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| Number | Title | Issue Date |
| 8097738 | Ruthenium (II) catalysts for use in stereoselective cyclopropanations Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral s... | 01/17/2012 |
| 8071796 | Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof The current invention describes novel chiral synthetic routes and intermediates for the manufacture of chiral anti-inflammatory agents of general formula VIII in which at least one of the groups X1, X2 | 12/06/2011 |
| 7928253 | Method of producing 6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one A method of producing 6,6-dimethyl-3 -oxabicyclo [3.1.0]hexan-2-one comprising subjecting a cyclopropane compound of the formula (1): (wherein, R1 represents an alkyl group, R2 represents an alkyl grou... | 04/19/2011 |
| 7834201 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified s... | 11/16/2010 |
| 7803956 | Benzofuran derivatives useful for treating hyper-proliferative disorders The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders. ... | 09/28/2010 |
| 7754902 | Ruthenium(II) catalysts for use in stereoselective cyclopropanations Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral s... | 07/13/2010 |
| 7732626 | Fused cyclic compounds The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug thereof has a GPR40 receptor function modulating action and is useful as an... | 06/08/2010 |
| 7723533 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified ... | 05/25/2010 |
| 7718815 | Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders Methods of using certain α-aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects. ... | 05/18/2010 |
| 7659412 | Benzofuran derivatives useful for treating hyper-proliferative disorders The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders. ... | 02/09/2010 |
| 7579488 | Vitamin D receptor modulators The present invention relates to novel, non-secosteroidal, phenyl-benzofuran compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.... | 08/25/2009 |
| 7521570 | Medicinal compositions containing 6-hydroxybenzbromarone or salts thereof To provide highly safe therapeutic or preventive agents for hyperuricemia, more specifically uricosuric agents, which have potent uricosuric effect and do not cause grave hepatic disorder. Medicinal compositions for the treatment or prevention of hyperuricemia or di... | 04/21/2009 |
| 7507839 | Therapeutic ion channel blocking agents and methods of use thereof Various divalent ligands based on khellinone derivatives are described. These derivatives can be useful in the modulation of potassium channel activity in cells, including among others Kv1.3 channels found in T-cells. The compounds may also be useful in the treatmen... | 03/24/2009 |
| 7420066 | Benzofuran derivatives useful for treating hyper-proliferative disorders The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders. ... | 09/02/2008 |
| 7332485 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 02/19/2008 |
| 7312230 | Carboxylic acid derivatives as IP antagonists This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 ... | 12/25/2007 |
| 7300908 | Fungicidal triazolopyrimidines, method for the production thereof and use thereof in controlling noxious fungi and agents containing said compounds Triazolopyrimidines of formula (I), wherein the index and substituents have the following meaning: n=0 or a whole number of 1-5; R=halogen, cyano, hydroxy, cyanate, alkyl, alkenyl, alkinyl, halogenalkyl, halogenalkenyl, alkoxy, alkenyloxy, alkinyloxy, halogenalkoxy,... | 11/27/2007 |
| 7285518 | Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions Dibenzo[b]perhydroheterocyclic amine compounds have shown to be particularly useful as stabilizers. The compounds may serve as antioxidants, antiozoants, heat stabilizers and ultraviolet light stabilizers and such compounds are oil soluble, thus particularly suited ... | 10/23/2007 |
| 7271406 | Electron transport agents for organic electronic devices Compounds and compositions are provided that can be used as electron transport agents in organic electronic devices such as organic electroluminescent devices. The compounds are non-polymeric and have an aromatic core conjugated to end capping groups. The aromatic c... | 09/18/2007 |
| 7271273 | Method for the preparation of citalopram The invention provides a new and improved method for the preparation of 5-cyano-phtalid, which is a key intermediate in the preparation of the antidepressant compound citalopram. ... | 09/18/2007 |
| 7256218 | Biguanide and dihydrotriazine derivatives Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide ... | 08/14/2007 |
| 7214686 | Pharmaceutical compositions and methods for effecting dopamine release Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attent... | 05/08/2007 |
| 7196108 | Bicyclic heterocycles for the treatment of diabetes and other diseases The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, and atherosclerosis. | 03/27/2007 |
| 7192939 | isolates and compounds derived therefrom The present invention relates to the novel isolated 12–30 strain of Pestalotiopsis microspora capable of producing novel antioxidant and antimycotic agents. The present invention also relates to the novel isolated 3,5,7 trisubstituted isobenzofuranone and d... | 03/20/2007 |
| 7176198 | 1-pyrazole and 1-pyrrole-azabicyclic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is where the variables have the definitions discussed herein. These compounds may be in the... | 02/13/2007 |
| 7161042 | Protected diols for prostaglandin synthesis A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralk... | 01/09/2007 |
| 7148364 | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile The present invention provides a process for the preparation of crude 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile base with substantially low levels of impurities by arresting the formation of substantial amount of carboxa... | 12/12/2006 |
| 7141706 | Protected and unprotected triols for prostaglandin synthesis A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralk... | 11/28/2006 |
| 7132294 | Functionalized small molecules for use in chemical sensors The invention provides a device for selective molecular recognition, the device comprising a sensing portion, wherein said sensing portion includes a substrate having coated thereon a layer comprising a non-volatile, small molecule compound having at least two penda... | 11/07/2006 |
| 7122547 | Anthranilic acid amides and the use thereof as medicaments The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products in the production of anthranilic acid amides. ... | 10/17/2006 |
| 7109371 | Prostaglandin synthesis A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralk... | 09/19/2006 |
| 7067515 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease The invention provides compounds of Formula I: where in W is These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or... | 06/27/2006 |
| 7005448 | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma The present invention provides novel compounds, compositions containing the compounds of the invention in a pharmaceutically acceptable excipient and methods for using the compositions for lowering intraocular pressure. ... | 02/28/2006 |
| 6998407 | Antagonists of MCP-1 function and methods of use thereof Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these compounds. The... | 02/14/2006 |
| 6987194 | Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives of Formula I are disclosed. These compounds provide unexpected insecticidal activity across a spectrum of insect pests combined with desirable physical properti... | 01/17/2006 |
| 6951868 | Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is any of: These compounds may be in the form of pharmaceutical salts or compositions, and racemic mixtu... | 10/04/2005 |
| 6949583 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method of preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives, to processes for preparing them, to pharmaceutical compositions comprising them, and to the method of use thereof in the treatment of pathological syndromes of the cardiovascular system. ... | 09/27/2005 |
| 6946462 | N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents New compounds represented by the formula or pharmaceutically acceptable salts or prodrugs thereof, wherein X1 and X2 are each independently selected from a CH group or a nit... | 09/20/2005 |
| 6930188 | Stable hydrate of a muscarinic receptor antagonist A stable solid hydrate of a muscarinic receptor antagonist is useful in the treatment of irritable bowel syndrome, diverticular disease, oesophageal achalasia, chronic obstructive airways disease, over active bladder (including symptoms of incontinence, urge and fre... | 08/16/2005 |
| 6911548 | Method for the preparation of 5-cyanophthalide A method for the preparation of 5-cyanophthalide comprising treatment of a compound of formula IV wherein X is O or S; R1-R2 are each independently selected from... | 06/28/2005 |
