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| Number | Title | Issue Date |
| 8088935 | Compounds and methods for the treatment of asthma Compounds and methods for the treatment of asthma are disclosed. The methods involve mast cell stabilization together with selective inhibition of iNOS. The compounds are combinations of a mast cell inhibiting moiety and an inhibitor of iNOS. An example is: | 01/03/2012 |
| 7812183 | Benzopyran derivatives as potassium channel openers The present invention is directed to novel benzopyran derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel. ... | 10/12/2010 |
| 7629477 | Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 12/08/2009 |
| 7598403 | Synthesis of chromanones Processes for the preparation of biologically active chromanones are disclosed, including processes for the preparation of intermediates useful in the preparation of the biologically active chromanones. The chromanones and the intermediates disclosed herein may be u... | 10/06/2009 |
| 7384976 | Nebivolol and its metabolites in combination with nitric oxide donors, compositions and methods of use The invention describes novel compositions comprising nebivolol and/or at least one metabolite of nebivolol and at least one nitric oxide donor, and, optionally, at least one antioxidant or a pharmaceutically acceptable salt thereof, and/or at least one compound use... | 06/10/2008 |
| 7345090 | Galenical formulation The invention relates to compounds of the formula I where R1, R2, R3, R4 and R5 have the meanings given in claim 1. The compound is suitable in particular for use in sk... | 03/18/2008 |
| 7326797 | Manufacture of isoflavones A process for manufacturing a hydroxylated isoflavone of the formula (I) given in the description comprises re-acting an appropriately substituted 2-hydroxydeoxybenzoin of the formula (II), also given in the description, with a formic acid anhydride of the formula H... | 02/05/2008 |
| 7285671 | Materials and methods for treating coagulation disorders The subject invention provides anticoagulant compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R3, n and Ar are as defined herein. The compounds of the subje... | 10/23/2007 |
| 7226644 | Chroman derivative and liquid-crystal composition containing the compound The present invention relates to a liquid crystal compound which has negative dielectric anisotropy and a large absolute value thereof; and a liquid crystal display element which contains the compound as a constituent element and has a negative value of dielectric a... | 06/05/2007 |
| 7138430 | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use The invention describes novel nitrosated and/or nitrosylated nebivolol, novel nitrosated and/or nitrosylated metabolites of nebivolol and novel compositions comprising at least one nitrosated and/or nitrosylated nebivolol and/or at least one nitrosated and/or nitros... | 11/21/2006 |
| 7138429 | Flavonoid compound and process for producing the same A preparation process is provided for preparing a novel flavonoid compound having a high level of antioxidative action. The flavonoid compound is obtained by subjecting hesperidin to microbial fermentation treatment with Aspergillus saitoi. ... | 11/21/2006 |
| 7094914 | Process for producing chromone compound A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R1 and R2 are the same or different and each represents lower alkyl and the wavy line indicates t... | 08/22/2006 |
| 7045514 | Therapeutic heterocyclic compounds Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementi... | 05/16/2006 |
| 7012149 | Process for the production of (−)-epigallocatechin gallate A process is provided for making (−)-epigallocatechin gallate (EGCG) by subjecting a green tea extract to chromatography on a macroporous polar resin, eluting EGCG from the resin with a polar elution solvent, optionally concentrating the eluate, optionally regener... | 03/14/2006 |
| 6949537 | PI-3 kinase inhibitor prodrugs The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine. ... | 09/27/2005 |
| 6936726 | Flavanol and cysteamine conjugates The present invention refers to new products generated by the conjugation of flavanols with molecules that contain the thiol group. New molecules are obtained from polyphenolic plant extracts rich in oligomeric and polymeric procyanidines and prodelfinidins. In this... | 08/30/2005 |
| 6924376 | Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 08/02/2005 |
| 6849746 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphe... | 02/01/2005 |
| 6750248 | Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof Methods for preparing an estrogenic preparation and isolating estrogenic compounds from a plant, such as an Epimedium plant, are provided. Also provided are estrogenic compounds from Epimedium plant that have been isolated and characterized, and methods for their us... | 06/15/2004 |
| 6737439 | Aromatase inhibitors from Broussonetia papyrifera A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of B. papyrifera, or compounds included therein having aromatase inhibition properties, as active cancer chemopreventative and treating agents in mammal... | 05/18/2004 |
| 6677371 | 4-oxybenzopyran derivative This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a C1-6 alkyl group or a phenyl group; R3 represents a hydroxyl group or C | 01/13/2004 |
| 6645997 | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, d... | 11/11/2003 |
| 6620842 | Chalcones Disclosed are novel chalcone derivatives having the formula (I) ##STR1## The compounds possess antiproliferative activity and are useful for the manufacture of a medicament for the treatment or prevention of neoplasms, particularly those located in the ut... | 09/16/2003 |
| 6608089 | Derivatives of flavones, xanthones and coumarins Compounds having the formula (I) Z--OCH2 --C.ident.CCH2 --NRR1 (I) or a pharmaceutically acceptable salt or solvate thereof wherein Z can represent the formula (1A) or (1B). ##STR1## The compounds possess antiproliferative act... | 08/19/2003 |
| 6579903 | Klainetins and their derivatives, method for their preparation and use thereof The invention relates to compounds of formula I ##STR1## and of formula II ##STR2## in which R1, R2, R3, R4, R5, X1, X2, X3, X4, X5 and Y are def... | 06/17/2003 |
| 6566397 | Acyclic isoprenoid ether derivatives as chemotherapeutics A method of and compositions for suppressing the growth of tumor cells in a patient are disclosed. In one embodiment, the method comprises treating the patient with an effective amount of an isoprenoid ether-linked compound, wherein the isoprenoid ether-l... | 05/20/2003 |
| 6531617 | Process for preparing hydroxychomanones and cis-aminochromanols Enantiomerically enriched hydroxychromanones are obtained by the AlCl3 -catalyzed intramolecular Friedel-Crafts acylation of the corresponding 3-phenoxy-2-alkylcarbonyloxy-propionic acid followed by cleavage of the carboxylate in the presence o... | 03/11/2003 |
| 6528664 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionali... | 03/04/2003 |
| 6514633 | Light emitting device material, light emitting device using thereof, and amine compound A light emitting device material comprising a compound represented by the following formula (I): ##STR1## wherein R1, R2 and R3, which may be the same or different, each represents an aryl group, a heterocyclic group or an... | 02/04/2003 |
| 6489365 | Amidine derivatives, the preparation and use thereof as medicaments with Itb4 antagonistic effect Compounds of the formula ##STR1## which is explained more fully in the specification, may be prepared by conventional methods and used therapeutically in conventional galenic preparations.... | 12/03/2002 |
| 6479671 | Process for producing optically active chromene derivative A process for producing a compound of the formula (II): ##STR1## (wherein R1, R2, R3 and R4 are each independently hydrogen, alkyl, alkoxy or the like, R5 is alkyl or alkoxyalkyl, A is O or S, Ar is a... | 11/12/2002 |
| 6462075 | Chalcone and its analogs as agents for the inhibition of angiogensis and related disease states The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The pres... | 10/08/2002 |
| 6436987 | Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl] -4-(trifluoromethyl)-benzoic acid The present invention provides novel polymorphic forms of anhydrous crystalline (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl] -4-(trifluoromethyl)-benzoic acid, hereinafter compound (I), and a novel salt, and a hydrate of ... | 08/20/2002 |
| 6353000 | 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I: ##STR1##... | 03/05/2002 |
| 6346626 | Chromanone and thiochromanone compounds The invention concerns the compounds of formula I ##STR1## wherein R1 and R2 independently are hydrogen, acyl, alkoxycarbonyl or alkyl; either the sulfamoyloxy side chain is bound to the 6 position; R3 is alkyl; alkenyl; alkiny... | 02/12/2002 |
| 6340694 | Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors The diarylbenzopyran derivatives represented by formula I, and the pharmaceutically acceptable salts thereof, are disclosed. The composition comprising the compound of formula I, or a pharmaceutically acceptable salt thereof, shows an excellent selective ... | 01/22/2002 |
| 6288242 | Processes and intermediates for preparing substituted chromanol derivatives The invention relates to processes for preparing a compound of the formula ##STR1## and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R1, R2, and R3 | 09/11/2001 |
| 6239171 | Tocotrienols and tocotrienol-like compounds and methods for their use The present invention relates to novel tocotrienols and tocotrienol-like compounds displaying biological activity. The tocotrienols and tocotrienol-like compounds of this invention may be conveniently obtained from biological sources or by chemical synthe... | 05/29/2001 |
| 6204290 | Tocotrienols and tocotrienol-like compounds and methods for their use The present invention relates to novel tocotrienols and tocotrienol-like compounds displaying biological activity. The tocotrienols and tocotrienol-like compounds of this invention may be conveniently obtained from biological sources or by chemical synthe... | 03/20/2001 |
| 6143770 | Tocotrienols and tocotrienol-like compounds and methods for their use The present invention relates to novel tocotrienols and tocotrienol-like compounds displaying biological activity. The tocotrienols and tocotrienol-like compounds of this invention may be conveniently obtained from biological sources or by chemical synthe... | 11/07/2000 |
