Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8088936 | Leukotriene B4 inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 01/03/2012 |
| 7319101 | COMT inhibitors for the treatment of depression and impaired cognition The present invention relates to compounds of formula I wherein R1 is as defined in the specification and to esters thereof which are hydrolyzable under physiological conditions and to the ph... | 01/15/2008 |
| 7232845 | Active substance combinations comprising insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties. ... | 06/19/2007 |
| 7220752 | Compounds active at the glucocorticoid receptor II This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose ... | 05/22/2007 |
| 7091233 | Active substance combinations comprising insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties. ... | 08/15/2006 |
| 7049388 | Process for manufacturing an α-dihydroxy derivative and epoxy resins prepared therefrom A process for manufacturing an α-dihydroxy derivative from an aryl allyl ether wherein such α-dihydroxy derivative can be used to prepare an α-halohydrin intermediate and an epoxy resin prepared therefrom including epoxidizing an α-halohydrin intermediate produc... | 05/23/2006 |
| 7037914 | Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as ... | 05/02/2006 |
| 7019028 | Endiandric acid H and its derivatives, process for their preparation and use thereof The invention relates to compounds of the formula (I) process for their preparation starting from the plant Beilschmiedia fulva, PLA 101037, and the use thereof for producing a medicament, in particular for the t... | 03/28/2006 |
| 6994866 | Combinations of active ingredients, which exhibit insecticidal and acaricidal properties The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in... | 02/07/2006 |
| 6867218 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Act... | 03/15/2005 |
| 6559179 | Fatty acid synthase inhibitors This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.... | 05/06/2003 |
| 6531485 | Prostaglandin agonists This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 03/11/2003 |
| 6498187 | Fatty acid synthase inhibitors This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.... | 12/24/2002 |
| 6448260 | Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 09/10/2002 |
| 6300514 | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient Pharmaceutical composition containing aryl (sulfide, sulfoxide, sulfone) derivatives of the formula (1) and the salts thereof as active ingredient (wherein R1 is H, alkyl; R2 is COOR7, CONHOR8 ; E is --CONR... | 10/09/2001 |
| 6288247 | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this inven... | 09/11/2001 |
| 6271399 | Endothelin receptor antagonists Indane and indene compounds are described which are endothelin receptor antagonists.... | 08/07/2001 |
| 6211197 | Prostaglandin receptor ligands Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula II: Ar1 --W--Ar2 --X--Q II The compounds of the invention are str... | 04/03/2001 |
| 6143907 | 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this inventio... | 11/07/2000 |
| 6107339 | Derivative of ester of carboxylic acid, and insecticide and insect proofing agent containing the same The derivatives of esters of carboxylic acids represented by the general formula I: ##STR1## wherein: R1 is an alkyl group having a chain or branched chain of 1 to 4 carbon atoms; and R2 is a group represented by the following g... | 08/22/2000 |
| 6043241 | Ketoacid endothelin antagonists Compounds of the Formula I ##STR1## are nonpeptide antagonists of endothelin which are useful in treating a variety of diseasses such as elevated levels of endothelin, acute respiratory distress syndrome (ARDS), atherosclerosis, restenosis, Rayn... | 03/28/2000 |
| 5962688 | Stereoselective deoxygenation reaction This invention relates to a key intermediate in the synthesis of an endothelin antagonist, the synthesis of this key intermediate and the synthesis of an endothelin antagonist using this intermediate in a stereoselective deoxygenation reaction.... | 10/05/1999 |
| 5945548 | Process for the synthesis of -substituted acrylic acids and their application Process for the synthesis of -substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##... | 08/31/1999 |
| 5817693 | Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 10/06/1998 |
| 5814657 | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Compounds of the formula ##STR1## wherein the variables are defined as in the specification, are capable of lowering introaocular pressure in the eye of a mammal.... | 09/29/1998 |
| 5786494 | Process for the synthesis of -substituted acrylic acids and their application Process for the synthesis of a-substituted acrylic acids and their application. Process for the synthesis of a-substituted acrylic acids of general formula (I) and their application to the synthesis of N- (mercaptoacyl) aminoacid derivatives of formula (I... | 07/28/1998 |
| 5719182 | Endothelin receptor anatagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 02/17/1998 |
| 5716984 | Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 02/10/1998 |
| 5708186 | Stereoselective process This invention relates to a method for the stereoselective synthesis of a 2-aryloxycarboxylic acid using a chiral auxiliary to enhance the stereoselectivity of the alkylation of the -halo acid with an aryloxy group.... | 01/13/1998 |
| 5686478 | Endothelin antagonists Novel derivatives of the general structural Formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cer... | 11/11/1997 |
| 5686633 | Inks, particularly for ink jet printing Inks, particularly inks for ink jet printing, contain at least one compound of the formula I ##STR1## as a stabilizer. The symbols R1, R2, R3, R4, R3 ' and R4 ' are as defined in claim... | 11/11/1997 |
| 5547983 | Aromatic and polycyclic compounds and their use in human or veterinary medicine and in cosmetics Aromatic bicyclic compounds of formula (I) ##STR1## where R.sub.1 is specifically --H, CH.sub.3, --CH.sub.2 OH, --OH, --CHO, --CONH.sub.2, --COOH, --COOalkyl, --SH, S-alkyl, etc. . . . ; R.sub.2 is H; R.sub.3 is H, aryl, aralkyl or lower alkyl option... | 08/20/1996 |
| 5493032 | Process for the preparation of substituted difluorobenzo-1,3-dioxoles The reaction of 2,2-difluorobenzo-1,3-dioxole with (a) an alkali metal or an alkali metal compound and then (b) a compound R1 -Z1 in which Z1 is a leaving group, or with an aldehyde produces compounds of formula I ##S... | 02/20/1996 |
| 5475132 | Antifungal agents based on amides containing a phenyl group R3, R4 and R5, each represents a hydrogen or halogen atom (at least one of R3, R4 and R5 being other than hydrogen or halogen); optionally substituted amino; optionally halogenated or hydro... | 12/12/1995 |
| 5475024 | Benzodioxole derivatives A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.... | 12/12/1995 |
| 5420273 | Condensed heterocyclic compounds The invention relates to compounds of the formula ##STR1## wherein R1 is hydrogen, acyl, lower-alkyl or --CHO, --CH2 OR10, --COR7 or OR13 ; R2, R3 and R4 are, ind... | 05/30/1995 |
| 5420301 | Process for the preparation of substituted difluorobenzo-1,3-dioxoles The reaction of 2,2-difluorobenzo-1,3-dioxole with (a) an alkali metal or an alkali metal compound and then (b) a compound R1 -Z1 in which Z1 is a leaving group, or with an aldehyde produces compounds of formula I ##S... | 05/30/1995 |
| 5380878 | Benzo[b]thiophen-5-yl derivative and process for producing the same This invention relates to a process for producing a compound represented by formula (6a) or (6b): ##STR1## wherein R2 represents a hydrogen atom or a hydroxyl-protecting group and R4 and R5, which may be the same or d... | 01/10/1995 |
| 5369127 | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Compounds of the formula ##STR1## where W is (CH2)n where n is 1 or 2, or n is O and W represents lower alkyl groups attached to each oxygen; m is an integer between 1 and 8; R1 is COOH or a pharmaceutically acceptable sal... | 11/29/1994 |
| 5320833 | Arylpolyenecarboxylic acids and their derivatives as sunscreen agents in cosmetic preparations Arylpolyenecarboxylic acids and their derivatives of the formula I ##STR1## where Ar is phenyl, biphenylyl or naphthyl, each of which can be substituted by one to three C1 -C4 -alkyl, C1 -C4 -alkoxy, hydrox... | 06/14/1994 |
