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| Number | Title | Issue Date |
| 8022232 | Method for manufacture of escitalopram This patent discloses a method for resolution of 4-[4-(dimethylamino)-1-(4′-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally c... | 09/20/2011 |
| 7989645 | Process for preparation of citalopram and enantiomers The present invention provides a process for preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran car-bonitrile comprising reacting a compound of formula IVa, in the presence of a base with a compound of formula RX, | 08/02/2011 |
| 7964742 | Process for preparation of citalopram and enantiomers The present invention provides a process for preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile comprising reacting a compound of formula IVa, in the presence of a base with a compound of formula RX, | 06/21/2011 |
| 7939680 | Process for the preparation of Escitalopram The present invention relates to an improved process for the preparation of Escitalopram of the Formula (I), which comprises, isolation of Diol compound as an oxalate salt, resolution of Diol compound and cyclization of resolved compound of Formula (VII). The presen... | 05/10/2011 |
| 7582780 | Method for the separation of intermediates which may be used for the preparation of escitalopram The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3... | 09/01/2009 |
| 7566793 | Process for resolving citalopram The (S)-citalopram content of a mixture of (R)- and (S)-citalopram can be enriched by using L-tartaric acid as the resolving agent in the presence of formaldehyde. ... | 07/28/2009 |
| 7560576 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified ... | 07/14/2009 |
| 7511161 | Process for the purification of citalopram A process of purifying citalopram, either in racemic or enantiomeric form, which process comprises (i) providing a crude mixture comprising citalopram, either in racemic or enantiomeric form, dissolved in a water immiscible organic solvent, and which mixture also in... | 03/31/2009 |
| 7482477 | Process for the preparation of citalopram and escitalopram A process is described for the preparation of citalopram (I) and of the active enantiomer thereof, escitalopram (II), which process comprises the cyclisation reaction of the corresponding precursor diol of the formula III or, respectively, IV in the presence of an a... | 01/27/2009 |
| 7482476 | Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide A new process is described for obtaining 5-cyanophthalide, which is an intermediate used for the synthesis of citalopram and its active enantiomer S(+) citalopram, both of which are known active ingredients commonly used for treating depression. The process involves... | 01/27/2009 |
| 7470799 | Dihydrobenzofuran derivatives and uses thereof Compounds of formula I are provided: wherein each of R1, R2, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of melatoninergic rec... | 12/30/2008 |
| 7439368 | Process for producing 3-acylaminobenzofuran-2-carboxylic acid derivative The present invention provides a process of preparing a compound of the formula [I]: wherein X is a group of the formula: —N═ or —CH═; R1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower a... | 10/21/2008 |
| 7435837 | Dihydrobenzofuranyl alkanamine derivatives and methods for using same Compounds of Formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compoun... | 10/14/2008 |
| 7420070 | Process for preparing optically active 2,3-dihydrobenzofuran compounds A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: ... | 09/02/2008 |
| 7420068 | Crystalline composition containing escitalopram The present invention discloses crystalline particles of escitalopram oxalate which either have a broad particle size distribution or comprise at least 0.01% (w/w) of Z-4-(4-dimethylamino-1-(4-fluorophenyl)-but-1-enyl)-3-hydroxymethyl-benzonitrile, said particles be... | 09/02/2008 |
| 7420069 | Crystalline composition containing escitalopram Crystalline particles of escitalopram oxalate with a particle size of at least 40 μm is disclosed. Method for the manufacture of said crystalline particles and pharmaceutical compositions comprising said crystalline particles are also disclosed. ... | 09/02/2008 |
| 7420001 | Biaryl sulfonamides and methods for using same The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. ... | 09/02/2008 |
| 7411077 | Process for the preparation of a cyano-isobenzofuran A process for the preparation of citalopram and the pharmaceutically acceptable salts therof is disclosed by reacting 5-cyanophthalide with a 4-fluorophenyl magnesium halide, reducing the 3-hydroxymethyl-4-(4-fluorobenzoyl)benzonitrile with an agent reducing ketones... | 08/12/2008 |
| 7405311 | Antagonist of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m... | 07/29/2008 |
| 7402687 | Dihydrobenzofuran derivatives and uses thereof Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, ... | 07/22/2008 |
| 7396857 | Therapeutic combinations for the treatment or prevention of depression Therapeutic combinations useful in the treatment or prevention of depression or other mood disorders, to pharmaceutical compositions containing said combinations, and to their use in the treatment or prophylaxis of depression or other mood disorders are provided. Su... | 07/08/2008 |
| 7368477 | Benzofuranyl alkanamine derivatives and uses thereof Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R1′, R2, R3, R4, n, and Ar are as defined, and described in clas... | 05/06/2008 |
| 7365216 | Process for the production of citalopram The invention relates to a process for the manufacture of salts of citalopram in high purity. By the careful selection of solvents and the careful manipulation of the pH value, citalopram salts may be isolated in the absence of 5-chlorocitalopram, 5-bromocitalo-pram... | 04/29/2008 |
| 7364823 | Amine compound, electrophotographic photoreceptor using the amine compound and image forming apparatus having the same An amine compound represented by the following general formula (1) is incorporated as a charge-transporting substance into a charge-transporting layer of an electrophotographic photoreceptor. ... | 04/29/2008 |
| 7351735 | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders ... | 04/01/2008 |
| 7351842 | Compounds for treatment of cardiac arrhythmia and methods of use The subject invention provides novel compounds for treatment of cardiac arrhythmia and methods of use. ... | 04/01/2008 |
| 7339078 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 03/04/2008 |
| 7332518 | Carboxamides as fungicides in agriculture The invention concerns novel carboxamides of formula (I) wherein A is (A1), (A2), (A3), (A4), (A5); Q is (Q1), (Q2), (Q3), (Q4), (Q5), (Q6); R1 is CH2 R2, CH2CH═CHR2, CH═C═CHR2 or COR3 | 02/19/2008 |
| 7276612 | Hydroxamates as therapeutic agents The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase... | 10/02/2007 |
| 7273886 | Benzofuran inhibitors of factor VIIa Compounds of Formula I are useful for inhibiting serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein and have improved pharmacokinetic properties. These compounds may be used in methods of preventing and/or treating clotting disorders... | 09/25/2007 |
| 7271273 | Method for the preparation of citalopram The invention provides a new and improved method for the preparation of 5-cyano-phtalid, which is a key intermediate in the preparation of the antidepressant compound citalopram. ... | 09/18/2007 |
| 7271194 | Treatment of neurotic disorders Use of escitalopram (the S-(+)-enantiomer of citalopram) or a pharmaceutically acceptable salt thereof for the preparation of a medicament useful in the treatment of neurotic disorders is provided, including anxiety states, in particular generalised anxiety disorder... | 09/18/2007 |
| 7262316 | Process for producing aromatic nitrile compound A novel process for industrially producing an aromatic nitrile compound represented by the following general formula (3): characterized in that one of an aromatic hydroxymethyl compound, an aromatic alkoxymethyl ... | 08/28/2007 |
| 7176238 | Nitrostated and nitrosylated prostaglandins, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide,... | 02/13/2007 |
| 7166729 | Process for the preparation of 5-substituted isobenzofurans There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5 isobenzofurancarbaldoxime, O-substituted preferably with a diphenylme... | 01/23/2007 |
| 7163957 | 3-(Cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia The invention provides compounds of the formula: wherein (a) is a single or double bond; W is CH, CH2, CHCH3, CCH3, C(CH3)2, C(CH2)2 or... | 01/16/2007 |
| 7161033 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 01/09/2007 |
| 7153871 | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs PDE4 inhibition is achieved by novel compounds, e.g., aminoindazole and aminobenzofuran analogs. The compounds of the present invention are of Formulas I and II: wherein R1, R2, R3 | 12/26/2006 |
| 7148364 | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile The present invention provides a process for the preparation of crude 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile base with substantially low levels of impurities by arresting the formation of substantial amount of carboxa... | 12/12/2006 |
| 7141604 | Citalopram for the treatment of elevated blood pressure The invention relates to the use of citalopram or a pharmaceutically acceptable salt thereof for the preparation of pharmaceutical compositions suitable for the treatment of elevated (high) blood pressure, normalization of blood pressure or the decrease of elevated ... | 11/28/2006 |
