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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 7323455 | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3)-one derivatives and their use as progesterone receptor modulators This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof. ... | 01/29/2008 |
| 6960344 | Use of imine-forming polysaccharides as adjuvants and immunostimulants The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or ... | 11/01/2005 |
| 6812229 | Carbamate derivative and agricultural/horticultural fungicide It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate derivative represented by the general formula [I] | 11/02/2004 |
| 6812352 | Multidentate phosphite ligands, catalytic compositions containing such ligands, and catalytic processes utilizing such catalytic compositions Multidentate phosphite ligands are disclosed for use in reactions such as hydrocyanation and isomerization. The catalyst compositions made therefrom and the various catalytic processes which employ such multidentate phosphite ligands are also disclosed. In particula... | 11/02/2004 |
| 6787559 | Sulfonamide compounds This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds. ... | 09/07/2004 |
| 6492394 | Sulfonamide hydroxamates A compound of the Formula (I): ##STR1## wherein Z, R1, R, and Ar2 are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceu... | 12/10/2002 |
| 6452000 | Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate The present invention concerns an improved process for the preparation of asymmetric cyclic ureas as well as intermediates in the preparation of asymmetric cyclic ureas. In the process, a diamine of formula (I-a) ##STR1## is selectively monoacylated to gi... | 09/17/2002 |
| 6414158 | 1,3,4-oxadiazine derivatives and their use as pesticides The invention relates to novel carbazate intermediates of formula (II), and to a process for their preparation, and their usefulness in the preparation of (1,3,4) oxadiazine derivatives useful as pesticides, in particular as anthelminthicides, insecticide... | 07/02/2002 |
| 6262084 | Compounds that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔ଲ.sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions the... | 07/17/2001 |
| 6235753 | Inhibitors of the production of S-CD23 and the secretion of TNF Inhibitors of the Production of s-CD23 and the secretion of TNF are provided.... | 05/22/2001 |
| 6222052 | Process for preparing optically active 2-amino-ω-oxoalkanoic acid derivatives A process is disclosed for preparing an (S)-2-amino-ω-oxoalkanoic acid derivative in which the corresponding aldehyde is converted into the corresponding acetal-protected aldehyde, the acetal-protected aldehyde is converted into the corresponding aminoni... | 04/24/2001 |
| 6177576 | Pyruvate saccaride ketals A novel composition for supplementing the human diet having a polyol-derived pyruvate (2-keto-propionic-acid) moeity as a component.... | 01/23/2001 |
| 6166227 | Preparation of (S)-2-amino-6, 6-dimethoxyhexanoic acid methyl ester via novel dioxolanes The glycinamide of the formula (I) ##STR1## is reacted with the dioxolane of the formula (II) ##STR2## wherein L is a leaving group such as iodo, bromo, alkylsulfonyloxy, or arylsulfonyloxy to give the dioxolane of the formula (III) ##STR3#... | 12/26/2000 |
| 6096773 | Compounds that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔 댡 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositi... | 08/01/2000 |
| 6084131 | Process for the preparation of protected dihydroxypropyl trialkylammonium salts and derivatives thereof A process for the preparation of protected dihydroxypropyl trialkylammonium salts, particularly in chiral form is described. In particular, a process for the preparation of (2,2-dimethyl-1,3-dioxolan-4-ylmethyl)trialkylammonium salts, particularly in... | 07/04/2000 |
| 6011174 | Cyclic amic acid derivatives The present invention relates to a compound of the formula (I), or its pharmaceutically acceptable salt or ester: ##STR1## wherein Ar1 is an aryl group or a heteroaromatic ring group; Ar is a group of the formula ##STR2## each of... | 01/04/2000 |
| 5990158 | Carboxylic acid derivatives, method of manufacturing the same and therapeutic agents containing these compounds New therapeutic agents of carboxylic acid derivatives are disclosed, which are represented by the compounds of the following formula (I) or its pharmaceutically acceptable salts, ##STR1## These compounds are useful as a matrix metalloproteinases (MMP... | 11/23/1999 |
| 5981511 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 11/09/1999 |
| 5962704 | Production of amide derivatives and intermediate compounds therefor A method for producing an amide derivative of the formula XV! ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The p... | 10/05/1999 |
| 5945408 | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 08/31/1999 |
| 5834498 | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate eit... | 11/10/1998 |
| 5801258 | Amide derivatives and dermatologic preparations containing the same The amide derivative of the present invention is one represented by the following general formula (I) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R1 represents a strai... | 09/01/1998 |
| 5753707 | Amide derivatives and their use in cosmetic composition An amide derivative represented by the following formula (1): ##STR1## wherein R1 represents a C1-40 hydrocarbon; R2 represents a C1-6 alkylene; R3 represents H, OH or alkoxyl; R4 repr... | 05/19/1998 |
| 5744569 | One-component and two-component polyurethane coating compositions In one-component and two-component polyurethane coating compositions comprising at least one reactive component capable of reacting with polyisocyanates, the reactive component is a compound A) containing an isocyanate group, a urethane, thiourethane or u... | 04/28/1998 |
| 5723646 | Substituted amino acid amide derivatives their preparation and use as fungicides There are described new amino acid amide derivatives, some of which are known, of the formula (I) ##STR1## in which R1 to R8 have the meaning given in the description, and a process for their preparation. The amino acid amide de... | 03/03/1998 |
| 5659052 | Amide derivatives and dermatologic preparations containing the same The amide derivative of the present invention is one represented by the following general formula (II) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R11 represents a str... | 08/19/1997 |
| 5656619 | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for ... | 08/12/1997 |
| 5616711 | Methods of producing aminobutene derivatives A method of producing an aminobutene derivative of formula (I) by allowing a butenol derivative of formula (II) to react with an amide derivative of formula (III) is disclosed. The aminobutene derivative of formula (I) can be deprotected to produce an ami... | 04/01/1997 |
| 5563168 | O-Benzyloxime ethers and crop protection agents containing these compounds O-Benzyloxime ethers of the formula I ##STR1## where 5 X is substituted or unsubstituted CH2, NOalkyl Y is O, S, NR5 R1, R2, R5 are H, alkyl Z1, Z2 are H, halogen, methyl, methoxy, cy... | 10/08/1996 |
| 5559134 | Leukotriene-B4 antagonists, process for their production and their use as pharmaceutical agents The invention relates to leukotriene-B4 antagonists of formula I ##STR1## in which n represents a whole number from 2 to 5, X represents a direct bond, 1 to 6 methylene units, an ortho-, meta- or para-substituted phenyl ring or a meta- or para-... | 09/24/1996 |
| 5543433 | Azine-substituted phenylacetic acid derivatives and fungicides containing these Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH3, CHOCH3 or NOCH3, R is hydrogen or alk... | 08/06/1996 |
| 5523320 | N-methyldeacetylcolchiceinamide derivatives N-methyldeacetylcolchiceinamide derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C3 -C7 sugar carboxylic acid, and hydroxyl groups present in the residue may properly b... | 06/04/1996 |
| 5516795 | Heteroatom substituted propanyl derivatives having 5-lipoxygenase inhibitory activity Compounds of the structure ##STR1## where R1 is alkyl of one to four carbon atoms and R2 is selected from (a) alkenyl of one to four carbon atoms, (b) ##STR2## (c) ##STR3## and (d) ##STR4## are potent in... | 05/14/1996 |
| 5302587 | Platinum (II) complex and agent for treating malignant tumor A novel platinum (II) complex represented by the following formula (A): ##STR1## wherein R1 represents C1 -C5 lower hydrocarbon group, R2 and R3 represents hydrogen atom or C1 -C3 | 04/12/1994 |
| 5298632 | Herbicidal pyrimidine compounds, compositions containing the same and method of use Herbicidal pyrimidine compound having the formula ##STR1## wherein the substitutents A, R1, R2, X, Y1, Y2, Y3 and Z are as herein below defined.... | 03/29/1994 |
| 5284962 | Multistage process for making methyl carbamates A continuous process employing at least two reaction stages for manufacturing pesticides from methyl isocyanate and oxime or phenol reactants in water.... | 02/08/1994 |
| 5268491 | Process for the dehalogenation of naphthalene derivatives A process for the selective dehalogenation in position 5 of the naphthalenic nucleus of compounds of formula ##STR1## (wherein X, X1 and R have the meanings reported in the description) by treatment with a dehalogenating agent selected amo... | 12/07/1993 |
| 5268007 | Dioxolanes and thio analogs, derivatives thereof and lubricants and fuels containing same Dioxolanes, thio analogs thereof, and derivatives of these and methods of preparation are described. These materials are useful as additives in lubricants and fuels. Methods for reducing fuel consumption in internal combustion engines employing the lubric... | 12/07/1993 |
| 5229424 | Pesticidal cyclopropyl 2,4-dieneamides The present invention discloses pesticidally active compounds of formula (II) ##STR1## or a salt thereof, wherein Q is a monocylcic aromatic ring, or fused bicyclic ring system of which at least one ring is aromatic containing 9 or 10 atoms of w... | 07/20/1993 |
| 5218124 | Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives as inhibitors of pla2 and lipoxygenase There are disclosed compounds of the formula A(CH2)n O--B wherein A is a group having the formula ##STR1## wherein X is --N-- or ##STR2## Z is ##STR3## R1 is hydrogen, lower alkyl or phenyl; R2 i... | 06/08/1993 |
