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| Number | Title | Issue Date |
| 7524978 | 2-oxabicyclo[3.3.0]octane compounds, process for producing the same, optical resolver, method of separating diastereomer mixture, and method of optically resolving alcohol 2-Oxabicyclo[3.3.0]octane compounds represented by the following formula (1) (compound (1)); an optical resolver comprising at least one of the compounds (1); a process for producing the compounds (1) which comprises reacting a compound (2) or compound (3) with an a... | 04/28/2009 |
| 7420067 | Process for the production of anhydrosugar alcohols A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst and under pressure. Optionally the resulting product is purified. Ver... | 09/02/2008 |
| 7318950 | Chiral compounds II The invention relates to chiral compounds of formula (I) R1—X1-(A1-Z1)m-G-(Z2-A2)n-X2—R2, wherein R1, R2, X1, X2 | 01/15/2008 |
| 7199148 | Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are ... | 04/03/2007 |
| 7157590 | Process for the preparation of 17-phenyl-18,19,20-thinor-pgf 2a and its derivatives The present invention provides a new and effective process for the synthesis of 17-phenyl-18,19,20-trinor-PGF2α and its derivatives, including the anti-glaucoma drugs Bimatoprost and Latanoprost. The benefit of the present invention rises inter alia from... | 01/02/2007 |
| 7157489 | HIV protease inhibitors Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed. ... | 01/02/2007 |
| 7148364 | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile The present invention provides a process for the preparation of crude 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile base with substantially low levels of impurities by arresting the formation of substantial amount of carboxa... | 12/12/2006 |
| 7078565 | Benzamide derivatives as antagonists of orexin receptors Disclosed are phenyl-alkylene benzamides useful as orexin antagonists ... | 07/18/2006 |
| 6958358 | Inhibitors of cruzipain and other cysteine proteases Compounds of general formula (I): wherein R1, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibi... | 10/25/2005 |
| 6930190 | Process for the preparation of heterocyclic pentalene derivatives A process for preparing heterocyclic pentalene derivative having formula (I): wherein w is a sulfur atom (S), an oxygen atom (O) or a NR or PR group, wherein R is an hydrocarbon group; R1, R2, R3, and R4, equal to or diffe... | 08/16/2005 |
| 6927300 | Process for the preparation of Latanoprost Disclosed is a process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process. ... | 08/09/2005 |
| 6906113 | Surface-active photoinitiators Compounds of formula Ia, Ib and Ic, (Ic), in which R, R1 and R2 are e.g. phenyl, naphthyl, anthracyl, phenanthryl or a heterocyclic radical, are suitable as photoinitiators which accumulate at the surface of coatings. ... | 06/14/2005 |
| 6858632 | Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I) in which A and B independently repr... | 02/22/2005 |
| 6828337 | Selective retinoid agonists This invention relates to new RAR selective retinoid agonists of formula I wherein the symbols are as defined in the specification to their pharmaceutically acceptable salts, individual isomers... | 12/07/2004 |
| 6818781 | Simultaneous reaction and separation process for the manufacture of dianhydro sugar alcohols A continuous process for the manufacture of dianhydro sugar alcohols by dehydration of the corresponding sugar alcohols or monoanhydro sugar alcohols in the presence of a dehydration catalyst, using evolved water vapor as a carrier for continuous separation of the p... | 11/16/2004 |
| 6720438 | Process for the preparation of Latanoprost Disclosed is a process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process. ... | 04/13/2004 |
| 6566373 | Protease inhibitors The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hy... | 05/20/2003 |
| 6562464 | Utilization of phenylglyoxalic acid esters as photoinitiators The use of phenylglyoxalic esters of the formula I ##STR1## in which the two radicals R1 and A are as defined in the description as photoinitiators in powder coating materials for exterior applications. The compounds of the formula I show little pro... | 05/13/2003 |
| 6492416 | 4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.... | 12/10/2002 |
| 6468444 | Chiral compounds and their use as chiral dopants for producing cholesteric liquid crystal compositions Chiral dopants of the formula I Z1 --Y1 --(A1)m --Y2 --M--Y3 --X--Y4 --(A2)n --Y5 --Z2 I in which the variables have, independently of one anot... | 10/22/2002 |
| 6403824 | Process for the preparation for 4,5-diamino shikimic acid derivatives The invention provides a multistep synthesis for the preparation of 4,5-diamino shikimic acid derivatives of formula ##STR1## wherein R1, R2, R3 and R4 are defined in the specification, starting from furan. 4,5-... | 06/11/2002 |
| 6248775 | - and ଲ-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors - and ଲ-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 06/19/2001 |
| 6147231 | Process for producing 2(2-hydroxymethylphenyl)acetamide derivative and intermediate for the production thereof A process for producing a compound of the formula (I): ##STR1## wherein R1 and R2 are the same or different and are hydrogen or alkyl, and R is hydrogen or alkyl, which comprises removing the protective group (P) of hydroxyl of ... | 11/14/2000 |
| 6057460 | Polymerizable hybrid monomers Polymerizable hybrid monomers with norbornenyl or norbornadienyl groups are described which can be radically cured at room temperature and are suitable in particular for use in the dental field.... | 05/02/2000 |
| 6048660 | Non-volatile phenylglyoxalic esters Compounds of the formula I ##STR1## in which R1 and R2 independently of one another are, for example, a group of the formula II ##STR2## R3, R4, R5, R6 and R7 independe... | 04/11/2000 |
| 6028101 | Fungicides for the control of take-all disease of plants A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula ##STR1## wherein Z1 and Z2 are C and are part of an aromatic ring that is furan; A is selected ... | 02/22/2000 |
| 5780629 | Polymerizable, chiral compounds and their use The invention relates to chiral compounds containing at least one divalent or polyvalent chiral group, at least one polymerizable group, at least one spacer and at least one mesogenic group, and to their use as polymerizable, chiral dopes for the preparat... | 07/14/1998 |
| 5747531 | Difluoroprostacyclins A difluoroprostacyclin of the following formula (V), its lower alkanol ester or its pharmaceutically acceptable salt: ##STR1## wherein A is an ethylene group, a vinylene group or an ethynylene group, R is a substituted or unsubstituted C1-10 | 05/05/1998 |
| 5616732 | Intermediates for difluoroprostacyclins and methods for their production A difluoroprostacyclin of the following formula (V), its lower alkanol ester or its pharmaceutically acceptable salt: ##STR1## wherein A is an ethylene group, a vinylene group or an ethynylene group, R is a substituted or unsubstituted C1-10 | 04/01/1997 |
| 5538995 | Difluoroprostacyclins A difluoroprostacyclin of the following formula (V), its lower alkanol ester or its pharmaceutically acceptable salt: ##STR1## wherein A is an ethylene group, a vinylene group or an ethynylene group, R is a substituted or unsubstituted C1-10 | 07/23/1996 |
| 5416231 | Prostaglandin I2 derivatives A novel prostaglandin I2 derivative selected from a prostaglandin I2 having a halogen atom on the carbon atom corresponding to the 7-position of natural prostaglandin I2 and having a cycloalkylene group in the -chai... | 05/16/1995 |
| 5281576 | Mixtures of aryl oxabicyclooctane derivatives, mixtures of phenyl norbornane derivatives, processes for preparing same, perfumery uses thereof and intermediates used in said processes Described are aryl oxabicyclooctane derivatives and phenyl norbornane derivatives defined according to the structures: ##STR1## wherein N is an integer selected from the group consisting of 1 and 2, processes for preparing same, perfumery uses thereo... | 01/25/1994 |
| 5276211 | Mixtures of aryl oxabicyclooctane derivatives, mixtures of phenyl norbornane derivatives, processes for preparing same, perfumery uses thereof and intermediates used in said processes Described are aryl oxabicyclooctane derivatives and phenyl norbornane derivatives defined according to the structures: ##STR1## wherein N is an integer selected from the group consisting of 1 and 2, processes for preparing same, perfumery uses thereo... | 01/04/1994 |
| 5235072 | 2-oxabicyclo(2,2,1)heptane derivatives and pharmaceutical The invention relates to 2-oxabicyclo[2.2.1]heptane derivatives of formula I ##STR1## as well as their enantiomers, in which, e.g., A means --(CH2)n --, (E)-- or (Z)--CH.dbd.CH--, --C.tbd.C, --O-- or --S--, B means hydrogen, C | 08/10/1993 |
| 5206414 | Process for the preparation of hydroxyphenylpropionic acid esters A process for the preparation of compounds of the general formula ##STR1## where R1 and R2 are identical or different and are hydrogen, C1 -C18 alkyl, phenyl, C1 -C4 alkyl-substituted ... | 04/27/1993 |
| 5190973 | 20-alkyl-7-oxoprostacyclin derivatives useful as pharmaceuticals The invention concerns 20-alkyl-7-oxoprostacyclin derivatives of general Formula I ##STR1## wherein R1 is the residue OR3 where R3 means hydrogen or alkyl of 1-10 carbon atoms optionally substituted by halogen, phenyl... | 03/02/1993 |
| 5128317 | Camphonyl spirocyclooxaoctane-containing compositions, organoleptic uses thereof and process for preparing same Described are camphonyl spirocyclooxaoctane-containing compositions having the generic structures: ##STR1## and mixtures of same with substituted cyclopentenyl-oxabicyclooctanes defined according to the generic structures: ##STR2## wherein ... | 07/07/1992 |
| 5109021 | Prostaglandin analogues, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel isomers of PGAs, PGDs, PGEs, PGFs, 6-keto-PGE1 s, 6-keto-PGF1 s, PGI2 s, 6,9-nitrilo-PGI1 s and 6,9-methano-PGI2 s, having a specific steric config... | 04/28/1992 |
| 5104861 | 7-oxoprostacyclin derivatives which are useful as pharmaceuticals The invention relates to 7-oxoprostacyclin derivatives of Formula I ##STR1## wherein R1 is the residue OR3 wherein R3 can mean hydrogen or alkyl of 1-10 carbon atoms optionally substituted by halogen, phenyl, C1 | 04/14/1992 |
| 5104855 | Demethylallosamidin and a process for production thereof An antifungal compound, demethylallosamidin, represented by the formula: ##STR1## is disclosed. Methods of production and antifungal compositions comprising demethylallosamidin are also provided.... | 04/14/1992 |
