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| Number | Title | Issue Date |
| 7615651 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such antagonism in animals are described herein. | 11/10/2009 |
| 7579487 | Process for making N-sulfonated-amino acid derivatives This invention relates to a process for preparing optically active α-amino acid substrates which are used to make potent lethal factor (LF) inhibitors for the treatment of anthrax. This invention further relates to a process for synthesis of potent LF-inhibitors fo... | 08/25/2009 |
| 7420002 | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed. ... | 09/02/2008 |
| 7417059 | Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of d... | 08/26/2008 |
| 7364804 | Pyran derivative, method for manufacturing the same, and light-emitting element containing the pyran derivative A light-emitting compound that has excellent carrier transportation properties and that can exhibit long wavelength light is disclosed. Further, a method for manufacturing the light-emitting compound in a high yield is disclosed. The disclosed light-emitting compoun... | 04/29/2008 |
| 7361388 | Liquid-crystalline compounds having a tetrahydropyran ring The invention relates to liquid-crystalline compounds of formula (I), wherein R11, X11, Z11, Z12, Z13, L11, L12, L13, L14, L15 and L16 have the m... | 04/22/2008 |
| 7314943 | Pyran derivatives containing an exocyclic double bond The invention relates to pyran derivatives of formula I and processes and intermediates for their preparation and derivatisation, and the use thereof in liquid-crystalline media. ... | 01/01/2008 |
| 7300953 | Process for preparing nitrile compound, carboxylic acid compound or carboxylic acid ester compound The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R repres... | 11/27/2007 |
| 7217465 | Pyran derivative A light-emitting compound that can be easily applied to vacuum vapor deposition and exhibit long wavelength light is disclosed. Further, a light-emitting element without inferior luminescence properties due to the carbonization of a light-emitting compound during va... | 05/15/2007 |
| 7196209 | Continuous process for the preparation of fructopyranose sulfamate derivatives The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein R1, R3, R | 03/27/2007 |
| 7157589 | One step process for the preparation of anticonvulsant derivatives The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R | 01/02/2007 |
| 6916948 | Bis(1,3-dihydroxy-prop-2-yl) amine and derivatives thereof in the manufacture of polymers Derivatives of bis-(1,3-dihydroxy-prop-2-yl)amine are disclosed, together with the use of such derivatives and of bis(1,3-dihydroxy-prop-2-yl)amine itself in the preparation of polymers, in particular dendrimers. Some of the derivatives may be useful as non-ionic su... | 07/12/2005 |
| 6905786 | Light emitting device material, light emitting device using thereof, and amine compound A compound represented by the following formula (I): wherein R1, R2 and R3each represents an aryl group, a heterocyclic group or an aliphatic hydrocarbon group, provided that at least o... | 06/14/2005 |
| 6902777 | Liquid-crystalline medium A liquid-crystalline mediums which contain one or more compounds of the formula A and at least one compound of the formula B wherein compounds of formula A contain at lea... | 06/07/2005 |
| 6890937 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9, and MMP-13, while exhibiti... | 05/10/2005 |
| 6869696 | Organic red electro-luminescent device including a heterocyclic emitter The invention concerns an electro-luminescent device in which the luminescent layer contains a compound of general formula I as doping agent or as luminescent compound, whereby the radicals R1 to R12 are identical or are different, and mean hyd... | 03/22/2005 |
| 6867309 | Red-emitting organic electroluminescent compound A red-emitting organic electroluminescent compound, the structure of the compound as follows: wherein n is an integer of 1˜6; Ar represents aryl or heteroaryl; R1 and R2 ... | 03/15/2005 |
| 6849660 | Antimicrobial biaryl compounds Provided are antibacterial compounds having Formula I: In such compositions, X is O or S; Y is CH2; n is 0 or 1. One of R1 and R1′ is —C(O)NR5R5′ | 02/01/2005 |
| 6835845 | Methine compound, material for organic luminescence element, and organic luminescence element using the same A is a novel methine compound, for example, which is represented by the following formula (I): wherein R1, R2, R3, R4 and R5 each represents a hydrogen atom or a s... | 12/28/2004 |
| 6833453 | Methods of producing oxazolidinone compounds Methods of synthesizing pharmacologically useful oxazolidinones are disclosed, and, in particular, a method of manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamin... | 12/21/2004 |
| 6818638 | Melvinolin derivatives Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions. ... | 11/16/2004 |
| 6812352 | Multidentate phosphite ligands, catalytic compositions containing such ligands, and catalytic processes utilizing such catalytic compositions Multidentate phosphite ligands are disclosed for use in reactions such as hydrocyanation and isomerization. The catalyst compositions made therefrom and the various catalytic processes which employ such multidentate phosphite ligands are also disclosed. In particula... | 11/02/2004 |
| 6809207 | Amino acid derivatives The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydroth... | 10/26/2004 |
| 6762198 | Dihetero-substituted metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): | 07/13/2004 |
| 6737420 | Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formula (XII): useful in treating Alzheimer's disease and other similar diseases. ... | 05/18/2004 |
| 6730783 | Process for preparing aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra | 05/04/2004 |
| 6703425 | Sulfonamide derivatives The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders ##STR1##... | 03/09/2004 |
| 6686348 | Metalloprotease inhibitors A compound of formula (I): ##STR1## wherein: R1 represents hydrogen, halogen, alkyl or alkoxy, X represents oxygen, sulphur or NR wherein R represents hydrogen or alkyl, A represents any one of the groups described in the description, their isomers and a... | 02/03/2004 |
| 6638931 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 -R4, R6 -R9, R11, R12, Ra, Rb, R | 10/28/2003 |
| 6566381 | Hetero-substituted metalloprotease inhibitors Heterocyclic substituted compounds having the general structure: ##STR1## which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes.... | 05/20/2003 |
| 6545022 | 4(3)substituted-4(3)-aminomethyl-(thio)pyran or piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders Novel amines of formulas 1D and 1E ##STR1## are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders,... | 04/08/2003 |
| 6541632 | Process for producing heterocyclic nitriles A carbocyclic or heterocyclic compound, ammonia and an oxygen-containing gas are subjected to fluid catalytic reaction in vapor phase in the presence of a catalyst containing alkali metal to produce an aromatic or heterocyclic nitrile. The use of the cata... | 04/01/2003 |
| 6518310 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 -R4, R6 -R9, R11, R12, Ra, Rb, R | 02/11/2003 |
| 6514633 | Light emitting device material, light emitting device using thereof, and amine compound A light emitting device material comprising a compound represented by the following formula (I): ##STR1## wherein R1, R2 and R3, which may be the same or different, each represents an aryl group, a heterocyclic group or an... | 02/04/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6482986 | Benzene derivatives, preparation method and pharmaceutical compositions containing same The invention concerns compounds of formula (I) wherein A, X, Y, n, R1, R2 and R3 are as defined in claim 1. Said compounds are specifically binding to sigma receptors particularly those of the peripheral nervous system. ... | 11/19/2002 |
| 6479674 | Carboxylic acid derivatives and process for producing same The present invention relates to compounds which are useful for efficient synthesis of 2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acids. The compounds according to the present invention comprise 2-oxobicyclo[3.1.0]hexane-6-carboxylic acid derivatives r... | 11/12/2002 |
| 6472422 | Analogs of cocaine The invention provides a compound of formula (I): ##STR1## wherein R1, R2, R3, and Y have any of the meanings defined in the specification; as well a pharmaceutical composition comprising a compound of formula I; intermedi... | 10/29/2002 |
| 6458474 | Methine compound, material for organic luminescence element, organic luminescence element using the same Disclosed is a novel methine compound, for example, which is represented by the following formula (I): ##STR1## wherein R1, R2, R3, R4 and R5 each represents a hydrogen atom or a substituent; X repres... | 10/01/2002 |
| 6451791 | Amidoaromatic ring sulfonamide hydroxamic acid compounds An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a contemplated amidoaromatic ring sulfonamide hydroxamic acid compoun... | 09/17/2002 |
