Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 7875737 | Pyran derivatives, process of preparation and use thereof in perfumery and flavouring Pyran derivatives of general formula (I) wherein Y is a 5-, 6- or 7-membered ring, preferably a 5-membered ring, methyl or ethyl mono- or polysubstituted, and optionally unsaturated, and R... | 01/25/2011 |
| 7354936 | 2-phenylpyran-4-one derivatives The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula processes for their preparation, pharmaceutical compositions containing them, and their medical uses. ... | 04/08/2008 |
| 7326798 | Chiral heptyne derivatives for the preparation of epothilones and processes for their preparation The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds. ... | 02/05/2008 |
| 7304169 | Process for producing tetrahydropyran-4-ol, intermediate therefor, and process for producing the same The present invention relates to a process for preparing tetrahydropyran-4-ol which comprises the steps of (A) a cyclization step of preparing tetrahydropyranyl-4-formate represented by the formula (1): by reacti... | 12/04/2007 |
| 7294278 | Method for oxygenating wastewater A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to fo... | 11/13/2007 |
| 7008535 | Apparatus for oxygenating wastewater A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to fo... | 03/07/2006 |
| 6919160 | Acrylic compounds for sub-200 nm photoresist compositions and methods for making and using same Disclosed herein is an acrylic compound that can be polymerized by itself or with at least one other ethylenically unsaturated monomer to provide a polymer. The polymer may be used, for example, within a sub-200 nm photoresist composition. Also disclosed is a method... | 07/19/2005 |
| 6828447 | Compounds and methods for the inhibition of the expression of VCAM-1 This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases. ... | 12/07/2004 |
| 6716999 | Pyrone derivatives and method for producing same A method for producing pyrone derivatives of the general formula (I), wherein X1 is halomethyl, whereby an acetoacetic acid derivative of the general formula (II), wherein X1 has the aforementioned meaning and X2 is chlorine or bromi... | 04/06/2004 |
| 6646170 | Intermediates for the synthesis of ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administer... | 11/11/2003 |
| 6479538 | Cyclic ether vitamin D3 compounds, 1(OH)3-EPI-vitamin D3 compounds and uses thereof Novel cyclic ether vitamin D3 compounds having a cyclic ether side chain are disclosed. These compounds were first identified as metabolites of 3-epi vitamin D3 produced via a tissue-specific metabolic pathway which catalyzes the formation of a cyclic eth... | 11/12/2002 |
| 6451766 | Neuraminic acid derivatives, their preparation and their medical use Compounds of formula (I) or their salts or esters: ##STR1## [wherein R1 is alkyl or haloalkyl; R2 and R3 each represents hydrogen or aliphatic acyl; X is hydroxy, halogen, alkoxy, or a group of formula Ra O--, w... | 09/17/2002 |
| 6426421 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present... | 07/30/2002 |
| 6392061 | Process for making (2S, 3S, 5S) oxetanone derivatives This invention relates to novel processes for making (2S, 3S, 5S) oxetanone derivative lipase inhibitor compounds and intermediates therefor, which processes for producing such derivatives that are useful as lipase inhibitors are capable of being scaled t... | 05/21/2002 |
| 6300106 | Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate A method of producing (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methane sulfonate using 1,3-butadiene and a ketoethanal to form an intermediate racemic mixture. The racemic mixture is resolved to remove one isomer from the ... | 10/09/2001 |
| 6211387 | Diol compounds as intermediates for preparing antimycotic compounds A compound of formula (II), wherein R1 is chloro, fluoro or trifluoromethyl; R2 is hydrogen, chloro, fluoro or trifluoromethyl; and R is hydrogen or a protective group for the hydroxy moiety useful as an intermediate for the synthesi... | 04/03/2001 |
| 6136986 | Process for preparing substituted chroman derivatives The invention relates to a process for preparing substituted chroman derivatives of the general formula VII, ##STR1## where X is the group --CN, --COOR3, --CHO, --CH2 OR7 or --CH(OR8)2, R2 | 10/24/2000 |
| 5981496 | -pyrones for treating -pyrone responsive states Novel -pyrones are described. The -pyrones are useful in a method for controlling -pyrone responsive states in a mammal. The method includes administering to a mammal a therapeutically effective amount of an -pyrone such that c... | 11/09/1999 |
| 5952376 | Trienyl compounds Triene-containing compounds which mimic the chemical and/or biological activity of the spongistatins are provided, as are methods and intermediates useful in their preparation.... | 09/14/1999 |
| 5888969 | Use of cytokine restraining agents to treat inflammatory bowel disease The present invention relates to the use of cytokine restraining agents to treat inflammatory bowel disease.... | 03/30/1999 |
| 5869523 | Process for the preparation of 6-(substitutedaminopropionyl)-derivatives of forskolin Process for the preparation of 6-(substitutedaminopropionyl)-derivatives of forskolin Process for the manufacture of 6ଲ-(3-substitutedamino) propionyloxy forskolin derivatives of the general formula ##STR1##... | 02/09/1999 |
| 5808111 | Stable acitretinoid compounds Novel acitretinamide compounds which are soluble and stable in water and useful in aqueous delivery systems, particularly to treat cancer, are provided. The novel acitretinamide compounds, 1-(D-glucopyranosyl)acitretinamide, 1-(D-glucopyranuronosyl)acitre... | 09/15/1998 |
| 5648379 | Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation and their use in the treatment of viral infections, in particular influenza, are described.... | 07/15/1997 |
| 5602262 | Process for the preparation of 2-deoxy-2,2-difluoro-ଲ-D-ribo-pentopyranose A process for producing intermediate compounds 2-deoxy 2,2-difluoro-ଲ-D-ribo-pentopyranose (III) from 3,3-difluoro-4,5,6-O-trihydroxy-5,6-O-(1-ethylpropylidene)hexene (I). The process of preparing intermediate compound (I) involves reacting D-g... | 02/11/1997 |
| 5453439 | Hydroxylamine derivatives The invention concerns hydroxylamine derivatives of the formula I ##STR1## wherein R4 is hydrogen, carbamoyl, (1-4C)alkyl, (2-5C)alkanoyl, N-(1-4C)alkylcarbamoyl, N,N-di-(1-4C)alkylcarbamoyl, benzoyl or phenylsulphonyl; R5 inclu... | 09/26/1995 |
| 5403857 | Benzenesulphonamide derivatives having 5-lipoxygenase inhibitory activity The invention concerns benzenesulphonamide derivatives of the formula I ##STR1## wherein R1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; R2 and R3 together form -A2 -X2 -A3 - which defin... | 04/04/1995 |
| 5387701 | Preparation of 4-hydroxymethyltetrahydropyran A process for preparing 4-hydroxymethyltetrahydropyran comprises reacting tetrahydrofurans of the general formula I ##STR1## where R1 is hydrogen, C1 - to C6 -alkyl or --CO--R2, and R2 is hydroge... | 02/07/1995 |
| 5376680 | Oxime derivatives The invention concerns oxime derivatives of the formula I ##STR1## wherein R4 is hydrogen, (1-4C)alkyl, halogeno-(2-4C)alkyl, hydroxy-(2-4C)alkyl, cyano-(1-4C)alkyl, phenyl or phenyl-(1-4C)alkyl; R5 is hydrogen, (1-4C)alkyl, hal... | 12/27/1994 |
| 5360817 | Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid and their use as antiviral agents Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation .and their use in the treatment of viral infections, in particular influenza, are described.... | 11/01/1994 |
| 5360815 | Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, ... | 11/01/1994 |
| 5350765 | Ether-containing inhibitors of 5-lipoxygenase Compounds of the structure ##STR1## where Ar is optionally substituted carbocyclic aryl, 5- or 6-membered heterocyclic aryl, 10-membered bicyclic heterocyclic aryl containing one or two nitrogen atoms, 9- or 10-membered heterocyclic containing one or... | 09/27/1994 |
| 5349071 | Process for preparing tertiary alkynols Processes for synthesizing tertiary alkynols by reacting carbonyl-group-containing compounds with alkynes in the presence of a basic catalyst are disclosed. Preferred products are 6,10,14-trimethyl-4-pentadecyn-6-ol compounds having the structure: ##... | 09/20/1994 |
| 5308852 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, ... | 05/03/1994 |
| 5260442 | Process for the manufacture of crystalline quinolinium salts and their oxidation to 1-alkyl-2-quinolones The invention concerns quinolinium salt intermediates of the formula I ##STR1## and processes for their manufacture; and their use in the manufacture of aryloxymethyl-substituted 1-alkyl-2-quinolone derivatives which are 5-lipoxygenase inhibitors.... | 11/09/1993 |
| 5254581 | Pyran derivatives and their use as inhibitors of 5-lipoxygenase The invention concerns a cyclic ether derivative of the formula I ##STR1## wherein Ar1 is optionally substituted phenyl, naphthyl or a 9- or 10-membered bicyclic heterocyclic moiety; A1 is a direct link to X1 or (1-3C)alky... | 10/19/1993 |
| 5250715 | Optically active 2-methylenepentane derivative and process for preparing same The present invention provides an optically active 2-methylenepentane derivative represented by the general formula ##STR1## (wherein R1 is a protective group for hydroxyl, R3 is a protective group for hydroxyl, X is a halogen a... | 10/05/1993 |
| 5250710 | Dihydropyran derivatives, processes for preparation and use The present invention relates to dihydropyran derivatives, processes for preparing, and processes of using the derivatives. The derivatives are prepared by condensation of lithium dienolate of prenal with an aldehyde or a ketone. The pyran derivative prep... | 10/05/1993 |
| 5225438 | Aryl derivatives The invention concerns an aryl derivative of the formula I, ##STR1## wherein Ar1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X1 is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alk... | 07/06/1993 |
| 5157133 | Dihydropyran derivatives, processes for preparation and use The present invention relates to dihydropyran derivatives, processes for preparing, and processes of using the derivatives. The derivatives are prepared by condensation of lithium dienolate of prenal with an aldehyde or a ketone. The pyran derivative prep... | 10/20/1992 |
| 5149843 | Conjugated diene compounds Conjugated diene compounds of the general formula: ##STR1## which are industrially advantageous intermediates for preparing sarcophytol A useful as an anticarcinogenic promotor or antitumor agent are provided.... | 09/22/1992 |
