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| Number | Title | Issue Date |
| 7423154 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention includes an asymmetric addition of organometallic compounds to chiral su... | 09/09/2008 |
| 7291621 | Substituted biaryl amides C5a receptor modulators Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5... | 11/06/2007 |
| 7141674 | Anti-inflammatory compounds This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure: ... | 11/28/2006 |
| 7122561 | Treatment of skin conditions The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or derivatives the... | 10/17/2006 |
| 7119049 | Oxathiinecarboxamides This invention relates to novel oxathiinecarboxamides of the formula (I) in which R, R1 and m are as defined in the disclosure, to a plurality of processes for preparing these ... | 10/10/2006 |
| 7087607 | Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: addition products thereof with acids, and methods for preparing the salts and addition products. Also disclosed are pharmaceut... | 08/08/2006 |
| 7078565 | Benzamide derivatives as antagonists of orexin receptors Disclosed are phenyl-alkylene benzamides useful as orexin antagonists ... | 07/18/2006 |
| 7067551 | Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties. ... | 06/27/2006 |
| 7026339 | Inhibitors of HCV NS5B polymerase The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions contai... | 04/11/2006 |
| 7022627 | Method for the heat treatment of substrates A substrate undergoes a semiconductor fabrication process at different temperatures in a reactor without changing the temperature of the reactor. The substrate is held suspended by flowing gas between two heated surfaces of the reactor. Moving the two heated surface... | 04/04/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 7019028 | Endiandric acid H and its derivatives, process for their preparation and use thereof The invention relates to compounds of the formula (I) process for their preparation starting from the plant Beilschmiedia fulva, PLA 101037, and the use thereof for producing a medicament, in particular for the t... | 03/28/2006 |
| 6878706 | Cyanamides useful as reversible inhibitors of cysteine proteases Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B... | 04/12/2005 |
| 6858648 | Laetispicine and laetispicine analogues, methods of use and preparation A compound having the following Formula: wherein R1, R2, Z, and Y are defined herein, and methods of preparation and application for treating mental disorders and inflammation are provided therewith. ... | 02/22/2005 |
| 6849649 | N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alk... | 02/01/2005 |
| 6767921 | Polymorphic forms of fasidotril, their methods of preparation and pharmaceutical compositions comprising them The subject of the present invention is the various polymorphic forms I, II, III, IV of benzyl (S,S)-2-(2-acetylsulphanylmethyl-3-benzo[1,3]dioxol-5-ylpropionyl-amino)propionate, hereinafter called Fasidotril, their methods of preparation and novel pharmaceutical co... | 07/27/2004 |
| 6762318 | Glucagon antagonists Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists. ... | 07/13/2004 |
| 6730705 | Alkoximino acetic acid amides The invention relates to new alkoximinoacetic acid amides, a process for their preparation and their use as agents for combating pests. ... | 05/04/2004 |
| 6680391 | Treatment of skin conditions The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or deri... | 01/20/2004 |
| 6677456 | Pentacyclic taxan compound This invention is to provide a novel taxol derivative useful as an antitumor compound having respective substituent groups, represented by the following formula (I) which can be orally administered ##STR1##... | 01/13/2004 |
| 6660756 | N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6 alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C... | 12/09/2003 |
| 6638970 | Substituted alkylene diamine compounds Novel compounds of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subse... | 10/28/2003 |
| 6603044 | Phthalamide derivatives, or salt thereof agrohorticultural insecticide, and method for using the same The present invention provides a phthalamide derivative of the formula (I): ##STR1## wherein A1 is (substituted) C1 -C8 alkylene, (substituted) C3 -C8 alkenylene, (substituted) C3 -C8... | 08/05/2003 |
| 6515124 | Dehydroamino acids Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasi... | 02/04/2003 |
| 6509379 | Phenylacetic acid derivatives, process and intermediate products for their preparation, and their use as fungicides and pesticides Phenylacetic acid derivatives of the formula I ##STR1## where the variables are as disclosed herein, their salts, processes and intermediates for their preparation, and their use for controlling harmful fungi and animal pests.... | 01/21/2003 |
| 6509369 | Anti-inflammatory compounds This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure: ##STR1##... | 01/21/2003 |
| 6472414 | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters... | 10/29/2002 |
| 6458801 | Benzofurane derivatives, preparation method, use as medicines and pharmaceutical compositions containing same A compound of the formula ##STR1## wherein the substituents are as defined in the specification and its pharmaceutically acceptable salts and its prodrug useful for treating osteoporosis.... | 10/01/2002 |
| 6376538 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 04/23/2002 |
| 6372779 | Anti-inflammatory compounds This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure: ##STR1##... | 04/16/2002 |
| 6344570 | Substituted urea derivatives as cell adhesion inhibitors Compounds of formula (II) ##STR1## where R1 is in the para or meta position and is (A); R2 and R3 are each independently selected from hydrogen, nitro, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alk... | 02/05/2002 |
| 6340704 | Cell differentiation inducing amide derivatives, their production and use The present invention provides a compound represented by the formula: ##STR1## wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which m... | 01/22/2002 |
| 6323227 | Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides This invention relates to compounds of formula ##STR1## which inhibit Factor Xa, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of patients suffering from conditions which can be ameliorated by t... | 11/27/2001 |
| 6306873 | Substituted ଲ-thiocarboxylic acids This invention relates to compounds of general formula (I): ##STR1## in which Ar is a group selected from: ##STR2## A1, A2, B, C, D, E, Q1-Q3, R1-R9, Z1 and Z2 are as defined in the disclosure, and Y represents carboxy or an acid bioisostere. These c... | 10/23/2001 |
| 6303799 | Polynucleotide crosslinking agents Novel aryl derivatives comprising an aryl olefin moiety linked to a non-nucleosidic backbone moiety are disclosed. The resulting molecules are typically used as photoactivated crosslinking groups when incorporated into oligonucleotides to crosslink nuclei... | 10/16/2001 |
| 6271399 | Endothelin receptor antagonists Indane and indene compounds are described which are endothelin receptor antagonists.... | 08/07/2001 |
| 6214870 | Dioxocyclopentyl hydroxamic acids The present invention relates to dioxocyclopentyl hydroxamide derivatives of the formula ##STR1## wherein X, Z and Q are as defined in the specification, and to pharmaceutical compositions and methods of treatment thereof.... | 04/10/2001 |
| 6214869 | Heterocyclic cis cyclopropane derivatives as melatonergic agents There is provided a novel series of cis cyclopropane compounds of Formula I ##STR1## wherein R1, R2, R3, R4, X, Y, Z and m are as defined herein which bind to the human melatonin receptor and therefore are useful ... | 04/10/2001 |
| 6214859 | Ethylamine derivatives Ethylamine derivatives of the formula (I): ##STR1## (wherein R1 is hydrogen, hydroxyl, lower alkoxy or halogen; R2 is alkyl having 2 to 5 carbon atoms; R3 is hydrogen, alkyl having 2 to 5 carbon atoms, alkylcarbonyl having... | 04/10/2001 |
| 6211240 | O-benzyl oxime ether derivatives and their use as pesticides Compounds of the formula I ##STR1## in which Y is hydrogen, C1 -C4 alkyl, C1 -C4 alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, Z is a group a) ##STR2## R1 ... | 04/03/2001 |
