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| Number | Title | Issue Date |
| 8097737 | Process for production of optically active amine derivatives An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reductio... | 01/17/2012 |
| 8084630 | Process for the synthesis of ramelteon and its intermediates The present invention provides processes and intermediates for the synthesis of ramelteon. ... | 12/27/2011 |
| 7910752 | Anticancer compound, intermediate therefor, and processes for producing these The present invention provides a method for easily and inexpensively preparing a racemate or an optically-active 2-(1 -hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione in high yields, 2-acetyl-2,3-dihydro-5-hydroxynaphtho[2,3-b]furan-4,9-dione which is useful as... | 03/22/2011 |
| 7728155 | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents Compounds of formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists and partial agonists of the 2c subtype of brain serotonin receptors. The compounds, and compositions containing the compou... | 06/01/2010 |
| 7635781 | Synthesis of cyclopentadiene derivatives A compound of formula (X): wherein R1, R2, equal to or different from each other are hydrogen or a linear or branched saturated or unsaturated C1-C | 12/22/2009 |
| 7538234 | Preparation of Optically active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4, 9-diones having anticancer activities An object of the present invention is to provide a method for efficiently preparing (S)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]-furan-4,9-dione useful as a medicine at a low cost and in large amounts. According to the present invention, the desired (S)-2-(1-hydro... | 05/26/2009 |
| 7468447 | Regiospecific Furan Compounds and Their Use in Fragrances The present invention is directed to the diastereoisomeric mixture and the individual isomeric components of the formula: ... | 12/23/2008 |
| 7442808 | Antidiabetic bicyclic compounds Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful a... | 10/28/2008 |
| 7345181 | Process for preparing prostaglandin derivatives and starting materials for the same The present invention provides a process for preparing benzoprostacycline derivatives of formula (1), i.e. 5,6,7-trinor-4,8-inter-m-phenylene PGI2 derivatives, and vinyl tin compounds of formula (III) as starting materials for the same. ... | 03/18/2008 |
| 7255900 | Fluorinated heterocycles and their use in liquid-crystal mixtures In the compound of the formula (I), where: R1, R2 are each independently, for example, H or a straight-chain or branched alkyl radical p, q are each independently 0... | 08/14/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7253207 | Quinones as disease therapies Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided. ... | 08/07/2007 |
| 7241903 | Metallocenes, use in catalyst system for producing olefin polymers A metallocene compound of formula (I): wherein M is zirconium, titanium and hafnium; X is a hydrogen atom, a halogen atom or a hydrocarbon radical; R1 is a linear C1-C20-alkyl radical; R2 is a hydrogen atom or hydrocarbon ... | 07/10/2007 |
| 7144885 | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders ... | 12/05/2006 |
| 7109327 | Total synthesis of galanthamine, analogues and derivatives thereof The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form ═O, R3, R4 | 09/19/2006 |
| 7018685 | Fluorinated aromatic compounds and the use of the same in liquid crystal mixtures The invention relates to fluorinated aromatics of the formula (I) where X is CH2, C═O, CF2, O or S, Y is H or F, with the proviso that Y has to be F when X is CH2 | 03/28/2006 |
| 7019152 | Process for the optical resolution of a precursor of sclareolide The present invention relates to the field of organic synthesis and more particularly to a new process for the optical resolution of a precursor of sclareolide. This process includes the reaction of [(1RS,2RS,4aSR,8aSR)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphtha... | 03/28/2006 |
| 7005527 | Process for the production of beraprost and its salts The present invention relates to a new process for the preparation of beraprost of formula (I) using new intermediates. ... | 02/28/2006 |
| 6951880 | Aryl and heteroaryl compounds as antibacterial and antifungal agents This invention provides novel compounds possessing antibacterial and/or antifungal and/or antitumor activity. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided. ... | 10/04/2005 |
| 6943182 | Cyclopentabenzofuran derivatives and their use The invention relates to cyclopentabenzofuran derivatives, process for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-κB-dependent diseases and medicaments which contain the cyclopentabenzofur... | 09/13/2005 |
| 6852754 | Biologically active linderazulene terpenes The subject invention provides novel compositions of biologically active linderazulene terpene compounds which can advantageously be used for treating cancer and stopping cell proliferation. ... | 02/08/2005 |
| 6809176 | Quinones as disease therapies Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided. ... | 10/26/2004 |
| 6710075 | Therapeutic compounds and methods The present invention provides compounds having a cyclopentabenzofuran core and the use of such compounds in therapy as well as compositions comprising said compounds. ... | 03/23/2004 |
| 6653345 | C-C chemokine synthesis inhibitor A method of inhibiting mammalian C--C chemokine production by using a mammalian C--C chemokine synthesis inhibitor containing a prostaglandin I derivative as an active component to treat a variety of circulatory diseases, inflammation, allergic diseases, ... | 11/25/2003 |
| 6605632 | Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them The invention concerns compounds of formula (I): R--A--R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the desc... | 08/12/2003 |
| 6602903 | Substituted heterocyclic compounds The invention relates to compounds of formula (I): ##STR1## and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.... | 08/05/2003 |
| 6518274 | Use of cyclopentabenzofuran-derivatives for combating (NF-.kappa.B)-dependent diseases The invention relates to the use of cycloventabenzofuran derivatives for the production of a medicament for the treatment of nuclear factor of .kappa.B-dependent diseases.... | 02/11/2003 |
| 6423870 | Tricyclic compounds, preparation method and pharmaceutical compositions containing same The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4 ; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2... | 07/23/2002 |
| 6420393 | Cyclopentabenzofuran derivatives and their use The invention relates to cyclopentabenzofuran derivatives, processes for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-.kappa.B-dependent diseases and medicaments which contain the ... | 07/16/2002 |
| 6420413 | Heterocycloalkylbenzocyclobutane and heteroarylbenzocyclobutane compounds A compound selected from those of formula (I): ##STR1## wherein: ##STR2## denotes single bond or double bond, n is integer from 1 to 6 inclusive, R1, and R2 represent a group selected from hydrogen, linear or branched (C1 -C | 07/16/2002 |
| 6420408 | Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and strome... | 07/16/2002 |
| 6395773 | Anti-drug resistant strain agents and antichlamydia agents In order to provide antibacterial agents for drug-resistant bacteria and anti-Chlamydia agents, the furanonaphthoquinone derivative represented by the following formula (1): ##STR1## wherein each R may be the same or different, representing any one of the... | 05/28/2002 |
| 6392059 | Hydronaphtho[2,3-c]furan derivatives and process for the preparation thereof Intermediates for the preparation of himbacine exhibiting muscarinic M2 receptor antagonism, which are hydronaphtho[2,3-c]furan derivatives represented by general formula (1) or intermediates for the preparation thereof: ##STR1## wherein R1 | 05/21/2002 |
| 6380404 | Preparation of norlabdane oxide Norlabdane oxide, which is a well known fragrance material having ambergris-type odors, is prepared from 12-acetoxy-norlabdane oxide by a hydrogenation reaction.... | 04/30/2002 |
| 6340693 | Protective agent for nervous system structural cells The present invention provides a protective agent for nervous system structural cells comprising a prostaglandin I derivative, preferably a prostaglandin I2 derivative, particularly beraplost, as an active component. This medicine exhibits exce... | 01/22/2002 |
| 6323348 | Process for producing cycloalkyl [b]benzofurans The present invention provides a process for producing an optically active compound of cycloalkyl[b]benzofuran using a readily available optically active compound as a starting material by a reaction using a transition metal or the Mitsunobu reaction, or ... | 11/27/2001 |
| 6300339 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein A, B, Q, T, X, Y, Z, R5, R6, R7, R8, Ar, k, m, n and p are as defined in the specification. These compounds are useful in treating or pr... | 10/09/2001 |
| 6262271 | ISO-CBI and ISO-CI analogs of CC-1065 and the duocarmycins A series of bioactive analogs of (+)-CC-1065 (1) and the duocarmycins 2 and 3 are synthesized. The bioactive analogs include either iso-CI or iso-CBI (6 and 7) as a DNA alkylation subunit. Conjugated to the DNA alkylating subunits are a variety of DNA bin... | 07/17/2001 |
| 6251936 | Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure ##STR1## E is S, SO, SO2, O, or NR1c ; X is hydrogen, halogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, CN, aryl, aralkyl of 6-12 carbon atoms, hydroxyalky... | 06/26/2001 |
| 6218429 | Tricyclic compounds, their production and use A compound of the formula: ##STR1## wherein R1 is an optionally substituted hydrocarbon, amino or heterocyclic group; R2 is H or an optionally substituted hydrocarbon group; R3 is H or an optionally substituted hydrocarbon... | 04/17/2001 |
