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| Number | Title | Issue Date |
| 7261995 | Nitrogen-containing organic compound, chemically amplified resist composition and patterning process Chemically amplified resist compositions comprising nitrogen-containing organic compounds having a 7-oxanorbornane-2-carboxylic ester structure have resolution and provide a precise pattern profile and are useful in microfabrication using electron beams or deep-UV l... | 08/28/2007 |
| 7179839 | Acylated indanyl amines and their use as pharmaceuticals The present invention relates to acylated indanyl amines according to the general formula (I) wherein R1–R4 have the meanings given in the description, A is CH | 02/20/2007 |
| 7144885 | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders ... | 12/05/2006 |
| 7122575 | Acylated indanyl amines and their use as pharmaceuticals The present invention relates to acylated indanyl amines according to the general formula (I) wherein R1–R4 have the meanings given in the description, A is CH | 10/17/2006 |
| 7101912 | Carbidopa prodrugs and derivatives, and compositions and uses thereof Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed... | 09/05/2006 |
| 7060847 | Ecstasy-class derivatives, immunogens, and antibodies and their use in detecting ecstasy-class drugs The present invention comprises novel analogs of ecstasy-class compounds and novel ecstasy-class immunogens leashed out of, i.e., derived from, the methylenedioxy position. The invention also comprises unique monoclonal antibodies generated using MDO-leashed MDMA im... | 06/13/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6998407 | Antagonists of MCP-1 function and methods of use thereof Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these compounds. The... | 02/14/2006 |
| 6939986 | Process for preparing 1,2-diamino compounds The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides. ... | 09/06/2005 |
| 6806365 | N-alkanoylphenylalamine derivatives Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related t... | 10/19/2004 |
| 6784292 | Method for the production of imidazo-(1,2-C)(2,3)-benzodiazepines and intermediates in the production thereof The invention relates to a method for the preparation of compound of formula (1). The invention further relates to the previously unknown compounds of formulas (5 and 6) as intermediates in the production of benzodiazepines of formula (1). ... | 08/31/2004 |
| 6686482 | Process for preparing piperonal The present invention is to provide a process for producing piperonal which comprises continuous three steps of: (A) an addition reaction step wherein 1,2-methylenedioxybenzene and glyoxylic acid are reacted to form 3,4-methylenedioxymandelic acid in the ... | 02/03/2004 |
| 6495725 | Process for the preparation of optically active enones and intermediates thereof The present invention provides a simplified and convenient process for the preparation of an optically active enone such as 7,7-dimethyl-6,8-dioxabicyclo-[3,3,0]oct-3-en-2-one. The invention further provides novel optically active intermediate compounds. ... | 12/17/2002 |
| 6448260 | Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 09/10/2002 |
| 6437171 | Process for preparing 1,2-diamino compounds The invention provides a multistep process for preparing 1,2-diamino compounds of formula ##STR1## wherein R1, R1', R2, R2', R3 and R4 have the meaning given in the specification and pharma... | 08/20/2002 |
| 6333337 | Potassium channel inhibitors Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.... | 12/25/2001 |
| 6310080 | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, rela... | 10/30/2001 |
| 6271399 | Endothelin receptor antagonists Indane and indene compounds are described which are endothelin receptor antagonists.... | 08/07/2001 |
| 6258603 | Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex This invention relates to an improved method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct co... | 07/10/2001 |
| 6214870 | Dioxocyclopentyl hydroxamic acids The present invention relates to dioxocyclopentyl hydroxamide derivatives of the formula ##STR1## wherein X, Z and Q are as defined in the specification, and to pharmaceutical compositions and methods of treatment thereof.... | 04/10/2001 |
| 6204398 | Preparation of cyclohexene carboxylate derivatives The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediat... | 03/20/2001 |
| 6143787 | Pharmaceutical composition containing 4-oxo-butynic acids The present invention relates to a pharmaceutical composition comprising, as active principle, a compound of formula: ##STR1## in which the groups A and B are chosen, independently of each other, from: a mono-, bi- or tricyclic aryl group having from... | 11/07/2000 |
| 6117870 | Cyclic amide derivatives A cyclic amide derivative of formula (I): ##STR1## wherein R1 represents a substituted alkyl group, a substituted alkenyl group, a substituted amino group, a substituted alkoxyl group, a substituted alkylthio group, a substituted carbamoyl... | 09/12/2000 |
| 6057459 | Preparation of carbocyclic compounds The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the syn... | 05/02/2000 |
| 5977289 | Colorless organic-soluble aromatic poly(ether-imide)s, the organic solutions and preparation thereof The present invention provides a series of easily processable poly(ether-imide)s that are organic-soluble and can afford colorless films, their organic solutions and their manufacturing process. The poly(ether-imide) is prepared from a dianhydride and a d... | 11/02/1999 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5914339 | Substituted 1,3-benzodioxoles The present invention provides new compounds having anti-diabetic and/or antihyperglycemia and/or anti-obesity activity, as well as pharmaceutical compositions and methods of treatment utilizing the compounds and processes for making the compounds, the co... | 06/22/1999 |
| 5859284 | Preparation of carbocyclic compounds The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the syn... | 01/12/1999 |
| 5847148 | Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation The present invention provides novel thiadiazole derivatives represented by formula I: ##STR1## or pharmaceutical acceptable salts thereof wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase f... | 12/08/1998 |
| 5817693 | Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 10/06/1998 |
| 5817878 | Process for the acylation of aromatic ethers The present invention concerns a process for the acylation of an aromatic ether. Preferably, the invention relates to a process for the acylation of an unsubstituted aromatic ether, in particular anisole. The acylation process of the invention consists of reac... | 10/06/1998 |
| 5777138 | Ring-opening amidation process A process for amidating a 2-azabicyclo2.2.1!heptan-3-one or a 2-azabicyclo2.2.1!hept-5-en-3-one by reaction with an amine, to form the corresponding ring-opened amide, is modified by the addition of an additive that accelerates the rate of reaction to... | 07/07/1998 |
| 5739332 | Cycloalkanediols and their use in preparing chiral compounds A process for the product of a 2,3-cis-dihydroxycycloalkane-1-carboxamide, comprises dihydroxylation of the corresponding cycloalkene-1-carboxamide. Some products are new. The stereoselective dihydroxylation is surprising.... | 04/14/1998 |
| 5726165 | Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, or solvate thereof, wherein, Ro represents an aryl group, optionally substituted; X represents O or S; R1 and R1a each independently represents hydrogen... | 03/10/1998 |
| 5696301 | Process for preparing protocatechualdehyde Protocatechualdehyde is prepared by the steps of reacting piperonyl dichloride with molecular chlorine in the presence of phosphorus trichloride, phosphorus pentachloride or sulfuryl chloride to prepare dichloropiperonylidene dichloride and hydrolyzing th... | 12/09/1997 |
| 5637737 | Process for the preparation of 2,2-difluorobenzo[1.3]dioxolecarbaldehydes 2,2-Difluorobenzo[1.3]dioxole-carbaldehydes are prepared in a particularly advantageous manner if methylbenzo[1.3]dioxoles are chlorinated, the resulting dichloromethyl-2,2-dichlorobenzo[1.3]dioxole is fluorinated with hydrogen fluoride and the dichlorome... | 06/10/1997 |
| 5559235 | Water soluble camptothecin derivatives The present invention relates to water soluble, camptothecin derivatives of formula (I), ##STR1## wherein: 1) R1 and R2 represent independently, hydrogen, lower alkyl, C3-7)cycloalkyl, C3-7)cycloalkyl lower... | 09/24/1996 |
| 5554772 | N-(3-hydroxy-4-piperidinyl) dihydrobenzofuran, (dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal motility stimulating properties, compositions containing ... | 09/10/1996 |
| 5530028 | Insecticidal N'-substituted-N,N'-diacylhydrazines Insecticidal compounds having the formula N-(2-Ra -3-Rb -4-Rh -benzoyl)-N'-(2-Rc -3-Rd -4-Re -5-Rf -benzoyl)-N'-Rg -hydrazine wherein Ra is a halo or lower alkyl... | 06/25/1996 |
| 5508461 | Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same An (S)-1-phenyl-2-substituted propane derivative shown by the following formula (I) ##STR1## wherein R1 and R2 represent a lower alkyl group, etc., or R1 and R2 may form together an alkylene group, etc.; R | 04/16/1996 |
