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| Number | Title | Issue Date |
| 7803955 | Method for preparing 2,5,7,8-tetramethyl-2-(2′-carboxyethyl)-6-acetoxychroman-precursor- α-CEHC precursor The contemplated invention relates to the field of synthesis of biologically active substances, namely to the synthesis of an acetate derivative of the main water-soluble α-tocopherol metabolite known under the name of α-CEHC, which is prepared by the acid-catalyz... | 09/28/2010 |
| 7435836 | Process for the manufacture of tocopheryl acylates The present invention relates to a process for the manufacture of a tocopheryl acylate which comprises reacting a tocopherol with an acylating agent in the presence of a solid basic catalyst comprising, an alkali metal and/or alkaline earth metal preferably on a sol... | 10/14/2008 |
| 7384558 | Compositions capable of inhibiting reactive oxygen and carbonyl species Therapeutic compositions are provided. The compositions include a single molecule that can display both antioxidant and carbonyl trapping properties. This can effectively reduce inflammation, oxidative stress and carbonyl stress, such as to prevent and/or treat card... | 06/10/2008 |
| 7357923 | Topical medicament for skin injuries and disorders A topical product for the application to the skin or mucosal surfaces comprises yellow beeswax in an oleaginous base of, e.g., olive oil, sunflower oil, almond oil, cod liver oil, castor oil, along with an excipient vehicle. The product is useful in connection with ... | 04/15/2008 |
| 7342121 | Method of producing high density tocopherol acid succinate A process is described for making high density tocopherol succinate powder. In this process, a solution of tocopherol succinate is prepared in hexane. The hexane is removed under heat and pressure. The resulting powder is then mixed with hexane yielding larger parti... | 03/11/2008 |
| 7312232 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein w... | 12/25/2007 |
| 7300954 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carbo... | 11/27/2007 |
| 7161055 | Method of extracting and isolating minor components from vegetable oil A process for the separation and recovery of minor components from vegetable oil such as palm oil. Esterified palm oil is subjected to molecular distillation giving a concentrate rich in minor components. The concentrate is then adsorbed to adsorbents such as normal... | 01/09/2007 |
| 7084172 | Bioprecursors for percutaneous application The invention concerns a bioprecursor of formula (I), wherein A1 and A2 represent independently of each other a radical derived from a molecule capable of being used in dermatology or in cosmetology; X and Y represent independently of each othe... | 08/01/2006 |
| 6930191 | Methods of preparing tocopherol compound salts in supercritical media Methods for preparing salts of tocopherol dibasic acid hemiesters in supercritical media are described. ... | 08/16/2005 |
| 6790967 | Process for the preparation of vitamin E The invention concerns a novel method for preparing vitamin E. More particularly, it concerns a novel method for the condensation of trimethylhydroquinone and isophytol. ... | 09/14/2004 |
| 6784303 | Method for continuously acylating chromanol ester derivatives A process is described for continuously preparing chromanol ester derivatives, in particular for continuously preparing carboxylic esters of tocopherols and tocotrienols by continuous acylation with carboxylic acids or carboxylic anhydrides. ... | 08/31/2004 |
| 6770672 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is... | 08/03/2004 |
| 6716873 | Tocopherol ester compounds Disclosed are novel tocopherol ester compounds having the formula wherein X is a chain of 2 or 3 carbon atoms, e.g., ethylene and trimethylene, joining the 2 carbonyl groups to which they are bonded; and R1 is... | 04/06/2004 |
| 6703384 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having a structural formula ##STR1## where X and Y independently are oxygen, nitrogen o r sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, ... | 03/09/2004 |
| 6696413 | Pharmaceutical preparation with cyclosporin A The invention relates to a pharmaceutical preparation which consists of or contains cyclosporin A, an emulsifying -tocopherol derivative, an ethoxylation product of vegetable oils, fatty acids or fats as a further emulsifier and a pharmaceutically ... | 02/24/2004 |
| 6683194 | Tocopherol derivatives Tocopherol derivatives are provided. In one embodiment, the tocopherol derivative includes a tocopherol moiety covalently coupled to branched hydrophilic moiety. In another embodiment, the tocopherol derivative includes a first tocopherol moiety covalentl... | 01/27/2004 |
| 6518439 | Method for preparing vitamin e The invention concerns a novel method for preparing vitamin E. More particularly, it concerns a novel method for the condensation of Arimethylhydroquinone and isophytol.... | 02/11/2003 |
| 6417223 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses therof The present invention provides an antiproliferative compound having the structural formula ##STR1## wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester,... | 07/09/2002 |
| 6387882 | Vitamin E derivatives The present invention provides novel vitamin E derivatives represented by the following formula (I) wherein: R1 and R2 are the same or different and each denotes hydrogen or methyl, R3 denotes an S-linked SH compound (glut... | 05/14/2002 |
| 6365758 | Preparation of tocopheral carboxylates or tocotrienyl esters by acid-catalyzed reaction with carboxylic acids A process for preparing tocopheryl esters or tocotrienyl esters by acid-catalyzed esterification of a tocopherol or a tocotrienol in a solvent while stirring at elevated temperature, which comprises a) carrying out the esterification with the appropriate carbo... | 04/02/2002 |
| 6329535 | Process for preparing esterified chroman compounds A process for preparing esterified chroman compounds from 2,6,6-trimethylcylohex-2-ene-1,4-dione, wherein the esterified intermediates are reacted directly to give the desired chroman derivatives without an additional purification step.... | 12/11/2001 |
| 6222051 | Alpha-tocopherol 4-aminobenzoic acid ester compounds and method for preparing the same Alpha-tocopherol 4-aminobenzoate compounds, represented by formula (I), are prepared by the esterification of alpha-tocopherol with 4-aminobenzoic acid. The esters are converted into the element compounds in vivo, so that they have alpha-tocopherol's biol... | 04/24/2001 |
| 6136985 | CLA esters and uses thereof The present invention provides CLA esters and uses thereof. More particularly, the present invention provides a composition for topical use comprising CLA esters and a topical carrier. In addition, the present invention specifically provides tocopheryl CL... | 10/24/2000 |
| 6136851 | Tocopherol esters and their cosmetic and pharmaceutical uses The invention relates to an ester. The ester is characterized in that it presents the following chemical formula (I): ##STR1## in which: R1, R2 and R3 independently represent an atom of hydrogen, a methyl radical, A r... | 10/24/2000 |
| 6130343 | Method of producing a tocopherol product A process of producing a coated tocopheryl succinate is provided. The process comprises contacting a tocopheryl succinate powder with a solution of a pharmaceutically acceptable binder, said tocopheryl succinate being maintained in a fluidized bed during ... | 10/10/2000 |
| 6096907 | Process for preparing chromanol derivatives A process for preparing chromanol derivatives of the formula I ##STR1## where n is from 1 to 10, R1, R2, R3, R4 independently of one another are hydrogen or C1 -C4 alkyl, R5 is h... | 08/01/2000 |
| 6090810 | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities Aryl-substituted and aryl and (3-oxo-1-propenly)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invented RAR antagonists... | 07/18/2000 |
| 6066731 | Aminomethylation of tocopherols A process for the production of a Mannich reagent comprises reacting formaldehyde, especially paraformaldehyde, with a secondary amine in the complete or almost complete absence of a solvent. An alternative comprises reacting a diaminomethane produced fro... | 05/23/2000 |
| 6048988 | Process for the production of -tocopherol esters A process for the production of -tocopherol esters, derivatives or homologs thereof of the general formula ##STR1## in which the mono- or diester of a hydroquinone is reacted with an allyl alcohol derivative or an allyl alcohol in the presence... | 04/11/2000 |
| 6005122 | Preparation of -tocopherol or -tocopheryl acetate by reacting trimethylhydroquinone and phytol or isophytol, with recycling of the zinc halide condensation catalyst A process for preparing -tocopherol or -tocopheryl acetate by reacting 2,3,5-trimethylhydroquinone with isophytol or phytol in the presence of a zinc halide condensation catalyst and a proton donor in a solvent with or without subsequent est... | 12/21/1999 |
| 5990322 | Alpha-tocopherol cyclopropylates, the new vitamin E derivatives and method for producing the same The present invention relates to novel alpha-tocopherol cyclopropylates, represented by the following formula I: ##STR1## wherein R1, R2, R2', R3 and R3', which may be the same or different, each... | 11/23/1999 |
| 5922889 | Synthesis of isochromans and their derivatives Isochromans and their derivatives have been chemically synthesized. These compounds possess significant phytotoxic activity which may be used as a biodegradable contact herbicide. The synthetic method allows for economic production of these herbicides.... | 07/13/1999 |
| 5917060 | Preparation of chromanyl derivatives A process for the preparation of chromanyl derivatives of the formula I ##STR1## where R1 is hydrogen, C1 -C8 -alkyl, aryl, aralkyl, Si(R4)3, C(.dbd.O)R4 or C1 -C4 -al... | 06/29/1999 |
| 5869704 | Water-dispersible or water-soluble D-tocotrienol compounds and methods for making therefor The invention relates to a water-dispersible or water-soluble compound having the structure I ##STR1## wherein, R1,R2, and R3 are, independently, hydrogen or methyl, and R4 is--(CH2 CH2 | 02/09/1999 |
| 5869703 | Nonionic vitamin E derivatives and a method for the preparation thereof, and polymeric ampliphilic vesicles made therefrom Disclosed herein are nonionic vitamin E or polyethoxylated vitamin E derivatives represented by the following formula (I) and a method for the preparation thereof, and polymeric amphiphilic vesicles made therefrom. ##STR1## wherein, n is an integer f... | 02/09/1999 |
| 5767290 | Preparation of protected amines or alkylated amino acids The present invention relates to a process for preparing protected amines or amino acids. The invention furthermore relates to the use of tocopheryl radicals or radicals derived therefrom as protective groups for amines and amino acids, and to compounds o... | 06/16/1998 |
| 5750564 | Anti-oxidant esters of non-steroidal anti-inflammatory agents Compounds having anti-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresp... | 05/12/1998 |
| 5719180 | Chroman derivatives having vitamin E-like activities Described herein is a chroman derivative represented by the following formula: ##STR1## wherein X represents H, --CH2 OH, --CHO, --COOH, --COOCH3, --CH.dbd.NOH, --CONH2, --COCH3, --CH(OH)CH3, Br,... | 02/17/1998 |
| 5686632 | Method of producing a tocopherol product A process of producing a tocopheryl succinate powder is provided. The process forming a tocopheryl succinate powder into a plastic mass. The plastic mass is then allowed to cool whereupon its sets to a solid state. The solid mass can then be subjected to ... | 11/11/1997 |
