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| Number | Title | Issue Date |
| 7932405 | Halogenated ester derivatives of coumarins for the treatment of coagulation disorders The subject invention provides anticoagulant compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R3, n and Ar are as defined herein. The compounds of the subject inventio... | 04/26/2011 |
| 7368434 | Compounds useful for the inhibition of ALDH The present invention provides novel antidipsotropic compounds. The invention further provides methods of inhibiting ALDH-2 using the compounds described herein. Methods for modulating alcohol consumption, alcohol dependence and/or alcohol abuse by administering the... | 05/06/2008 |
| 7354945 | 2-oxadiazolechromone derivatives Novel compounds of the formula I in which R, X and n are as defined herein, are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection o... | 04/08/2008 |
| 7141601 | Dendrite elongation inhibitor for melanocyte and skin preparation for external use containing the same The present invention relates to a dendrite elongation inhibitor for melanocytes consisting of a compound represented by the following general formula (1): and/or a salt thereof, | 11/28/2006 |
| 7109211 | Substituted benzopyran derivatives for the treatment of inflammation A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A | 09/19/2006 |
| 7094914 | Process for producing chromone compound A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R1 and R2 are the same or different and each represents lower alkyl and the wavy line indicates t... | 08/22/2006 |
| 7045514 | Therapeutic heterocyclic compounds Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementi... | 05/16/2006 |
| 6924376 | Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 08/02/2005 |
| 6818668 | 5-alkyl-7-alkylcarbonate-isoflavone ester and related method A compound is provided for increasing the concentration of a parent isoflavone in a subject in vivo. The parent isoflavone has a skeletal structure including a 5 position and a 7 position, a 5 alkyl group, and a 7-hydroxy group with a 7-hydroxy oxygen appended to th... | 11/16/2004 |
| 6645997 | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, d... | 11/11/2003 |
| 6630506 | Bicyclic acyl guanidine sodium/proton exchange inhibitors and method Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR1## wherein n is 0 to 4; X is a bond, O, S, SO, SO2, CO, ##STR2## or NR7 ; Y is a bond, O, S, SO, SO2, CO, #... | 10/07/2003 |
| 6566508 | Fluorogenic compounds and uses therefor Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when cleaved by target enzymes. Preferred compounds include sugar... | 05/20/2003 |
| 6552054 | Chromone derivatives, process for the preparation of the same and uses thereof The invention provides chromone derivatives of the following general formula, a process for preparing such chromone derivatives and a prophylactic and therapeutic agent comprising such chromone derivatives for bone diseases and chondropathy: ##STR1##... | 04/22/2003 |
| 6541613 | Isoflavone derivatives Isoflavones are modified by esterification at one or more of the C4', C5, C6, and C7 positions to promote bioavailability, and especially to enhance solubility over the corresponding unesterified isoflavones. Preferred modifications produce a carboxylic a... | 04/01/2003 |
| 6372895 | Fluorogenic compounds Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when cleaved by target enzymes. Preferred compounds include sugar... | 04/16/2002 |
| 6350431 | Compounds This invention provides a physiologically tolerable light imaging contrast agent compound having a molecular weight in the range 500 to 5000000 and containing at least two chromophores having delocalized electron systems as well as at least one polyalkyle... | 02/26/2002 |
| 6331640 | Diaminopropionic acid derivatives A compound of formula 1a ##STR1## which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.... | 12/18/2001 |
| 6291518 | Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof The present invention relates to novel hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the general formulae I, II, III and IV: ##STR1## wherein R1 =R2 =4-hydroxycoumarin; R1 =R | 09/18/2001 |
| 6265423 | Aromatic polycyclic retinoid-type derivatives, method for preparing same, and use thereof for making pharmaceutical and cosmetic compositions Novel aromatic polycyclic retinoid-type derivatives of general formula (I), ##STR1## wherein groupings R3 and R4 attached to the double bond between carbons 11 and 12 are cis groupings, and pharmaceutical and cosmetic compositions co... | 07/24/2001 |
| 6262108 | Medicinal use of cromoglycic acid compounds The cromoglycic acid compound of the formula (I) ##STR1## has an antirheumatic action, an antiinflammatory action and an immunomodulating action. This compound is effective for the inhibition of the symptoms of chronic rheumatoid arthritis and is associat... | 07/17/2001 |
| 6225481 | Robustaflavone, intermediates and analogues and method for preparation thereof Robustaflavone, intermediates and analogues thereof and a method for synthesizing the same are provided. The method involves constructing apigenin ethers containing functionalities at the 6- and 3'-positions which could be cross-coupled using transition m... | 05/01/2001 |
| 6218427 | Chromene-3-carboxylate derivatives The present invention provides a compound of the formula (I): ##STR1## wherein R1, R2, R3 and R4 are each independently hydrogen, optionally substituted alkyl, hydroxy, optionally substituted alkoxy or the like,... | 04/17/2001 |
| 6191289 | Production process and intermediate of tetrazole compound There are disclosed an industrially favorable process for producing a tetrazole compound of general formula (1): ##STR1## characterized in that a nitrile of general formula (2): R1 CN (2) is reacted with hydrazine or a salt thereof in the presence ... | 02/20/2001 |
| 6066642 | Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivative, their preparation and their use as adenosine receptor antagonists The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the present invention. Examples of the present inventive compound... | 05/23/2000 |
| 6051601 | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists This invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds or a pharmaceutically acce... | 04/18/2000 |
| 6004998 | Flavonoid and biflavonoid derivatives, their pharmaceutical compositions, their anxiolytic activity Certain flavonoids, notably derivatives of flavone, chrysin and apigenin, together with dimers thereof such as amentoflavone, have been found to possess anxiolytic properties (i.e., anxiety reducing properties) without exhibiting a sedative effect. Novel ... | 12/21/1999 |
| 5990142 | Benzopyran derivatives having leukotriene-antagonistic action The present invention relates to novel 4-oxo-4H-1-benzopyran compounds containing benzyloxymethyl, 3-phenylpropyl, or other araliphatic substituents in their 8-position. These compounds show a leukotriene-antagonistic activity. The compounds are character... | 11/23/1999 |
| 5919829 | Gastrin and cck receptor ligands Compounds of formula (Ia), (Ib), or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R1.sub.(m) represents up to 6 substituents, K represents --O--, --S--, --CH2 --, --N(R2)-- or --N(C... | 07/06/1999 |
| 5874593 | Production process and intermediate of tetrazole compound There are disclosed an industrially favorable process for producing a tetrazole compound of general formula (1): ##STR1## characterized in that a nitrile of general formula (2): R1 CN (2) is react... | 02/23/1999 |
| 5851792 | Aglucone isoflavone enriched vegetable protein whey whey protein material aglucone isoflavone material high genistein content material and high daidzein content material and process for producing the same from a vegetable protein whey An aglucone isoflavone enriched vegetable protein whey, whey protein material, high genistein material, high daidzein material, and aglucone isoflavone material are provided, as well as a process for producing the same from a vegetable protein whey. Isofl... | 12/22/1998 |
| 5827682 | Two-step conversion of vegetable protein isoflavone conjugates to aglucones Disclosed are methods for converting isoflavone conjugates in vegetable protein materials to isoflavone aglucones by forming an aqueous mixture of a vegetable protein material containing isoflavone conjugates, converting the isoflavone conjugates to isofl... | 10/27/1998 |
| 5756538 | Flavonoid and biflavonoid derivatives, their pharmaceutical compositions, their anxiolytic activity Certain flavonoids, notably derivatives of flavone, chrysin and apigenin, together with dimers thereof such as amentoflavone, have been found to possess anxiolytic properties (i.e., anxiety reducing properties) without exhibiting a sedative effect. Novel ... | 05/26/1998 |
| 5726034 | Aglucone isoflavone enriched vegetable protein extract and protein material, and high genistein and daidzein content materials and process for producing the same An aglucone is isoflavone enriched vegetable protein extract and protein material are provided, as well as a high genistein content material and a high daidzein content material. Isoflavone conjugates in a vegetable material are converted to isoflavone gl... | 03/10/1998 |
| 5672723 | Process for preparation of 1-acyl-2-substituted hydrazines The present invention can provide a process for the preparation of an 1-acyl-2-substituted hydrazine compound from a mixture containing the 1-acyl-2-substituted hydrazine and an 1-acyl-1-substituted hydrazine by selective hydrolysis or alcoholysis of the ... | 09/30/1997 |
| 5659051 | Process of producing 2-cyano-4-oxo-4H-benzopyran compounds There is disclosed a process of producing a 2-cyano-4-oxo-4H-benzopyran compound of the general formula (2): ##STR1## wherein R1 and R2 are independently hydrogen, halogen, hydroxy, C1 -C5 alkyl, C1 | 08/19/1997 |
| 5639783 | Ketone derivatives A novel ketone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell ... | 06/17/1997 |
| 5508451 | Process for the preparation of dialkali metal cromoglycates A process for preparing a dialkali metal cromoglycate which comprises (1) condensing a hydroxy substituted ketone with a condensing agent in the presence of a base material and an organic solvent; (2) subjecting the condensed material to ring-closure cond... | 04/16/1996 |
| 5420307 | 2-amino-4-oxo-4H-benzopyrans, their preparataion and their use as antidotes 2-Amino-4-oxo-4H-benzopyrans I ##STR1## (m=0, 1 or 2; R1 -R4 have the meanings stated in the description) and the salts of I, and herbicides which contain 2-(4-hetaryloxy)- and 2-(4-aryloxy)-phenoxyacetic acid derivatives and/or... | 05/30/1995 |
| 5352690 | 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists This invention provides 1,2,4-trioxygenated benzene derivatives which are leukotriene B4 antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment of conditions characterized by an excessive relea... | 10/04/1994 |
| 5348973 | Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis Hydroxychroman-2-carboxylic acid esters can be resolved by enantiospecific hydrolysis by the use of liver enzymes, particularly solvent treated (acetone) enzymes. Liver enzymes from calf, cat, dog, eel, goat, lungfish, mouse, rat and seal have been found ... | 09/20/1994 |
