Quotables
"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8153829 | Methods for the preparation of hexahydrofuro[2,3-B]furan-3-ol Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol and especially its enantiomer (3R,3aS,6aR) hexahydrofuro[2,3-b]furan-3-ol, as well as certain novel intermediates for use in such methods are disclosed. ... | 04/10/2012 |
| 8124796 | Method for preparing 3-hydroxytetrahydrofuran using cyclodehydration Disclosed is a method of preparing 3-hydroxytetrahydrofuran using cyclodehydration. More particularly, this invention relates to a method of preparing 3-hydroxytetrahydrofuran, including subjecting 1,2,4-butanetriol to cyclodehydration under reaction conditions of a... | 02/28/2012 |
| 7622598 | Phenol derivatives and antitrypanosoma preventive/therapeutic agent comprising the same as active ingredient A compound represented by formula (I): [wherein, for example, X is a hydrogen atom or a halogen atom; R1 is a hydrogen atom; R2 | 11/24/2009 |
| 7402606 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle ... | 07/22/2008 |
| 7361745 | Process for the preparation of 1-chloro-3,5-di-o-acyl-2-deoxy-l-ribofuranoside derivatives Herein described is a process for the preparation of 1-chloro-3,5-di-O-acyl-2-de-oxy-L-ribofuranoside derivatives of general formula (I) useful as intermediates in processes for preparing nucleotides of the L series having antiviral activity | 04/22/2008 |
| 7300948 | Alkynyl compounds as non nucleoside reverse transcriptase inhibitors Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula wherein the substituents are as defined in the following table ... | 11/27/2007 |
| 7232930 | Compounds and methods for preparing methanesulfonamides A process for preparing (S)-(−)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the pre... | 06/19/2007 |
| 7202274 | Cyclic hemiacetal derivative and use thereof A compound represented by the following formula (I) wherein R1 is a lower alkyl group, R2 is a hydrogen, a halogen, a cyano group, a lower alkyl group or a lower alkoxy group, and n is 0 or ... | 04/10/2007 |
| 7196089 | EPreceptor antagonists Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O... | 03/27/2007 |
| 7160956 | Vulcanizable rubber compounds and process for their production The present invention relates to sulfur-vulcanizable silica-containing rubber compounds with improved processability and a process for their production. ... | 01/09/2007 |
| 7148363 | Process for preparing acrylate compound An acrylate compound of formula (4): is produced by allowing an acrylic acid compound of formula (1): to react with an unsaturated compound of formula (2) or... | 12/12/2006 |
| 7144897 | Hydroxy alkyl amines Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compou... | 12/05/2006 |
| 7132449 | Inhibitors of cruzipain and other cysteine proteases Compounds of general formula (I): wherein R1, R2, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cys... | 11/07/2006 |
| 7122661 | Method for purifying a composition containing at least one internal dehydration product of a hydrogenated sugar The invention concerns a method for purifying a composition containing at least a product for internal dehydration of a hydrogenated sugar. The invention is characterised in that it comprises: (a) an optional step whereby said composition is treated, whether after r... | 10/17/2006 |
| 7102027 | Adamantanetricarboxylic acid derivatives An adamantanetricarboxylic acid derivative is represented by following Formula (1): wherein X is a hydrogen atom or a hydrocarbon group; and R1, R2 and R3 may be the same as or di... | 09/05/2006 |
| 7052742 | Five membered-ring compounds and utilization thereof in liquid crystal mixtures Fluorinated five-membered ring compounds of the formula (I) R1—X—(A1—M1)a—(A2—M2)b—A3—Y—E (I) where E is a radical T—Z—R2 | 05/30/2006 |
| 7049338 | Antiproliferative agents This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions containing such compounds and their use as anti-proliferative agents... | 05/23/2006 |
| 7037937 | Cytotoxic compounds Compounds are described that bind to tubulin causing tubulin depolymerization and inhibiting tubulin polymerization. The compounds of the invention are therapeutically effective to inhibit cellular proliferation, for example, as effective anti-cancer agents. The com... | 05/02/2006 |
| 7034046 | NR1H4 nuclear receptor binding compounds The present invention relates to compounds according to the general formula (I) which bind to the nuclear receptor, NR1H4, and act as agonists and antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through... | 04/25/2006 |
| 7029606 | Hyperpolarizable organic chromophores A dihydrofuran-containing nonlinear optical chromophore having a π-electron donor group conjugated to the dihydrofuran group through a π-electron conjugated bridge group. The nonlinear optical chromophore is a hyperpolarizable chromophore that can be used as an el... | 04/18/2006 |
| 6998111 | Storage stable polymerizable compositions A composition is adapted to be stored for at least 24 hours at between 0° C. to 40° C. and between 0 percent and 100 percent humidity. The composition includes from 0.2 to 5 percent by weight of a peroxide, from 0.2 to 3 percent by weight of a metal containing mat... | 02/14/2006 |
| 6969731 | Protease inhibitors that overcome drug resistance HIV protease inhibitors are among the most powerful drugs in suppressing HIV in human patients. However, HIV developed resistance to all protease inhibitor drugs so far marketed or used in clinical trials. HIV generates resistance by mutating its protease. The strai... | 11/29/2005 |
| 6964981 | Tetrahydrofuran derivatives and their use as NK-1 antagonists The present invention relates compounds that are NK-1 antagonists and that are of use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia. ... | 11/15/2005 |
| 6906196 | Processes for the preparation of 1,5-diaryl-3-substituted-pyrazoles Provided are processes and chemical intermediates useful for preparing a compound of the formula I wherein X is selected from the group consisting of C1-C6 | 06/14/2005 |
| 6897324 | Process for the preparation of 11-oxaprostaglandins and intermediates therein For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-{tetrahydro-2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester derivatives, a novel process uses a novel enantiomerically enriched compound ... | 05/24/2005 |
| 6875784 | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for... | 04/05/2005 |
| 6864285 | Covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids functionally active on the CB2 cannabinoid receptor The present invention relates to novel covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids with aminoalcohols of general formula (I) which can usefully be used as agonists of the CB2 cannabinoid receptor and hence as drugs active in pathol... | 03/08/2005 |
| 6864283 | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity Compounds of formula (I) wherein R1is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubs... | 03/08/2005 |
| 6849733 | Neuropeptide-Y ligands There are disclosed novel neuropeptide Y ligands having the general formula I Wherein the symbols W, A, D, R1, R2, R3, R4 are further defined in the description. Compounds of... | 02/01/2005 |
| 6844452 | Process for the co-production of aliphatic diols and cyclic ethers A process for the co-production of a diol product (e.g. butane-1,4-diol) and a cyclic ether (e.g. tetrahydrofuran) by hydrogenation of an aliphatic diester or lactone feedstock (e.g. dimethyl or diethyl maleate), which contains a minor amount of acidic material, suc... | 01/18/2005 |
| 6841571 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R2, R3, R4, R6, R8 and Y are defined herein. The compounds are useful for treating autoimmune and othe... | 01/11/2005 |
| 6833462 | Process for preparing acrylate compound An acrylate compound of formula (4): is produced by allowing an acrylic acid compound of formula (1): to react with an unsaturated compound of formula (2) or (3): | 12/21/2004 |
| 6818664 | Angiogenesis inhibitor A compound represented by the following formula (I) or a salt thereof and a medicament such as an angiogenesis inhibitor and an antitumor agent which comprises said compound or a physiologically acceptable salt thereof as an active ingredient. | 11/16/2004 |
| 6764829 | Nucleoside hydrolase and nucleoside phosphorylase detection kits, dipsticks and substrates The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I) where X is OH, or H, and Y is the residue of Y—OH where Y—OH is a c... | 07/20/2004 |
| 6710078 | 5-Substituted-3(2H)-furanones useful for inhibition of farnesyl-protein transferase Compounds of Formula (I): wherein R1, R2, R3, X, Y, Z and Q are as defined in the specification which compounds are inhibitors of Ras farnesyl-protein transferase enzyme (FPTase), and use... | 03/23/2004 |
| 6673934 | Primary intermediates for oxidative coloration of hair Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): ##STR1## wherein R is hydrogen, hydroxy, nitro, amino, halogen, C1 to C5 alkyl or haloalkyl, C1 to C5... | 01/06/2004 |
| 6613743 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides of formula I which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and phy... | 09/02/2003 |
| 6593478 | Stereospecific hydrolysis of optically active esters A new, more efficient and highly stereospecific process is described for the preparation of compounds with general formula (R)-(I) and of absolute configuration (R), where the groups M, W, Q and Q1 are as defined in the description, starting fr... | 07/15/2003 |
| 6566375 | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula ##STR1## wherein: R | 05/20/2003 |
| 6559137 | Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solu... | 05/06/2003 |
