamino derivatives as protease inhibitors The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by...	05/13/2008
7365094	Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents The present invention relates to compounds of the general formula (II) and salts and physiologically functional derivatives thereof, for the use as a medicament. ...	04/29/2008
7241795	Synthesis and antimicrobial activity of novel dicationic “reversed amidines” The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each indep...	07/10/2007
7214678	Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain According to the invention there is provided a compound the formula I; wherein A, X, B, R1, R2, R3 and R4 are as defined in the specification.	05/08/2007
7202383	Compounds useful for modulating abnormal cell proliferation There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1...	04/10/2007
7186831	5-halo-2-alkyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amines This invention relates to novel triazolopyrimidines of the formula in which R1, R2, R3, R4and X have the meanings given in the disclosure, to a...	03/06/2007
7163955	Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)–(VI) as recited throughout the application.	01/16/2007
7119112	Sulfonamides as potassium channel blockers Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfonamides, and compositions and met...	10/10/2006
7101867	Benzofuran derivatives, their production and use Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carb...	09/05/2006
7098201	Heteroaromatic derivatives having an inhibitory activity against HIV integrase A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORA wherein RA is hydrogen or ester residue, —CONRBRC wher...	08/29/2006
7087639	Organoselenium compounds for cancer chemoprevention A compound containing an alkylene selenocyanate or an alkylene isoselenocyanate moiety effective to prevent the occurrence or progression of cancer or a precancerous condition. The compound can be provided and administered in the form of a pharmaceutical composition...	08/08/2006
7071338	Process for the synthesis of bis-aryl diamidoxime compounds Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl] furans, can be prepared from 2,5-bis tri-alkylstannanes via a one step palladium-catalyzed cross reaction. Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-O-alkyl...	07/04/2006
7034015	Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ...	04/25/2006
7019024	Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ...	03/28/2006
7012094	Substituted furans and furanones for the treatment of inflammation A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defin...	03/14/2006
6987112	Organic compound having cyano group and insecticides/miticides The present invention is directed to compounds represented by Formula (1); wherein A, R, X, Y and n are as defined in the description, the salts thereof, and insecticide/acaricide compositions characterized by comprisi...	01/17/2006
6984738	Process for production of optically active amino alcohols The present invention is to provide a process for producing an optically active amino alcohol which is useful for the synthesis of natural substances and as an intermediate for drugs and agricultural chemicals in a high yield, a high selectivity and an economical ma...	01/10/2006
6916956	Calcium receptor antagonist A compound of the formula [I] wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 c...	07/12/2005
6903086	Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as IP antagonists This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein G1 is selected from the group consisting of a, b1 and b2,...	06/07/2005
6887871	Use of phenylheteroakylamine derivatives There is disclosed the use of a compound of formula (I) wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the t...	05/03/2005
6864254	Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular dis...	03/08/2005
6861561	Substituted aromatic policyclic tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aromatic polycyclic tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and o...	03/01/2005
6852750	Benzenedicarboxylic acid derivatives New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase le...	02/08/2005
6812352	Multidentate phosphite ligands, catalytic compositions containing such ligands, and catalytic processes utilizing such catalytic compositions Multidentate phosphite ligands are disclosed for use in reactions such as hydrocyanation and isomerization. The catalyst compositions made therefrom and the various catalytic processes which employ such multidentate phosphite ligands are also disclosed. In particula...	11/02/2004
6762198	Dihetero-substituted metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I):	07/13/2004
6737440	Synthesis and antimicrobial activity of novel dicationic “reversed amidines” The present invention relates to novel 2,5-bis {[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently ...	05/18/2004
6737420	Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formula (XII): useful in treating Alzheimer's disease and other similar diseases. ...	05/18/2004
6723753	Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle...	04/20/2004
6677353	Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating...	01/13/2004
6624316	Method for obtaining 2-bromo-5-(2-bromo-2-nitrovinyl)-furan The present invention refers to a new procedure for obtaining and purifying 2-bromo-5-(2-bromo-2-nitrovinyl)-furan in one reaction step starting with 2-nitrovinylfuran, and maintains high indexes of purity and an appropriate yield. The process involves th...	09/23/2003
6599932	Alpha, beta-unsaturated sulfones for treating proliferative disorders Sulfones of formula I are useful as antiproliferative agents, including, for example, anticancer agents: ##STR1## wherein: Q1 is selected from the group consisting of (a) a phenyl radical according to formula II ##STR2## wherein R1,...	07/29/2003
6599924	2-hetaryl-3,4-dihydro-2H-pyrrole derivatives The invention relates to novel 2-hetaryl-3,4-dihydro-2H-pyrrole derivatives of the formula (I) ##STR1## in which Hetaryl represents substituted heterocyclyls and Ar represents substituted phenyl, to a plurality of processes for their preparation and to their u...	07/29/2003
6566381	Hetero-substituted metalloprotease inhibitors Heterocyclic substituted compounds having the general structure: ##STR1## which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes....	05/20/2003

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Class 549/491 - Nitrogen attached indirectly to the hetero ring by nonionic bonding