Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 7601856 | Benzofurans as potassium ion channel modulators The present invention is directed to compounds of Formula I: that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compoun... | 10/13/2009 |
| 7417157 | Hexahydrodibenzofuran derivatives Disclosed are hexahydrodibenzofuran compounds of formula I, the preparation thereof, the use thereof as components in liquid-crystalline media, and to electro-optical display elements which contain the liquid-crystalline me... | 08/26/2008 |
| 7393846 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 07/01/2008 |
| 7351825 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/01/2008 |
| 7288543 | Opioid receptor antagonists A compound of the formula (I) (I) wherein the variables X1 to X6, Ra, Rb, R1 to R7 including R3′, E, p, j, y, z, A, B and C are as described or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the trea... | 10/30/2007 |
| 7238725 | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes. ... | 07/03/2007 |
| 7223789 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 05/29/2007 |
| 7196089 | EPreceptor antagonists Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O... | 03/27/2007 |
| 7186752 | Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species. ... | 03/06/2007 |
| 6809176 | Quinones as disease therapies Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided. ... | 10/26/2004 |
| 6624177 | Matrix metalloproteinase inhibitors and their therapeutic uses The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I ##STR1## More particularly, the present invention relates to a method of treating dis... | 09/23/2003 |
| 6620835 | Method of inhibiting matrix metalloproteinases The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I ##STR1## More particularly, the present invention relates to a method of treating dis... | 09/16/2003 |
| 6562842 | Protease inhibitors The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gi... | 05/13/2003 |
| 6472545 | Protein tyrosine phosphatase inhibitors Compounds of formula (I) ##STR1## or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclo... | 10/29/2002 |
| 6420408 | Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and strome... | 07/16/2002 |
| 6407100 | Fungicidal aromatic oximes The invention relates to novel compounds of the formula ##STR1## in which R1 is C1-4 alkyl and (Y--X) is CH2, C1-2 alkylthio-CH.dbd. or C1-2 alkyl-ON.dbd. and Z is an aldimino or ketimino group, and t... | 06/18/2002 |
| 6350885 | Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases Tricyclic heteroaromatic compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and str... | 02/26/2002 |
| 6218426 | Non-peptide GnRH agents Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are of the following general formula, where X1, X2, Y, and are defined variables: ##STR1## Such compounds and their pharmaceutically acceptabl... | 04/17/2001 |
| 6172104 | Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof Methods of treating Pneumocystis carinii pneumonia comprise administering a therapeutically effective amount of a dicationic dibenzofuran compound described by Formula (I). Methods of treating Pneumocystis carinii pneumonia also comprise administering a t... | 01/09/2001 |
| 6132984 | Method for inhibiting eukaryotic protein kinases Lichen-derived organic acids such as vulpinic acid and usnic acid have been found to be effective inhibitors of eukaryotic protein kinase activity. Thus, eukaryotic protein kinase activity present in a sample or organism can be inhibited by adding to the ... | 10/17/2000 |
| 6069166 | Fused heterocyclic benzenecarboxamide derivatives and PGD2 antagonists comprising them A compound, pharmaceutically acceptable salt thereof, or hydrate thereof having a PGD2 -antagonistic activity, and an inhibitory activity against infiltration of eosinophils, useful for treating mast cell dysfunction-associated diseases, such a... | 05/30/2000 |
| 6057362 | Protease inhibitors The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gi... | 05/02/2000 |
| 6037367 | Substituted-pent-4-ynoic acids Compounds of formula (I) wherein: R1 is --(CR4 R5)n C(O)O(CR4 R5)m R6, --(CR4 R5)n C(O)NR4 (CR4 R5)m | 03/14/2000 |
| 6037361 | Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase)... | 03/14/2000 |
| 6020366 | Butyric acid matrix metalloproteinase inhibitors Compounds of the formula ##STR1## wherein R1 and R2 include hydrogen, alkyl, substituted alkyl, halo, and arylalkyl; R3 is hydroxy, alkoxy, or hydroxyamino; X is O, S, or NOH; and R4 and R5 inclu... | 02/01/2000 |
| 5969163 | Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth A process for the preparation of ଲ-lapachone and dunnione derivatives of formulae I and II ##STR1## wherein, the a solution of lawsone in dimethylsufoxide at a temperature of -78° C. or less is reacted with lithium hydride forming the lithium ... | 10/19/1999 |
| 5932739 | Substituted 1,2,3,4-tetrahydro-2-dibenzofuranamines and 2-aminocyclohepta6,!benzofurans The invention provides substituted-2-amino-1,2,3,4-tetrahydrodibenzofurans and 2-aminocycloheptab!benzo-furans useful as 5-HT1F agonists.... | 08/03/1999 |
| 5846995 | Substituted 1, 2, 3, 4-tetrahydro-2-dibenzofuranamines and 2-amino-cyclohepta (6, 7-B) Benzofurans The invention provides substituted-2-amino-1,2,3,4-tetrahydrodibenzofurans and 2-aminocycloheptab!benzo-furans useful as 5-HT1F agonists.... | 12/08/1998 |
| 5843997 | Excitatory amino acid receptor antagonists The present invention provides novel compounds that affect excitatory amino acid receptors and are useful in the treatment of neurological disorders. This invention also provides synthetic methods for the preparation of the novel compounds.... | 12/01/1998 |
| 5840927 | Sesquiterpene compounds Novel anti-microbial sesquiterpene compounds isolated from the fruit bodies of Roseofomes subflexibilis (Hounen-take) having the general formula ##STR1##... | 11/24/1998 |
| 5716986 | Oxaindene derivatives and process for the preparation thereof This invention relates to new oxaindene derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The compounds according to the invention are characterized by the general formula (1) ##STR1## wherein R | 02/10/1998 |
| 5665764 | Tricyclic inhibitors of matrix metalloproteinases Tricyclic compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treat... | 09/09/1997 |
| 5627206 | Tricyclic inhibitor of matrix metalloproteinases A tricyclic compound is described as well as pharmaceutical compositions of same, which is useful as an inhibitor of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) for the treatment of multiple sclerosis or other autoimmune or inf... | 05/06/1997 |
| 5543433 | Azine-substituted phenylacetic acid derivatives and fungicides containing these Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH3, CHOCH3 or NOCH3, R is hydrogen or alk... | 08/06/1996 |
| 5541333 | Carbazole derivatives Novel tethered hapten intermediates and related conjugates based on carbazole and/or dibenzofuran, as well as methods for making and using such conjugates. Haptens based on the above core structures may be substituted at any position on the aromatic rings... | 07/30/1996 |
| 5536746 | Insecticidal phenylhydrazine derivatives Compounds having the structural formula ##STR1## where X, Y, R and Z are defined in the specification are disclosed. The compounds of this invention are effective for controlling mites, nematodes, rice planthopper, tobacco budworm, and southern corn ... | 07/16/1996 |
| 5496849 | Sulfonic acid derivative and its pharmaceutical application The present invention discloses sulfonamide derivative represented by the following general formula: ##STR1## [wherein, R1 is (i) --COOR2 (where, R2 is (1) hydrogen, (2) a pharmacologically acceptable cation, or (3) a... | 03/05/1996 |
| 5457237 | Dihydroxyindanone tyrosine kinase inhibitors Certain dihydroxyindanone compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).... | 10/10/1995 |
| 5401769 | Dibenzofuranyl N-alkyl carbamates A compound of formula A: ##STR1## wherein R1 and R2 are, independently, hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, cyano, nitro, alkyl, alkoxy, --CO2 H, alkylcarbonyl, alkylcarbonyloxy, alkoxycarb... | 03/28/1995 |
| 5278323 | Process for preparing chiral dibenzofurans via intramolecular heck reaction The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzofuran-4-carboxy lic acid by an intramolecular Heck stereospecific synthesis substantially free of undesirable 8-chloro-2,6-methano-2H-3,4,... | 01/11/1994 |
