Class 549/49 - Bicyclo ring system having the hetero ring as one of the cyclos

Subclass of Class 549 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the polycyclo ring system consists of
No. of patents: 199
Last issue date: 03/20/2012

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Number	Title	Issue Date
8138356	Chemical inhibitors of inhibitors of differentiation The present invention provides identification of inhibitors of inhibitors of differentiation (Id) for use in the treatment and prevention of diseases in mammals. The inhibitors of Id are effective alone in the treatment of a variety of cellular proliferative disorde...	03/20/2012
7897789	Vitamin D receptor modulators The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoria...	03/01/2011
7777055	Photochromic and electrochromic compounds and methods of synthesizing and using same This invention relates to novel photochromic and electrochromic monomers and polymers based on 1,2-dithienylcyclopentene derivatives and method of using and synthesizing same. The compounds are reversibly interconvertible between different isomeric forms under suita...	08/17/2010
7582775	Vitamin D receptor modulators The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoria...	09/01/2009
7393865	Sleep inducing compounds and methods relating thereto Compounds having the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R1, R2, R3a, R3b, L	07/01/2008
7329764	Substitute benzothiophene compounds Disclosed are compounds of the formula I shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds ...	02/12/2008
7300952	NF-κb inhibitors The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in ...	11/27/2007
7276518	Substituted cyclohexane-1,4-diamine compounds Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds. ...	10/02/2007
7256219	Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula I: wherein Ar and R6-R10 are defined herein. The present invent...	08/14/2007
7253165	Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as Dantagonists The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These c...	08/07/2007
RE39754	Benzamide derivatives and pharmaceutical compositions containing same The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune...	07/31/2007
7196081	Compounds with hydroxycarbonyl-halogenoalkyl side chains The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the following general f...	03/27/2007
7173043	Heteroaromate OSC inhibitors The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vasc...	02/06/2007
7122081	Process for aqueous milling of quinacridone pigments The present invention is directed to an aqueous process for reducing particle size of organic pigments by milling the crude pigment in the presence of a water soluble styrene copolymer dispersant, optionally a defoamer, optionally an additive, and greater than about...	10/17/2006
7084136	Drug composition antagonistic to both PGD/TXA receptors A compound of the formula (I): wherein A is alkylene optionally having an unsaturated bond; R is —C(═O)—R1; R1 is hydroxy or the like; m is 0 or 1; p is 0 or 1; X1 and X	08/01/2006
7008958	2-substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same Compounds having the formula (I), are effective as inhibitors of IMPDH enzyme, wherein R3 is alkyl, substituted alkyl, alkoxy, haloalkoxy, or halogen, preferably methoxy, ethoxy, or trifluoromethoxy; and R	03/07/2006
6946462	N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents New compounds represented by the formula or pharmaceutically acceptable salts or prodrugs thereof, wherein X1 and X2 are each independently selected from a CH group or a nit...	09/20/2005
6930190	Process for the preparation of heterocyclic pentalene derivatives A process for preparing heterocyclic pentalene derivative having formula (I): wherein w is a sulfur atom (S), an oxygen atom (O) or a NR or PR group, wherein R is an hydrocarbon group; R1, R2, R3, and R4, equal to or diffe...	08/16/2005
6900196	Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardi...	05/31/2005
6884896	Benzo[b]thiophene derivatives and process for preparing the same The present invention is 3,4-disubstituted-benzo[b]thiophene derivatives represented by general formula (I) and processes for preparing compounds represented by general formula (V) from compounds represented by general formula (IV), preparing a mixture of compounds ...	04/26/2005
6869953	N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents New compounds represented by the formula or pharmaceutically acceptable salts or prodrugs thereof, wherein X1 and X2 are each independently selected fr...	03/22/2005
6869974	Pharmaceutical compounds Compounds or their salts having general formulas (I) and (II): wherein s is an integer equal to 1 or 2, A is the radical of a drug that satisfies certain pharmacological tests, C and C1 are bivalent radicals, and precursors of the radicals B and B1	03/22/2005
6849658	Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R1 is CH3, —CH2—O—R6, —OR6 or —COR7; R2 is —OR8, —SR8	02/01/2005
6831075	Heterocyclic substituted pyrazolones The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to...	12/14/2004
6818666	Bi-aromatic compounds linked via a heteroethylene radical, and pharmaceutical and cosmetic compositions using them Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use. ...	11/16/2004
6756342	Substituted thienocycloalk(en) ylamino -1,3,5-triazine The invention relates to novel substituted thienocycloalk(en)ylamino-1,3,5-triazines of the general formula (I) in which Z, R1, R2, R3 are as defined in the description, and to processes ...	06/29/2004
6730705	Alkoximino acetic acid amides The invention relates to new alkoximinoacetic acid amides, a process for their preparation and their use as agents for combating pests. ...	05/04/2004
6696110	Liquid crystalline alkenyl compounds incorporating an heterocyclic five-membered ring Liquid crystal mixtures comprising at least one of the compounds of formula (I) containing a heterocyclic five-membered ring and with a carbon-carbon double bond in the termninal group are new. ##STR1## RJ=CnH2n+1CH=CHCmH2mZ1; n=1-5; m=0-5; and q=0, 1 or ...	02/24/2004
6686386	Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis The present invention relates to pharmaceutical and cosmetic compositions comprising at least one agonist ligand, which is specific for receptors of the RAR-γ type, which are characterized as inducers of apoptosis in at least one cell population in which...	02/03/2004
6660868	Photo-induced phase transition organic material A photo-induced phase transition organic material is composed of a diheteroarylethene-based compound within which the photo-chromic reaction occurs in the crystalline state. The diheteroarylethene-based compound of the present invention reversibly changes...	12/09/2003
6653328	3-benzyl-benzothiophenes This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzothiophenes which are ଱-substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indi...	11/25/2003
6605632	Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them The invention concerns compounds of formula (I): R--A--R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the desc...	08/12/2003
6555697	Method of preparing a benzofuran or benzothiophene compound The invention concerns a novel method for preparing a benzofuran or benzothiophene compound by cyclizing an aromatic compound bearing a side-chain comprising at least two carbon atoms, one of the carbon atoms being bound to the benzene cycle by an oxygen ...	04/29/2003
6465508	Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs....	10/15/2002
6455525	Heterocyclic substituted pyrazolones The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also ...	09/24/2002
6451824	Sulfonylaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved....	09/17/2002
6444709	Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same The invention relates to novel heteroethynylenic compounds having the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, r...	09/03/2002
6432982	Benzothiophenes, and formulations and methods using same The invention provides novel benzothiophenes of the formula: ##STR1## wherein R1 is --H, --OH, --O(C1 -C4 alkyl), --O--CO(C1 -C6 alkyl), --OSO2 (C4 -C6 alkyl, or --OCOAr wh...	08/13/2002
6410586	Modulators of protein tyrosine phosphatases (PTPases) The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B. CD45, SHP-1...	06/25/2002
6403172	Benzothiophenes, and their use in liquid-crystalline mixtures Benzothiophene derivatives of the formula (I) are used as components of liquid-crystal mixtures ##STR1## where the symbols and indices have the following meanings: X1 and X2, independently of one another, are --CH--, --CF--, the --(R...	06/11/2002

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Class 549/49 - Bicyclo ring system having the hetero ring as one of the cyclos