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| Number | Title | Issue Date |
| 7122228 | Compound having negative Δε The invention relates to indanes having negative Δε of the formula Ia or Ib in which R, A, Z, X, Y, V, W, n and m are as defined in claim 1. The compounds are particularly suitable for producing VA-TFT ... | 10/17/2006 |
| 6998407 | Antagonists of MCP-1 function and methods of use thereof Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these compounds. The... | 02/14/2006 |
| 6852854 | Preformed carboxylated active ester for labeling biomolecules The present invention is directed, in general, to a method for making high yields of functionalized cyclic or acyclic tertiary amine-containing compounds, termed active esters, the functionalized compounds themselves, and diagnostic or therapeutic systems incorporat... | 02/08/2005 |
| 6838557 | Process for making a chelating agent for labeling biomolecules using preformed active esters The present invention is directed, in general, to a method for making high yields of functionalized cyclic or acyclic tertiary amine-containing compounds, termed active esters, the functionalized compounds themselves, and diagnostic or therapeutic systems incorporat... | 01/04/2005 |
| 6653340 | Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation The present invention is concerned with new compounds, and particularly those having a fused bicyclic ring substituted with an amidine moiety. These compounds are each potent inhibitors of Factor D of the alternate pathway of complement, C1s of the classi... | 11/25/2003 |
| 6465508 | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.... | 10/15/2002 |
| 6441196 | Processes and novel intermediates for 11-oxa prostaglandin synthesis Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.... | 08/27/2002 |
| 6342610 | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolyls... | 01/29/2002 |
| 6069166 | Fused heterocyclic benzenecarboxamide derivatives and PGD2 antagonists comprising them A compound, pharmaceutically acceptable salt thereof, or hydrate thereof having a PGD2 -antagonistic activity, and an inhibitory activity against infiltration of eosinophils, useful for treating mast cell dysfunction-associated diseases, such a... | 05/30/2000 |
| 5968908 | Restricted 9-cis retinoids The invention is novel analogs of 9-cis-retinoic acid which are useful for the treatment and prevention of coronary artery disease and to protect against premature atherosclerosis by increasing HDL levels. The invention includes processes for preparing th... | 10/19/1999 |
| 5919955 | Combinatorial solid phase synthesis of a library of benzofuran derivatives The present invention relates to a process for the generation of a plurality of different benzofuran derivatives, and to the use of said benzofuran derivatives to search for novel classes of compounds and individual compounds possessing selected propertie... | 07/06/1999 |
| 5750564 | Anti-oxidant esters of non-steroidal anti-inflammatory agents Compounds having anti-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresp... | 05/12/1998 |
| 5739396 | Asymmetric ligands useful for transition metal catalyzed bond forming reactions Ligands useful for transition metal catalyzed bond forming reactions are provided with a metal binding portion having at least one metal binding moiety ##STR1## wherein Ar and Ar' each is an aryl or a heteroaryl. These ligands may be prepared by... | 04/14/1998 |
| 5705507 | Aplha-substituted-3-benzyl-benzofurans This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzofurans which are -substituted with ether, thioether, amino, hydrazino, cyano or halo that are useful for the treatment of the various medi... | 01/06/1998 |
| 5635107 | Fluorine-containing five-membered ring compounds, and a liquid-crystaline medium containing them Fluorine-containing five-membered ring compounds of the formula I R1 -(A1 -Z1)m -A2 -Z2 -W I in which W is ##STR1## is a cyclohexane, cyclohexene or phenyl, Y1 is O or S, Y2 | 06/03/1997 |
| 5627205 | Substituted phenoxyisobutyric acids and esters New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R1, R2, R3, R4, R5, R6, R7 and Z ... | 05/06/1997 |
| 5622974 | -substituted-3-benzyl-benzofurans This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzofurans which are -substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indicati... | 04/22/1997 |
| 5470999 | Cyclohexene and bicyclic aromatic substituted ethyne compounds having retinoid-like biological activity Compounds of Formula 1 ##STR1## where R1 -R5 are hydrogen, lower alkyl of 1-6 carbons, or halogen; A is (CH2)n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, a... | 11/28/1995 |
| 5451605 | 1,2-epoxycyclohexanyl and bicyclic aromatic substituted ethyne compounds having retinoid-like biological activity Compounds of the formula ##STR1## where R1 -R5 are hydrogen, lower alkyl of 1-6 carbons, or halogen; A is (CH2)n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons,... | 09/19/1995 |
| 5403953 | 1-phenylbicyclo[2.2.2]octane compounds Compound of formula (I): ##STR1## in which: R1 represents halogen, or hydroxy, alkyl, alkoxy, cyano, amino, mercapto, alkylthio or phenoxy, R2 and R'2 represent two hydrogen when the ring is unsaturated, or alternativ... | 04/04/1995 |
| 5391819 | Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists Disclosed herein is a process of making chiral 2-aryl-1,4-butanediamine derivatives useful as neurokinin-A antagonists of Formula 7 ##STR1##... | 02/21/1995 |
| 5387702 | Process for the preparation of cabofuran A process for the preparation of carbofuran which is used as an insecticide. Carbofuran is the N-methylcarbamate of 7-benzofuranol. Carbofuran is prepared by reacting catechol with beta methallyl halide or the alcohol in the presence of a catalyst composi... | 02/07/1995 |
| 5332841 | Preparation of 2,3-dihydro-2,2-dimethyl-7-benzofuranyl chloroformate with aqueous phase removal A process for the production of 2,3-dihydro-2,2-dimethyl-7-benzofuranyl chloroformate which comprises treating 2,3-dihydro-2,2-dimethyl-7-benzofuranol and phosgene in a water immiscible organic medium with aqueous base and removing aqueous phase from the ... | 07/26/1994 |
| 5287962 | Vacuum seal indicator for flexible packaging material Plastic encapsulated semiconductor devices are susceptible to moisture due to the permeability of molding compounds. Devices may be baked until dry before being shipped to the customer to reduce the risk of cracking. To retain this dry condition, devices ... | 02/22/1994 |
| 5284962 | Multistage process for making methyl carbamates A continuous process employing at least two reaction stages for manufacturing pesticides from methyl isocyanate and oxime or phenol reactants in water.... | 02/08/1994 |
| 5126364 | 4-amino-5-chloro-n-(2-pyrrolidinylmethyl)-2,3-dihydrobenzo[b]fura n-7-carboxamide and pharmaceutical compositions containing the same The compound (R) (-)-4-amino-5-chloro-N-(2-pyrrolidinylmethyl)-2,3-dihydrobenzo[b]furan-7-c arboxamide; the S isomer thereof, and pharmaceutical compositions containing the same.... | 06/30/1992 |
| 5114966 | 2,3-dihydro-5-oxy-4,6,7-trimethylbenzofurans 2-(RS)-substituted, useful as antioxidizing pharmaceutical products having mucoregulating and anti-ischemic properties The herein-described invention concerns new 2,3-dihydro-5-oxy-4,6,7-trimethylbenzofuranes 2-(RS)-substituted, the synthesis procedure and the relative therapeutic use as antioxidizing and radical-scavenging pharmaceuticals with mucoregulation and anti-isc... | 05/19/1992 |
| 5091533 | 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors Compounds of the formula: ##STR1## where R2 contains certain aryls or heteroaryls are effective leukotriene inhibitors.... | 02/25/1992 |
| 5077423 | S-(N-alkoxycarbonyl, N-substituted)aminomethyl isothiourea derivative S-(N-alkoxycarbonyl, N-substituted)amino methyl isothiourea derivative, which is a useful intermediate for the production of 1,3,5-thiadiazine-4-one derivative, is disclosed. The above compound can be produced by reacting the carbamate compound of the for... | 12/31/1991 |
| 5066819 | Process for the preparation of aryl esters of N-alkyl carbamic acids The invention relates to a process for the preparation of aryl esters of N-alkyl carbamic acids. The process comprises reacting an alkyl N-alkyl carbamate of the general formula: R1 --NH--COO--R3 wherein R1 and R3 ar... | 11/19/1991 |
| 5041568 | Production of (RS)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl) acetic acid and related compounds The present invention relates to (RS)-2-(2,3-dihydro-5-hydroxy-4-,6-trimethylbenozfuranyl) acetic acids and 2-(2,3-dihydro-5-acyloxy-4-,6,7-trimethylbenzofuranyl) acetic acids and esters thereof, the process for producing them and their relevant ther... | 08/20/1991 |
| 5021590 | Process for producing N-alkyl-carbamates A process is provided for the preparation of N-alkyl-carbamates by directly reacting low-molecular weight alkyl-isocyanates, in particular methyl isocyanate, and a substituted phenolic precursor in solution in the presence of a basic catalyst compound sel... | 06/04/1991 |
| 4983779 | Process for the preparation of vinyl ethers An improved process for the preparation of vinyl ethers by the coupling reaction of an ester of the formula ##STR1## with a carbonyl containing compound of the formula ##STR2## wherein A and R are passive organic groups and OY is a hydroxyl grou... | 01/08/1991 |
| 4978761 | 5-hydroxy-2-substituted-2,4,6,7-tetramethyl-2,3-dihydrobenzofurans The present invention relates to a compound of the formula: ##STR1## wherein R1 is hydrogen or a lower alkyl; R2 is methyl which is substituted by a carboxy, alkoxycarbonyl, cyano, halogen, aryl or heterocyclic group of C2-... | 12/18/1990 |
| 4966973 | 2-substituted coumaran derivatives The present invention relates to a compound of the formula ##STR1## wherein R1 stands for hydrogen or a lower alkyl; n denotes an integer of 1 to 6; X stands for an optionally oxidized sulphur atom, oxygen atom or an optionally substituted... | 10/30/1990 |
| 4966896 | Derivative of N-methylcarbamate and insecticide containing the same An insecticide having high insecticidal activities against various harmful insects, which is low in toxicity to warm-blooded animals and fishes to be used safely. The insecticide comprises a derivative of 2,3-dihydro-2,2-dimethylbenzofuran-7-yl N-(substit... | 10/30/1990 |
| 4912131 | 4,7-diacyloxybenzofuran derivatives 4,7-Diacyloxybenzofuran derivatives of Formula I, are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascula... | 03/27/1990 |
| 4863958 | Benzofuran derivatives useful as inhibitors of mammalian leukotriene biosynthesis Benzofuran derivatives, pharmaceutical compositions and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic condit... | 09/05/1989 |
| 4857516 | Coumaran derivatives and their pharmaceutical use A compound of the formula ##STR1## wherein R is a lower alkyl group, R0 is hydrogen or an acyl group, R1 and R2 are lower alkyl groups which may optionally be substituted or wherein R1 and R2 are... | 08/15/1989 |
| 4800228 | 4,7-diacetoxy-2-(4-methoxybenzyl)-3,5,6-trimethylbenzofuran 4,7-Diacyloxybenzofuran derivatives of Formula I, are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascula... | 01/24/1989 |
