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| Number | Title | Issue Date |
| 7294620 | Lipid analogs for inhibiting HIV-1 activity The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7294619 | Lipid analogs for inhibiting the activity of hepatitis B antigen The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7294621 | Lipid analogs for combating tumors The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7273856 | Linear basic compounds having NK-2 antagonist activity and formulations thereof Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of formula (I) ... | 09/25/2007 |
| 7205320 | Phosphodiesterase 4 inhibitors PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 ... | 04/17/2007 |
| 7145003 | Process for synthesizing 1,5 dinosyl-3,3,7,7-tetrakis(difluoramino)octahydro-1,5-diazocine (DNTDFD) A process for synthesizing 1,5-Dinosyl-3,3,7,7-tetrakis(difluoramino) octahydro-1,5-diazocine (DNTDFD) by reacting tetrahydro-1,5-bis(4-nitrobenzenesulfonyl)-1,5-diazocine-3,7-(2H, 6H) dione with HNF2/oleum initially approximately between −5 and 0 degrees C., and ... | 12/05/2006 |
| 7060248 | Matrix metalloproteinase inhibitors Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties; a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targeting moiety i... | 06/13/2006 |
| 7041345 | Chiral compounds III The invention relates to chiral compounds of formula (I) wherein Y1, Y2, Y3, Y4, X1, X2, X3 and X4 have the meaning given in claim 1, to liquid crystalline mixtures comprising at... | 05/09/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 6936627 | Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use The invention describes novel nitrosated and/or nitrosylated H2 receptor antagonist compounds, and novel compositions comprising at least one H2 receptor antagonist compound that is optionally substituted with at least one NO and/or NO2 | 08/30/2005 |
| 6861561 | Substituted aromatic policyclic tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aromatic polycyclic tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and o... | 03/01/2005 |
| 6825231 | Substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and a medicament comprising them The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising them Substituted norbornylamino derivatives having exo-configured nitrogen and an endo-fused... | 11/30/2004 |
| 6649652 | Prodrugs for antimicrobial amidines A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I) ##STR1##... | 11/18/2003 |
| 6562985 | Geminal-dinitro-1-5 diazocine derivatives This invention involves a new class of compounds, certain geminal-dinitro-substituted heterocycles, including geminal-bis(difluoramino)-substituted heterocyclic nitramines and the production thereof. More specifically, this invention involves the pro... | 05/13/2003 |
| 6503940 | Prodrugs for antimicrobial amidines A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I): ##STR1## wherein: X may be O, S, or NR' wherein R' is H or loweralkyl, R1 and R2 may be indepen... | 01/07/2003 |
| 6486200 | Prodrugs for antimicrobial amidines A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I): ##STR1## wherein: X may be O, S, or NR' wherein R' is H or loweralkyl; R1 and R2 may be indepen... | 11/26/2002 |
| 6399628 | N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting alpha- amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 06/04/2002 |
| 6323366 | Arylamine synthesis The present invention provides a method for the preparation of a wide range of primary arylamines. The arylamines are prepared in two efficient, straightforward transformations: 1) an activated aryl group and an imine group are combined, in the presence o... | 11/27/2001 |
| 6166227 | Preparation of (S)-2-amino-6, 6-dimethoxyhexanoic acid methyl ester via novel dioxolanes The glycinamide of the formula (I) ##STR1## is reacted with the dioxolane of the formula (II) ##STR2## wherein L is a leaving group such as iodo, bromo, alkylsulfonyloxy, or arylsulfonyloxy to give the dioxolane of the formula (III) ##STR3#... | 12/26/2000 |
| 6143790 | L-N6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors There is disclosed a novel amino glycol derivatives of L-N6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.... | 11/07/2000 |
| 6090852 | Substituted alpha-aminosulphonyl-acetohydroxamic acids as therapeutic agents Compounds of formula (I): ##STR1## where the substituents are as defined herein, and salts thereof, are matrix metalloprotease inhibitors.... | 07/18/2000 |
| 6084131 | Process for the preparation of protected dihydroxypropyl trialkylammonium salts and derivatives thereof A process for the preparation of protected dihydroxypropyl trialkylammonium salts, particularly in chiral form is described. In particular, a process for the preparation of (2,2-dimethyl-1,3-dioxolan-4-ylmethyl)trialkylammonium salts, particularly in... | 07/04/2000 |
| 6060493 | Phenyl benzyl ethers, process for producing them and their use as pesticide and fungicide A compound of the general formula I ##STR1## where the indices and the substituents have the following meanings: R1 is C(CO2 CH3).dbd.CHOCH3, C(CO2 CH3).dbd.NOCH3, N(OCH | 05/09/2000 |
| 6051711 | Synthesis of swainsonine salts A method for synthesizing swainsonine salts and intermediates thereof comprising subjecting a compound of the formula I ##STR1## wherein R2 and R2' are the same or different and represent alkyl, halogen, alkenyl, alkoxy, cycloa... | 04/18/2000 |
| 6040464 | Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relates to the process ... | 03/21/2000 |
| 5990158 | Carboxylic acid derivatives, method of manufacturing the same and therapeutic agents containing these compounds New therapeutic agents of carboxylic acid derivatives are disclosed, which are represented by the compounds of the following formula (I) or its pharmaceutically acceptable salts, ##STR1## These compounds are useful as a matrix metalloproteinases (MMP... | 11/23/1999 |
| 5981511 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 11/09/1999 |
| 5969154 | Liquid crystalline diketopyrrolopyrroles A liquid crystalline compound of formula ##STR1## wherein B and D are each independently of the other C6 -C24 alkyl, ##STR2## L is ##STR3## methyl or C10 -C18 alkyl, wherein R1 is ... | 10/19/1999 |
| 5961668 | 4-(2,4-diaminophenoxymethyl)-1,3-dioxolane secondary intermediates, processes for their production, and hair colorants Compounds of the formula (I): ##STR1## wherein R1, R2, R3 and R4 independently of one another may represent a hydrogen atom, a (C1-4) alkyl group, a hydroxy (C2-3) alkyl group, an alko... | 10/05/1999 |
| 5962704 | Production of amide derivatives and intermediate compounds therefor A method for producing an amide derivative of the formula XV! ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The p... | 10/05/1999 |
| 5945408 | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 08/31/1999 |
| 5880295 | Process for the preparation of diamine intermediates useful in the synthesis of HIV protease inhibitors The present invention provides a process for the preparation of compounds of formula (V) below, and analogs thereof, which are useful as intermediates for the synthesis of HIV protease inhibitors, including cyclic ureas. ##STR1##... | 03/09/1999 |
| 5846907 | Herbicidally active pyrazol-4-ylbenzoyl compounds Pyrazol-4-ylbenzoyl compounds of the formula I ##STR1## where Z is a 5- or 6-membered heterocyclic saturated or unsaturated radical, Q is a pyrazole ring and L and M are as defined in the specification, their use as herbicidal compounds and to proces... | 12/08/1998 |
| 5846906 | Herbicidally active phenyldiketone compounds Herbicidally active phenyldiketone compounds of the formula I ##STR1## in which the substituents have the following meanings: L and M are hydrogen, C1 -C6 -alkyl, C2 -C6 -alkenyl, C2 -C6 | 12/08/1998 |
| 5744569 | One-component and two-component polyurethane coating compositions In one-component and two-component polyurethane coating compositions comprising at least one reactive component capable of reacting with polyisocyanates, the reactive component is a compound A) containing an isocyanate group, a urethane, thiourethane or u... | 04/28/1998 |
| 5698718 | Energetic azidomethyl-substituted 1,3-dioxolanes Methylazide-substituted 1,3-dioxolanes of the generic formula ##STR1## in which R1, R2, R3, R4, R5 and R6 are independently selected from H, C1 -C6 alkyl and CH2 | 12/16/1997 |
| 5670666 | Process for preparing intermediates for the synthesis of D1 antagonists Disclosed are a process and intermediates of the formulae ##STR1## wherein X- is halide, BF4-, R3 SO3-, wherein R3 is C1 -C6 alkyl, CF3, C1... | 09/23/1997 |
| 5656619 | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for ... | 08/12/1997 |
| 5574000 | Cyclohexenone oxime ethers, their preparation and their use as herbicides Cyclohexenone oxime ethers of the general formula I ##STR1## where R1 is C1 -C6 -alkyl, A is substituted or unsubstituted C4 -alkylene or C4 -alkenylene, X is nitro, cyano, halogen, C1 -C | 11/12/1996 |
| 5563168 | O-Benzyloxime ethers and crop protection agents containing these compounds O-Benzyloxime ethers of the formula I ##STR1## where 5 X is substituted or unsubstituted CH2, NOalkyl Y is O, S, NR5 R1, R2, R5 are H, alkyl Z1, Z2 are H, halogen, methyl, methoxy, cy... | 10/08/1996 |
