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| Number | Title | Issue Date |
| 7714151 | Aminated isoflavonoid derivatives and uses thereof Aminated isoflavonoid synthesized by aminating the 4-keto group of isoflavanone and isoflavanone ring systems, pharmaceutical compositions containing same and uses thereof as therapeutic agents. ... | 05/11/2010 |
| 7683189 | Process for producing aminobenzopyran compound There is provided a method for producing aminobenzopyran compound, which results in little wastes, has no influence on reactors and necessitates a simple work-up procedure. Concretely, it is a method for producing aminobenzopyran compound of formula (2) | 03/23/2010 |
| 7371874 | 6-Alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor The present invention relates to a noble 6-alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic t... | 05/13/2008 |
| 7368575 | 6-alkylamino-2,2′-disubstituted-7,8-disubstituted-2H-1-benzopyran derivatives as 5-lipoxygenase inhibitor When a multi-step process reaction is carried out in a solution, it generally requires several treatments and purification procedures to go through with after the reaction, however, the inventive method for preparing 2,2′-disubstituted-3,4-dihydro-7,8-disubstitute... | 05/06/2008 |
| 7351738 | Substituted ureas and carbamates The invention provides compounds of formula I: useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer... | 04/01/2008 |
| 7312232 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein w... | 12/25/2007 |
| 7265251 | Process for the preparation of nitroalkenes A process for the nitration of conjugated alkenes of formula (I) wherein R, R1, R2, R3 and R4 have the meanings reported in the description, which allows to obtain the corresponding β-nitro-alkenes, characterised in that the nitrating agent is a mixture of an inorg... | 09/04/2007 |
| 7259271 | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkyl... | 08/21/2007 |
| 7223774 | Benzamide 2-hydroxy-3-diaminoalkanes The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 05/29/2007 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7122573 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate (EGCG), and have the structure of formula (I) | 10/17/2006 |
| 7115657 | Bifunctional agents possessing antioxidant and antiarrhythmic activity The present invention relates to novel bifunctional agents possessing antioxidant and antiarrhytmic activity, methods for the synthesis of the same and their applications in treating ischemia-reperfusion injury, as well as a variety of disorders related to free radi... | 10/03/2006 |
| 7109236 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate (EGCG), and have the structure of formula (I) | 09/19/2006 |
| 7084138 | Active ingredient combinations with insecticidal and acaricidal properties The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the gro... | 08/01/2006 |
| 7053117 | Substituted 4H-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: wherein R1–R5, A, Y and Z are defined herein. The present invention... | 05/30/2006 |
| 6962929 | Pentafluorobenzenesulfonamides and analogs The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states... | 11/08/2005 |
| 6919371 | 2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions. ... | 07/19/2005 |
| 6919090 | Active substance combinations with insecticidal and acaricidal properties The invention relates to novel active combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/19/2005 |
| 6906082 | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines Cholesteryl ster transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels,... | 06/14/2005 |
| 6903227 | Synthesis of 2-acyl substituted chromanes and intermediates thereof Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent pl... | 06/07/2005 |
| 6903218 | Sulfonamide substituted chroman derivatives This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions. ... | 06/07/2005 |
| 6858645 | Tartrate salts of (R) -3-N,N- dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1- benzopyran-5-carboxamide A new salt (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen tartrate, particularly the (2R,3R)-tartrate thereof, most particularly the (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen (2R,... | 02/22/2005 |
| 6855833 | Methods for producing amino substituted chromanes and intermediates thereof Disclosed are processes for producing chromane compounds, preferably chroman-2-yl acetic acid compounds and 6-amino-chroman-2-yl acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregatio... | 02/15/2005 |
| 6809114 | 4-aminobenzopyran derivatives This invention relates to benzopyran derivatives of the formula (I) wherein, R1 and R2 represent each independently a C1-6alkyl group, etc, R3 represents a hydroxyl group, etc, R4 represents a hydrogen atom, etc... | 10/26/2004 |
| 6803129 | Organic light emitting diode and organic luminescent materials thereof The present invention relates to an organic light emitting diode (OLED) device, comprising an anode disposed on a substrate, an organic EL layer disposed on the anode and a cathode disposed on the organic EL layer. The material of the organic EL layer comprises a co... | 10/12/2004 |
| 6800657 | Substituted 5-oxo-5, 6, 7, 8-tetrahydro-4H-1-benzopyrans Disclosed is a method for treating a disorder responsive to the positive modulation of AMPA receptors in animals suffering therefrom, comprising administering to an animal in need thereof a compound of Formula I: or a ph... | 10/05/2004 |
| 6790965 | Combinatorial dihydrobenzopyran library Combinatorial libraries are disclosed which are represented by Formula I: (T′—L)q—Ŝ—C(O)—L′—II′ I wherein: Ŝ is a solid support; T′—L— is an identifier residue; and —L′—II′ is a l... | 09/14/2004 |
| 6756403 | Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platel... | 06/29/2004 |
| 6750346 | Stable near-infrared (NIR) marker dyes based on benzopyrylium-polymethines The disclosure is directed to so-called laser-compatible NIR marker dyes based on polymethines for use in optical, in particular, fluorescence optical determination and detection methods, for example, in the fields of medicine, pharmaceutics and in the areas of life... | 06/15/2004 |
| 6713651 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 03/30/2004 |
| 6706757 | Chroman derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 03/16/2004 |
| 6680332 | Substituted 5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyrans and benzothiopyrans and the use thereof as potentiators of AMPA Disclosed is a method for treating a disorder responsive to the positive modulation of AMPA receptors in animals suffering therefrom, comprising administering to an animal in need thereof a compound of Formula I: ##STR1## or a pharmaceutically acceptable ... | 01/20/2004 |
| 6660871 | Synthesis of 4H-chromene derivatives Substituted 4H-chromene derivatives are a new class of compounds that bind to Bcl-2 protein and induce apoptosis in tumor cells. The present invention is directed to an efficient synthetic method for the preparation of these compounds from salicylaldehyde... | 12/09/2003 |
| 6645997 | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, d... | 11/11/2003 |
| 6613917 | Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity Compounds of the formula ##STR1## where the symbols are as defined in the specification, have retinoid agonist, antagonist or negative hormone-like biological activity.... | 09/02/2003 |
| 6593497 | 댢-adrenergic receptor agonists The present invention is directed to multibinding compounds which are 댢 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the... | 07/15/2003 |
| 6589983 | Benzopyran derivative ##STR1## This invention relates a benzopyran denvative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a (substituted)C1-6 alkyl group or a (substituted)phenyl group,R3 represents... | 07/08/2003 |
| 6586460 | Heteroarotinoids containing urea or thiourea linker Compounds, known as heteroarotinoids, having varying abilities to inhibit growth of certain cancerous cells, induce normal cell differentiation, and induce apoptosis or death of cancerous cells, of the general formula: ##STR1## in which: Ar and Ar' denote... | 07/01/2003 |
| 6573295 | Bicyclic signal transduction inhibitors, compositions containing them & uses thereof This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to ... | 06/03/2003 |
| 6566397 | Acyclic isoprenoid ether derivatives as chemotherapeutics A method of and compositions for suppressing the growth of tumor cells in a patient are disclosed. In one embodiment, the method comprises treating the patient with an effective amount of an isoprenoid ether-linked compound, wherein the isoprenoid ether-l... | 05/20/2003 |
