Class 549/412 - Processes for chemical modification of substituents on the carbocyclic ring of the bicyclo ring system (e.g., alkylation of tocopherols, etc.)

Subclass of Class 549 - Organic compounds -- part of the class 532-570 series
Definition: Processes whereby substituents on the carbocyclic ring of
No. of patents: 32
Last issue date: 01/31/2012

Number	Title	Issue Date
8106223	Process for the production of alpha-tocotrienol and derivatives The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols. ...	01/31/2012
7384558	Compositions capable of inhibiting reactive oxygen and carbonyl species Therapeutic compositions are provided. The compositions include a single molecule that can display both antioxidant and carbonyl trapping properties. This can effectively reduce inflammation, oxidative stress and carbonyl stress, such as to prevent and/or treat card...	06/10/2008
7312232	Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein w...	12/25/2007
7145023	Processes for preparing solid tocopherol succinate calcium and magnesium salts Processes for preparing salts of alcohol polybasic acid partial esters are described wherein an alcohol polybasic acid partial ester is reacted with a compound selected from the group consisting of metal oxides, metal hydroxides, metal carbonates and mixtures thereo...	12/05/2006
7034054	Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions. ...	04/25/2006
6930191	Methods of preparing tocopherol compound salts in supercritical media Methods for preparing salts of tocopherol dibasic acid hemiesters in supercritical media are described. ...	08/16/2005
6790967	Process for the preparation of vitamin E The invention concerns a novel method for preparing vitamin E. More particularly, it concerns a novel method for the condensation of trimethylhydroquinone and isophytol. ...	09/14/2004
6784303	Method for continuously acylating chromanol ester derivatives A process is described for continuously preparing chromanol ester derivatives, in particular for continuously preparing carboxylic esters of tocopherols and tocotrienols by continuous acylation with carboxylic acids or carboxylic anhydrides. ...	08/31/2004
6703384	Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having a structural formula ##STR1## where X and Y independently are oxygen, nitrogen o r sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, ...	03/09/2004
6566571	Method of producing biaryls Process for preparing monofunctional, bifunctional and/or polyfunctional biaryls of the formula (I) Ar--Ar' (I) by reacting haloaromatics of the formula (II) Ar--X (II) with boron compounds of the formula (IIIa), (IIIb) and/or (IIIc) ##STR1## in the presence...	05/20/2003
6518439	Method for preparing vitamin e The invention concerns a novel method for preparing vitamin E. More particularly, it concerns a novel method for the condensation of Arimethylhydroquinone and isophytol....	02/11/2003
6452023	Process for preparing d,l-଱-tocopherol A process for the manufacture of d,l-଱-tocopherol by the acid-catalyzed condensation of trimethylhydroquinone with isophytol or phytol in ethylene or propylene carbonate or a mixture of both carbonates, or in a mixture of one or both of the carbonat...	09/17/2002
6417223	Tocopherols, tocotrienols, other chroman and side chain derivatives and uses therof The present invention provides an antiproliferative compound having the structural formula ##STR1## wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester,...	07/09/2002
6410752	Tocopherol derivatives and method for preparation thereof An object of the present invention is to provide the tocopherol derivatives represented by the following formula (I), and their salts: ##STR1## Wherein, R1, R2 and R3 are H or methyl group, and at least one positions selec...	06/25/2002
6384245	Method for preparing DL-଱-tocopherol with high yield Disclosed is a method for preparing DL-଱-tocopherol with a high yield through the condensation of isophytol or phytol derivatives with trimethylhydroquinone (TMHQ) in the presence of a Zn--Al heterogeneous catalyst system. At 80 to 120° C., the con...	05/07/2002
6355811	Polyoxypropylenepolyethylene vitamin E and preparation thereof Disclosed is polyoxypropylenepolyoxyethylene vitamin E, represented by formula (I). It is prepared by subjecting vitamin E to polyethoxylation and then, to polypropoxylation to a proper extent. The vitamin E is of superior anti-oxidation activity with wat...	03/12/2002
6348605	Process for preparing 3-hydroxymethyl chromen-4-ones 3-(Hydroxymethyl)chromen-4-ones of formula (I) are described and a process for preparing said compounds. The process consists in reacting the compounds of general formula (II) wherein R is hydrogen, halogen, alkyl having 1 to 4 carbon atoms or alkoxy havi...	02/19/2002
6262279	Preparation of tocopherols The invention provides methods for producing tocopherol compounds of the Vitamin E family by reduction of various 4-chromanone trienol materials. In preferred embodiments the invention provides methods of preparing and hydrogenating 4-chromanone trienols ...	07/17/2001
6222051	Alpha-tocopherol 4-aminobenzoic acid ester compounds and method for preparing the same Alpha-tocopherol 4-aminobenzoate compounds, represented by formula (I), are prepared by the esterification of alpha-tocopherol with 4-aminobenzoic acid. The esters are converted into the element compounds in vivo, so that they have alpha-tocopherol's biol...	04/24/2001
6218552	3-phenyl-7-[4-(tetrahydrofurfuryloxy)phenyl]-1,5-dioxa-s-indacene-2,6-dione A compound, 3-phenyl-7-[4-(tetrahydrofurfuryloxy)phenyl]-1,5-dioxa-s-indacene-2,6-dion e, which has a structure of crystals exhibiting the strongest peak at an angle of diffraction, 2θ, of 4.7°, among peaks appearing within the range of not smaller ...	04/17/2001
6096907	Process for preparing chromanol derivatives A process for preparing chromanol derivatives of the formula I ##STR1## where n is from 1 to 10, R1, R2, R3, R4 independently of one another are hydrogen or C1 -C4 alkyl, R5 is h...	08/01/2000
6066731	Aminomethylation of tocopherols A process for the production of a Mannich reagent comprises reacting formaldehyde, especially paraformaldehyde, with a secondary amine in the complete or almost complete absence of a solvent. An alternative comprises reacting a diaminomethane produced fro...	05/23/2000
6005122	Preparation of ଱-tocopherol or ଱-tocopheryl acetate by reacting trimethylhydroquinone and phytol or isophytol, with recycling of the zinc halide condensation catalyst A process for preparing ଱-tocopherol or ଱-tocopheryl acetate by reacting 2,3,5-trimethylhydroquinone with isophytol or phytol in the presence of a zinc halide condensation catalyst and a proton donor in a solvent with or without subsequent est...	12/21/1999
5932748	Process for permethylating non-଱-tocopherols to produce ଱-tocopherol A process for the conversion of non-଱-tocopherols into (଱-tocopherol by the catalytic permethylation is disclosed. The methylating agent is methanol in the near-critical or super-critical pressure and temperature region or a mixture which is e...	08/03/1999
5917060	Preparation of chromanyl derivatives A process for the preparation of chromanyl derivatives of the formula I ##STR1## where R1 is hydrogen, C1 -C8 -alkyl, aryl, aralkyl, Si(R4)3, C(.dbd.O)R4 or C1 -C4 -al...	06/29/1999
5892058	Hydroxymethylation of tocopherols A method of producing ଱-tocopherol from non-଱-tocopherols is disclosed. In the disclosed method, non-଱-tocopherols are hydroxymethylated and reduced to ଱-tocopherol in a single step by reacting formaldehyde or a formaldehyde-produc...	04/06/1999
5869704	Water-dispersible or water-soluble D-tocotrienol compounds and methods for making therefor The invention relates to a water-dispersible or water-soluble compound having the structure I ##STR1## wherein, R1,R2, and R3 are, independently, hydrogen or methyl, and R4 is--(CH2 CH2	02/09/1999
5869703	Nonionic vitamin E derivatives and a method for the preparation thereof, and polymeric ampliphilic vesicles made therefrom Disclosed herein are nonionic vitamin E or polyethoxylated vitamin E derivatives represented by the following formula (I) and a method for the preparation thereof, and polymeric amphiphilic vesicles made therefrom. ##STR1## wherein, n is an integer f...	02/09/1999
5504220	Preparation of ଱-tocopherol Disclosed is an improved process for the preparation of alpha-tocopherol by the hydroxymethylation followed by the hydrogenation of non-଱-tocopherols comprising ଲ-, γ-, and δ-tocopherols using a particular palladium on alumina catalyst ...	04/02/1996
4977282	Production of d-alpha-tocopherol from natural plant sources Quantities of natural tocopherol can be aminoalkylated to selectively introduce functional groups onto the 5 and 7 positions of the non-alpha-tocopherol homologues. Natural d-alpha-tocopherol can then be separated from the aminoalkylated non-alpha-tocophe...	12/11/1990
4925960	Preparation of d-଱-tocopherol from natural intermediates d-଱-Tocopherol is prepared from a mixture obtained from natural intermediates and containing ଱-, ଲ-, γ- and δ-tocopherols, by methylation at the aromatic ring of the tocopherols by reaction with formaldehyde or with a compound which do...	05/15/1990
4353906	Chromanol derivatives and their use for treating hypertension Compounds of the formula (I): ##STR1## wherein: R1 and R2 are independently selected from a hydrogen atom and a C1-3 alkyl group; R3 is a hydrogen atom, a C1-3 alkyl or C2-4 acyl group; R	10/12/1982

PatentStorm

Bizarre Patents

PatentStorm News

Class 549/412 - Processes for chemical modification of substituents on the carbocyclic ring of the bicyclo ring system (e.g., alkylation of tocopherols, etc.)