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| Number | Title | Issue Date |
| 7348358 | Use of cyclolignans The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9′ have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, suc... | 03/25/2008 |
| 7192982 | Modulators of peroxisome proliferator activated receptors Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or uns... | 03/20/2007 |
| 7157589 | One step process for the preparation of anticonvulsant derivatives The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R | 01/02/2007 |
| 7144885 | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders ... | 12/05/2006 |
| 7019150 | 1-deoxy taxol analogs 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof. ... | 03/28/2006 |
| 6949574 | (Oxime)carbamoyl fatty acid amide hydrolase inhibitors The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical compositions are useful for the treatment of conditions which can be effected... | 09/27/2005 |
| 6762326 | C2-substituted idan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals Embodiments of the invention relate to C2-substituted indan-1-ones and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention include compounds of formula I | 07/13/2004 |
| 6605632 | Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them The invention concerns compounds of formula (I): R--A--R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the desc... | 08/12/2003 |
| 6566393 | Etoposide analogs and methods of use thereof Etoposide analogs such as 4'-O-demethyl-4ଲ-[4"-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy -podophyllotoxin (12) and 4'-O-demethyl-4ଲ-[4"-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-deso xypodophyllotoxin (13) are described, along with... | 05/20/2003 |
| 6489489 | Organic electroluminescent device Disclosed is a practical, organic, blue-emitting EL device having a long life and having high luminous efficiency and good thermal stability. The device comprises organic compound layers, of which at least one is an organic blue-emitting layer, as sandwic... | 12/03/2002 |
| 6340704 | Cell differentiation inducing amide derivatives, their production and use The present invention provides a compound represented by the formula: ##STR1## wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which m... | 01/22/2002 |
| 6306899 | Inhibition and treatment of Hepatitis B virus and Flavivirus by Helioxanthin and its analogs This invention relates to anti-viral drugs such as Helioxanthin and its analogs. The present compounds may be used alone or in combination with other drugs for the treatment of Hepatitis B virus (HBV), Hepatitis C virus (HCV), Yellow Fever, Dengue Virus, ... | 10/23/2001 |
| 6268520 | Tricyclic compounds Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.... | 07/31/2001 |
| 6034120 | Insect antifeedant for agriculture The present invention provides an antifeedant and a contact insecticide using the components contained in Cyperaceae species. In particular, the present invention provides an insect antifeedant and a contact insecticide comprising as an active ingredient ... | 03/07/2000 |
| 6020506 | Synthesis of D-3 phosphorylated phosphoinositides and analogues Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated ... | 02/01/2000 |
| 6011059 | Acyl guanidine sodium/proton exchange inhibitors and method Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR1## wherein n is 1 to 5; X is N or C--R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; an... | 01/04/2000 |
| 5986114 | Benzopyranol derivatives The invention relates to benzopyranol derivatives which are intermediates in a process for stereoselectively forming N-substituted dihydro-2,3 benzodiazopines which are useful as AMPA receptor antagonists. The process includes an opening reduction step wh... | 11/16/1999 |
| 5922771 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a... | 07/13/1999 |
| 5919455 | Non-antigenic branched polymer conjugates Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologicall... | 07/06/1999 |
| 5834507 | Antineoplastic cyclolignan derivatives Antineoplastic cyclolignan derivatives are of formula (I): ##STR1## in which Ar is a 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; X is an oxygen, sulphur or nitrogen atom, a methine group .dbd.CH-- or an alkylmethine group .dbd.C(alkyl)--; ... | 11/10/1998 |
| 5801123 | Epoxycyclohexane derivative and plant growth regulator The present invention relates to a plant growth regulator comprising as an active ingredient an epoxycyclohexane derivative represented by general formula (1): ##STR1## wherein R1 is a hydrogen atom, a C1 -C6, alkyl g... | 09/01/1998 |
| 5756774 | Synthesis of myo-inositol phosphates Provided herein are novel syntheses of the phosphate-based inositol derivatives 1-O-(+)-menthoxycarbonyl!-6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inos itol (D4P), D-myo-inositol 1,4,5-trisphosphate (D-IP3), 6-O-benzyl-2,3:4,5-di-O-isop... | 05/26/1998 |
| 5747529 | Antineoplastic cyclolignan derivatives Antineoplastic cyclolignan derivatives are of formula (I): ##STR1## in which Ar is a 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; X is an oxygen, sulphur or nitrogen atom, a methine group .dbd.CH-- or an alkylmethine group .dbd.C(alkyl)--; ... | 05/05/1998 |
| 5719182 | Endothelin receptor anatagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 02/17/1998 |
| 5708018 | 2-aminoindans as selective dopamine D3 ligands Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of Formula I: ##STR1## wherein R1 and R2 are independently chosen fro... | 01/13/1998 |
| 5700448 | Use of persistent free-radicals in magnetic resonance imaging The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based π-bonded electronic system available for delocalization of the unpaired electrons as image enhancing agents in magnetic res... | 12/23/1997 |
| 5681567 | Method of preparing polyalkylene oxide carboxylic acids The present invention is directed to methods of preparing high purity polyalkylene oxide carboxylic acids. The methods include reacting a polyalkylene oxide such as polyethylene glycol with a t-butyl haloacetate in the presence of a base followed by treat... | 10/28/1997 |
| 5648376 | Immunosuppressant diterpene compound An immunosuppressant compound is produced having the structure: ##STR1## or a mirror image thereof, wherein X1 is 2,2-dimethylvinyl and X2 and X3 together are .dbd.CH2 ; or X1 is 2,2-dimethyloxir... | 07/15/1997 |
| 5637738 | Processes for preparing 1,2-epoxy-1,2,3,4-tetrahydronaphthalenes Described herein is a process for the preparation of (1S,2R)-1,2-epoxy-1,2,3,4-tetrahydronaphthalene having the Formula (I): ##STR1## which comprises the steps of (a) hydrogenating the compound of Formula (II) to form cis-(1R, 2S)-1,2-dihydroxy-1,2,3... | 06/10/1997 |
| 5602263 | Syntheses of D-chiro-3-inosose and (+)-D-chiro inositol There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permag... | 02/11/1997 |
| 5599522 | Triarylmethyl radicals and the use of inert carbon free radicals in MRI A radical compound of formula Ia .C(Ar12)3 (Ia) wherein: each Ar12, which may be the same or different, represents a 6-membered carbocyclic, at least one group Ar12 being a group Ar | 02/04/1997 |
| 5578738 | Syntheses of D-chiro-3-inosose and (+)-D-chiro inositol There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permag... | 11/26/1996 |
| 5563281 | Syntheses of D-chiro-3-inosose and (+)-D-chiro inositol There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permag... | 10/08/1996 |
| 5530140 | Free radicals The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula ##STR1## (wherein each X which may be the same or different is an oxygen or sulphur ... | 06/25/1996 |
| 5510376 | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents The invention is antiobesity/antidiabetic/beta-3 agonists of the formula ##STR1## wherein the substituents Ro, R1, R4, R4 ', R5, R6 or n are as defined in the specification.... | 04/23/1996 |
| 5498629 | Anticonvulsant pseudofructopyranose sulfamates A compound of the general formula I: ##STR1## is disclosed as a potent anticonvulsant drug. Pharmaceutical compositions and methods of treatment are also disclosed.... | 03/12/1996 |
| 5488167 | Synthesis of sphingosines Provided by the present invention is a process for the biocatalytic synthesis of optically pure sphingosines from achiral starting material. The stereoisomers of sphingosine are prepared from chiral arene diols using stereospecific reaction techniques to ... | 01/30/1996 |
| 5488166 | Synthesis of sphingosines Provided by the present invention is a process for the biocatalytic synthesis of optically pure sphingosines from achiral starting material. The stereoisomers of sphingosine are prepared from chiral arene diols using stereospecific reaction techniques to ... | 01/30/1996 |
| 5387700 | Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-O-(1-methylethylidene)-ଲ-D-fructopyranose and (1-methylcyclohexyl)methanol A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)-ଲ-D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step procedure involving in the first step reacting of an a... | 02/07/1995 |
| 5382596 | Substituted 2-aminotetralins Optically active or racemic compounds represented by the formula ##STR1## where R2 is OA and R3 is selected from the group consisting of H and OA; where A is H or is selected from the group consisting of hydrocarbyl radicals com... | 01/17/1995 |
