Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 7745649 | Processes for preparing tetrahydropyran-4-one and pyran-4-one The present invention relates to a process for preparing tetrahydropyran-4-one represented by the formula (1): which comprises reacting at least one kind of dihydropyran-4-one and pyran-4-one represented by the formula (2):... | 06/29/2010 |
| 7417059 | Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of d... | 08/26/2008 |
| 7361388 | Liquid-crystalline compounds having a tetrahydropyran ring The invention relates to liquid-crystalline compounds of formula (I), wherein R11, X11, Z11, Z12, Z13, L11, L12, L13, L14, L15 and L16 have the m... | 04/22/2008 |
| 7288680 | Benzotropolone derivatives and modulation of inflammatory response The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective ant... | 10/30/2007 |
| 7265110 | Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates compounds of the formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, and R10 represent a variety of substituents; A represents NR9 ... | 09/04/2007 |
| 7265230 | Herbicides Compounds of formula I wherein the substituents are defined as in claim 1, as well as the agronomically acceptable salts, isomers and enantiomers of these compounds, as well as the agronomically acceptable salts/... | 09/04/2007 |
| 7230125 | Methods of performing cycloadditions, reaction mixtures, and methods of performing asymmetric catalytic reactions Methods of performing cycloadditions are described that include (a) combining a first reactant and a second reactant in a hydrogen bonding solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form a cycloadduct. Methods ... | 06/12/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7087790 | Benzotropolone derivatives and modulation of inflammatory response The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective ant... | 08/08/2006 |
| 7071359 | Neuropathy improvers containing nitrogenous compounds as the active ingredient A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. [Here, G represents G1 shown below | 07/04/2006 |
| 7071212 | N-(4-carbamimidoyl-phenyl)-glycine derivatives The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: wherein R1, E, X1 to X4 and G1 and G2 are as defined in ... | 07/04/2006 |
| 7026498 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming react... | 04/11/2006 |
| 6949538 | Compounds, compositions, and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 09/27/2005 |
| 6946560 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming react... | 09/20/2005 |
| 6942980 | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities Methods of characterizing and identifying negative hormones of nuclear receptors. Also disclosed are methods of making modulators of retinoid nuclear receptor transactivation activity, assays for agonists, antagonists, and negative hormones of the RAR receptor, and ... | 09/13/2005 |
| 6916844 | Hydroxy pyranone derivative and preparation method thereof The present invention provides hydroxy pyranone derivatives and a method for preparing the hydroxy pyranone derivatives. The hydroxy pyranone derivatives of the present invention are significantly effective in promoting the biosynthesis of collagen and in inhibiting... | 07/12/2005 |
| 6916847 | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade The invention relates to polycyclic aryl and heteroaryl substituted 4-pyrone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety... | 07/12/2005 |
| 6909014 | Intermediates for the synthesis of ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 06/21/2005 |
| 6906085 | Tetrahydropyran derivatives as neurokinin receptor antagonists The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7 and R8 represent a variety of subst... | 06/14/2005 |
| 6905786 | Light emitting device material, light emitting device using thereof, and amine compound A compound represented by the following formula (I): wherein R1, R2 and R3each represents an aryl group, a heterocyclic group or an aliphatic hydrocarbon group, provided that at least o... | 06/14/2005 |
| 6902777 | Liquid-crystalline medium A liquid-crystalline mediums which contain one or more compounds of the formula A and at least one compound of the formula B wherein compounds of formula A contain at lea... | 06/07/2005 |
| 6875791 | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade The invention relates to polycyclic aryl and heteroaryl substituted 4-pyrone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety... | 04/05/2005 |
| 6870058 | Compounds which mimic the chemical and biological properties of discodermolide Compounds which mimic the chemical and/or biological activity of discodermolide are provided and intermediates useful in their preparation. ... | 03/22/2005 |
| 6864278 | Antifungal agents of sordarin derivatives Sordarin derivatives prepared from C-11-hydroxysordarin are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops. ... | 03/08/2005 |
| 6800785 | Process for the synthesis of estrogen receptor modulators The present invention relates to processes for the synthesis of intermediates useful for the synthesis of estrogen receptor modulators. The process includes new methods for annelating 5-, 6- and 7-membered cycloalkenones onto an indanone. ... | 10/05/2004 |
| 6790968 | Substance FKI-0076 and process for producing the same A microorganism having ability to produce FKI-0076 substance represented by the following formula [I] is cultured in a medium allowing for the accumulation of FKI-0076 substance in the culture liquid. The FKI-0076 substan... | 09/14/2004 |
| 6790953 | Ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 09/14/2004 |
| 6723858 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosa... | 04/20/2004 |
| 6693178 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present... | 02/17/2004 |
| 6680340 | Anti-hypercholesterolemic drug combination This invention provides a drug combination comprised of a thyroid hormone receptor beta agonist with a fibrate in therapeutically effective amounts, which is useful for reducing cholesterol synthesis, lowering plasma cholesterol levels and lowering plasma... | 01/20/2004 |
| 6664411 | Heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptab... | 12/16/2003 |
| 6664272 | Curcumin analogs with anti-tumor and anti-angiogenic properties The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.... | 12/16/2003 |
| 6653296 | Antiretroviral enantiomeric nucleotide analogs Resolved enantiomers of the formula (IA) and (IB) ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.... | 11/25/2003 |
| 6653489 | Processes for producing tetrahydropyranyl-4-sulfonates and 4-aminotetrahydropyran compounds The present invention is to provide a process for producing a tetrahydropyranyl-4-sulfonate which comprises allowing 3-buten-1-ol which is easily available to react with a formaldehyde compound and an organic sulfonic acid, and a process for producing a 4... | 11/25/2003 |
| 6552073 | Compounds and methods of treating cell proliferative diseases The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative activities, as well as methods for treating various diseases associated with abnormal cell ... | 04/22/2003 |
| 6537527 | Skin lightening compositions This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure: ##STR1## wherein each X is halo; m is 1 to 4; each R' and R" is independently selected from hydrogen, halo, C1 | 03/25/2003 |
| 6489343 | Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates to compounds of the formula (I): ##STR1## wherein R1 is fluorine or trifluoromethyl; R2 is fluorine or trifluoromethyl; R3 is methyl or hydroxymethyl; R4 represents a variety of substituents;... | 12/03/2002 |
| 6479673 | Antiretroviral enantiomeric nucleotide analogs Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.... | 11/12/2002 |
| 6458830 | Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates to compounds of the formula (I): ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are defined herein. The ... | 10/01/2002 |
| 6448260 | Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 09/10/2002 |
