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| Number | Title | Issue Date |
| 8115019 | Cis-2, 6-disubstituted tetrahydropyran derivatives and preparation method thereof Disclosed are cis-2,6-disubstituted tetrahydropyran derivatives represented by Chemical Formula 1 and a preparation method thereof. The tetrahydropyran derivatives can be prepared by Prins-reacting tetrahydropyran derivatives with homopargylicalcohol derivatives in ... | 02/14/2012 |
| 8008514 | Process for preparing 2-methoxycarbonylmethyl-6,6-dimethyl-2-tetrahydropyran carboxylic acid Process for preparing 2-methoxycarbonylmethyl-6,6-dimethyl-2-tetrahydropyran carboxylic acid (I) comprising: a) Reaction of 5-bromo-2-methyl-2-pentene (III) with magnesium and then diethyloxalate to obtain ethyl-2-oxo-6-methyl-5-heptenoate (IV); ... | 08/30/2011 |
| 7741497 | Processes for preparing alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound and 4-acyltetrahydropyrane The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be t... | 06/22/2010 |
| 7442793 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 10/28/2008 |
| 7402687 | Dihydrobenzofuran derivatives and uses thereof Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, ... | 07/22/2008 |
| 7390803 | Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28... | 06/24/2008 |
| 7317125 | Diacylglycerol acyltransferase inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutica... | 01/08/2008 |
| 7230028 | Dimeric compounds and their use as anti-viral agents The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; and n is an integer from 10 to 18 or a pharmaceutically acceptable derivative thereof, methods for their preparation, ph... | 06/12/2007 |
| 7223790 | Dimeric compounds and their use as anti-viral agents The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2–C8 alkyl C3-8 cycloalk... | 05/29/2007 |
| 7214707 | Dimeric compounds and their use as anti-viral agents The invention relates to compounds of general formula (I), in which: R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; n and q are either the same or different and selected from 0, 1 or 2; and X is an optionally substituted phenyl, option... | 05/08/2007 |
| 7169774 | Cephalotaxane derivatives and their processes of preparation and purification The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constit... | 01/30/2007 |
| 7157494 | Dimeric compounds and their use as anti-viral agents The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, SO2NH, NHCO or NHCONH; m is either 0 or 1; n is an integer from 2 to 6; q is an integer from 0 to ... | 01/02/2007 |
| 7053109 | Aminediols for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 05/30/2006 |
| 6884897 | Preparation of 3,6-dihydro-2H-pyran-2-carboxylic esters A process is provided for preparing 3,6-dihydro-2H-pyran-2-carboxylic esters via a thermal hetero Diels-Alder reaction of 1,3-dienes with glyoxylic esters without the use of catalysts and stabilizers using a special metering technique. ... | 04/26/2005 |
| 6849660 | Antimicrobial biaryl compounds Provided are antibacterial compounds having Formula I: In such compositions, X is O or S; Y is CH2; n is 0 or 1. One of R1 and R1′ is —C(O)NR5R5′ | 02/01/2005 |
| 6835841 | Asymmetric catalytic hydrogenation process for preparation of chiral cyclic β-aminoesters A novel process for the asymmetric synthesis of substituted cyclic β-amino-carboxylates of the type shown in the specification from appropriate β-enamino-ester starting materials is described. These compounds are useful as intermediates for MMP and TACE inhibitors... | 12/28/2004 |
| 6831180 | Cephalotaxane derivatives and process for their preparation The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloids used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constit... | 12/14/2004 |
| 6818638 | Melvinolin derivatives Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions. ... | 11/16/2004 |
| 6790953 | Ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 09/14/2004 |
| 6716881 | Carbanilides used as pesticides The present invention provides carbanilides of formula (I), wherein A, Q, R, X, Z and m are as defined herein. A plurality of processes for preparing these compounds is provided, along with methods of using the compounds... | 04/06/2004 |
| 6686348 | Metalloprotease inhibitors A compound of formula (I): ##STR1## wherein: R1 represents hydrogen, halogen, alkyl or alkoxy, X represents oxygen, sulphur or NR wherein R represents hydrogen or alkyl, A represents any one of the groups described in the description, their isomers and a... | 02/03/2004 |
| 6680338 | Hydroxamic and carboxylic acid derivatives Compounds having therapeutic utility are of formula (I) wherein n=0-1; X is S(O)0-2 ; Y is OR1 or NHOH; R2 and R4 are independently H or a group (optionally substituted with R10) selected from C... | 01/20/2004 |
| 6590110 | Method for synthesizing C-glycosides of ulosonic acids The invention is directed to a method for synthesizing C-glycosides of ulosonic acids, as well as intermediates thereof and C-glycosides prepared by this method.... | 07/08/2003 |
| 6576596 | Substituted 2-benzoyl-cyclohexan-1,3-diones with herbicidal effect The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I ##STR1## where R1, R2 are each hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, --OR5, --OCOR6, ... | 06/10/2003 |
| 6534532 | Carbanilides as pesticides The invention concerns novel carbanilides of formula (I), ##STR1## in which A, Q, R, X, Z and m have the meanings given in the description. The invention further concerns a plurality of processes for preparing these substances, in their use as microbiocid... | 03/18/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6472422 | Analogs of cocaine The invention provides a compound of formula (I): ##STR1## wherein R1, R2, R3, and Y have any of the meanings defined in the specification; as well a pharmaceutical composition comprising a compound of formula I; intermedi... | 10/29/2002 |
| 6469215 | Process for the production of an intermediate mixture of ଲ-isophorone epoxide and its isomer 4-hydroxyisophorone (HIP) A process for the production of an intermediate mixture of ଲ-isophorone epoxide and its isomer 4-hydroxyisophorone (HIP), comprising reacting ଲ-isophorone with an organic percarboxylic acid, in the form of its non-aqueous solution, in an inert... | 10/22/2002 |
| 6440996 | Monomeric and dimeric heterocycles, and therapeutic uses thereof The invention provides compounds of formula (I): X--L--X1 (I) wherein X and X1 are substituted piperidine, cyclohexane, or tetrahydropyran rings, and L is a linking group between X and X1 ; as well a pharmaceutical composition... | 08/27/2002 |
| 6420573 | Processes for preparing 3-arylsulfur hydroxamic acids This invention provides processes for the preparation of a compound of Formula I: Y--C(.dbd.O)--C(R1)(R2)--CH2 --S(O)n R3 wherein: Y is hydroxy or XONX, where each X is independently hydrogen, lower alkyl ... | 07/16/2002 |
| 6380258 | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroa... | 04/30/2002 |
| 6376468 | Protein:prenyl transferase inhibitors The invention pertains to novel peptide analogs suitable for inhibiting protein:prenyl transferases. As such they are therapeutically useful in e.g. inhibiting oncogenesis and other unwanted cell proliferation, and in supressing aberrant high signal trans... | 04/23/2002 |
| 6316462 | Methods of inducing cancer cell death and tumor regression Methods are provided for treating cancer, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an additional Ras signaling pathway inhibitor to induce cancer cell death and tumor regression.... | 11/13/2001 |
| 6300368 | Anilide derivatives and antiarrhythmic agents containing the same Preparation of antiarrhythmic agents containing novel anilide derivatives represented by the following formula as active ingredient provides a new type of antiarrhythmic agent of highly safe and effective, without effects on cardiac function. ##STR1#... | 10/09/2001 |
| 6201133 | Certain cyclic thio substituted acylaminoacid amide derivatives Disclosed are compound of formula I ##STR1## wherein R represents hydrogen, lower alkyl, cycloalkyl, bicycloalkyl, adamantyl, aryl, biaryl, or mono- or di-(cycloalkyl, aryl or biaryl)-lower alkyl, di-(lower alkyl or aryl-lower alkyl)amino-lower alkyl, or ... | 03/13/2001 |
| 6197817 | Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders Disclosed are compounds of the formula: ##STR1## R represents hydrogen or is a C-3 to C-6 cycloalkyl or C-4 to C-10 straight or branched carbon chain alkyl-cycloalkyl or a group --B--D, where B is C-2 to C-10 straight or branched carbon chain alkyl and D ... | 03/06/2001 |
| 6187924 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity Compounds of formula (I) ##STR1## are useful as therapeutic agents, by virtue of having MMP and TNF inhibitory activity.... | 02/13/2001 |
| 6150532 | Modulators of proteins with phosphotyrosine recognition units The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to their use for treatment of human an... | 11/21/2000 |
| 6057342 | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a... | 05/02/2000 |
| 6013836 | Insecticidal N'-substituted-N,N'-disubstitutedhydrazines This invention relates to N'-substituted-N,N'-disubstitutedhydrazines of formula I ##STR1## wherein X and X' are independently O, S, or NR; A' and B' are independently substituted or unsubstituted aryl or aromatic heterocycle; wherein F is alkyl... | 01/11/2000 |
