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| Number | Title | Issue Date |
| 7915433 | Tri-substituted 2-benzhydryl 5-benzlamino-tetrahydro-pyran-4-OL and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-OL analogues, and novel 3,6 disubstituted pyran derivatives Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti-depressants. ... | 03/29/2011 |
| 7795457 | Carbamate compounds Carbamate compounds having a structure represented by formula I (where R1, R2, R3, R4, R5 and R6 are as defined herein) are useful as anti-tumor agents. ... | 09/14/2010 |
| 7402687 | Dihydrobenzofuran derivatives and uses thereof Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, ... | 07/22/2008 |
| 7365215 | Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (1): wherein R represents a hydrogen atom or a hydrocarbo... | 04/29/2008 |
| 7361388 | Liquid-crystalline compounds having a tetrahydropyran ring The invention relates to liquid-crystalline compounds of formula (I), wherein R11, X11, Z11, Z12, Z13, L11, L12, L13, L14, L15 and L16 have the m... | 04/22/2008 |
| 7354936 | 2-phenylpyran-4-one derivatives The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula processes for their preparation, pharmaceutical compositions containing them, and their medical uses. ... | 04/08/2008 |
| 7304148 | Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain, and processes for producing these An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose ... | 12/04/2007 |
| 7297802 | Production methods of epoxytriazole derivative and intermediate therefor An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with ... | 11/20/2007 |
| 7259166 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of... | 08/21/2007 |
| 7205333 | Multivalent neuraminidase inhibitor conjugates The invention relates to a multimeric compound or a pharmaceutically acceptable salt or derivative thereof which comprises three or more neuraminidase-binding groups attached to a spacer or linking group, in which the neuraminidase-binding group is a compound which ... | 04/17/2007 |
| 7189879 | Process for the production of 1-hydroxymethyl-1,3,5-triazapentane, trihydrochloride A new process for the production of 1-hydroxymethyl-1,3,5-triazapentane, trihydrochloride is described. ... | 03/13/2007 |
| 7186709 | Dihydropyrancarboxamides and uses thereof The present invention provides novel dihydropyrancarboxamide compounds of formula (I): and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R1–R... | 03/06/2007 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7129238 | Mandelic acid derivatives The invention is concerned with novel mandelic acid derivatives of formula (I) wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acc... | 10/31/2006 |
| 7098195 | Fluorinated glucosamine analogs useful for modulating post-translational glycosylations on cells The present invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated N-acetylglucosamines. ... | 08/29/2006 |
| 7091221 | Partial ester of cellulose with nitrogenous carboxylic acid and process for producing the same According to the present invention, there are provided a novel partial ester of a nitrogenous carboxylic acid ester with cellulose, the partial ester being useful as an antibacterial agent, a flame retardant, etc., and a simple and convenient process for preparing t... | 08/15/2006 |
| 7045535 | Compounds useful for inhibiting paramyxovirus neuraminidase Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas: ... | 05/16/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 6949538 | Compounds, compositions, and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 09/27/2005 |
| 6906085 | Tetrahydropyran derivatives as neurokinin receptor antagonists The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7 and R8 represent a variety of subst... | 06/14/2005 |
| 6905786 | Light emitting device material, light emitting device using thereof, and amine compound A compound represented by the following formula (I): wherein R1, R2 and R3each represents an aryl group, a heterocyclic group or an aliphatic hydrocarbon group, provided that at least o... | 06/14/2005 |
| 6852866 | Triazole linked carbohydrates Disclosed is an invention concerning triazolyloligosaccharides, oligosaccharides wherein the bonding between the saccharide groups is via a triazole group and methods for their preparation. ... | 02/08/2005 |
| 6852717 | Compounds useful as anti-inflammatory agents Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds. ... | 02/08/2005 |
| 6849660 | Antimicrobial biaryl compounds Provided are antibacterial compounds having Formula I: In such compositions, X is O or S; Y is CH2; n is 0 or 1. One of R1 and R1′ is —C(O)NR5R5′ | 02/01/2005 |
| 6723858 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosa... | 04/20/2004 |
| 6677355 | Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors Compounds of the formula; ##STR1## are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also disclosed are methods for the preparation of such ... | 01/13/2004 |
| 6638947 | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof This invention is related to carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones represented by Formula I: ##STR1## or a pharmaceutically acceptable salt or prodrug thereof, wherein: Y is oxygen or sulfur; R1, R21... | 10/28/2003 |
| 6617350 | Inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical ... | 09/09/2003 |
| 6608218 | -acyl- and -heteroatom-substituted benzene acetamide glucokinase activators Substituted benzene acetamide compounds and pharmaceutically acceptable salts thereof are useful as glucokinase activators.... | 08/19/2003 |
| 6583299 | -amino-ଲ-sulfonyl hydroxamic acid compounds A family of molecules is disclosed that inhibit matrix metalloprotease (MMP) activity, and particularly inhibit the activity of one or more of MMP-2, MMP-9, or MMP-13, while generally exhibiting little activity against MMP-1. A contemplated compound also ... | 06/24/2003 |
| 6458830 | Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates to compounds of the formula (I): ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are defined herein. The ... | 10/01/2002 |
| 6451766 | Neuraminic acid derivatives, their preparation and their medical use Compounds of formula (I) or their salts or esters: ##STR1## [wherein R1 is alkyl or haloalkyl; R2 and R3 each represents hydrogen or aliphatic acyl; X is hydroxy, halogen, alkoxy, or a group of formula Ra O--, w... | 09/17/2002 |
| 6436930 | Thio derivatives of sordarin as antifungal agents The present invention relates to antifungal compounds having the structural formula: ##STR1## and pharmaceutically acceptable salts, solvates and prodrugs thereof. The present invention further relates to pharmaceutical compositions containing said c... | 08/20/2002 |
| 6391918 | N-sulphonyl and N-sulphinyl phenylglycinamide Novel -amino acid amides of formula (I) as well as possible isomers and mixtures of isomers thereof, wherein the substituents are defined as follows: n is the number zero or one; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycl... | 05/21/2002 |
| 6350761 | Benzenamine derivatives as anti-coagulants This invention is directed to benzenamine derivatives of formula (I): ##STR1## wherein A, W, m, n, R1, R2, R3, R4, R5 and R6 are defined herein. These compounds are useful as anti-coagulants.... | 02/26/2002 |
| 6340702 | Neuraminic acid derivatives, their preparation and their medical use Compounds of formula (I) or their salts or esters: ##STR1## have excellent sialidase inhibitory activity and are therefore useful for the treatment and prevention of influenza and other viral diseases where the replication of the virus is susceptible to s... | 01/22/2002 |
| 6331563 | N-Hydroxy-2-(Alkyl, Aryl, or Heteroaryl, Sulfanyl, Sulfinyl or Sulfonyl)-3-Substituted Alkyl, Aryl or Heteroarylamides as Matrix Metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 12/18/2001 |
| 6265446 | Hydrazine derivatives Hydrazine derivatives of the formula ##STR1## wherein R1 represents lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl, R2 represents heterocyclyl or NR5 R6, R | 07/24/2001 |
| 6242616 | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.... | 06/05/2001 |
| 6235922 | Processes and intermediates for preparing benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## wherein: Y1 and Y2 are each independently hydrogen, alkyl, aryl,... | 05/22/2001 |
