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Class 549/418 - Hydroxy bonded directly at the 3-position and oxygen double bonded directly at the 4-position of the hetero ring (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)


Subclass of Class 549 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which hydroxy is bonded directly at the 3-position
No. of patents: 56
Last issue date: 08/31/2010


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NumberTitleIssue Date
7786316Metalloprotein inhibitors
The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherei...
08/31/2010
7579486Metalloprotein inhibitors
The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherei...
08/25/2009
7419959D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
D-pyranosyl-substituted phenyls of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on ...
09/02/2008
7384558Compositions capable of inhibiting reactive oxygen and carbonyl species
Therapeutic compositions are provided. The compositions include a single molecule that can display both antioxidant and carbonyl trapping properties. This can effectively reduce inflammation, oxidative stress and carbonyl stress, such as to prevent and/or treat card...
06/10/2008
6916844Hydroxy pyranone derivative and preparation method thereof
The present invention provides hydroxy pyranone derivatives and a method for preparing the hydroxy pyranone derivatives. The hydroxy pyranone derivatives of the present invention are significantly effective in promoting the biosynthesis of collagen and in inhibiting...
07/12/2005
6696475Substituted phenyl derivatives, their preparation and use
The present invention discloses compounds having the formula ##STR1## wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers....
02/24/2004
6436930Thio derivatives of sordarin as antifungal agents
The present invention relates to antifungal compounds having the structural formula: ##STR1## and pharmaceutically acceptable salts, solvates and prodrugs thereof. The present invention further relates to pharmaceutical compositions containing said c...
08/20/2002
6384246Process for the preparation of maltol from plants belonging to the genus Abies
A process has been developed for production of a food flavoring compound maltol which comprises (a) extracting the dried and pulverized leaves of the plants belonging to the genus Abies with an alcohol at 20-40° C. and concentrating the solvent to obtain...
05/07/2002
6339162Process for the preparation of tetrahydropyran derivatives
A process of making arbutin and its derivatives comprises solvolyzing an acylated precursor of arbutin or its derivative in a solution comprising an organic solvent and a base, neutralizing the solution with an acid, and crystillizing the product arbutin ...
01/15/2002
6297261Substituted phenyl derivatives, their preparation and use
A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia. ##STR1##...
10/02/2001
6225342Use of calendula glycosides for the treatment of psoriasis
A method and compound for the treatment of disease involving hyperproliferation of dermis cells is provided. In particular, compounds isolated from the species of plants known as calendula have been found to be beneficial in the treatment of psoriasis. An...
05/01/2001
6184245Cyclic ketone derivatives and their medical applications
The present invention relates to cyclic ketones represented by the following formula ##STR1## and to drugs in which an effective component is such a cyclic ketone or a pharmacologically acceptable salt thereof. The cyclic ketones of the present invention ...
02/06/2001
6136853Sordarin derivatives
PURPOSE: To produce a novel antibiotic substance zofimarin having antimicrobial activity against fungi and obtain an antimicrobial agent containing the antibiotic substance zofimarin as an active constituent, by cultivating a microorganism, belonging to t...
10/24/2000
6054478Antifungal sordaridin derivatives
Compounds of the formula (I) ##STR1## and pharmaceutically acceptable salts or metabolically labile derivatives thereof, processes for their preparation, their use as antifungal agents and intermediates for use in their preparation....
04/25/2000
6040463Sordarin derivatives
Sordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops....
03/21/2000
6030997Acid labile prodrugs
The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and a blocking group, characterized by the presence of a covalent bond which is cleaved at pH values below 7.0. The prodrug...
02/29/2000
6030996Mur D inhibiting compounds, compositions containing such compounds and methods of use
The present invention addresses compounds which inhibit Mur D. The compounds are represented by structural formula 1: ##STR1## wherein: X represents OH, OC1-6 alkyl, O-aryl, O-Har, uridinyl, 5-iodouridinyl or O--Y+, wherein Y
02/29/2000
59729964-cyano-4-deformylsordarin derivatives
4-Cyano-4-deformylsordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops....
10/26/1999
5939565Recovery of γ-pyrones
A process for recovering γ-pyrones such as maltol and/or ethyl maltol from solutions containing other substances involves an elution chromatographic treatment using a stationary phase that separates the γ-pyrones from the other substances by means of io...
08/17/1999
5908941Method of synthesizing gamma pyrones
Maltol and ethyl maltol can be produced from a haloenone intermediate by reacting the intermediate with acid in a reaction medium comprising an aprotic solvent....
06/01/1999
5777136Process for the glycosidation of colchicine derivatives and the products obtained thereby
A process for the preparation of compounds having the formula ##STR1## wherein: R is a methoxy or thiomethyl group; R1 is a ଲ-D-glycopyranosyloxy or 6-deoxygalactopyranosyloxy residue; and R2 is a C1 -C7 alkyl ...
07/07/1998
5767094Propiophenone derivative and processes for preparing the same
A propiophenone derivative the formula ›I!: ##STR1## wherein R' is a lower alkanoyl group and R" is a hydrogen atom, or R' is a hydrogen atom and R" is a lower alkoxycarbonyl group, or a pharmaceutically acceptable salt thereof. Said compounds have ...
06/16/1998
5763626Maltol recovery
Pure maltol is recovered from a mixture containing maltol by extraction into an aqueous solution, optionally in the presence of a substantially water-immiscible solvent in which the maltol in the mixture is substantially insoluble....
06/09/1998
5646312Process of aqueous extraction of maltol
Disclosed herein is a process where maltol is extracted from a source material containing maltol by employing an aqueous extraction process wherein reverse osmosis is utilized to concentrate an aqueous extract of maltol. The maltol in the concentrated aqu...
07/08/1997
5633089Sorbitan ester lubricant and magnetic recording medium employing the same
There is provided a lubricant which is produced by dissolving a sorbitan ester compound in a solvent such as hexane or toluene. In the sorbitan ester compound, at least one of hydroxyl groups of 1,5-sorbitan is linked by ester linkage to a perfluoro polye...
05/27/1997
5602262Process for the preparation of 2-deoxy-2,2-difluoro-ଲ-D-ribo-pentopyranose
A process for producing intermediate compounds 2-deoxy 2,2-difluoro-ଲ-D-ribo-pentopyranose (III) from 3,3-difluoro-4,5,6-O-trihydroxy-5,6-O-(1-ethylpropylidene)hexene (I). The process of preparing intermediate compound (I) involves reacting D-g...
02/11/1997
5536850Substance DC114-A1
The present invention relates to a novel substance DC114-A1 represented by the following formula (I): ##STR1##...
07/16/1996
5523421Kojic acid derivatives
Disclosed herein is novel kojic acid derivatives represented by the following formula (I): ##STR1## wherein, R1 is a hydrogen atom or hydroxyl group; and R2 is a hydroxyl group, having a strong activity of inhibiting tyrosinase,...
06/04/1996
5486624Kojic acid derivative
Kojic acid derivatives of the following formula (I) ##STR1## where R is a hydrogen atom or methyl group, as radical scavengers and strong inhibitors of tyrosinase, an enzyme involved in a melanin formation....
01/23/1996
5440053Recovery of maltol through aqueous extraction
Disclosed is a process for recovering maltol from water-insoluble source material containing maltol, comprising extracting the maltol with a hot aqueous solution containing a solute which increases the immiscibility between said source material and said s...
08/08/1995
5334518Process for preparation of gamma-pyrone derivatives
Disclosed is a novel process for the production of pyrocomenic acid [3-hydroxy-4(1H)-pyran-4-one and rubiginol [3,5-dihydroxy-4(1H)-pyran-4-one, which are starting materials for synthesis of maltols useful as food spices as well as additives for cosm...
08/02/1994
5231190Squarylium compounds, and processes and intermediates for the synthesis of these compounds
Squarylium compounds of the formula: ##STR1## wherein Q1 and Q2 are each independently a pyrylium, thiopyrylium, selenopyrylium, benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus, and R1 and R2 a...
07/27/1993
5221756Method for the recovery and purification of maltol
Pure maltol is recovered from maltol containing mixture by co-distillation with an aliphatic or cylcloaliphatic hydrocarbon or hydrocarbon mixture in which the maltol is substantially insoluble....
06/22/1993
5141954Antifungal carbazate
A new carbazate represented by the formula ##STR1## is found to be antifungal and especially useful in the treatment of mycotic infections caused by the Cryptococcus species....
08/25/1992
5093505Novel heterocyclic compound, carcinostatic agent, and carcinoma controlling method
Heterocyclic compounds of the general formula: ##STR1## wherein R11 is a hydroxyl group or a lower alkoxy group, R12 is a lower alkoxy group, R13 is a saturated or unsaturated hydrocarbon group, X is an oxygen atom or...
03/03/1992
5075461Process for the manufacture of γ-pyrones
A process for the manufacture of 3-hydroxy-2-alkyl-4-pyrones of formula I is provided. ##STR1## The process comprises cyclizing a compound of formula II, ##STR2## in acidic medium and hydrolyzing the ester formed thereby to produce compound...
12/24/1991
4545982Pyranone compounds and skin-lightening cosmetic preparations or local demelanizing agents containing the same
Novel acyl compounds 3-acyloxy-4(H)-pyran-4-ones were obtained by reacting 3-hydroxy-4(H)-pyran-4-one with acyl halides. The acyl compounds and their starting compound exhibit a skin-lightening effect on the skin and are preferably used as an active const...
10/08/1985
4443621p-Nitrophenyl 3-bromo-2,2-diethoxy-propionate and synthetic utility therefor
p-Nitrophenyl 3-bromo-2,2-diethoxypropionate, useful in the synthesis of highly functionalized small molecules and heterocycles, including pyromeconic acid and 6-methylpyromeconic acid....
04/17/1984
4435584Preparation of gamma-pyrones
2-Methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is subs...
03/06/1984
4390709Preparation of gamma-pyrones
Maltol (3-hydroxy-2-methyl-gamma-pyrone) is prepared from furfural through intermediates (a) 1-(2-furyl)-1-ethanol; (b) 2-(1-hydroxyethyl)-2,5-dialkoxy-2,5-dihydrofuran; (c) alkyl or aralkyl-2-methyl-2H-pyran-3(6H)-one; and (d) 2-alkyl or aralkyl-4-m...
06/28/1983
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