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| Number | Title | Issue Date |
| 7932406 | Method for preparing 4β-amino-4′-demethyl-4-desoxypodophyllotoxin The invention relates to a method for synthesizing 4β-amino-4′-demethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic s... | 04/26/2011 |
| 7261995 | Nitrogen-containing organic compound, chemically amplified resist composition and patterning process Chemically amplified resist compositions comprising nitrogen-containing organic compounds having a 7-oxanorbornane-2-carboxylic ester structure have resolution and provide a precise pattern profile and are useful in microfabrication using electron beams or deep-UV l... | 08/28/2007 |
| 7087641 | 4β-1″-[(2″-substituted benzoyl) anilino]podophyllotoxin analogues useful as anticancer agents The present invention provides a new class of compounds 4β-1″-[{2″-benzoyl substituted}anilino] podophyllotoxin exhibiting anti cancer activity and a process for preparing the same. ... | 08/08/2006 |
| 6906101 | Taxane derivatives and processes for the preparation thereof A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-β-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by an isoserine residue. ... | 06/14/2005 |
| 6903086 | Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as IP antagonists This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein G1 is selected from the group consisting of a, b1 and b2,... | 06/07/2005 |
| 6881850 | Heterocyclically annellated indenochromene derivatives The present invention relates to specific photochromic heterocyclically annellated indenochromene derivatives and the use thereof in plastics of all types, particularly for ophthalmic applications. In particular, the present invention relates to indeno[1,2-h]chromen... | 04/19/2005 |
| 6872841 | Etoposide analogs and methods of use thereof Etoposide analogs such as 4′-O-demethyl-4β-[4″-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy-podophyllotoxin (12) and 4′-O-demethyl-4β-[4″-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-desoxypodophyllotoxin (13) are described, along with pharmaceutical fo... | 03/29/2005 |
| 6861537 | Tricyclic and tetracyclic taxane intermediates The synthesis of taxol and other tricyclic and tetracyclic taxanes. ... | 03/01/2005 |
| 6686386 | Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis The present invention relates to pharmaceutical and cosmetic compositions comprising at least one agonist ligand, which is specific for receptors of the RAR-γ type, which are characterized as inducers of apoptosis in at least one cell population in which... | 02/03/2004 |
| 6660727 | Photochromic heterocyclically anellated indenochromene compounds The present invention relates to specific photochromic heterocyclically annellated indenochromene derivatives and the use thereof in plastics of all types, particularly for ophthalmic applications. In particular, the present invention relates to indeno[2,... | 12/09/2003 |
| 6653344 | Pharmaceutical preparations containing a dibenzocyclooctane lignan derivative for treatment of neurodegenerative disease The present invention relates to the use of a dibenzocyclooctane lignan derivative of the following general formula (I) for treatment of neurodegenerative disorders: ##STR1## wherein R1 is H or C1-4 lower alkyl; R2, R... | 11/25/2003 |
| 6566393 | Etoposide analogs and methods of use thereof Etoposide analogs such as 4'-O-demethyl-4ଲ-[4"-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy -podophyllotoxin (12) and 4'-O-demethyl-4ଲ-[4"-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-deso xypodophyllotoxin (13) are described, along with... | 05/20/2003 |
| 6462074 | Substituted , ଲ-anellated butyrolactones The present invention relates to novel substituted (,ଲ-fused butyrolactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in... | 10/08/2002 |
| 6448412 | Methods for the preparation and characterization of multi-substituted fullerenes The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of fo... | 09/10/2002 |
| 6433189 | Tricyclic and tetracyclic taxane intermediates The synthesis of taxol and other tricyclic and tetracyclic taxanes.... | 08/13/2002 |
| 6399785 | Multiply-substituted fullerenes The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of fo... | 06/04/2002 |
| 6383521 | Wondonin A and process for preparing the same The present invention provides Wondonin A of general formula (I), which is extracted from a two-sponge association of phylum Porifera (sponge) and has antiangiogenic activity, and a process for preparing the same. Wondonin A has no cytotoxicity, but has a... | 05/07/2002 |
| 6355813 | process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this inventio... | 03/12/2002 |
| 6340704 | Cell differentiation inducing amide derivatives, their production and use The present invention provides a compound represented by the formula: ##STR1## wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which m... | 01/22/2002 |
| 6284789 | Formation and composition of new optically active compounds The present invention is directed to tetrahydronaphthalene derivatives of -conindendrin, ଲ-conindendrin, sikkimotoxin, and podophyllotoxin having at least one methyleneoxy bridge wherein the oxygen atom extends to the benzhydrylic carbon atom... | 09/04/2001 |
| 6207673 | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors The present invention provides covalent conjugates of topoisomerase I and topoisomerase II inhibitors. Such compounds have a structure according to formula I: TI --L--TII (I) wherein: TI is a topoisomerase I inhibitor such as ... | 03/27/2001 |
| 6187819 | Protein kinase C activators and their use in decreasing expression of cell antigens A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells ... | 02/13/2001 |
| 6162926 | Multi-substituted fullerenes and methods for their preparation and characterization The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of fo... | 12/19/2000 |
| 6114549 | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this inven... | 09/05/2000 |
| 6075140 | Pentacyclic compound The present invention relates to a novel taxol derivative having an antitumor activity which is represented by formula (1). ##STR1## [In the formula (I), R1 : a phenyl group, R2 : an alkyl group, an alkenyl group, an alkynyl gro... | 06/13/2000 |
| 6069174 | Protein kinase C activators and their use in increasing expression of cell antigens A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells ... | 05/30/2000 |
| 6005120 | Tricyclic and tetracyclic taxanes The synthesis of taxol and other tricyclic and tetracyclic taxanes.... | 12/21/1999 |
| 5998408 | Triterpene derivatives with immunosuppressant activity The compounds of Formula I ##STR1## are useful as immunosuppressive agents.... | 12/07/1999 |
| 5948817 | Polycyclic ethyl alkylamide melatonergic agents Novel polycyclic ethyl alkylamides of formula I are active as melatonergic agents. ##STR1## wherein Z=CH (when a double bond is present) or (CH2)n, wherein n is 1-4; X=O, CH2, or CH (when a double bond is present); R=... | 09/07/1999 |
| 5917056 | 10-deacetyl-14ଲ-hydroxybaccactine III derivatives, a process for the preparation thereof and formulations containing them The present invention relates to novel 10-deacetyl-14ଲ-hydroxybaccatine III derivatives. The novel derivatives, having cytotoxic and antitumour activity, are prepared from this synton after functionalization of the hydroxyls at 1-, 14- as thioc... | 06/29/1999 |
| 5892062 | Cyclic cedrene acetals, their preparation and their use Cyclic cedrene acetals of the general formula A are described, in which the wavy lines represent the - and ଲ-configurations, and R and R1 are the radicals below: ##STR1## R=R1 =H R=H, R1 =Me/R=Me, R1... | 04/06/1999 |
| 5777137 | Pancratistatins and processes for their production Disclosed are novel pancratistatins and methods for their total asymmetric synthesis. In particular embodiments, processes for the total asymmetric synthesis of (+)-pancratistatin, (-)-pancratistatin, (+)-7-deoxypancratistatin, (-)-7-deoxypancratistatin, ... | 07/07/1998 |
| 5750734 | Process for the preparation of steroid derivatives A process is described for the preparation of a compound of formula (I) or a stereoisomeric compound thereof, in which the 1,2-position is saturated or is a double bond; X1 and X2 are each independently hydrogen or halogen; R1 | 05/12/1998 |
| 5705704 | Tricyclic compounds Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.... | 01/06/1998 |
| 5681964 | Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trih... | 10/28/1997 |
| 5681860 | Method of increasing expression of HLA, cell surface and TAA antigens of cells using 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells ... | 10/28/1997 |
| 5541223 | 4ଲ-amino podophyllotoxin analog compounds and methods Novel podophyllotoxin compounds and their use in treating tumors are disclosed. The analogs have the general formula: ##STR1## wherein NH--R is a selected aryl amine, dialkylaminoalkyleneamino, or dialkylaminoanilino group.... | 07/30/1996 |
| 5534499 | Lipophilic drug derivatives for use in liposomes The present invention provides novel lipophilic drug derivatives which are capable of being formulated in liposomes or micelles. These drug derivatives are known therapeutic agents which are covalently attached to a fatty acid chain of a phospholipid, gly... | 07/09/1996 |
| 5481010 | 7-deacetoxy beccatine IV derivative and preparation and use thereof This invention relates to a novel 7-deacetoxy baccatine IV derivative having formula (I): ##STR1## the preparation thereof from taxine B, and its use in preparing biologically active products. In said formula (I), R is a hydrogen atom or acetyl ... | 01/02/1996 |
| 5264591 | Baccatine III derivatives Isolation of a new taxane having pharmaceutical activity, 1a 14-beta-hydroxy-10-deacetyl-baccatine III and hemisynthesis of some derivatives useful as antitumor agents and intermediates.... | 11/23/1993 |
