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Class 549/484 - The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens


Subclass of Class 549 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the -- is part of a --X- group, wherein
No. of patents: 163
Last issue date: 04/20/2010


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NumberTitleIssue Date
7700788Hydroxymethyl furfural oxidation methods
A method of oxidizing hydroxymethylfurfural (HMF) includes providing a starting material which includes HMF in a solvent comprising water into a reactor. At least one of air and O2 is provided into the reactor. The starting material is contacted with the ...
04/20/2010
7429669Therapeutic compounds
Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed. ...
09/30/2008
7411078Method for producing furan-2,5-dicarboxylic acid
A method for producing furan-2,5-dicarboxylic acid (FDCA) is provided which can efficiently and quantitatively producing FDCA under mild conditions, without employing an expensive catalyst and with a reduced energy consumption. A furan ring compound having two funct...
08/12/2008
7371777Cyclic compound and PPAR agonist
The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. ...
05/13/2008
7351843Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them
The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same. Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isofor...
04/01/2008
7300956Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analog...
11/27/2007
7273952Substituted C-cyclohexylmethylamine derivatives
Substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds, the use of substituted C-cyclohexylmethylamine derivatives for producing pharmaceuticals, and method of pain treatment using the pharmaceu...
09/25/2007
7196089EPreceptor antagonists
Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O...
03/27/2007
7166726Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity
Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br...
01/23/2007
7034053Phenethanolamine derivatives, compositions, and their use as agonists at atypical beta-adrenoreceptors
The present invention disclosed compounds of Formula I. The present invention also discloses beta-3 agonists of formula I and methods for treating beta-3 mediated diseases and condition using the compounds of formula I, in particular methods for treating diabetes or...
04/25/2006
7019024Pharmaceutical for treatment of neurological and neuropsychiatric disorders
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ...
03/28/2006
7012050Skin cleansing composition comprising a quaternized lanolin
A cleansing composition comprising (a) a cleansing amount of a surfactant or mixture of surfactants, (b) a skin slip inducing amount of a quaternized lanolin or mixture of quaternized lanolins, and (c) a skin slip enhancing ind...
03/14/2006
6982279Arylated furan- and thiophenecarboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
Compounds of the formulae IA and Ib. in which X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel antiarrhythmic active compou...
01/03/2006
6942980Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
Methods of characterizing and identifying negative hormones of nuclear receptors. Also disclosed are methods of making modulators of retinoid nuclear receptor transactivation activity, assays for agonists, antagonists, and negative hormones of the RAR receptor, and ...
09/13/2005
6924396α-haloenamine reagents
The present invention describes immobilized haloenamine reagents, immobilized tertiary amides, methods for their preparation, and methods of use. ...
08/02/2005
6875884Urea derivatives as inhibitors for CCR-3 receptor
Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful urea and thiourea derivatives can be synt...
04/05/2005
6831180Cephalotaxane derivatives and process for their preparation
The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloids used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constit...
12/14/2004
6812237N-substituted peptidyl nitriles as cysteine cathepsin inhibitors
Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7-alkyl in ...
11/02/2004
6790997Preparation of carbonyl compounds from alcohols
The invention relates to a process for the preparation of carbonyl compounds by the oxidation of alcohols in the presence of osmium compounds as catalysts in water or a solvent mixture containing water. ...
09/14/2004
6720425Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity. ...
04/13/2004
6693209Synthesis of anhydroglycitol esters of improved colour
Diesters of dianhydroglycitols can be prepared by esterification of dianhydroglycitols, anhydroglycitols and/or glycitols with alkylcarboxylic or arylcarboxylic acids in the presence of an acid catalyst, the acid catalyst being a macroporous acid ion exch...
02/17/2004
6677487଱-haloenamine reagents
The present invention describes immobilized haloenamine reagents, immobilized tertiary amides, methods for their preparation, and methods of use....
01/13/2004
6649657Prevention of loss and restoration of bone mass by certain prostaglandin agonists
Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disor...
11/18/2003
6627652Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist...
09/30/2003
6566375Elevation of HDL cholesterol by 4-[(aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula ##STR1## wherein: R
05/20/2003
6492338Therapeutic agents
Therapeutic or preventive agents for diseases due to the action of aldose reductase; and aldose reductase inhibitors, characterized by containing at least one compound having an aldose reductase inhibiting activity which is selected from among 2,5-dihydro...
12/10/2002
6433189Tricyclic and tetracyclic taxane intermediates
The synthesis of taxol and other tricyclic and tetracyclic taxanes....
08/13/2002
6420418Heterocycle amides as cell adhesion inhibitors
Compounds of Formula I are antagonists of VLA-4 and/or 댔댧, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and...
07/16/2002
6420392Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammato...
07/16/2002
6392047Process for preparing biaryls in the presence of palladophosphacyclobutane catalysts
Biaryls, e,g,. biphenyls, phenylpyridines, phenylfurans, phenylpyrroles, phenylthiophenes, bipyridines, pyridylfurans or pyridylpyrroles are prepared in high yields by coupling aromatics with an aromatic boric acid or boric ester in the presence of a pall...
05/21/2002
6369225Compounds having activity as inhibitors of cytochrome P450RAI
Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##...
04/09/2002
6316636Synthesis of fluorocarbon compounds
Fluorocarbon compounds are synthesized by reacting a substrate hydrocarbyl compound containing at least one sp3 -hybridized halophoric carbon atom bearing at least two halogen atom substituents, at least one of which is a halogen atom having an...
11/13/2001
6150532Modulators of proteins with phosphotyrosine recognition units
The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to their use for treatment of human an...
11/21/2000
6133238Tetrahydrofurans
2,5-dihydroxytetrahydro-2-furancarboxylic acid represented by the following formula [I], its optically active substance or salt thereof. ##STR1##...
10/17/2000
6124455Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
Compounds of the formula ##STR1## wherein the symbols have the meaning defined in the specification have retinoid-like biological activity....
09/26/2000
6057342Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a...
05/02/2000
5892091Catalyst for decarbonylation reaction
A catalyst composed of an organic phosphorus compound having a trivalent or pentavalent phosphorus atom and at least one carbon-phosphorus bonding or a combination of the organic phosphorus compound and a halogen atom-containing compound is effective for ...
04/06/1999
5856323Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira...
01/05/1999
5808124O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity....
09/15/1998
5786379Adamantyl-substituted biaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active adamantyl-substituted biaromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a')-(f'): ##STR2## and are useful for the treatment of a wide var...
07/28/1998
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