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| Number | Title | Issue Date |
| 8183398 | 5-hydroxy-2-methyl-4H-pyran-4-one esters as novel tyrosinase inhibitors Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions. ... | 05/22/2012 |
| 8183397 | Synthesis of statins The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin. ... | 05/22/2012 |
| 7902384 | Estrogenic-active compounds and application thereof The present invention relates to compounds having estrogenic activity selected from the group consisting of Loliolide, (4S,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one, (4R,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one and analogues thereof. The compounds of ... | 03/08/2011 |
| 7737287 | Anomeric derivatives of monosaccharides This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other pro... | 06/15/2010 |
| 7576225 | 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy) heptanoic acid, preparation process for the same and dauer effect thereof The present invention relates to a determination of a stereochemistry, a synthesis and dauer effect of 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy) heptanoic acid as a pheromone isolated from the Caenorhabditis elegance related to suppress of aging and stress. It bec... | 08/18/2009 |
| 7521568 | Enantiopure 4-deoxypentenosides, dihydropyrans and tetrahydropyrans and syntheses thereof Enantiopure substituted 4-deoxypentenosides (4-DPs) and related dihydropyrans (DHPs) are prepared from common carbohydrates via a novel process. The 4-DPs and related DHPs are amenable to a broad range of stereoselective transformations and are used as synthetic int... | 04/21/2009 |
| 7442839 | Phenethanolamine derivative for the treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis an... | 10/28/2008 |
| 7439352 | Process for the production of anhydrosugar alcohols A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst, and subsequent purification of the anhydrosugar alcohol. In some emb... | 10/21/2008 |
| 7419959 | D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture D-pyranosyl-substituted phenyls of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on ... | 09/02/2008 |
| 7358273 | Inhibitors of caspases The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and... | 04/15/2008 |
| 7288624 | Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace... | 10/30/2007 |
| 7258902 | Chiral 3,4-dihydro-2H-pyran compounds The invention relates to chiral 3,4-dihydro-2H-pyran compounds and diastereomers thereof, and to the use of these compounds as chiral dopants for liquid-crystalline systems. The invention furthermore relates to non-polymerizable or polymerizable liquid-crysta... | 08/21/2007 |
| 7153498 | Water-in-oil emulsion and its use as a cosmetic A composition, comprising, in a physiologically acceptable medium, an aqueous phase dispersed in an oily phase by means of an emulsifier of at least one oligomer or one polymer derived from a polyolefin, comprising a polyolefinic apolar component comprising at least... | 12/26/2006 |
| 7138550 | Bridged carbocyclic compounds and methods of making and using same Disclosed herein is a fluorinated bridged carbocyclic compound that can be polymerized by itself or with at least one other ethylenically unsaturated monomer to provide a polymer. The polymer may be used, for example, within a sub-300 nm photoresist composition. Als... | 11/21/2006 |
| 7132447 | Substance FKI-1083 and process for producing the same The present invention is comprised of culturing microorganism having ability to produce FKI-1083 substance represented by the formula: in a medium, accumulating FKI-1083 substance in the cultured medium, and isol... | 11/07/2006 |
| 7119213 | Pharmacologically active isolated or purified dauer pheromone compound for controlling aging and stress and method for isolating and characterizing the same The present invention discloses a method for effectively isolating and purifying a physiological active dauer pheromone compound having the following structural formula I related to aging and stress of C. elegans, and determination of the structure of such ma... | 10/10/2006 |
| 7056742 | High Level production of arbutin in green plants This invention relates to methods and materials to produce hydroquinone glucoside in genetically modified green plants and microorganisms. ... | 06/06/2006 |
| 7030156 | Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to ... | 04/18/2006 |
| 6949660 | Chiral (1pyrrolino) fullerene derivatives An E-isomeric fulleropyrrolidine compound of formula (I): is disclosed. Also disclosed is a method for preparing and polymers prepared from such a compound. ... | 09/27/2005 |
| 6949538 | Compounds, compositions, and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 09/27/2005 |
| 6919160 | Acrylic compounds for sub-200 nm photoresist compositions and methods for making and using same Disclosed herein is an acrylic compound that can be polymerized by itself or with at least one other ethylenically unsaturated monomer to provide a polymer. The polymer may be used, for example, within a sub-200 nm photoresist composition. Also disclosed is a method... | 07/19/2005 |
| 6902777 | Liquid-crystalline medium A liquid-crystalline mediums which contain one or more compounds of the formula A and at least one compound of the formula B wherein compounds of formula A contain at lea... | 06/07/2005 |
| 6878727 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus ... | 04/12/2005 |
| 6852711 | HIV protease inhibitors The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the... | 02/08/2005 |
| 6852866 | Triazole linked carbohydrates Disclosed is an invention concerning triazolyloligosaccharides, oligosaccharides wherein the bonding between the saccharide groups is via a triazole group and methods for their preparation. ... | 02/08/2005 |
| 6849748 | Process for the production of anhydrosugar alcohols A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst, and subsequent purification of the anhydrosugar alcohol. Very high p... | 02/01/2005 |
| 6828447 | Compounds and methods for the inhibition of the expression of VCAM-1 This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases. ... | 12/07/2004 |
| 6828276 | Herbicidally active benzoylcyclohexanediones There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radic... | 12/07/2004 |
| 6818657 | Bioprecursors of a retinoic derivative and pharmaceutical and/or cosmetic compositions The present invention relates to a ternary glucosyl complex which is a bioprecursor of at least one retinoic active ingredient for percutaneous application, having formula (I), wherein E represents a linear hydrocarbon spacer group that is branched or cyclized and h... | 11/16/2004 |
| 6790953 | Ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 09/14/2004 |
| 6723858 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosa... | 04/20/2004 |
| 6686481 | Highly purified simvastatin compositions The present invention relates to a process to prepare semi synthetic statins, to intermediates formed during said process and to highly purified simvastatin produced by the process.... | 02/03/2004 |
| 6608061 | Bisaryl compound and medicament for cancer treatment comprising the same A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1 --S--R1 --S--Ar2 wherein R1 represents a nonmetal bridging... | 08/19/2003 |
| 6608104 | Gem substituted hydroxamic acids A compound of the formula ##STR1## wherein R1 -R13, X, Z and Q are as defined above, useful in the treatment of arthritis, cancer, and other diseases involving the dysregulated production/release of reprolysins such as Aggrecanase an... | 08/19/2003 |
| 6552073 | Compounds and methods of treating cell proliferative diseases The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative activities, as well as methods for treating various diseases associated with abnormal cell ... | 04/22/2003 |
| 6537527 | Skin lightening compositions This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure: ##STR1## wherein each X is halo; m is 1 to 4; each R' and R" is independently selected from hydrogen, halo, C1 | 03/25/2003 |
| 6528510 | HIV protease inhibitors The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therap... | 03/04/2003 |
| 6500963 | Process for preparing optically active dihydropyrones The invention relates to a new process for preparing optically active dihydropyrones, new intermediate products which may be obtained by this synthesis, and their use as starting compounds in the preparation of pharmaceutically active compounds.... | 12/31/2002 |
| 6458830 | Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates to compounds of the formula (I): ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are defined herein. The ... | 10/01/2002 |
| 6455709 | E-isomeric fullerene derivatives An E-isomeric fulleropyrrolidine compound of formula (I): ##STR1## is disclosed. Also disclosed is a method for preparing and polymers prepared from such a compound.... | 09/24/2002 |
