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| Number | Title | Issue Date |
| 7888519 | Pyran compound or at least one derivative thereof The invention relates to pyran derivatives of the formula I and to a process and intermediates for their preparation and derivatisation, and to the use thereof in liquid-crystalline media. ... | 02/15/2011 |
| 7638641 | Tetrahydropyran derivatives The invention relates to tetrahydropyran derivatives of the general formula I and to processes for the preparation thereof. ... | 12/29/2009 |
| 7417059 | Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of d... | 08/26/2008 |
| 7361388 | Liquid-crystalline compounds having a tetrahydropyran ring The invention relates to liquid-crystalline compounds of formula (I), wherein R11, X11, Z11, Z12, Z13, L11, L12, L13, L14, L15 and L16 have the m... | 04/22/2008 |
| 7314943 | Pyran derivatives containing an exocyclic double bond The invention relates to pyran derivatives of formula I and processes and intermediates for their preparation and derivatisation, and the use thereof in liquid-crystalline media. ... | 01/01/2008 |
| 7291367 | Liquid-crystalline compounds The invention relates to liquid-crystalline compounds of the formula (I) in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, a, b and c have the meanings indicated in Claim | 11/06/2007 |
| 7253194 | Compounds and inhibitors of phospholipases The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is, the same stereochemistry, with the chiral α-carbon of D-α-amino acids... | 08/07/2007 |
| 7214681 | Tri(cyclo) substituted amide compounds Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes. ... | 05/08/2007 |
| 7157589 | One step process for the preparation of anticonvulsant derivatives The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R | 01/02/2007 |
| 7148363 | Process for preparing acrylate compound An acrylate compound of formula (4): is produced by allowing an acrylic acid compound of formula (1): to react with an unsaturated compound of formula (2) or... | 12/12/2006 |
| 7145015 | Benzocycloheptenes, process for their production, pharmaceutical preparations that contain that latter as well as their use for the production of pharmaceutical agents Benzocycloheptenes of formula (I), in which R1, R2 and Y have the meanings that indicated herein, exhibit selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therap... | 12/05/2006 |
| 7081347 | Method for predicting cardiovascular events A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is measured and compared to a set of standardized quartile concentrations.... | 07/25/2006 |
| 7064221 | Process for producing pyran This invention provides a process for producing a pyran efficiently with high productivity and simplified production facilities. The process for producing a pyran comprises reacting aldehyde (I) represented by: R1—CHO (I) | 06/20/2006 |
| 6958395 | Method for producing water-soluble saccharide conjugates and saccharide mimetics by Diels-Alder reaction The present invention relates to a method by which saccharide compounds can be prepared in a very easy way. This method comprises the steps of: (a) attaching at least one saccharide to a cyclic or acyclic diene, (b) reacting the saccharide-... | 10/25/2005 |
| 6902777 | Liquid-crystalline medium A liquid-crystalline mediums which contain one or more compounds of the formula A and at least one compound of the formula B wherein compounds of formula A contain at lea... | 06/07/2005 |
| 6867323 | Cross-coupling reaction of organosilicon nucleophiles Improved methods for generating a —C—C— bond by cross-coupling of a transferable group with an acceptor group. The transferable group is a substituent of an organosilicon nucleophile and the acceptor group is provided as an organic electrophile. The reaction i... | 03/15/2005 |
| 6864254 | Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular dis... | 03/08/2005 |
| 6841709 | Method of cutting polymer chains and method for producing chemical raw materials The present invention is to provide a technology to establish a new cycle-based organic chemical industry, which may be called a polymer cascade (polymer reflux industry) wherein the polymer substances shall not remain the final products, but still give birth to syn... | 01/11/2005 |
| 6835845 | Methine compound, material for organic luminescence element, and organic luminescence element using the same A is a novel methine compound, for example, which is represented by the following formula (I): wherein R1, R2, R3, R4 and R5 each represents a hydrogen atom or a s... | 12/28/2004 |
| 6833462 | Process for preparing acrylate compound An acrylate compound of formula (4): is produced by allowing an acrylic acid compound of formula (1): to react with an unsaturated compound of formula (2) or (3): | 12/21/2004 |
| 6818638 | Melvinolin derivatives Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions. ... | 11/16/2004 |
| 6812352 | Multidentate phosphite ligands, catalytic compositions containing such ligands, and catalytic processes utilizing such catalytic compositions Multidentate phosphite ligands are disclosed for use in reactions such as hydrocyanation and isomerization. The catalyst compositions made therefrom and the various catalytic processes which employ such multidentate phosphite ligands are also disclosed. In particula... | 11/02/2004 |
| 6762198 | Dihetero-substituted metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): | 07/13/2004 |
| 6713507 | Ether compounds and compositions for cholesterol management and related uses The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 03/30/2004 |
| 6696569 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C--C double bond substituted at one carbon with two oxygen or sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence by reaction with a peroxidase enz... | 02/24/2004 |
| 6686348 | Metalloprotease inhibitors A compound of formula (I): ##STR1## wherein: R1 represents hydrogen, halogen, alkyl or alkoxy, X represents oxygen, sulphur or NR wherein R represents hydrogen or alkyl, A represents any one of the groups described in the description, their isomers and a... | 02/03/2004 |
| 6566381 | Hetero-substituted metalloprotease inhibitors Heterocyclic substituted compounds having the general structure: ##STR1## which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes.... | 05/20/2003 |
| 6541655 | Catalytic compositions and methods for asymmetric allylic alkylation Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates.... | 04/01/2003 |
| 6525206 | Compounds with high monoamine transporter affinity Featured compounds have high monoamine transport affinity and are characterized by one of the following two general formulas set out above. The compounds bind selectively or non-selectively to monoamine transporters. The compounds are useful to treat vari... | 02/25/2003 |
| 6482950 | Squarylium compounds, and processes and intermediates for the synthesis of these compounds Squarylium compounds of the formula: ##STR1## wherein Q1 and Q2 are each independently a pyrylium, thiopyrylium, selenopyrylium, benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus, and R1 and R2 are ea... | 11/19/2002 |
| 6472422 | Analogs of cocaine The invention provides a compound of formula (I): ##STR1## wherein R1, R2, R3, and Y have any of the meanings defined in the specification; as well a pharmaceutical composition comprising a compound of formula I; intermedi... | 10/29/2002 |
| 6458474 | Methine compound, material for organic luminescence element, organic luminescence element using the same Disclosed is a novel methine compound, for example, which is represented by the following formula (I): ##STR1## wherein R1, R2, R3, R4 and R5 each represents a hydrogen atom or a substituent; X repres... | 10/01/2002 |
| 6420573 | Processes for preparing 3-arylsulfur hydroxamic acids This invention provides processes for the preparation of a compound of Formula I: Y--C(.dbd.O)--C(R1)(R2)--CH2 --S(O)n R3 wherein: Y is hydroxy or XONX, where each X is independently hydrogen, lower alkyl ... | 07/16/2002 |
| 6395910 | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate The present invention provides a production method of a 5-phthalancarbonitrile compound, which comprises the use of a novel compound of the formula [I] ##STR1## wherein X is chlorine atom, bromine atom or iodine atom, as a key intermediate. The metho... | 05/28/2002 |
| 6384237 | Pyrylium compound, process for making the same, nucleic acid stain, and labeled nucleic acid A novel pyrylium compound is represented by the general formula (I): ##STR1## wherein X is oxygen or sulfur, Y- is a monovalent anion, n is an integer of 2 or 3, and M is hydrogen or an alkali metal. This pyrylium compound functions as a labeli... | 05/07/2002 |
| 6376468 | Protein:prenyl transferase inhibitors The invention pertains to novel peptide analogs suitable for inhibiting protein:prenyl transferases. As such they are therapeutically useful in e.g. inhibiting oncogenesis and other unwanted cell proliferation, and in supressing aberrant high signal trans... | 04/23/2002 |
| 6376429 | Benzoylcyclohexanediones, process for their preparation and their use as herbicides and plant growth regulators Benzoylcyclohexanediones of the formula (I), process for their preparation and their use as herbicides and plant growth regulators are described. ##STR1## In this formula (I), R11, R2, R3, R4, R5 | 04/23/2002 |
| 6350431 | Compounds This invention provides a physiologically tolerable light imaging contrast agent compound having a molecular weight in the range 500 to 5000000 and containing at least two chromophores having delocalized electron systems as well as at least one polyalkyle... | 02/26/2002 |
| 6337411 | Stromelysin inhibitors Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of conditions whose course involves an increased activity of matrix-degrading enzymes, in particular stromelysin.... | 01/08/2002 |
| 6307067 | Palladium and boron co-catalyzed addition of oxygen nucleophiles to vinyl epoxides Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 1,2-diols and oxygen-containing h... | 10/23/2001 |
