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| Number | Title | Issue Date |
| 7893282 | 7-substituted fused ring tetracycline compounds 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described. ... | 02/22/2011 |
| 7217802 | Method and kit for detecting, or determining, 3,4-methylenedioxymethamphetamine The invention provides a hapten, an immunogen comprising the hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable... | 05/15/2007 |
| 7169907 | Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, re... | 01/30/2007 |
| 7101912 | Carbidopa prodrugs and derivatives, and compositions and uses thereof Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed... | 09/05/2006 |
| 7078431 | 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are ... | 07/18/2006 |
| 7037669 | Assays for amphetamine and methamphetamine using stereospecific reagents Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of Formula I may be employed to prepare antibodies for an amphetamine and/... | 05/02/2006 |
| 7022492 | Ecstasy haptens and immunogens Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a methylenedioxymethamphetamine. Immunogenic conjugates of Formula I ar... | 04/04/2006 |
| 7019028 | Endiandric acid H and its derivatives, process for their preparation and use thereof The invention relates to compounds of the formula (I) process for their preparation starting from the plant Beilschmiedia fulva, PLA 101037, and the use thereof for producing a medicament, in particular for the t... | 03/28/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6991911 | Assay for entactogens Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-ethylamphetamine (MDEA)... | 01/31/2006 |
| 6743566 | Cyclic acetal compound, polymer, resist composition and patterning process Cyclic acetal compounds of formula (1) wherein k=0 or 1 and n is an integer of 0 to 6 are novel. Using the cyclic acetal compounds as a monomer, polymers are obtained. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation ... | 06/01/2004 |
| 6677456 | Pentacyclic taxan compound This invention is to provide a novel taxol derivative useful as an antitumor compound having respective substituent groups, represented by the following formula (I) which can be orally administered ##STR1##... | 01/13/2004 |
| 6642270 | 7-substituted fused ring tetracycline compounds 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.... | 11/04/2003 |
| 6579987 | Diaryl-enynes Provided, among other things, is a compound of Formula I: ##STR1## wherein: Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of a... | 06/17/2003 |
| 6559179 | Fatty acid synthase inhibitors This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.... | 05/06/2003 |
| 6482962 | Pesticidal and parasiticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds The present invention relates to the pesticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds having the structural formula I ##STR1##... | 11/19/2002 |
| 6448260 | Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 09/10/2002 |
| 6426364 | Diaryl-enynes Provided, among other things, is a compound of Formula I: ##STR1## wherein: Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of a... | 07/30/2002 |
| 6329536 | Stereoselective process for producing nitro compounds The present invention relates to producing stereoselective nitro compounds by reacting a dicarbonyl compound with a nitrostyrene compound in the presence of a catalyst complex and a base.... | 12/11/2001 |
| 6271399 | Endothelin receptor antagonists Indane and indene compounds are described which are endothelin receptor antagonists.... | 08/07/2001 |
| 6242637 | Substituted heterocylic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH2 | 06/05/2001 |
| 6197770 | Alkenyl- and alkynl-containing metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): #... | 03/06/2001 |
| 5998667 | Substituted biphenyl oxazolines The invention relates to new substituted biphenyloxazolines of the formula (I) ##STR1## in which R1 represents C1 -C6 -halogenoalkylthio and R2 represents hydrogen, or R1 and R2 together wi... | 12/07/1999 |
| 5945548 | Process for the synthesis of -substituted acrylic acids and their application Process for the synthesis of -substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##... | 08/31/1999 |
| 5919954 | Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to ... | 07/06/1999 |
| 5817693 | Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 10/06/1998 |
| 5801250 | Process for the stereoselective production of nitro-enamine compounds The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.... | 09/01/1998 |
| 5686478 | Endothelin antagonists Novel derivatives of the general structural Formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cer... | 11/11/1997 |
| 5658943 | Phenylalanine derivatives as endothelin antagonists Novel antagonists of endothelin are described, as well as novel intermediates used in their preparation, methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, essential, renova... | 08/19/1997 |
| 5506270 | Venlafaxine in the treatment of hypothalamic amenorrhea in non-depressed women This invention provides a method for treating hypothalamic amenorrhea in a non-depressed female mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine compound of the following structural formula: ##STR1## ... | 04/09/1996 |
| 5420273 | Condensed heterocyclic compounds The invention relates to compounds of the formula ##STR1## wherein R1 is hydrogen, acyl, lower-alkyl or --CHO, --CH2 OR10, --COR7 or OR13 ; R2, R3 and R4 are, ind... | 05/30/1995 |
| 5270301 | Fluoro-amide derivatives The present invention relates to certain fluoro-amide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic a... | 12/14/1993 |
| 5194628 | Process for the preparation of substituted difluorobenzo-1,3-dioxoles The reaction of 2,2-difluorobenzo-1,3-dioxole with (a) an alkali metal or an alkali metal compound and then (b) a compound R1 -Z1 l in which Z1 is a leaving group, or with an aldehyde produces compounds of formula I #... | 03/16/1993 |
| 5120759 | Tetrahydronaphthalene derivatives for improving short-term memory Novel compounds of the formula ##STR1## wherein R1 is lower-alkyl, lower-alkoxy-lower-alkyl, lower-alkylthio-lower-alkyl or furyl, R2 is lower-alkyl, phenyl-lower-alkyl or cyclohexyl-lower-alkyl, each of R3 and R... | 06/09/1992 |
| 5061727 | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.... | 10/29/1991 |
| 4971981 | Substituted dioxolan and dioxan derivatives useful as pesticides Novel substituted 1,3-dioxolan and 1,4-dioxan derivatives of formula I ##STR1## in which R1, R2, R3, R4, R5 and R6 each independently of the others represents hydrogen or C1 -C | 11/20/1990 |
| 4943591 | Dichloroaniline derivatives The invention provides compounds of the general formula (I) ##STR1## wherein X represents a C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene chain and Y represents a bond, or a C1-4 alkylene, C2-4 al... | 07/24/1990 |
| 4929741 | Propiolophenone derivatives Propiolophenone derivatives of the formula ##STR1## wherein R6 is hydrogen, lower alkyl or a group of the formula ##STR2## as well as corresponding hydroxy compounds of the formula ##STR3## wherein R6' is hydrogen, lo... | 05/29/1990 |
| 4734121 | Cyclohexane-1,3-dione derivatives and their use for controlling undesirable plant growth Cyclohexane-1,3-dione derivatives of the formula ##STR1## where R1, R2, R3 and R4 have the meanings stated in the description, are used for controlling undesirable plant growth.... | 03/29/1988 |
| 4730008 | Aminophenol derivatives The invention provides compounds of the general formula (I) ##STR1## wherein Ar, R1, R2, X, Y and Q are defined in the specification and physiologically acceptable salts and solvates thereof. The compounds have a selective stimulant ... | 03/08/1988 |
