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| Number | Title | Issue Date |
| 8129549 | Method for preparing dianhydrohexitol diester compositions A method for preparing a dianhydrohexitol diester composition, characterized in that it comprises a step which consists in esterifying a dianhydrohexitol composition with a carboxylic acid in the presence of an acid catalyst and hypophosphorous acid. Preferably, the... | 03/06/2012 |
| 8106224 | Stereospecific method for the preparation of dioxa-bicyclooctane nitrate compounds This invention relates to a new method for the stereospecific thiocarboxylation and nitration of organic compounds for the preparation of compounds according to formula (I): comprising the following... | 01/31/2012 |
| 8003811 | Nitric oxide donor compounds The invention relates to nitric oxide donors of the formula (I) and pharmaceutically acceptable salts or stereoisomers thereof: wherein A and A′ are independently selected from the group consisting of H and —(X)s | 08/23/2011 |
| 7982059 | Sorbitol conversion process A process for converting aqueous sorbitol to xylitol and isosorbide in the presence of an acid catalyst, and in the absence of an enzyme or of a hydrogenating catalyst, is disclosed. In the process, a sorbitol solution is reacted with an acid zeolite to produce xyli... | 07/19/2011 |
| 7777058 | Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses thereof In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof: as well as pharmaceutica... | 08/17/2010 |
| 7772412 | Methods for dehydration of sugars and sugar alcohols The invention includes a method of dehydration of a sugar using a dehydration catalyst and a co-catalyst within a reactor. A sugar is introduced and H2 is flowed through the reactor at a pressure of less than or equal to about 300 psig to convert at least... | 08/10/2010 |
| 7772411 | Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate The present invention relates to a process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate as well as intermediates for use in said process. More in particular... | 08/10/2010 |
| 7728156 | Method of performing sugar dehydration and catalyst treatment The invention includes a method of treating a solid acid catalyst. After exposing the catalyst to a mixture containing a sugar alcohol, the catalyst is washed with an organic solvent and is then exposed to a second reaction mixture. The invention includes a process ... | 06/01/2010 |
| 7674923 | Process for preparing forms of atorvastatin calcium substantially free of impurities The preparation of atorvastatin calcium epoxide dihydroxy (AED) is described. AED can be used as a standard or marker in determining the amount of AED in a sample. AED can therefore be used as a tool in preparing atorvastatin calcium substantially free of AED. ... | 03/09/2010 |
| 7649099 | Method of forming a dianhydrosugar alcohol The invention includes methods of producing dianhydrosugars. A polyol is reacted in the presence of a first catalyst to form a monocyclic sugar. The monocyclic sugar is transferred to a second reactor where it is converted to a dianhydrosugar alcohol in the presence... | 01/19/2010 |
| 7635782 | Stereospecific method for the preparation of dioxa-bicyclooctane compounds This invention relates to a new method for the stereospecific thiocarboxylation of organic compounds for the preparation of compounds according to formula (I): wherein a compound of formula (II): | 12/22/2009 |
| 7615652 | Two-stage dehydration of sugars The invention includes methods for producing dianhydrosugar alcohol by providing an acid catalyst within a reactor and passing a starting material through the reactor at a first temperature. At least a portion of the staring material is converted to a monoanhydrosug... | 11/10/2009 |
| 7521571 | Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof as well as pharmaceutical compositions comprising these compounds an... | 04/21/2009 |
| 7468448 | Production method of hexahydrofurofuranol derivative, intermediate therefor and production method thereof The present invention provides a method for producing compound (XIV) useful as an intermediate for pharmaceutical agents efficiently and economically on an industrial scale without using ozone oxidation and highly toxic reagent, and an intermediate used for this met... | 12/23/2008 |
| 7439352 | Process for the production of anhydrosugar alcohols A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst, and subsequent purification of the anhydrosugar alcohol. In some emb... | 10/21/2008 |
| 7420067 | Process for the production of anhydrosugar alcohols A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst and under pressure. Optionally the resulting product is purified. Ver... | 09/02/2008 |
| 7378441 | Resistance-repellent retroviral protease inhibitors Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided. ... | 05/27/2008 |
| 7361775 | Process for the preparation of (S)-glyceraldehyde acetonide The invention relates to a process for the preparation of (S)-glyceraldehyde acetonide in aqueous solution from 3,4-O-isopropylidene-L-threonic acid or a salt thereof in aqueous solution, and hypochlorite in aqueous solution wherein the aqueous hypochlorite solution... | 04/22/2008 |
| 7318950 | Chiral compounds II The invention relates to chiral compounds of formula (I) R1—X1-(A1-Z1)m-G-(Z2-A2)n-X2—R2, wherein R1, R2, X1, X2 | 01/15/2008 |
| 7311948 | Isosorbide derivatives The invention pertains to an isosorbide derivative having at least one polymerizable group, characterized in that the isosorbide derivative further comprises at least one photo-convertible group for adjusting the helical twisting power of the isosorbide derivative. ... | 12/25/2007 |
| 7241906 | Bycyclic tetrahydrofuran derivatives and process for the preparation thereof The present invention relates to bicyclic tetrahydrofuran derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1) by performing an intramolecular cyclization of tetrahydrofuran-allen... | 07/10/2007 |
| 7220749 | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compo... | 05/22/2007 |
| 7220710 | Carbohydrate esters for using as lubricants The present invention relates to compositions which comprise mixtures of open-chain and cyclic molecules of the sugar alcohols D-sorbitol and D-mannitol which have been esterified with at least one carboxylic acid, processes for preparing these compositions and the ... | 05/22/2007 |
| 7145024 | Process for preparing protease inhibitor intermediates The present invention includes a method for preparing cyclic alcohols. The method includes a reduction, deprotection, and rearrangement scheme. The present invention further provides a method of preparation of an intermediate useful in the synthesis of compounds tha... | 12/05/2006 |
| 7126015 | Method for the preparation of hexahydro-furo-[2,3-b]furan-3-ol The present invention relates to a method for the preparation of hexahydro-furo[2,3-b]furan-3-ol as well as novel intermediates for use in said method. More in particular the invention relates to a stereoselective method for the preparation of hexahydro-furo[2,3-b]f... | 10/24/2006 |
| 7122661 | Method for purifying a composition containing at least one internal dehydration product of a hydrogenated sugar The invention concerns a method for purifying a composition containing at least a product for internal dehydration of a hydrogenated sugar. The invention is characterised in that it comprises: (a) an optional step whereby said composition is treated, whether after r... | 10/17/2006 |
| 7115757 | 1,2-dioxetane derivatives and reagents employing them A 1,2-dioxetane derivative of the formula (I): wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl... | 10/03/2006 |
| 7033726 | Photoresist polymeric compound and photoresist resin composition A polymeric compound for photoresist of the present invention includes a monomer unit having 2,6-dioxabicyclo[3.3.0]octane skeleton in the structure. The monomer unit having 2,6-dioxabicyclo[3.3.0]octane skeleton includes a monomer unit represented by the following ... | 04/25/2006 |
| 6982336 | 1,2-dioxetane derivatives, luminescent reagents, luminescence methods and measuring methods A 1,2-dioxetane derivative of the formula (I): wherein R1–R3 and Ar are defined in the claims is provided. ... | 01/03/2006 |
| 6919465 | Method of preparing (3R, 3aS, 6aR)-3-hydroxyhexahydrofuro[2,3,-b] furan and related compounds A method of synthesizing (3R,3aS,6aR)-3-hydroxyhexahydrofuro[2,3-b]furan (I), and related compounds, in high yield and high enantiomeric selectivity is disclosed. Also disclosed is a method of manufacturing (5S)-5-(ben... | 07/19/2005 |
| 6905739 | Optically active materials A compound is of formula (I), in which: A1 to A4, E1 and E2 each independently represent hydrogen or an optionally-substituted hydrocarbon group; B1 and B2 each independently represent a single bond, ... | 06/14/2005 |
| 6902687 | OPTICALLY ACTIVE ISOSORBIDE DERIVATIVE AND OPTICALLY ACTIVE ISOMANNIDE DERIVATIVE, PRODUCTION METHODS THEREOF, PHOTO-REACTIVE CHIRAL AGENT, LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL COLOR FILTER, OPTICAL FILM AND RECORDING MEDIUM, METHOD FOR CHANGING HELICAL STRUCTURE OF LIQUID CRYSTAL AND METHOD FOR FIXING HELICAL STRUCTURE OF LIQUID CRYSTAL The invention relates to an optically active isosorbide derivative represented by general formula (I) and an optically active isomannide derivative represented by general formula (V), wherein R... | 06/07/2005 |
| 6878728 | Inhibitors of aspartyl protease The invention provides novel compounds of formula (I) wherein all variables are as defined in the specification, that are useful as inhibitors of aspartyl proteases. ... | 04/12/2005 |
| 6867296 | Recovery and purification of anhydro sugar alcohols from a vapor stream This invention concerns a process for recovering and purifying dianhydro sugar alcohols from a vapor stream comprising dianhydro sugar alcohols, such as isosorbide, and water vapor. ... | 03/15/2005 |
| 6864378 | Integrated continuous process for anhydro sugar alcohol manufacture An integrated continuous process is disclosed for the manufacture of high purity, polymer grade dianhydro sugar alcohols, such as isosorbide, by the dehydration of corresponding sugar alcohols. The water vapors evolved during the dehydration are used to separate pro... | 03/08/2005 |
| 6858632 | Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I) in which A and B independently repr... | 02/22/2005 |
| 6849748 | Process for the production of anhydrosugar alcohols A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst, and subsequent purification of the anhydrosugar alcohol. Very high p... | 02/01/2005 |
| 6831181 | High yield byproduct recycle process for anhydro sugar alcohols A process for recycling reaction byproducts in the manufacture of dianhydro sugar alcohols, such as isosorbide, from corresponding sugar alcohols. ... | 12/14/2004 |
| 6689892 | Process for the manufacture of anhydro sugar alcohols with the assistance of a gas purge This invention concerns a process for the manufacture of anhydro- and dianhydro- hexitols, pentitols, and tetritols by the dehydration of sugar alcohols (alditols) in the presence of a dehydration catalyst and with the assistance of an inert gas sparge.... | 02/10/2004 |
| 6617350 | Inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical ... | 09/09/2003 |
