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| Number | Title | Issue Date |
| 7339078 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 03/04/2008 |
| 7256204 | Amine compounds, their production and use A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2... | 08/14/2007 |
| 7202261 | Calcilytic compounds The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect i... | 04/10/2007 |
| 7169907 | Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, re... | 01/30/2007 |
| 7161033 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 01/09/2007 |
| 7157589 | One step process for the preparation of anticonvulsant derivatives The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R | 01/02/2007 |
| 7157454 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the B1 receptors; they may be used for the preparation of medicinal pr... | 01/02/2007 |
| 7037669 | Assays for amphetamine and methamphetamine using stereospecific reagents Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of Formula I may be employed to prepare antibodies for an amphetamine and/... | 05/02/2006 |
| 7022492 | Ecstasy haptens and immunogens Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a methylenedioxymethamphetamine. Immunogenic conjugates of Formula I ar... | 04/04/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6991911 | Assay for entactogens Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-ethylamphetamine (MDEA)... | 01/31/2006 |
| 6864282 | 9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma 9,11-Cycloendoperoxide derivatives of biologically active prostaglandin analogs, and particularly of the ocular hypotensive drugs Bimatoprost, Latanaprost, Unoprostone, Travoprost and prostaglandin H2 1-ethanolamide or of structurally closely related anal... | 03/08/2005 |
| 6861539 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 03/01/2005 |
| 6818660 | Calcilytic compounds The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect i... | 11/16/2004 |
| 6753429 | 1,4-disubstituted benzenes as insecticides Compounds of formula I: wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amo... | 06/22/2004 |
| 6683210 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, ... | 01/27/2004 |
| 6642270 | 7-substituted fused ring tetracycline compounds 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.... | 11/04/2003 |
| 6482962 | Pesticidal and parasiticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds The present invention relates to the pesticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds having the structural formula I ##STR1##... | 11/19/2002 |
| 6436914 | 2-hydroxy-3--(4-hydroxy-3-sulfonamidophenyl)--propylamines useful as beta 3 adrenergic agonists Compounds are provided having the formula ##STR1## including pharmaceutically acceptable salts thereof, wherein R1 is lower alkyl, aryl or arylalkyl; A is hydrogen or ##STR2## B is hydrogen, alkyl, alkenyl, or ##STR3## but when A is hydrogen, B... | 08/20/2002 |
| 6316496 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, ... | 11/13/2001 |
| 6310080 | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, rela... | 10/30/2001 |
| 6288071 | 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.... | 09/11/2001 |
| 6242637 | Substituted heterocylic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH2 | 06/05/2001 |
| 6143788 | Bis-amino acid hydroxyethlamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, ... | 11/07/2000 |
| 5998667 | Substituted biphenyl oxazolines The invention relates to new substituted biphenyloxazolines of the formula (I) ##STR1## in which R1 represents C1 -C6 -halogenoalkylthio and R2 represents hydrogen, or R1 and R2 together wi... | 12/07/1999 |
| 5962737 | 2-amino-1-phenylpropanols, stereospecific synthesis thereof, and method of optically resolving the same Stereospecific synthesis of the racemic threo isomers of 2-nitro-1-phenylpropanols by reacting a benzaldehyde derivative with nitroalkane in the presence of a tertiary amine and reducing 2-nitro-1-phenylpropanols with, for example, lithium aluminum hydrid... | 10/05/1999 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5919954 | Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to ... | 07/06/1999 |
| 5776983 | Catecholamine surrogates useful as ଲ3 agonists Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH2)n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R9)R9' or --CO2... | 07/07/1998 |
| 5739166 | Substituted terphenyl compounds for the treatment of inflammation A class of terphenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein each of R2 and R3 is independently sel... | 04/14/1998 |
| 5665878 | Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to ... | 09/09/1997 |
| 5658904 | 1,2-ethanediol derivative and salt thereof and cerebral function-improving agent comprising the same This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebro... | 08/19/1997 |
| 5506270 | Venlafaxine in the treatment of hypothalamic amenorrhea in non-depressed women This invention provides a method for treating hypothalamic amenorrhea in a non-depressed female mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine compound of the following structural formula: ##STR1## ... | 04/09/1996 |
| 5482971 | Beta3 -adrenergic agents and their use in pharmaceutical compositions This invention is concerned with novel compounds of formula I: ##STR1## which are selective beta3 -adrenergic agents.... | 01/09/1996 |
| 5420273 | Condensed heterocyclic compounds The invention relates to compounds of the formula ##STR1## wherein R1 is hydrogen, acyl, lower-alkyl or --CHO, --CH2 OR10, --COR7 or OR13 ; R2, R3 and R4 are, ind... | 05/30/1995 |
| 5387700 | Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-O-(1-methylethylidene)-ଲ-D-fructopyranose and (1-methylcyclohexyl)methanol A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)-ଲ-D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step procedure involving in the first step reacting of an a... | 02/07/1995 |
| 5371247 | Preparation of substituted ethenes A potassium salt useful in the production of certain N-substituted alkyl or arylalkyl thionitroethenamines is produced by the reaction of the dipotassium salt of a 2-nitrodithio aliphatic acid such as 2-nitrodithio acetic acid with branched chain primary ... | 12/06/1994 |
| 5329023 | Method of preparing optically active alcohols which consist substantially or entirely of one enantiomer The invention relates to a method of preparing optically active alcohols which consist substantially (at least 75% e.e.) or entirely of one enantiomer of formula 4 ##STR1## wherein R and A are as defined therein. The method comprises, which main... | 07/12/1994 |
| 5294638 | Phenyalkylaminoalkyl compounds and pharmaceutical compositions containing them Pharmacologically active compounds corresponding to the general formula I: ##STR1## wherein m represents 1-4, n represents 2-5, R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and... | 03/15/1994 |
| 5272144 | Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene derivatives of amines and pharmaceutical use Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula ##STR1## wherein each of A and B is a group of formula (i) to (iii): ##STR2## wherein Y is --O--, --S-- or --NR-- in which R is hydrogen or C1 -C6 alkyl;... | 12/21/1993 |
